Development Level

Tbio 2,841 | 11,445
Tdark 622 | 6,588
Tchem 508 | 1,598
Tclin 123 | 613

Collection

RFA-RM-18-021 78 | 328
Kinase: IDG Consortium (Target... 65 | 125
Kinase: IDG Consortium (Comple... 21 | 37
Ion Channel: IDG Consortium (T... 9 | 99
GPCR: IDG Consortium (Targets) 4 | 126

IMPC Phenotype

preweaning lethality, complete... 246 | 979
preweaning lethality, incomple... 149 | 499
abnormal behavior 82 | 298
abnormal bone structure 65 | 187
embryonic lethality prior to o... 64 | 239
embryonic lethality prior to t... 62 | 278
abnormal embryo size 59 | 220
decreased total body fat amoun... 57 | 207
enlarged heart 54 | 210
increased lean body mass 53 | 172
decreased vertical activity 49 | 208
decreased lean body mass 44 | 135
decreased body weight 42 | 161
decreased grip strength 39 | 116
increased circulating alkaline... 39 | 122
decreased bone mineral content 38 | 151
increased total body fat amoun... 38 | 134
hyperactivity 36 | 148
abnormal heart morphology 35 | 162
increased startle reflex 35 | 112
decreased bone mineral density 34 | 126
male infertility 34 | 123
hypoactivity 32 | 132
decreased circulating glucose ... 31 | 126
increased mean corpuscular hem... 29 | 96
cataract 28 | 92
increased or absent threshold ... 28 | 101
prenatal lethality prior to he... 27 | 87
short tibia 27 | 97
decreased body length 26 | 101
decreased startle reflex 26 | 75
increased bone mineral content 26 | 108
increased circulating HDL chol... 26 | 80
abnormal lens morphology 25 | 81
increased circulating choleste... 25 | 66
abnormal seminal vesicle morph... 23 | 114
decreased prepulse inhibition 23 | 82
increased heart weight 23 | 62
decreased circulating serum al... 22 | 82
improved glucose tolerance 22 | 79
increased mean corpuscular vol... 22 | 92
decreased circulating choleste... 21 | 93
decreased leukocyte cell numbe... 21 | 73
decreased mean corpuscular vol... 21 | 79
thrombocytopenia 21 | 56
abnormal sleep behavior 20 | 70
decreased circulating insulin ... 20 | 76
decreased lymphocyte cell numb... 20 | 83
embryonic growth retardation 20 | 106
abnormal eye morphology 19 | 68
abnormal retina morphology 19 | 71
decreased circulating triglyce... 19 | 79
increased bone mineral density 19 | 72
decreased fasted circulating g... 18 | 65
edema 18 | 59
increased circulating sodium l... 18 | 71
abnormal skin morphology 17 | 50
decreased hemoglobin content 17 | 68
decreased mean corpuscular hem... 17 | 50
increased neutrophil cell numb... 17 | 46
abnormal kidney morphology 16 | 65
abnormal spleen morphology 16 | 55
decreased blood urea nitrogen ... 16 | 51
female infertility 16 | 60
increased circulating chloride... 16 | 41
small superior vagus ganglion 16 | 74
small testis 16 | 58
abnormal behavioral response t... 15 | 66
abnormal coat-hair pigmentatio... 15 | 64
increased blood urea nitrogen ... 15 | 48
increased fasted circulating g... 15 | 76
increased monocyte cell number 15 | 63
abnormal cranium morphology 14 | 36
abnormal gait 14 | 69
decreased circulating HDL chol... 14 | 68
decreased circulating total pr... 14 | 49
increased grip strength 14 | 41
anophthalmia 13 | 33
impaired glucose tolerance 13 | 75
increased hematocrit 13 | 46
increased mean platelet volume 13 | 45
decreased erythrocyte cell num... 12 | 62
decreased mean corpuscular hem... 12 | 31
increased circulating triglyce... 12 | 42
tremors 12 | 39
abnormal bone mineralization 11 | 38
abnormal neural tube closure 11 | 46
cardiovascular system phenotyp... 11 | 36
corneal opacity 11 | 32
decreased circulating alanine ... 11 | 47
decreased circulating alkaline... 11 | 46
decreased circulating phosphat... 11 | 27
decreased hematocrit 11 | 46
decreased neutrophil cell numb... 11 | 42
increased circulating creatini... 11 | 38
increased hemoglobin content 11 | 45
limb grasping 11 | 41
prolonged ST segment 11 | 36
decreased circulating free fat... 10 | 31
prolonged QT interval 10 | 38

Disease

Carcinoma 2,615 | 11,493
ovarian cancer 2,126 | 8,520
osteosarcoma 1,921 | 7,950
medulloblastoma, large-cell 1,553 | 6,241
psoriasis 1,542 | 6,694
glioblastoma 1,448 | 5,792
lung cancer 1,277 | 4,740
atypical teratoid / rhabdoid tumor 1,265 | 5,112
ependymoma 1,174 | 4,679
group 3 medulloblastoma 1,044 | 4,104
adult high grade glioma 954 | 3,801
Breast cancer 936 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 828 | 3,291
malignant mesothelioma 805 | 3,232
Cancer 799 | 2,499
primitive neuroectodermal tumor 761 | 3,035
Astrocytoma, Pilocytic 747 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 745 | 2,989
oligodendroglioma 742 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 733 | 2,955
non-small cell lung cancer 729 | 2,890
invasive ductal carcinoma 722 | 2,951
lung carcinoma 669 | 2,843
Kidney cancer 667 | 2,613
pancreatic cancer 659 | 2,398
lung adenocarcinoma 646 | 2,716
astrocytic glioma 645 | 2,597
subependymal giant cell astrocytoma 597 | 2,287
interstitial cystitis 527 | 2,312
Pick disease 487 | 1,894
tuberculosis 485 | 2,010
pituitary cancer 478 | 1,972
group 4 medulloblastoma 469 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 464 | 1,962
ulcerative colitis 453 | 1,819
ductal carcinoma in situ 442 | 1,745
breast carcinoma 428 | 1,638
cystic fibrosis 427 | 1,696
Multiple myeloma 416 | 1,332
colon cancer 405 | 1,478
diabetes mellitus 386 | 1,728
acute quadriplegic myopathy 365 | 1,158
juvenile dermatomyositis 354 | 1,187
Autosomal recessive predisposition 345 | 1,442
adrenocortical carcinoma 344 | 1,428
astrocytoma 330 | 1,146
Schizophrenia 321 | 1,160
spina bifida 316 | 1,074
nasopharyngeal carcinoma 310 | 1,058
Rheumatoid arthritis 307 | 1,191
dermatomyositis 301 | 966
primary pancreatic ductal adenocarcinoma 298 | 1,109
Intellectual disability 274 | 1,016
cutaneous lupus erythematosus 259 | 1,057
pediatric high grade glioma 255 | 1,064
Waldenstrons macroglobulinemia 248 | 765
Atopic dermatitis 239 | 952
acute myeloid leukemia 216 | 783
esophageal adenocarcinoma 215 | 737
non primary Sjogren syndrome sicca 205 | 891
Liver Cirrhosis, Experimental 203 | 769
active Crohn's disease 203 | 922
primary Sjogren syndrome 193 | 735
Epilepsy 191 | 792
progressive supranuclear palsy 186 | 676
gastric carcinoma 181 | 807
medulloblastoma 180 | 720
Alzheimer's disease 177 | 658
Bipolar Disorder 176 | 666
Melanoma 173 | 711
Dull intelligence 168 | 645
Low intelligence 168 | 645
Mental Retardation 168 | 645
Mental deficiency 168 | 645
Poor school performance 168 | 645
active ulcerative colitis 168 | 764
aldosterone-producing adenoma 168 | 665
pancreatic carcinoma 166 | 562
Amyotrophic lateral sclerosis 164 | 451
Down syndrome 162 | 499
Breast Neoplasms 158 | 445
chronic rhinosinusitis 158 | 512
Duchenne muscular dystrophy 156 | 601
Neurodegenerative disease 153 | 414
Obesity 153 | 678
Liver cancer 151 | 604
hepatocellular carcinoma 151 | 547
Endometriosis 147 | 540
Seizures 147 | 596
Cognitive delay 146 | 608
Global developmental delay 146 | 608
Mammary Neoplasms 146 | 425
Mental and motor retardation 146 | 608
Prostatic Neoplasms 145 | 495
fibroadenoma 143 | 559
Short stature 142 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 142 | 510
Depressive disorder 130 | 409
gastric cancer 125 | 459
Multiple Sclerosis 123 | 540

Tissue

Endocrine System 3,950 | 18,159
Digestive Tract 3,863 | 17,369
Skin and soft tissues 3,856 | 17,230
Female tissues 3,850 | 17,400
Male tissues 3,803 | 17,142
Blood and immune system 3,784 | 16,909
Nervous System 3,771 | 16,725
Urinary Tract 3,755 | 16,678
Liver and Pancreas 3,753 | 16,750
Respiratory system 3,703 | 16,393
Cardiovascular System 3,542 | 15,192

Target Family

Non-IDG 2,433 | 12,091
Enzyme 922 | 4,145
Kinase 322 | 634
Transcription Factor 222 | 1,400
Epigenetic 62 | 242
GPCR 37 | 408
Ion Channel 37 | 344
Transporter 37 | 473
Nuclear Receptor 15 | 48
TF/Epigenetic 7 | 38

GO Component

cytoplasm 4,094 | 4,094
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Hexosaminidase D HEXDC Tbio Enzyme -0.60206 3.83 63
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Kinesin-like protein KIF25 KIF25 Tbio Non-IDG -0.75019 5.59 191
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127