Development Level

Tbio 3,605 | 11,651
Tchem 585 | 1,388
Tdark 501 | 6,593
Tclin 143 | 612

Collection

Kinase: IDG Consortium (Target... 47 | 125
Kinase: IDG Consortium (Comple... 19 | 37
GPCR: IDG Consortium (Targets) 5 | 126
Ion Channel: IDG Consortium (T... 5 | 99

IMPC Phenotype

preweaning lethality, complete... 390 | 979
preweaning lethality, incomple... 169 | 499
embryonic lethality prior to t... 107 | 278
embryonic lethality prior to o... 100 | 239
abnormal behavior 90 | 298
abnormal embryo size 85 | 220
decreased body weight 69 | 161
decreased total body fat amoun... 69 | 207
abnormal bone structure 57 | 187
increased lean body mass 54 | 172
decreased bone mineral content 47 | 151
hyperactivity 46 | 148
embryonic growth retardation 43 | 106
enlarged heart 43 | 210
decreased circulating choleste... 42 | 93
decreased bone mineral density 41 | 126
increased startle reflex 41 | 112
decreased vertical activity 39 | 208
increased mean corpuscular hem... 39 | 96
decreased lean body mass 37 | 135
hypoactivity 37 | 132
abnormal heart morphology 36 | 162
increased circulating alkaline... 36 | 122
male infertility 36 | 123
prenatal lethality prior to he... 36 | 87
decreased circulating glucose ... 34 | 126
increased mean corpuscular vol... 34 | 92
increased or absent threshold ... 34 | 101
increased total body fat amoun... 34 | 134
cataract 32 | 92
decreased grip strength 32 | 116
abnormal lens morphology 31 | 81
decreased mean corpuscular vol... 31 | 79
decreased circulating triglyce... 30 | 79
decreased lymphocyte cell numb... 30 | 83
decreased body length 28 | 101
decreased circulating HDL chol... 28 | 68
increased bone mineral density 28 | 72
abnormal gait 27 | 69
increased heart weight 27 | 62
thrombocytopenia 27 | 56
decreased leukocyte cell numbe... 26 | 73
impaired glucose tolerance 26 | 75
increased bone mineral content 26 | 108
abnormal retina morphology 25 | 71
decreased circulating insulin ... 25 | 76
decreased prepulse inhibition 25 | 82
edema 25 | 59
decreased circulating serum al... 24 | 82
abnormal seminal vesicle morph... 23 | 114
decreased hemoglobin content 23 | 68
increased fasted circulating g... 23 | 76
decreased erythrocyte cell num... 22 | 62
improved glucose tolerance 22 | 79
short tibia 22 | 97
abnormal sleep behavior 21 | 70
decreased fasted circulating g... 21 | 65
decreased startle reflex 21 | 75
increased circulating HDL chol... 21 | 80
decreased caudal vertebrae num... 20 | 53
decreased circulating LDL chol... 20 | 38
increased blood urea nitrogen ... 20 | 48
increased monocyte cell number 20 | 63
small superior vagus ganglion 20 | 74
decreased circulating alanine ... 19 | 47
decreased mean corpuscular hem... 19 | 50
decreased neutrophil cell numb... 19 | 42
small testis 19 | 58
decreased circulating iron lev... 18 | 32
increased circulating chloride... 18 | 41
increased grip strength 18 | 41
increased mean platelet volume 18 | 45
abnormal craniofacial morpholo... 17 | 33
abnormal eye morphology 17 | 68
hydrometra 17 | 53
increased hemoglobin content 17 | 45
increased neutrophil cell numb... 17 | 46
decreased hematocrit 16 | 46
enlarged lymph nodes 16 | 37
increased hematocrit 16 | 46
abnormal behavioral response t... 15 | 66
abnormal bone mineralization 15 | 38
abnormal coat-hair pigmentatio... 15 | 64
abnormal cranium morphology 15 | 36
anophthalmia 15 | 33
decreased blood urea nitrogen ... 15 | 51
decreased circulating creatini... 15 | 39
decreased mean corpuscular hem... 15 | 31
female infertility 15 | 60
increased circulating choleste... 15 | 66
increased circulating sodium l... 15 | 71
decreased circulating aspartat... 14 | 34
decreased circulating fructosa... 14 | 30
decreased heart left ventricle... 14 | 28
decreased red blood cell distr... 14 | 41
microphthalmia 14 | 26
tremors 14 | 39
abnormal kidney morphology 13 | 65
abnormal skin morphology 13 | 50
pallor 13 | 34

Disease

Carcinoma 3,096 | 11,493
ovarian cancer 2,724 | 8,520
osteosarcoma 2,327 | 7,950
psoriasis 1,970 | 6,694
medulloblastoma, large-cell 1,871 | 6,241
glioblastoma 1,761 | 5,792
lung cancer 1,606 | 4,740
atypical teratoid / rhabdoid tumor 1,501 | 5,112
ependymoma 1,306 | 4,679
group 3 medulloblastoma 1,211 | 4,104
adult high grade glioma 1,129 | 3,801
Breast cancer 1,092 | 3,578
malignant mesothelioma 1,019 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,002 | 3,291
Cancer 957 | 2,499
primitive neuroectodermal tumor 914 | 3,035
invasive ductal carcinoma 906 | 2,951
non-small cell lung cancer 882 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 881 | 2,989
oligodendroglioma 867 | 2,850
Astrocytoma, Pilocytic 853 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 848 | 2,955
astrocytic glioma 790 | 2,597
Kidney cancer 788 | 2,613
lung adenocarcinoma 778 | 2,716
subependymal giant cell astrocytoma 755 | 2,287
lung carcinoma 750 | 2,843
pancreatic cancer 729 | 2,398
Pick disease 612 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 609 | 1,962
tuberculosis 592 | 2,010
interstitial cystitis 575 | 2,312
Multiple myeloma 572 | 1,332
group 4 medulloblastoma 560 | 1,855
diabetes mellitus 555 | 1,728
breast carcinoma 521 | 1,638
ductal carcinoma in situ 518 | 1,745
ulcerative colitis 506 | 1,819
pituitary cancer 495 | 1,972
Autosomal recessive predisposition 490 | 1,442
colon cancer 486 | 1,478
cystic fibrosis 453 | 1,696
acute quadriplegic myopathy 452 | 1,158
adrenocortical carcinoma 446 | 1,428
astrocytoma 418 | 1,146
juvenile dermatomyositis 416 | 1,187
Intellectual disability 403 | 1,016
dermatomyositis 400 | 966
Rheumatoid arthritis 396 | 1,191
Schizophrenia 386 | 1,160
Waldenstrons macroglobulinemia 359 | 765
spina bifida 356 | 1,074
primary pancreatic ductal adenocarcinoma 337 | 1,109
Atopic dermatitis 319 | 952
cutaneous lupus erythematosus 318 | 1,057
pediatric high grade glioma 308 | 1,064
nasopharyngeal carcinoma 307 | 1,058
acute myeloid leukemia 276 | 783
Epilepsy 269 | 792
esophageal adenocarcinoma 269 | 737
non primary Sjogren syndrome sicca 262 | 891
Cognitive delay 257 | 608
Global developmental delay 257 | 608
Mental and motor retardation 257 | 608
active Crohn's disease 257 | 922
Liver Cirrhosis, Experimental 252 | 769
Dull intelligence 248 | 645
Low intelligence 248 | 645
Mental Retardation 248 | 645
Mental deficiency 248 | 645
Poor school performance 248 | 645
primary Sjogren syndrome 241 | 735
Seizures 231 | 596
gastric carcinoma 225 | 807
Bipolar Disorder 215 | 666
active ulcerative colitis 213 | 764
Alzheimer's disease 212 | 658
Short stature 211 | 531
aldosterone-producing adenoma 208 | 665
medulloblastoma 202 | 720
Muscle hypotonia 201 | 571
Obesity 201 | 678
progressive supranuclear palsy 198 | 676
Amyotrophic lateral sclerosis 193 | 451
Prostatic Neoplasms 186 | 495
hepatocellular carcinoma 186 | 547
Neurodegenerative disease 182 | 414
Breast Neoplasms 178 | 445
Melanoma 178 | 711
pancreatic carcinoma 177 | 562
Endometriosis 175 | 540
Duchenne muscular dystrophy 170 | 601
Mammary Neoplasms 167 | 425
autosomal dominant Emery-Dreifuss muscular dystrophy 163 | 510
Down syndrome 162 | 499
tuberculosis and treatment for 6 months 157 | 409
Small head 155 | 374
Liver cancer 150 | 604
Parkinson's disease 149 | 392
gastric cancer 146 | 459

Tissue

Endocrine System 4,705 | 18,159
Female tissues 4,678 | 17,400
Skin and soft tissues 4,678 | 17,230
Digestive Tract 4,672 | 17,369
Blood and immune system 4,626 | 16,909
Male tissues 4,626 | 17,142
Liver and Pancreas 4,604 | 16,750
Urinary Tract 4,595 | 16,678
Nervous System 4,579 | 16,725
Respiratory system 4,549 | 16,393
Cardiovascular System 4,429 | 15,192

Target Family

Non-IDG 2,758 | 12,091
Enzyme 1,404 | 4,145
Kinase 354 | 634
Transcription Factor 189 | 1,400
Epigenetic 59 | 242
Transporter 20 | 473
Ion Channel 19 | 344
GPCR 12 | 408
Nuclear Receptor 9 | 48
TF/Epigenetic 9 | 38
oGPCR 1 | 421

GO Component

cytosol 4,834 | 4,834
nucleus 5,097 | 5,097
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35