Development Level

Tbio 34 | 11,445
Tdark 5 | 6,588
Tchem 4 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
abnormal behavior 6 | 298
embryonic lethality prior to t... 3 | 278
hypoactivity 3 | 132
abnormal embryo size 2 | 220
abnormal embryo turning 2 | 31
embryonic growth retardation 2 | 106
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal embryo development 1 | 7
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal stomach morphology 1 | 10
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
impaired glucose tolerance 1 | 75
increased bone mineral content 1 | 108
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating magnesiu... 1 | 10
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
long tibia 1 | 25
male infertility 1 | 123
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33

Disease

Carcinoma 33 | 11,493
ependymoma 26 | 4,679
osteosarcoma 24 | 7,950
ovarian cancer 24 | 8,520
Polydactyly 23 | 107
atypical teratoid / rhabdoid tumor 17 | 5,112
Ciliopathy 16 | 71
glioblastoma 15 | 5,792
medulloblastoma, large-cell 15 | 6,241
Asphyxiating thoracic dystrophy 14 | 44
lung cancer 13 | 4,740
psoriasis 12 | 6,694
Bardet-Biedl syndrome 11 | 51
Sensenbrenner syndrome 11 | 17
chronic rhinosinusitis 11 | 512
group 3 medulloblastoma 11 | 4,104
Kidney cancer 10 | 2,613
Nephronophthisis 10 | 80
malignant mesothelioma 10 | 3,232
Breast cancer 9 | 3,578
Gastrointestinal Stromal Tumors 9 | 48
Jeune thoracic dystrophy 9 | 10
Short Rib-Polydactyly Syndrome 9 | 13
adult high grade glioma 9 | 3,801
Brachydactyly 8 | 156
Congenital hypoplasia of penis 8 | 176
Ellis-Van Creveld syndrome 8 | 19
primitive neuroectodermal tumor 8 | 3,035
Hydrocephalus 7 | 152
Intellectual disability 7 | 1,016
Obesity 7 | 678
Short stature 7 | 531
Broad flat nasal bridge 6 | 236
Nasal bridge wide 6 | 236
Pick disease 6 | 1,894
Retinitis Pigmentosa 6 | 226
lung carcinoma 6 | 2,843
medulloblastoma 6 | 720
Abnormality of the metaphyses 5 | 48
Anteverted nostril 5 | 191
Autosomal recessive predisposition 5 | 1,442
Cancer 5 | 2,499
Cleft Lip 5 | 141
Cranioectodermal Dysplasia 5 | 5
Cryptorchidism 5 | 296
Dull intelligence 5 | 645
Joubert syndrome 5 | 66
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Micromelia 5 | 58
Narrow thorax 5 | 53
Nevoid basal cell carcinoma syndrome 5 | 16
Nystagmus 5 | 317
Poor school performance 5 | 645
Respiratory Insufficiency 5 | 132
Short rib-polydactyly syndrome, Verma-Naumoff type 5 | 5
Short-rib thoracic dysplasia 3 with or without polydactyly 5 | 9
Sternal anomalies 5 | 19
Ulnar polydactyly of fingers 5 | 47
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
pediatric high grade glioma 5 | 1,064
Abnormal skeletal development 4 | 60
Abnormality of pelvic girdle bone morphology 4 | 37
Abnormality of retinal pigmentation 4 | 111
Abnormality of the clavicle 4 | 14
Abnormality of the ribs 4 | 32
Abnormally small eyeball 4 | 97
Acrofacial dysostosis 4 | 8
Cataract 4 | 297
Cone-shaped epiphyses 4 | 24
Craniosynostosis 4 | 74
Decreased size of eyeball 4 | 97
Electroretinogram abnormal 4 | 95
Frontal bossing 4 | 157
Glaucoma 4 | 239
Holoprosencephaly 4 | 56
Hypogonadism 4 | 173
Hypoplastic feet 4 | 66
Lens Opacities 4 | 231
Microphthalmos 4 | 100
Osteochondrodysplasias 4 | 72
Respiratory function loss 4 | 121
Retinal pigment epithelial abnormality 4 | 111
Senior-Loken syndrome 4 | 22
Short thorax 4 | 21
cystic fibrosis and chronic rhinosinusitis 4 | 214
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung adenocarcinoma 4 | 2,716
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
pancreatic cancer 4 | 2,398
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Epilepsy 3 | 792
acute myeloid leukemia 3 | 783
hepatocellular carcinoma 3 | 547
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
primary pancreatic ductal adenocarcinoma 3 | 1,109
progressive supranuclear palsy 3 | 676

Tissue

Blood and immune system 44 | 16,909
Digestive Tract 44 | 17,369
Endocrine System 44 | 18,159
Female tissues 44 | 17,400
Nervous System 44 | 16,725
Respiratory system 44 | 16,393
Skin and soft tissues 44 | 17,230
Urinary Tract 44 | 16,678
Cardiovascular System 43 | 15,192
Liver and Pancreas 43 | 16,750
Male tissues 43 | 17,142

Target Family

Non-IDG 35 | 12,091
Enzyme 3 | 4,145
Transcription Factor 3 | 1,400
Kinase 2 | 634
GPCR 1 | 408

GO Component

ciliary tip 44 | 44
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Intraflagellar transport protein 25 homolog HSPB11 Tbio Non-IDG -1.40552 26.1 61
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
WD repeat-containing protein 60 WDR60 Tbio Non-IDG -0.64761 3.98 23
Intraflagellar transport protein 52 homolog IFT52 Tbio Non-IDG -1.09507 12.7 13
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.60757 39.5 23
Intraflagellar transport protein 140 homolog IFT140 Tbio Non-IDG -1.42568 23.3 45
Serine/threonine-protein kinase ICK ICK Tchem Kinase -2.63650 422.2 179
Dynein light chain roadblock-type 1 DYNLRB1 Tbio Non-IDG -2.23639 168.6 41
Dynein light chain roadblock-type 2 DYNLRB2 Tbio Non-IDG -0.65444 2.59 77
WD repeat-containing protein 35 WDR35 Tbio Non-IDG -1.31497 20.6 39