Development Level

Tbio 220 | 11,651
Tchem 45 | 1,388
Tclin 44 | 612
Tdark 21 | 6,593

Collection

Ion Channel: IDG Consortium (T... 8 | 99
RFA-RM-18-021 8 | 328
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 22 | 979
abnormal behavior 15 | 298
preweaning lethality, incomple... 13 | 499
decreased total body fat amoun... 11 | 207
hyperactivity 10 | 148
increased bone mineral content 9 | 108
decreased startle reflex 7 | 75
embryonic lethality prior to t... 7 | 278
increased circulating triglyce... 7 | 42
increased lean body mass 7 | 172
decreased vertical activity 6 | 208
embryonic lethality prior to o... 6 | 239
increased heart weight 6 | 62
increased or absent threshold ... 6 | 101
abnormal bone structure 5 | 187
abnormal gait 5 | 69
enlarged heart 5 | 210
cataract 4 | 92
decreased circulating alanine ... 4 | 47
decreased circulating aspartat... 4 | 34
decreased circulating triglyce... 4 | 79
decreased grip strength 4 | 116
decreased neutrophil cell numb... 4 | 42
impaired righting response 4 | 26
increased mean corpuscular vol... 4 | 92
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
abnormal behavioral response t... 3 | 66
abnormal locomotor behavior 3 | 24
abnormal retina morphology 3 | 71
abnormal sleep behavior 3 | 70
decreased bone mineral content 3 | 151
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
decreased fasted circulating g... 3 | 65
decreased lean body mass 3 | 135
decreased mean corpuscular vol... 3 | 79
hypoactivity 3 | 132
increased bone mineral density 3 | 72
increased circulating chloride... 3 | 41
increased lymphocyte cell numb... 3 | 32
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
small superior vagus ganglion 3 | 74
thin ventricular wall 3 | 24
abnormal coat appearance 2 | 31
abnormal cornea morphology 2 | 31
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating fructosa... 2 | 30
decreased heart left ventricle... 2 | 28
decreased lactate dehydrogenas... 2 | 16
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased red blood cell distr... 2 | 41
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating LDL chol... 2 | 13
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased grip strength 2 | 41
increased mean corpuscular hem... 2 | 96
increased prepulse inhibition 2 | 32
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
increased vertical activity 2 | 24
pallor 2 | 34
abnormal ear morphology 1 | 9
abnormal hair growth 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
absent spleen 1 | 3
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased mean corpuscular hem... 1 | 31
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased cardiac muscle contr... 1 | 8
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
tremors 1 | 39

Disease

Carcinoma 239 | 11,493
medulloblastoma, large-cell 182 | 6,241
glioblastoma 172 | 5,792
atypical teratoid / rhabdoid tumor 154 | 5,112
osteosarcoma 144 | 7,950
ovarian cancer 144 | 8,520
ependymoma 141 | 4,679
psoriasis 130 | 6,694
adult high grade glioma 125 | 3,801
group 3 medulloblastoma 121 | 4,104
Astrocytoma, Pilocytic 116 | 3,081
oligodendroglioma 115 | 2,850
Kidney cancer 111 | 2,613
lung cancer 109 | 4,740
astrocytic glioma 91 | 2,597
primitive neuroectodermal tumor 90 | 3,035
Schizophrenia 88 | 1,160
Breast cancer 86 | 3,578
lung carcinoma 77 | 2,843
Cancer 72 | 2,499
subependymal giant cell astrocytoma 70 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,291
invasive ductal carcinoma 65 | 2,951
Pick disease 63 | 1,894
non-small cell lung cancer 63 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 60 | 2,989
malignant mesothelioma 60 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 59 | 2,955
pituitary cancer 58 | 1,972
Bipolar Disorder 54 | 666
lung adenocarcinoma 54 | 2,716
Epilepsy 48 | 792
group 4 medulloblastoma 47 | 1,855
Intellectual disability 46 | 1,016
colon cancer 45 | 1,478
Alzheimer's disease 44 | 658
pancreatic cancer 43 | 2,398
interstitial cystitis 42 | 2,312
tuberculosis 41 | 2,010
Autosomal recessive predisposition 39 | 1,442
Depressive disorder 38 | 409
Neurodegenerative disease 37 | 414
Liver cancer 35 | 604
diabetes mellitus 35 | 1,728
Melanoma 34 | 711
Alcoholic Intoxication, Chronic 33 | 289
Seizures 33 | 596
astrocytoma 33 | 1,146
ductal carcinoma in situ 33 | 1,745
Mental Depression 32 | 333
acute quadriplegic myopathy 32 | 1,158
breast carcinoma 32 | 1,638
cystic fibrosis 32 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
ulcerative colitis 30 | 1,819
pediatric high grade glioma 28 | 1,064
Multiple myeloma 27 | 1,332
Parkinson's disease 27 | 392
Skin cancer 26 | 469
cutaneous lupus erythematosus 26 | 1,057
juvenile dermatomyositis 26 | 1,187
Major Depressive Disorder 25 | 301
Mood Disorders 25 | 184
adrenocortical carcinoma 25 | 1,428
spina bifida 25 | 1,074
Dull intelligence 24 | 645
Low intelligence 24 | 645
Mental Retardation 24 | 645
Mental deficiency 24 | 645
Poor school performance 24 | 645
Toxic encephalopathy 24 | 141
Autistic Disorder 23 | 364
active Crohn's disease 23 | 922
Rheumatoid arthritis 22 | 1,191
Amyotrophic lateral sclerosis 21 | 451
Multiple Sclerosis 21 | 540
dermatomyositis 21 | 966
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Kidney disease 20 | 430
Mental and motor retardation 20 | 608
Unipolar Depression 20 | 250
Hypertension 19 | 396
Hypertensive disease 19 | 292
aldosterone-producing adenoma 19 | 665
Atopic dermatitis 18 | 952
Down syndrome 18 | 499
nasopharyngeal carcinoma 18 | 1,058
primary pancreatic ductal adenocarcinoma 18 | 1,109
Obesity 17 | 678
Cerebellar Ataxia 16 | 304
Dementia 16 | 175
Muscle hypotonia 16 | 571
esophageal adenocarcinoma 16 | 737
medulloblastoma 16 | 720
progressive supranuclear palsy 16 | 676
Attention deficit hyperactivity disorder 15 | 278
Short stature 15 | 531
Vascular disease 15 | 319
Waldenstrons macroglobulinemia 15 | 765

Tissue

Endocrine System 325 | 18,159
Nervous System 323 | 16,725
Male tissues 317 | 17,142
Digestive Tract 316 | 17,369
Female tissues 315 | 17,400
Skin and soft tissues 314 | 17,230
Liver and Pancreas 309 | 16,750
Urinary Tract 303 | 16,678
Blood and immune system 302 | 16,909
Respiratory system 296 | 16,393
Cardiovascular System 280 | 15,192

Target Family

Non-IDG 193 | 12,091
Enzyme 38 | 4,145
Ion Channel 33 | 344
Kinase 29 | 634
GPCR 20 | 408
Transcription Factor 6 | 1,400
Transporter 5 | 473
Epigenetic 4 | 242
Nuclear Receptor 2 | 48

GO Component

dendrite 330 | 330
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Contactin-associated protein-like 4 CNTNAP4 Tbio Non-IDG -0.73408 0.00000 148
Protein TANC1 TANC1 Tdark Non-IDG -1.18264 15.5 31
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Palmitoyltransferase ZDHHC5 ZDHHC5 Tbio Enzyme -0.94454 9.00 61
Metabotropic glutamate receptor 2 GRM2 Tchem GPCR -2.77035 612.3 315
Neurotrypsin PRSS12 Tbio Non-IDG -1.46986 30.6 77
Myotubularin-related protein 2 MTMR2 Tbio Enzyme -1.64906 46.5 124
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 GNB3 Tbio Non-IDG -2.34836 235.8 161