Development Level

Tbio 47 | 11,445
Tchem 6 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

decreased vertical activity 3 | 208
preweaning lethality, complete... 3 | 979
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
decreased bone mineral density 2 | 126
decreased circulating serum al... 2 | 82
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hydrometra 2 | 53
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
small superior vagus ganglion 2 | 74
abnormal cecum morphology 1 | 7
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal heart shape 1 | 5
abnormal seminal vesicle morph... 1 | 114
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating glucose ... 1 | 126
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating unsatura... 1 | 2
decreased erythrocyte cell num... 1 | 62
decreased prepulse inhibition 1 | 82
enlarged cecum 1 | 5
enlarged seminal vesicle 1 | 10
hydrops fetalis 1 | 1
hypoactivity 1 | 132
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating insulin ... 1 | 3
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
preweaning lethality, incomple... 1 | 499

Disease

psoriasis 26 | 6,694
ovarian cancer 25 | 8,520
Rheumatoid arthritis 21 | 1,191
Carcinoma 20 | 11,493
diabetes mellitus 18 | 1,728
Narcolepsy 17 | 72
lung carcinoma 17 | 2,843
sarcoidosis 16 | 370
Berylliosis 15 | 28
glioblastoma 15 | 5,792
Multiple Sclerosis, Susceptibility to 14 | 15
Narcolepsy-cataplexy 14 | 21
Systemic lupus erythematosus 14 | 194
invasive ductal carcinoma 14 | 2,951
lung cancer 14 | 4,740
Diffuse cutaneous systemic sclerosis 13 | 17
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
ependymoma 13 | 4,679
follicular lymphoma 13 | 20
interstitial cystitis 13 | 2,312
limited scleroderma 13 | 19
osteosarcoma 13 | 7,950
atypical teratoid / rhabdoid tumor 12 | 5,112
medulloblastoma, large-cell 12 | 6,241
non-small cell lung cancer 12 | 2,890
Multiple Sclerosis 11 | 540
breast carcinoma 11 | 1,638
tuberculosis 11 | 2,010
Breast cancer 10 | 3,578
ductal carcinoma in situ 10 | 1,745
Astrocytoma, Pilocytic 9 | 3,081
Cancer 9 | 2,499
esophageal adenocarcinoma 9 | 737
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
malignant mesothelioma 9 | 3,232
ulcerative colitis 9 | 1,819
Hypersensitivity reaction type II disease 8 | 253
adult high grade glioma 8 | 3,801
cystic fibrosis 8 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
pancreatic cancer 8 | 2,398
subependymal giant cell astrocytoma 8 | 2,287
Duchenne muscular dystrophy 7 | 601
Juvenile rheumatoid arthritis 7 | 111
astrocytic glioma 7 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Cataract 8 multiple types 6 | 33
Schizophrenia 6 | 1,160
Type 1 diabetes mellitus 6 | 109
adrenocortical carcinoma 6 | 1,428
group 4 medulloblastoma 6 | 1,855
head and neck cancer and chronic obstructive pulmonary disease 6 | 239
juvenile dermatomyositis 6 | 1,187
lung adenocarcinoma 6 | 2,716
primary Sjogren syndrome 6 | 735
Atopic dermatitis 5 | 952
Autosomal recessive predisposition 5 | 1,442
Down syndrome 5 | 499
Hepatitis B 5 | 108
Hypersensitivity 5 | 63
Liver disease 5 | 237
active Crohn's disease 5 | 922
astrocytoma 5 | 1,146
cutaneous lupus erythematosus 5 | 1,057
group 3 medulloblastoma 5 | 4,104
oligodendroglioma 5 | 2,850
primitive neuroectodermal tumor 5 | 3,035
Addison's disease 4 | 31
Asthma 4 | 385
Autoimmune thyroiditis 4 | 27
Becker muscular dystrophy 4 | 191
Bipolar Disorder 4 | 666
Celiac disease 4 | 116
Cognitive delay 4 | 608
Cryptorchidism 4 | 296
Global developmental delay 4 | 608
Graves' disease 4 | 24
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Liver Cirrhosis 4 | 181
Mental and motor retardation 4 | 608
Pick disease 4 | 1,894
Proteinuria 4 | 144
Vasculitis 4 | 80
active ulcerative colitis 4 | 764
gastric carcinoma 4 | 807
nephrosclerosis 4 | 333
pediatric high grade glioma 4 | 1,064
spina bifida 4 | 1,074
Alzheimer's disease 3 | 658
Atherosclerosis 3 | 291
Collagen disease 3 | 27
Coronary artery disease 3 | 268
Long philtrum 3 | 137
Waldenstrons macroglobulinemia 3 | 765
colon cancer 3 | 1,478
fibroadenoma 3 | 559
pancreatic carcinoma 3 | 562

Tissue

Skin and soft tissues 39 | 17,230
Blood and immune system 38 | 16,909
Digestive Tract 38 | 17,369
Endocrine System 38 | 18,159
Female tissues 38 | 17,400
Liver and Pancreas 38 | 16,750
Male tissues 38 | 17,142
Respiratory system 37 | 16,393
Urinary Tract 37 | 16,678
Cardiovascular System 36 | 15,192
Nervous System 36 | 16,725

Target Family

Non-IDG 49 | 12,091
GPCR 3 | 408
Enzyme 1 | 4,145
Kinase 1 | 634

GO Component

clathrin-coated endocytic vesi... 54 | 54
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

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