Development Level

Tbio 117 | 11,651
Tdark 40 | 6,593
Tchem 11 | 1,388
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 10 | 499
abnormal behavior 4 | 298
male infertility 4 | 123
abnormal embryo size 3 | 220
abnormal embryo turning 3 | 31
decreased body weight 3 | 161
decreased grip strength 3 | 116
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
hypoactivity 3 | 132
increased circulating chloride... 3 | 41
increased lean body mass 3 | 172
prenatal lethality prior to he... 3 | 87
abnormal retina morphology 2 | 71
decreased body length 2 | 101
decreased circulating alkaline... 2 | 46
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased vertical activity 2 | 208
edema 2 | 59
embryonic growth retardation 2 | 106
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased fasted circulating g... 2 | 76
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
long tibia 2 | 25
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal limb morphology 1 | 13
abnormal locomotor behavior 1 | 24
abnormal midbrain morphology 1 | 10
abnormal nail morphology 1 | 8
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
anophthalmia 1 | 33
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
sclerocornea 1 | 2
short tibia 1 | 97

Disease

Carcinoma 121 | 11,493
ependymoma 84 | 4,679
ovarian cancer 82 | 8,520
osteosarcoma 80 | 7,950
medulloblastoma, large-cell 53 | 6,241
glioblastoma 48 | 5,792
psoriasis 47 | 6,694
atypical teratoid / rhabdoid tumor 45 | 5,112
lung cancer 37 | 4,740
Polydactyly 35 | 107
chronic rhinosinusitis 35 | 512
group 3 medulloblastoma 35 | 4,104
Kidney cancer 34 | 2,613
Ciliopathy 31 | 71
Autosomal recessive predisposition 30 | 1,442
Breast cancer 30 | 3,578
Nephronophthisis 29 | 80
Pick disease 29 | 1,894
adult high grade glioma 29 | 3,801
malignant mesothelioma 28 | 3,232
primitive neuroectodermal tumor 28 | 3,035
astrocytic glioma 27 | 2,597
lung adenocarcinoma 27 | 2,716
Retinitis Pigmentosa 26 | 226
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
lung carcinoma 26 | 2,843
Intellectual disability 25 | 1,016
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
Bardet-Biedl syndrome 23 | 51
Obesity 23 | 678
invasive ductal carcinoma 23 | 2,951
nasopharyngeal carcinoma 23 | 1,058
oligodendroglioma 23 | 2,850
Joubert syndrome 21 | 66
Astrocytoma, Pilocytic 20 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
Asphyxiating thoracic dystrophy 19 | 44
Nystagmus 19 | 317
non-small cell lung cancer 19 | 2,890
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
ductal carcinoma in situ 18 | 1,745
pancreatic cancer 17 | 2,398
subependymal giant cell astrocytoma 17 | 2,287
Congenital hypoplasia of penis 16 | 176
Primary ciliary dyskinesia 16 | 76
Short stature 15 | 531
Situs Inversus 15 | 65
group 4 medulloblastoma 14 | 1,855
Anteverted nostril 13 | 191
Hypertensive disease 13 | 292
Liver cancer 13 | 604
pituitary cancer 13 | 1,972
Abnormality of retinal pigmentation 12 | 111
Blind Vision 12 | 111
Cognitive delay 12 | 608
Electroretinogram abnormal 12 | 95
Global developmental delay 12 | 608
Meckel syndrome 12 | 46
Mental and motor retardation 12 | 608
Retinal pigment epithelial abnormality 12 | 111
Sensenbrenner syndrome 12 | 17
interstitial cystitis 12 | 2,312
pediatric high grade glioma 12 | 1,064
tuberculosis 12 | 2,010
Autosomal recessive polycystic kidney disease 11 | 41
Blindness, Legal 11 | 110
Broad flat nasal bridge 11 | 236
Cataract 11 | 297
Ciliary Motility Disorders 11 | 38
Cystic kidney disease 11 | 26
Ellis-Van Creveld syndrome 11 | 19
Fundus dystrophy 11 | 83
Glaucoma 11 | 239
Hypogonadism 11 | 173
Lens Opacities 11 | 231
Nasal bridge wide 11 | 236
Ulnar polydactyly of fingers 11 | 47
breast carcinoma 11 | 1,638
cystic fibrosis and chronic rhinosinusitis 11 | 214
Brachydactyly 10 | 156
Hydrocephalus 10 | 152
Hyperinsulinism 10 | 133
Optic Atrophy 10 | 242
Photodysphoria 10 | 121
Photophobia 10 | 121
Retinal Degeneration 10 | 106
Senior-Loken syndrome 10 | 22
progressive supranuclear palsy 10 | 676
Increase in blood pressure 9 | 119
Multiple myeloma 9 | 1,332
Muscle hypotonia 9 | 571
Sensorineural Hearing Loss (disorder) 9 | 284
adrenocortical carcinoma 9 | 1,428
medulloblastoma 9 | 720
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
posterior fossa group B ependymoma 9 | 416

Tissue

Endocrine System 171 | 18,159
Female tissues 168 | 17,400
Male tissues 168 | 17,142
Digestive Tract 167 | 17,369
Skin and soft tissues 167 | 17,230
Respiratory system 166 | 16,393
Urinary Tract 165 | 16,678
Liver and Pancreas 164 | 16,750
Nervous System 163 | 16,725
Blood and immune system 161 | 16,909
Cardiovascular System 153 | 15,192

Target Family

Non-IDG 124 | 12,091
Enzyme 23 | 4,145
Kinase 10 | 634
Transcription Factor 7 | 1,400
Ion Channel 4 | 344
GPCR 3 | 408

GO Component

cilium 171 | 171
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase MAK MAK Tchem Kinase -1.20155 15.2 266
Tubby-related protein 4 TULP4 Tdark Transcription Factor -1.15928 14.0 44
Dynein heavy chain 6, axonemal DNAH6 Tbio Non-IDG -0.53057 4.17 18
Cilia- and flagella-associated protein 20 CFAP20 Tbio Non-IDG -1.78803 43.9 88
Cilia- and flagella-associated protein 45 CFAP45 Tbio Non-IDG -0.55977 0.00000 116
Tubulin monoglycylase TTLL3 TTLL3 Tbio Enzyme -0.53902 4.01 18
Tetratricopeptide repeat protein 30A TTC30A Tdark Non-IDG 0.60 0.00000 57
Protein tilB homolog LRRC6 Tbio Non-IDG -1.29587 19.2 150
Kinesin-like protein KIF3A KIF3A Tbio Non-IDG -2.06068 113.6 153
Lebercilin LCA5 Tbio Non-IDG -1.24990 16.8 78