Development Level

Tbio 2,298 | 10,625
Tchem 628 | 1,890
Tdark 224 | 7,003
Tclin 115 | 602

Collection

Eligible Kinase Proteins 40 | 134
Eligible Ion Channel Proteins 4 | 117

IMPC Term

preweaning lethality, complete... 175 | 633
embryonic lethality prior to t... 59 | 187
abnormal behavior 57 | 226
preweaning lethality, incomple... 57 | 260
decreased lean body mass 53 | 195
embryonic lethality prior to o... 52 | 148
decreased body weight 46 | 174
decreased bone mineral content 44 | 157
decreased total body fat amoun... 42 | 186
abnormal embryo size 37 | 112
decreased bone mineral density 32 | 126
increased circulating alkaline... 31 | 119
decreased circulating choleste... 29 | 85
abnormal bone structure 27 | 131
decreased circulating glucose ... 27 | 121
increased or absent threshold ... 27 | 128
abnormal retina morphology 26 | 100
hyperactivity 26 | 108
increased mean corpuscular hem... 26 | 93
decreased circulating HDL chol... 25 | 77
decreased grip strength 25 | 123
decreased body length 23 | 108
decreased circulating triglyce... 23 | 83
increased grip strength 21 | 83
abnormal lens morphology 20 | 73
abnormal retinal pigmentation 19 | 61
increased mean corpuscular vol... 19 | 91
decreased mean corpuscular vol... 18 | 50
hypoactivity 18 | 89
increased lean body mass 18 | 107
decreased circulating serum al... 17 | 79
decreased startle reflex 17 | 48
increased bone mineral density 17 | 52
abnormal bone mineralization 16 | 55
decreased circulating alanine ... 16 | 53
decreased fasted circulating g... 16 | 49
decreased hemoglobin content 16 | 53
decreased circulating LDL chol... 15 | 37
decreased circulating insulin ... 15 | 75
enlarged heart 15 | 111
prenatal lethality prior to he... 15 | 64
abnormal coat/hair pigmentatio... 14 | 54
decreased caudal vertebrae num... 14 | 49
decreased erythrocyte cell num... 14 | 43
decreased lumbar vertebrae num... 14 | 62
decreased rib number 14 | 59
impaired glucose tolerance 14 | 52
increased blood urea nitrogen ... 14 | 44
increased body weight 14 | 42
increased bone mineral content 14 | 92
increased circulating HDL chol... 14 | 63
increased fasted circulating g... 14 | 68
increased heart weight 14 | 37
increased sacral vertebrae num... 14 | 62
decreased circulating iron lev... 13 | 25
increased circulating sodium l... 13 | 71
decreased T cell number 12 | 31
decreased circulating fructosa... 12 | 31
decreased mean corpuscular hem... 12 | 34
decreased prepulse inhibition 12 | 52
enlarged lymph nodes 12 | 27
increased circulating chloride... 12 | 43
increased circulating choleste... 12 | 53
male infertility 12 | 62
short tibia 12 | 82
thrombocytopenia 12 | 46
abnormal gait 11 | 51
abnormal neural tube closure 11 | 37
improved glucose tolerance 11 | 56
increased leukocyte cell numbe... 11 | 37
abnormal sleep behavior 10 | 63
decreased circulating free fat... 10 | 39
decreased neutrophil cell numb... 10 | 37
increased exploration in new e... 10 | 56
increased rib number 10 | 41
limb grasping 10 | 35
abnormal behavioral response t... 9 | 52
abnormal hindbrain development 9 | 24
abnormal midbrain development 9 | 22
decreased circulating alkaline... 9 | 41
decreased circulating aspartat... 9 | 27
decreased hematocrit 9 | 25
decreased leukocyte cell numbe... 9 | 54
decreased threshold for audito... 9 | 32
embryonic growth retardation 9 | 28
increased circulating iron lev... 9 | 25
increased hematocrit 9 | 36
increased hemoglobin content 9 | 45
increased startle reflex 9 | 38
abnormal cranium morphology 8 | 32
abnormal rib morphology 8 | 28
abnormal spleen morphology 8 | 36
abnormal testis morphology 8 | 30
anophthalmia 8 | 20
decreased circulating calcium ... 8 | 33
decreased circulating creatini... 8 | 31
decreased heart weight 8 | 44
increased mean platelet volume 8 | 19
increased total body fat amoun... 8 | 57
small testis 8 | 37

Disease

ovarian cancer 1,879 | 8,484
osteosarcoma 1,593 | 7,933
psoriasis 1,378 | 6,685
medulloblastoma, large-cell 1,315 | 6,234
glioblastoma 1,227 | 5,572
lung cancer 1,108 | 4,466
atypical teratoid / rhabdoid tumor 902 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 730 | 3,289
malignant mesothelioma 700 | 3,162
Cancer 699 | 2,346
Breast cancer 678 | 3,094
primitive neuroectodermal tumor 659 | 3,031
invasive ductal carcinoma 658 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 642 | 2,988
oligodendroglioma 635 | 2,849
non-small cell lung cancer 630 | 2,798
pilocytic astrocytoma 623 | 3,086
pediatric high grade glioma 599 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 597 | 2,956
lung adenocarcinoma 580 | 2,713
lung carcinoma 549 | 2,844
subependymal giant cell astrocytoma 529 | 2,287
ependymoma 525 | 2,514
pancreatic cancer 512 | 2,300
astrocytic glioma 478 | 2,241
group 3 medulloblastoma 454 | 2,254
ulcerative colitis 447 | 2,087
Multiple myeloma 434 | 1,327
Pick disease 433 | 1,893
Carcinoma 414 | 2,147
adult high grade glioma 413 | 2,148
interstitial cystitis 413 | 2,299
group 4 medulloblastoma 400 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 398 | 1,795
astrocytoma 391 | 1,493
ductal carcinoma in situ 380 | 1,745
breast carcinoma 379 | 1,614
colon cancer 368 | 1,475
diabetes mellitus 368 | 1,663
tuberculosis 352 | 1,557
pituitary cancer 341 | 1,972
medulloblastoma 337 | 1,524
acute quadriplegic myopathy 336 | 1,157
adrenocortical carcinoma 321 | 1,427
sonic hedgehog group medulloblastoma 315 | 1,482
posterior fossa group A ependymoma 307 | 1,511
cystic fibrosis 300 | 1,665
juvenile dermatomyositis 293 | 1,189
Waldenstrons macroglobulinemia 292 | 765
dermatomyositis 291 | 933
Rheumatoid Arthritis 270 | 1,160
primary pancreatic ductal adenocarcinoma 267 | 1,271
posterior fossa group B ependymoma 248 | 1,530
atypical teratoid/rhabdoid tumor 236 | 1,095
cutaneous lupus erythematosus 226 | 1,056
spina bifida 218 | 1,064
Atopic dermatitis 212 | 944
nasopharyngeal carcinoma 207 | 1,056
active Crohn's disease 195 | 918
acute myeloid leukemia 189 | 780
primary Sjogren syndrome 187 | 789
esophageal adenocarcinoma 186 | 737
Intellectual disability 171 | 573
Alzheimer's disease 167 | 644
gastric carcinoma 165 | 832
non primary Sjogren syndrome sicca 164 | 840
Obesity 160 | 616
tuberculosis and treatment for 6 months 159 | 686
Amyotrophic Lateral Sclerosis 140 | 431
aldosterone-producing adenoma 140 | 664
pancreatic carcinoma 136 | 567
IGA Glomerulonephritis 133 | 454
Prostatic Neoplasms 133 | 471
Neurodegenerative disease 132 | 383
hepatocellular carcinoma 130 | 532
Duchenne muscular dystrophy 129 | 602
progressive supranuclear palsy 128 | 674
Endometriosis 124 | 535
Down syndrome 121 | 548
Mammary Neoplasms 118 | 410
Schizophrenia 116 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 116 | 499
Parkinson's disease 114 | 364
hereditary spastic paraplegia 104 | 313
Stomach Neoplasms 102 | 282
gastric cancer 102 | 430
mucosa-associated lymphoid tissue lymphoma 102 | 480
fibroadenoma 98 | 557
Liver carcinoma 94 | 217
Vascular disease 94 | 281
inflammatory breast cancer 94 | 404
Multiple Sclerosis 92 | 498
non-small cell lung carcinoma 90 | 413
Polycystic Ovary Syndrome 87 | 332
chronic rhinosinusitis 87 | 512
tuberculosis and treatment for 3 months 85 | 327
Kidney disease 83 | 396
active ulcerative colitis 82 | 477
sarcoidosis 78 | 358
Autistic Disorder 76 | 320

Tissue

Nervous System 3,245 | 18,561
Female tissues 3,243 | 18,647
Digestive Tract 3,242 | 18,473
Male tissues 3,238 | 17,969
Blood and immune system 3,237 | 17,995
Urinary Tract 3,237 | 18,444
Endocrine System 3,235 | 18,512
Liver and Pancreas 3,235 | 18,136
Cardiovascular System 3,231 | 17,958
Skin and soft tissues 3,215 | 18,115
Respiratory system 3,212 | 17,484

Target Family

Non-IDG 1,723 | 11,971
Enzyme 1,102 | 4,146
Kinase 303 | 634
Transcription Factor 77 | 1,400
Epigenetic 27 | 242
Ion Channel 14 | 341
Transporter 10 | 473
Nuclear Receptor 4 | 48
GPCR 3 | 406
TF/Epigenetic 2 | 38

GO Component

cytosol 3,265 | 3,265
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729