Development Level

Tbio 36 | 10,625
Tchem 12 | 1,890
Tdark 7 | 7,003

IMPC Phenotype

cardiovascular system phenotyp... 4 | 35
decreased total body fat amoun... 4 | 186
increased or absent threshold ... 4 | 128
preweaning lethality, complete... 4 | 633
abnormal behavior 3 | 226
abnormal lens morphology 3 | 73
decreased grip strength 3 | 123
increased circulating alkaline... 3 | 119
abnormal sleep behavior 2 | 63
decreased heart rate variabili... 2 | 11
decreased lean body mass 2 | 195
decreased mean corpuscular hem... 2 | 34
embryonic lethality prior to t... 2 | 187
hyperactivity 2 | 108
increased circulating HDL chol... 2 | 63
increased startle reflex 2 | 38
preweaning lethality, incomple... 2 | 260
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat- hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal limb bud morphology 1 | 15
abnormal nail morphology 1 | 7
abnormal pericardium morpholog... 1 | 11
abnormal retinal inner nuclear... 1 | 5
abnormal sensory capabilities-... 1 | 3
abnormal spleen morphology 1 | 36
abnormal vitreous body morphol... 1 | 7
decreased Ly6C low monocyte nu... 1 | 23
decreased alpha-beta T cell nu... 1 | 12
decreased bone mineral content 1 | 157
decreased cardiac output 1 | 2
decreased cardiac stroke volum... 1 | 3
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
decreased respiratory quotient 1 | 12
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased cardiac muscle contr... 1 | 5
increased circulating LDL chol... 1 | 15
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased erythrocyte cell num... 1 | 26
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased kidney weight 1 | 4
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased prepulse inhibition 1 | 21
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
premature death 1 | 5

Disease

ovarian cancer 31 | 8,491
osteosarcoma 30 | 7,933
medulloblastoma, large-cell 26 | 6,234
lung cancer 24 | 4,473
psoriasis 24 | 6,685
glioblastoma 23 | 5,572
atypical teratoid / rhabdoid tumor 21 | 4,369
malignant mesothelioma 19 | 3,163
pilocytic astrocytoma 17 | 3,086
Pick disease 16 | 1,893
ependymoma 16 | 2,514
invasive ductal carcinoma 16 | 2,950
oligodendroglioma 16 | 2,849
lung carcinoma 15 | 2,844
Alzheimer's disease 14 | 644
astrocytic glioma 14 | 2,241
non-small cell lung cancer 14 | 2,798
pediatric high grade glioma 14 | 2,712
subependymal giant cell astrocytoma 14 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,289
primitive neuroectodermal tumor 13 | 3,031
Breast cancer 12 | 3,098
Cancer 12 | 2,346
Carcinoma 12 | 2,147
ductal carcinoma in situ 12 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
ulcerative colitis 11 | 2,087
astrocytoma 10 | 1,493
diabetes mellitus 10 | 1,663
lung adenocarcinoma 10 | 2,714
medulloblastoma 10 | 1,524
pituitary cancer 10 | 1,972
tuberculosis 10 | 1,563
pancreatic cancer 9 | 2,300
adult high grade glioma 8 | 2,148
spina bifida 8 | 1,064
Down syndrome 7 | 548
Intellectual disability 7 | 573
Kidney disease 7 | 397
Neurodegenerative disease 7 | 383
dermatomyositis 7 | 966
interstitial cystitis 7 | 2,299
mucosa-associated lymphoid tissue lymphoma 7 | 480
progressive supranuclear palsy 7 | 674
sonic hedgehog group medulloblastoma 7 | 1,482
Obesity 6 | 616
atypical teratoid/rhabdoid tumor 6 | 1,095
colon cancer 6 | 1,475
cystic fibrosis 6 | 1,670
esophageal adenocarcinoma 6 | 737
group 4 medulloblastoma 6 | 1,875
posterior fossa group A ependymoma 6 | 1,511
Atopic dermatitis 5 | 944
adrenocortical carcinoma 5 | 1,427
breast carcinoma 5 | 1,614
hereditary spastic paraplegia 5 | 313
posterior fossa group B ependymoma 5 | 1,530
primary pancreatic ductal adenocarcinoma 5 | 1,271
Anemia 4 | 252
Coronary artery disease 4 | 240
Gaucher disease type 1 4 | 171
Microcephaly 4 | 149
Paraplegia 4 | 71
acute quadriplegic myopathy 4 | 1,157
fibroadenoma 4 | 557
gastric carcinoma 4 | 832
group 3 medulloblastoma 4 | 2,254
juvenile dermatomyositis 4 | 1,189
nephrosclerosis 4 | 329
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Arthritis 3 | 248
Atherosclerosis 3 | 275
Cardiovascular Diseases 3 | 50
Cardiovascular system disease 3 | 194
Cerebral palsy 3 | 28
Chronic obstructive pulmonary disease 3 | 147
Hypersensitivity reaction type II disease 3 | 235
Hypertension 3 | 293
Lipid metabolism disorder 3 | 102
Malaria 3 | 140
Metabolic syndrome X 3 | 155
Multiple myeloma 3 | 1,327
Myocardial Ischemia 3 | 169
Parkinson's disease 3 | 364
Polycystic Ovary Syndrome 3 | 334
Quadriplegia 3 | 14
Rheumatoid Arthritis 3 | 1,170
Vascular disease 3 | 281
Waldenstrons macroglobulinemia 3 | 764
active Crohn's disease 3 | 918
aldosterone-producing adenoma 3 | 664
chronic lymphocytic leukemia 3 | 244
chronic rhinosinusitis 3 | 512
glioblastoma multiforme 3 | 347
nasopharyngeal carcinoma 3 | 1,056
non diabetic and post-ischemic heart failure 3 | 200
non primary Sjogren syndrome sicca 3 | 840
primary Sjogren syndrome 3 | 788
type II diabetes mellitus and post-ischemic heart failure 3 | 89

Tissue

Blood and immune system 55 | 17,994
Cardiovascular System 55 | 17,957
Digestive Tract 55 | 18,472
Endocrine System 55 | 18,511
Female tissues 55 | 18,646
Liver and Pancreas 55 | 18,135
Male tissues 55 | 17,968
Nervous System 55 | 18,560
Respiratory system 55 | 17,483
Skin and soft tissues 55 | 18,114
Urinary Tract 55 | 18,443

Target Family

Non-IDG 47 | 11,969
Enzyme 3 | 4,146
Kinase 2 | 634
Epigenetic 1 | 242
GPCR 1 | 408
Transporter 1 | 473

GO Component

clathrin-coated pit 55 | 55
nucleus 5,106 | 5,106
cytoplasm 4,984 | 4,984
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,264 | 3,264
extracellular exosome 2,757 | 2,757
nucleoplasm 2,716 | 2,716
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 536 | 536
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E-selectin SELE Tchem Non-IDG -3.43650 2598.8 820
Adaptin ear-binding coat-associated protein 2 NECAP2 Tdark Non-IDG 0.03 1.26 31
Low-density lipoprotein receptor-related protein 12 LRP12 Tdark Non-IDG -0.53997 3.72 131
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.04462 893.1 512
Disabled homolog 2 DAB2 Tbio Non-IDG -2.24622 174.6 226
Atypical chemokine receptor 3 ACKR3 Tchem GPCR -1.80879 81.4 385
Formin-binding protein 1 FNBP1 Tbio Non-IDG -1.08779 13.3 127
Unconventional myosin-VI MYO6 Tbio Non-IDG -1.66390 49.9 93
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.17795 160.1 198
Protein amnionless AMN Tbio Non-IDG -1.30941 14.9 28