Development Level

Tbio 24 | 11,445

IMPC Phenotype

decreased fasted circulating g... 3 | 65
preweaning lethality, complete... 3 | 979
decreased total body fat amoun... 2 | 207
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
cataract 1 | 92
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased coping response 1 | 8
decreased lean body mass 1 | 135
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
male infertility 1 | 123
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small kidney 1 | 16

Disease

Carcinoma 21 | 11,493
ovarian cancer 17 | 8,520
Breast cancer 15 | 3,578
psoriasis 14 | 6,694
malignant mesothelioma 12 | 3,232
interstitial cystitis 11 | 2,312
non-small cell lung cancer 11 | 2,890
cystic fibrosis 10 | 1,696
esophageal adenocarcinoma 10 | 737
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung cancer 10 | 4,740
osteosarcoma 10 | 7,950
spina bifida 10 | 1,074
medulloblastoma, large-cell 9 | 6,241
Kidney cancer 8 | 2,613
atypical teratoid / rhabdoid tumor 8 | 5,112
ependymoma 8 | 4,679
glioblastoma 8 | 5,792
Arrhythmogenic right ventricular cardiomyopathy 7 | 30
Melanoma 7 | 711
Skin cancer 7 | 469
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung adenocarcinoma 7 | 2,716
primitive neuroectodermal tumor 7 | 3,035
Autosomal recessive predisposition 6 | 1,442
Cancer 6 | 2,499
Pemphigus 6 | 23
group 3 medulloblastoma 6 | 4,104
pancreatic cancer 6 | 2,398
Atopic dermatitis 5 | 952
Bullous pemphigoid 5 | 18
Cardiomyopathy 5 | 116
Cardiomyopathy, right ventricular 5 | 7
Dilated cardiomyopathy 5 | 56
Hypotrichosis 5 | 47
Palmoplantar keratosis 5 | 74
Pick disease 5 | 1,894
Ritter's disease 5 | 10
adult high grade glioma 5 | 3,801
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
oligodendroglioma 5 | 2,850
pituitary cancer 5 | 1,972
Astrocytoma, Pilocytic 4 | 3,081
Dermatitis 4 | 157
Sudden Cardiac Death 4 | 29
breast carcinoma 4 | 1,638
ductal carcinoma in situ 4 | 1,745
group 4 medulloblastoma 4 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
periodontitis 4 | 293
ulcerative colitis 4 | 1,819
Acantholysis 3 | 6
Afro-textured hair 3 | 13
Alopecia 3 | 115
Cardiomyopathy, Dilated 3 | 83
Epidermolysis bullosa 3 | 21
Fragile skin 3 | 18
Kinky hair texture 3 | 13
Liver cancer 3 | 604
Nail Diseases 3 | 24
Nail abnormality 3 | 22
Nappy hair texture 3 | 13
Netherton syndrome 3 | 15
Nikolsky sign 3 | 6
Palpitations 3 | 18
Peeling skin syndrome 3 | 17
Rheumatoid arthritis 3 | 1,191
Syncope 3 | 22
Tachycardia, Ventricular 3 | 22
Ventricular arrhythmia 3 | 27
Wooly hair 3 | 17
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
aldosterone-producing adenoma 3 | 665
astrocytic glioma 3 | 2,597
colon cancer 3 | 1,478
nasopharyngeal carcinoma 3 | 1,058
urothelial carcinoma 3 | 318
Congestive heart failure 2 | 113
Duchenne muscular dystrophy 2 | 601
Failure to gain weight 2 | 365
Heart failure 2 | 162
Multiple Sclerosis 2 | 540
Pediatric failure to thrive 2 | 365
Prostatic Neoplasms 2 | 495
Waldenstrons macroglobulinemia 2 | 765
astrocytoma 2 | 1,146
atypical teratoid/rhabdoid tumor 2 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
cystic fibrosis and chronic rhinosinusitis 2 | 214
hepatocellular carcinoma 2 | 547
limb girdle muscular dystrophy 2A 2 | 213
mucosa-associated lymphoid tissue lymphoma 2 | 484
pediatric high grade glioma 2 | 1,064
posterior fossa group A ependymoma 2 | 468
progressive supranuclear palsy 2 | 676
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010

Tissue

Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Skin and soft tissues 23 | 17,230
Blood and immune system 22 | 16,909
Female tissues 22 | 17,400
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Cardiovascular System 21 | 15,192
Urinary Tract 21 | 16,678
Liver and Pancreas 20 | 16,750
Respiratory system 20 | 16,393

Target Family

Non-IDG 23 | 12,091
Enzyme 1 | 4,145

GO Component

desmosome 24 | 24
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,4-galactosyltransferase 1 B4GALT1 Tbio Enzyme -2.34454 211.1 130
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Plakophilin-3 PKP3 Tbio Non-IDG -1.37372 26.0 200
Plakophilin-1 PKP1 Tbio Non-IDG -1.86062 76.3 103
Trichoplein keratin filament-binding protein TCHP Tbio Non-IDG -2.34455 143.0 113
Kelch-like protein 24 KLHL24 Tbio Non-IDG -1.02438 10.2 69
Desmoplakin DSP Tbio Non-IDG -2.95735 853.9 198
Desmocollin-1 DSC1 Tbio Non-IDG -1.46161 25.1 146
Corneodesmosin CDSN Tbio Non-IDG -3.23661 1709.5 0
Desmoglein-2 DSG2 Tbio Non-IDG -2.03972 117.7 407