Development Level

Tbio 165 | 11,651
Tchem 23 | 1,388
Tdark 18 | 6,593
Tclin 11 | 612

Collection

GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 8 | 499
abnormal embryo size 7 | 220
decreased body weight 6 | 161
decreased grip strength 5 | 116
decreased prepulse inhibition 5 | 82
decreased startle reflex 5 | 75
embryonic lethality prior to o... 5 | 239
decreased circulating glucose ... 4 | 126
embryonic lethality prior to t... 4 | 278
increased startle reflex 4 | 112
abnormal seminal vesicle morph... 3 | 114
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased mean corpuscular hem... 3 | 96
increased or absent threshold ... 3 | 101
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal retina morphology 2 | 71
abnormal whole-body plethysmog... 2 | 4
anophthalmia 2 | 33
decreased bone mineral content 2 | 151
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 32
prenatal lethality prior to he... 2 | 87
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal ear morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal head shape 1 | 10
abnormal hindbrain development 1 | 16
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tail movements 1 | 12
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
cyanosis 1 | 7
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
dilated heart left ventricle 1 | 11
edema 1 | 59
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
trunk curl 1 | 16

Disease

Carcinoma 146 | 11,493
ovarian cancer 112 | 8,520
osteosarcoma 111 | 7,950
medulloblastoma, large-cell 86 | 6,241
atypical teratoid / rhabdoid tumor 85 | 5,112
psoriasis 84 | 6,694
ependymoma 81 | 4,679
glioblastoma 78 | 5,792
lung cancer 67 | 4,740
Astrocytoma, Pilocytic 58 | 3,081
invasive ductal carcinoma 57 | 2,951
adult high grade glioma 55 | 3,801
malignant mesothelioma 55 | 3,232
Breast cancer 52 | 3,578
lung adenocarcinoma 48 | 2,716
Cancer 47 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 47 | 2,989
lung carcinoma 47 | 2,843
non-small cell lung cancer 46 | 2,890
astrocytic glioma 45 | 2,597
group 3 medulloblastoma 45 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,955
interstitial cystitis 41 | 2,312
oligodendroglioma 41 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
Kidney cancer 39 | 2,613
pancreatic cancer 36 | 2,398
primitive neuroectodermal tumor 36 | 3,035
subependymal giant cell astrocytoma 36 | 2,287
ductal carcinoma in situ 35 | 1,745
tuberculosis 35 | 2,010
ulcerative colitis 32 | 1,819
Autosomal recessive predisposition 29 | 1,442
Schizophrenia 28 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
Pick disease 26 | 1,894
breast carcinoma 26 | 1,638
spina bifida 26 | 1,074
cystic fibrosis 24 | 1,696
pituitary cancer 24 | 1,972
colon cancer 23 | 1,478
diabetes mellitus 23 | 1,728
Neurodegenerative disease 22 | 414
gastric carcinoma 21 | 807
group 4 medulloblastoma 21 | 1,855
dermatomyositis 20 | 966
juvenile dermatomyositis 20 | 1,187
pediatric high grade glioma 20 | 1,064
primary pancreatic ductal adenocarcinoma 20 | 1,109
Alzheimer's disease 19 | 658
Intellectual disability 19 | 1,016
Multiple myeloma 19 | 1,332
astrocytoma 19 | 1,146
Amyotrophic lateral sclerosis 18 | 451
cutaneous lupus erythematosus 18 | 1,057
nasopharyngeal carcinoma 18 | 1,058
Bipolar Disorder 17 | 666
Liver Cirrhosis, Experimental 17 | 769
Rheumatoid arthritis 17 | 1,191
Epilepsy 16 | 792
Seizures 16 | 596
Waldenstrons macroglobulinemia 16 | 765
acute quadriplegic myopathy 16 | 1,158
adrenocortical carcinoma 16 | 1,428
Depressive disorder 15 | 409
Down syndrome 14 | 499
esophageal adenocarcinoma 14 | 737
Atopic dermatitis 13 | 952
non primary Sjogren syndrome sicca 13 | 891
primary Sjogren syndrome 13 | 735
Breast Neoplasms 12 | 445
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mammary Neoplasms 12 | 425
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Nerve Degeneration 12 | 121
Poor school performance 12 | 645
aldosterone-producing adenoma 12 | 665
mucosa-associated lymphoid tissue lymphoma 12 | 484
Liver cancer 11 | 604
Multiple Sclerosis 11 | 540
Nystagmus 11 | 317
Parkinson's disease 11 | 392
active Crohn's disease 11 | 922
fibroadenoma 11 | 559
sonic hedgehog group medulloblastoma 11 | 467
urothelial carcinoma 11 | 318
Fatigue 10 | 182
Hypertension 10 | 396
Mental Depression 10 | 333
Neuropathy 10 | 261
Obesity 10 | 678
Short stature 10 | 531
hepatocellular carcinoma 10 | 547
Cognitive delay 9 | 608
Duchenne muscular dystrophy 9 | 601
Glaucoma 9 | 239
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608

Tissue

Endocrine System 215 | 18,159
Female tissues 215 | 17,400
Digestive Tract 214 | 17,369
Skin and soft tissues 213 | 17,230
Blood and immune system 212 | 16,909
Liver and Pancreas 212 | 16,750
Nervous System 211 | 16,725
Urinary Tract 210 | 16,678
Male tissues 209 | 17,142
Respiratory system 206 | 16,393
Cardiovascular System 199 | 15,192

Target Family

Non-IDG 144 | 12,091
Enzyme 41 | 4,145
Kinase 12 | 634
Transporter 8 | 473
GPCR 6 | 408
Ion Channel 6 | 344

GO Component

cytoplasmic vesicle 217 | 217
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Protein wntless homolog WLS Tbio Non-IDG -2.50699 316.3 71
Desmocollin-2 DSC2 Tbio Non-IDG -1.89689 79.7 173
Neurotrypsin PRSS12 Tbio Non-IDG -1.46986 30.6 77
Sorting nexin-9 SNX9 Tbio Non-IDG -2.00279 102.8 241
Syntabulin SYBU Tbio Non-IDG -0.98265 12.1 14
Phosphatidylinositol 4-kinase type 2-alpha PI4K2A Tbio Kinase -2.88003 745.1 146
Ubiquinol-cytochrome-c reductase complex assembly factor 1 UQCC1 Tbio Enzyme -1.25175 17.6 19
Ubiquitin carboxyl-terminal hydrolase 14 USP14 Tbio Enzyme -1.85726 75.4 223
Protransforming growth factor alpha TGFA Tbio Non-IDG -2.15761 135.3 697