Development Level

Tbio 193 | 10,625
Tchem 56 | 1,890
Tclin 47 | 602
Tdark 33 | 7,003

Collection

Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 16 | 633
preweaning lethality, incomple... 12 | 260
abnormal behavior 10 | 226
decreased lean body mass 7 | 195
decreased total body fat amoun... 7 | 186
abnormal bone structure 6 | 131
embryonic lethality prior to t... 6 | 187
hyperactivity 6 | 108
embryonic lethality prior to o... 5 | 148
increased lean body mass 5 | 107
abnormal sleep behavior 4 | 63
decreased fasted circulating g... 4 | 49
decreased startle reflex 4 | 48
increased heart weight 4 | 37
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
increased or absent threshold ... 4 | 128
abnormal gait 3 | 51
abnormal lens morphology 3 | 73
decreased bone mineral content 3 | 157
decreased circulating alanine ... 3 | 53
decreased circulating aspartat... 3 | 27
decreased grip strength 3 | 123
enlarged heart 3 | 111
impaired righting response 3 | 19
increased blood urea nitrogen ... 3 | 44
increased bone mineral content 3 | 92
increased circulating sodium l... 3 | 71
increased grip strength 3 | 83
increased total body fat amoun... 3 | 57
prenatal lethality prior to he... 3 | 64
abnormal QRS complex 2 | 25
abnormal behavioral response t... 2 | 52
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
abnormal retinal blood vessel ... 2 | 18
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
decreased blood urea nitrogen ... 2 | 31
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating chloride... 2 | 32
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased lactate dehydrogenas... 2 | 14
decreased mean corpuscular vol... 2 | 50
decreased total retina thickne... 2 | 20
improved glucose tolerance 2 | 56
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating creatini... 2 | 29
increased circulating iron lev... 2 | 25
increased hemoglobin content 2 | 45
persistence of hyaloid vascula... 2 | 22
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal ear morphology 1 | 5
abnormal eye morphology 1 | 38
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating calcium ... 1 | 33
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased vertical activity 1 | 22
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
increased circulating alanine ... 1 | 11
increased circulating bilirubi... 1 | 16
increased circulating triglyce... 1 | 24
increased coping response 1 | 3
increased mean corpuscular hem... 1 | 25
increased startle reflex 1 | 38
polycystic kidney 1 | 9
prenatal lethality 1 | 16
short tibia 1 | 82
small kidney 1 | 10
stereotypic behavior 1 | 3
straub tail 1 | 26
thin ventricular wall 1 | 5
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
tremors 1 | 34
trunk curl 1 | 15

Disease

medulloblastoma, large-cell 181 | 6,234
glioblastoma 158 | 5,572
ovarian cancer 136 | 8,484
osteosarcoma 133 | 7,933
psoriasis 124 | 6,685
atypical teratoid / rhabdoid tumor 120 | 4,369
pilocytic astrocytoma 120 | 3,086
oligodendroglioma 113 | 2,849
primitive neuroectodermal tumor 97 | 3,031
lung cancer 89 | 4,466
Carcinoma 86 | 2,147
pediatric high grade glioma 84 | 2,712
Breast cancer 74 | 3,094
astrocytic glioma 73 | 2,241
lung carcinoma 73 | 2,844
subependymal giant cell astrocytoma 70 | 2,287
ependymoma 69 | 2,514
invasive ductal carcinoma 65 | 2,950
adult high grade glioma 64 | 2,148
Cancer 62 | 2,346
Pick disease 61 | 1,893
intraductal papillary-mucinous neoplasm (IPMN) 61 | 3,289
malignant mesothelioma 57 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 56 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 55 | 2,988
medulloblastoma 55 | 1,524
pituitary cancer 55 | 1,972
group 3 medulloblastoma 54 | 2,254
non-small cell lung cancer 53 | 2,798
Schizophrenia 52 | 501
lung adenocarcinoma 50 | 2,713
posterior fossa group A ependymoma 50 | 1,511
astrocytoma 49 | 1,493
group 4 medulloblastoma 44 | 1,875
colon cancer 43 | 1,475
interstitial cystitis 43 | 2,299
Alzheimer's disease 42 | 644
Epilepsy 40 | 346
pancreatic cancer 40 | 2,300
atypical teratoid/rhabdoid tumor 38 | 1,095
posterior fossa group B ependymoma 38 | 1,530
ulcerative colitis 38 | 2,087
diabetes mellitus 36 | 1,663
Neurodegenerative disease 35 | 383
ductal carcinoma in situ 35 | 1,745
tuberculosis 34 | 1,557
Intellectual disability 33 | 573
breast carcinoma 33 | 1,614
acute quadriplegic myopathy 31 | 1,157
Parkinson's disease 29 | 364
cystic fibrosis 29 | 1,665
Autistic Disorder 28 | 320
Multiple myeloma 28 | 1,327
sonic hedgehog group medulloblastoma 27 | 1,482
cutaneous lupus erythematosus 26 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
Obesity 25 | 616
adrenocortical carcinoma 25 | 1,427
Bipolar Disorder 23 | 266
active Crohn's disease 23 | 918
juvenile dermatomyositis 23 | 1,189
dermatomyositis 22 | 933
Amyotrophic Lateral Sclerosis 21 | 431
spina bifida 21 | 1,064
Rheumatoid Arthritis 20 | 1,160
primary pancreatic ductal adenocarcinoma 20 | 1,271
Alcohol dependence 19 | 107
Toxic encephalopathy 19 | 131
Atopic dermatitis 18 | 944
Multiple Sclerosis 18 | 498
aldosterone-producing adenoma 18 | 664
Duchenne muscular dystrophy 17 | 602
nasopharyngeal carcinoma 17 | 1,056
Down syndrome 16 | 548
Major Depressive Disorder 16 | 106
progressive supranuclear palsy 16 | 674
Kidney disease 15 | 396
Migraine 15 | 79
Seizures 15 | 95
Waldenstrons macroglobulinemia 15 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
esophageal adenocarcinoma 15 | 737
non primary Sjogren syndrome sicca 15 | 840
Cocaine-Related Disorders 14 | 88
General anesthesia 14 | 53
Hypertension 14 | 287
Hypertensive disease 14 | 193
Melanoma 14 | 261
Pain agnosia 14 | 99
Vascular disease 14 | 281
gastric carcinoma 14 | 832
Attention deficit hyperactivity disorder 13 | 156
Cerebellar Ataxia 13 | 72
Mammary Neoplasms 13 | 410
Endometriosis 12 | 535
Heart disease 12 | 279
Atherosclerosis 11 | 275
Dementia 11 | 129
IGA Glomerulonephritis 11 | 454
Pain 11 | 70

Tissue

Female tissues 326 | 18,647
Digestive Tract 324 | 18,473
Urinary Tract 324 | 18,444
Endocrine System 323 | 18,512
Nervous System 323 | 18,561
Liver and Pancreas 321 | 18,136
Skin and soft tissues 318 | 18,115
Cardiovascular System 317 | 17,958
Blood and immune system 313 | 17,995
Male tissues 313 | 17,969
Respiratory system 310 | 17,484

Target Family

Non-IDG 172 | 11,971
Enzyme 40 | 4,146
Ion Channel 37 | 341
GPCR 26 | 406
Kinase 25 | 634
oGPCR 12 | 421
Transcription Factor 6 | 1,400
Transporter 5 | 473
Epigenetic 4 | 242
Nuclear Receptor 2 | 48

GO Component

dendrite 329 | 329
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788