Development Level

Tbio 3,373 | 10,625
Tdark 820 | 7,003
Tchem 658 | 1,890
Tclin 134 | 602

Collection

Eligible Kinase Proteins 61 | 134
Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 7 | 143

IMPC Term

preweaning lethality, complete... 219 | 633
preweaning lethality, incomple... 108 | 260
decreased lean body mass 76 | 195
abnormal behavior 72 | 226
decreased body weight 63 | 174
decreased total body fat amoun... 62 | 186
embryonic lethality prior to t... 61 | 187
decreased bone mineral content 57 | 157
increased or absent threshold ... 54 | 128
abnormal bone structure 52 | 131
embryonic lethality prior to o... 51 | 148
abnormal embryo size 49 | 112
decreased bone mineral density 47 | 126
decreased grip strength 46 | 123
increased circulating alkaline... 45 | 119
decreased body length 43 | 108
increased lean body mass 40 | 107
decreased circulating glucose ... 39 | 121
hyperactivity 33 | 108
increased mean corpuscular hem... 32 | 93
enlarged heart 31 | 111
decreased circulating HDL chol... 30 | 77
decreased circulating choleste... 30 | 85
increased bone mineral content 30 | 92
abnormal retina morphology 29 | 100
decreased circulating triglyce... 28 | 83
prenatal lethality prior to he... 28 | 64
decreased circulating insulin ... 27 | 75
increased grip strength 27 | 83
increased mean corpuscular vol... 27 | 91
abnormal lens morphology 26 | 73
abnormal sleep behavior 26 | 63
increased circulating HDL chol... 26 | 63
hypoactivity 24 | 89
improved glucose tolerance 24 | 56
increased circulating choleste... 23 | 53
increased exploration in new e... 23 | 56
short tibia 23 | 82
abnormal bone mineralization 22 | 55
increased circulating chloride... 21 | 43
abnormal coat/hair pigmentatio... 20 | 54
decreased lumbar vertebrae num... 20 | 62
decreased startle reflex 20 | 48
decreased circulating serum al... 19 | 79
decreased heart weight 19 | 44
decreased leukocyte cell numbe... 19 | 54
decreased prepulse inhibition 19 | 52
increased circulating sodium l... 19 | 71
increased sacral vertebrae num... 19 | 62
increased total body fat amoun... 19 | 57
decreased mean corpuscular vol... 18 | 50
increased fasted circulating g... 18 | 68
thrombocytopenia 18 | 46
abnormal behavioral response t... 17 | 52
decreased rib number 17 | 59
increased body weight 17 | 42
increased heart weight 17 | 37
male infertility 17 | 62
abnormal cranium morphology 16 | 32
abnormal retinal pigmentation 16 | 61
abnormal eye morphology 15 | 38
abnormal gait 15 | 51
decreased circulating alanine ... 15 | 53
increased blood urea nitrogen ... 15 | 44
increased bone mineral density 15 | 52
increased startle reflex 15 | 38
abnormal neural tube closure 14 | 37
abnormal spleen morphology 14 | 36
decreased circulating alkaline... 14 | 41
decreased fasted circulating g... 14 | 49
abnormal rib morphology 13 | 28
abnormal tooth morphology 13 | 24
decreased circulating free fat... 13 | 39
decreased mean corpuscular hem... 13 | 34
increased hemoglobin content 13 | 45
limb grasping 13 | 35
abnormal hindbrain development 12 | 24
abnormal kidney morphology 12 | 30
cataract 12 | 26
decreased blood urea nitrogen ... 12 | 31
decreased eosinophil cell numb... 12 | 41
decreased hemoglobin content 12 | 53
decreased neutrophil cell numb... 12 | 37
increased rib number 12 | 41
abnormal cornea morphology 11 | 24
abnormal heart morphology 11 | 51
abnormal seminal vesicle morph... 11 | 47
cardiovascular system phenotyp... 11 | 35
corneal opacity 11 | 25
decreased caudal vertebrae num... 11 | 49
decreased circulating total pr... 11 | 41
decreased mean corpuscular hem... 11 | 19
impaired glucose tolerance 11 | 52
increased leukocyte cell numbe... 11 | 37
small testis 11 | 37
tremors 11 | 34
anophthalmia 10 | 20
decreased NK T cell number 10 | 28
decreased circulating calcium ... 10 | 33
decreased circulating iron lev... 10 | 25

Disease

ovarian cancer 2,679 | 8,484
osteosarcoma 2,346 | 7,933
medulloblastoma, large-cell 1,897 | 6,234
psoriasis 1,877 | 6,685
glioblastoma 1,712 | 5,572
lung cancer 1,515 | 4,466
atypical teratoid / rhabdoid tumor 1,320 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,030 | 3,289
Breast cancer 1,008 | 3,094
malignant mesothelioma 1,004 | 3,162
primitive neuroectodermal tumor 942 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 929 | 2,988
Cancer 923 | 2,346
pilocytic astrocytoma 904 | 3,086
invasive ductal carcinoma 901 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 899 | 2,956
oligodendroglioma 899 | 2,849
non-small cell lung cancer 889 | 2,798
pediatric high grade glioma 845 | 2,712
lung adenocarcinoma 816 | 2,713
lung carcinoma 783 | 2,844
ependymoma 779 | 2,514
pancreatic cancer 771 | 2,300
subependymal giant cell astrocytoma 732 | 2,287
Carcinoma 689 | 2,147
group 3 medulloblastoma 680 | 2,254
astrocytic glioma 674 | 2,241
adult high grade glioma 643 | 2,148
interstitial cystitis 643 | 2,299
ulcerative colitis 616 | 2,087
Pick disease 606 | 1,893
group 4 medulloblastoma 593 | 1,875
pituitary cancer 566 | 1,972
ductal carcinoma in situ 548 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 535 | 1,795
Multiple myeloma 534 | 1,327
breast carcinoma 527 | 1,614
astrocytoma 524 | 1,493
cystic fibrosis 505 | 1,665
colon cancer 499 | 1,475
medulloblastoma 476 | 1,524
acute quadriplegic myopathy 458 | 1,157
tuberculosis 457 | 1,557
diabetes mellitus 452 | 1,663
sonic hedgehog group medulloblastoma 451 | 1,482
posterior fossa group A ependymoma 444 | 1,511
posterior fossa group B ependymoma 442 | 1,530
adrenocortical carcinoma 440 | 1,427
juvenile dermatomyositis 439 | 1,189
primary pancreatic ductal adenocarcinoma 414 | 1,271
spina bifida 392 | 1,064
dermatomyositis 384 | 933
nasopharyngeal carcinoma 372 | 1,056
Rheumatoid Arthritis 366 | 1,160
atypical teratoid/rhabdoid tumor 336 | 1,095
Waldenstrons macroglobulinemia 323 | 765
cutaneous lupus erythematosus 315 | 1,056
Atopic dermatitis 290 | 944
acute myeloid leukemia 262 | 780
esophageal adenocarcinoma 255 | 737
primary Sjogren syndrome 252 | 789
non primary Sjogren syndrome sicca 243 | 840
active Crohn's disease 237 | 918
progressive supranuclear palsy 232 | 674
gastric carcinoma 225 | 832
Alzheimer's disease 222 | 644
tuberculosis and treatment for 6 months 219 | 686
aldosterone-producing adenoma 212 | 664
Down syndrome 208 | 548
Intellectual disability 199 | 573
pancreatic carcinoma 197 | 567
Endometriosis 190 | 535
Amyotrophic Lateral Sclerosis 189 | 431
Mammary Neoplasms 175 | 410
Duchenne muscular dystrophy 174 | 602
chronic rhinosinusitis 173 | 512
Prostatic Neoplasms 172 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 168 | 499
hepatocellular carcinoma 168 | 532
Neurodegenerative disease 166 | 383
Obesity 161 | 616
IGA Glomerulonephritis 157 | 454
fibroadenoma 157 | 557
Schizophrenia 146 | 501
Parkinson's disease 130 | 364
Multiple Sclerosis 129 | 498
gastric cancer 127 | 430
inflammatory breast cancer 126 | 404
non-small cell lung carcinoma 125 | 413
active ulcerative colitis 122 | 477
Stomach Neoplasms 121 | 282
mucosa-associated lymphoid tissue lymphoma 118 | 480
Kidney disease 117 | 396
hereditary spastic paraplegia 117 | 313
Peripheral Neuropathy 114 | 303
Polycystic Ovary Syndrome 114 | 332
glioblastoma multiforme 114 | 347
tuberculosis and treatment for 3 months 107 | 327
Liver carcinoma 106 | 217
Crohn's disease 105 | 304

Tissue

Female tissues 4,888 | 18,647
Endocrine System 4,884 | 18,512
Nervous System 4,883 | 18,561
Digestive Tract 4,876 | 18,473
Liver and Pancreas 4,846 | 18,136
Urinary Tract 4,843 | 18,444
Male tissues 4,840 | 17,969
Blood and immune system 4,838 | 17,995
Cardiovascular System 4,828 | 17,958
Skin and soft tissues 4,802 | 18,115
Respiratory system 4,746 | 17,484

Target Family

Non-IDG 2,977 | 11,971
Enzyme 1,141 | 4,146
Kinase 331 | 634
Transcription Factor 305 | 1,400
Epigenetic 86 | 242
Transporter 43 | 473
Ion Channel 39 | 341
GPCR 37 | 406
Nuclear Receptor 14 | 48
TF/Epigenetic 12 | 38

GO Component

cytoplasm 4,985 | 4,985
nucleus 5,107 | 5,107
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788