Development Level

Tbio 42 | 11,445
Tdark 21 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
decreased fasted circulating g... 2 | 65
decreased total body fat amoun... 2 | 207
preweaning lethality, complete... 2 | 979
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal vibrissa morphology 1 | 25
cataract 1 | 92
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating insulin ... 1 | 76
decreased coping response 1 | 8
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
male infertility 1 | 123
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small kidney 1 | 16

Disease

psoriasis 37 | 6,694
Carcinoma 29 | 11,493
ovarian cancer 21 | 8,520
esophageal adenocarcinoma 20 | 737
Breast cancer 18 | 3,578
lung cancer 17 | 4,740
non-small cell lung cancer 16 | 2,890
Atopic dermatitis 15 | 952
cystic fibrosis 14 | 1,696
diabetes mellitus 13 | 1,728
nasopharyngeal carcinoma 13 | 1,058
osteosarcoma 13 | 7,950
spina bifida 12 | 1,074
Kidney cancer 11 | 2,613
Palmoplantar keratosis 11 | 74
interstitial cystitis 11 | 2,312
malignant mesothelioma 11 | 3,232
medulloblastoma, large-cell 11 | 6,241
pancreatic cancer 11 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung adenocarcinoma 10 | 2,716
periodontitis 10 | 293
Cancer 9 | 2,499
Melanoma 9 | 711
Epidermolytic hyperkeratosis 8 | 14
Skin cancer 8 | 469
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
glioblastoma 8 | 5,792
Arrhythmogenic right ventricular cardiomyopathy 7 | 30
Autosomal recessive predisposition 7 | 1,442
Congenital ichthyosiform erythroderma 7 | 28
Ichthyosis vulgaris 7 | 11
Squamous cell carcinoma 7 | 129
cutaneous lupus erythematosus 7 | 1,057
Carcinoma, Squamous Cell 6 | 110
Dermatitis 6 | 157
Erythema 6 | 58
Flushing 6 | 60
Hypotrichosis 6 | 47
Pemphigus 6 | 23
breast carcinoma 6 | 1,638
ependymoma 6 | 4,679
lung carcinoma 6 | 2,843
Alopecia 5 | 115
Astrocytoma, Pilocytic 5 | 3,081
Bullous pemphigoid 5 | 18
Cardiomyopathy 5 | 116
Cardiomyopathy, right ventricular 5 | 7
Dilated cardiomyopathy 5 | 56
Ichthyosis 5 | 56
Liver cancer 5 | 604
Nail Diseases 5 | 24
Nail abnormality 5 | 22
Ritter's disease 5 | 10
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
invasive ductal carcinoma 5 | 2,951
pituitary cancer 5 | 1,972
primitive neuroectodermal tumor 5 | 3,035
ulcerative colitis 5 | 1,819
Asthma 4 | 385
Contact Dermatitis 4 | 81
DOID:2627 4 | 94
Dermatitis, Contact 4 | 71
Endometrial cancer 4 | 311
Exfoliative dermatitis 4 | 24
Hyperkeratosis, Epidermolytic 4 | 7
Ichthyoses 4 | 41
Keratosis 4 | 37
Netherton syndrome 4 | 15
Peeling of skin 4 | 8
Prostatic Neoplasms 4 | 495
Rheumatoid arthritis 4 | 1,191
Skin Neoplasms 4 | 69
Skin disease 4 | 66
Sudden Cardiac Death 4 | 29
atypical teratoid/rhabdoid tumor 4 | 357
cystic fibrosis and chronic rhinosinusitis 4 | 214
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
subependymal giant cell astrocytoma 4 | 2,287
Abnormal blistering of the skin 3 | 54
Blister of skin 3 | 54
Cardiomyopathy, Dilated 3 | 83
Dystrophia unguium 3 | 53
Failure to gain weight 3 | 365
Pediatric failure to thrive 3 | 365
Peeling skin syndrome 3 | 17
Pick disease 3 | 1,894
Pruritus 3 | 58
Skin bulla 3 | 54
Ventricular arrhythmia 3 | 27
Wooly hair 3 | 17
acute myeloid leukemia 3 | 783
hair abnormalities (non-specific) 3 | 30
interstitial lung disease 3 | 298
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
urothelial carcinoma 3 | 318

Tissue

Skin and soft tissues 62 | 17,230
Female tissues 58 | 17,400
Digestive Tract 53 | 17,369
Blood and immune system 52 | 16,909
Endocrine System 46 | 18,159
Urinary Tract 36 | 16,678
Liver and Pancreas 35 | 16,750
Nervous System 35 | 16,725
Male tissues 33 | 17,142
Cardiovascular System 29 | 15,192
Respiratory system 28 | 16,393

Target Family

Non-IDG 63 | 12,091
Enzyme 1 | 4,145

GO Component

cornified envelope 64 | 64
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Small proline-rich protein 2F SPRR2F Tbio Non-IDG 0.44 0.31 12
Plakophilin-3 PKP3 Tbio Non-IDG -1.37372 26.0 200
Small proline-rich protein 4 SPRR4 Tdark Non-IDG -0.32647 2.13 9
Envoplakin-like protein EVPLL Tdark Non-IDG 0.00000 61
Late cornified envelope protein 3D LCE3D Tdark Non-IDG -0.13175 1.11 0
Late cornified envelope protein 5A LCE5A Tdark Non-IDG 0.50 0.32 0
Small proline-rich protein 2G SPRR2G Tbio Non-IDG 0.39 0.31 1
Cornifelin CNFN Tdark Non-IDG -0.56002 3.82 7
Hornerin HRNR Tbio Non-IDG -1.33117 22.2 69