Development Level

Tbio 30 | 11,445
Tchem 6 | 1,598
Tdark 6 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
abnormal ovary morphology 1 | 7
abnormal placement of pupils 1 | 6
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged thymus 1 | 5
increased aggression 1 | 4
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased grip strength 1 | 41
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 28 | 11,493
osteosarcoma 22 | 7,950
ovarian cancer 22 | 8,520
medulloblastoma, large-cell 17 | 6,241
Cancer 12 | 2,499
psoriasis 9 | 6,694
ependymoma 8 | 4,679
glioblastoma 8 | 5,792
group 3 medulloblastoma 8 | 4,104
Breast cancer 7 | 3,578
Intellectual disability 7 | 1,016
Kidney cancer 7 | 2,613
atypical teratoid / rhabdoid tumor 7 | 5,112
lung cancer 7 | 4,740
Fanconi anemia 6 | 56
Pick disease 6 | 1,894
Short stature 6 | 531
adult high grade glioma 6 | 3,801
primitive neuroectodermal tumor 6 | 3,035
Atrophic condition of skin 5 | 25
Autosomal recessive predisposition 5 | 1,442
Dry skin 5 | 75
Dull intelligence 5 | 645
Dyskeratosis congenita 5 | 24
Low intelligence 5 | 645
Melanoma 5 | 711
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Osteoporosis 5 | 363
Poor school performance 5 | 645
Premature canities 5 | 24
Telangiectasia of the skin 5 | 39
Xerosis 5 | 75
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
juvenile dermatomyositis 5 | 1,187
pancreatic cancer 5 | 2,398
Anemia 4 | 365
Aplasia/Hypoplasia of the skin 4 | 16
Bone marrow hypocellularity 4 | 20
Cerebellar Ataxia 4 | 304
Cognitive delay 4 | 608
Cryptorchidism 4 | 296
Decreased platelet count 4 | 111
Dystrophia unguium 4 | 53
Failure to gain weight 4 | 365
Fetal Growth Retardation 4 | 189
Freckles 4 | 33
Global developmental delay 4 | 608
Hair shaft abnormalities 4 | 30
Hyperpigmented macules 4 | 42
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Malabsorption 4 | 82
Mental and motor retardation 4 | 608
Pediatric failure to thrive 4 | 365
Skin Ulcer 4 | 48
Small head 4 | 374
Sparse hair 4 | 59
Sparse scalp hair 4 | 42
Thin, sparse hair 4 | 59
Thrombocytopenia 4 | 197
Tracheoesophageal Fistula 4 | 36
acute quadriplegic myopathy 4 | 1,158
hair abnormalities (non-specific) 4 | 30
hypopigmented skin patch 4 | 59
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
periodontitis 4 | 293
Amyotrophic lateral sclerosis 3 | 451
Blood Coagulation Disorders 3 | 42
Cellular immunodeficiency 3 | 17
Cerebral atrophy 3 | 178
Coagulation abnormalities 3 | 27
Congenital deafness 3 | 185
Deafness 3 | 198
Dilated ventricles (finding) 3 | 121
Frequent fractures 3 | 53
Hearing Loss, Partial 3 | 185
Hemoglobin low 3 | 124
Hemorrhagic Disorders 3 | 30
Highly variable clinical phenotype 3 | 150
Highly variable phenotype and severity 3 | 150
Highly variable phenotype, even within families 3 | 150
Increased fracture rate 3 | 53
Leukopenia 3 | 72
Lung Neoplasms 3 | 232
Muscle Hypertonia 3 | 88
Neutrophil abnormality 3 | 20
Phenotypic variability 3 | 150
Recurrent respiratory infections 3 | 141
Varying degree of multiple fractures 3 | 53
adrenocortical carcinoma 3 | 1,428
dermatomyositis 3 | 966
hearing impairment 3 | 199
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis and treatment for 6 months 3 | 409

Tissue

Endocrine System 41 | 18,159
Blood and immune system 40 | 16,909
Digestive Tract 39 | 17,369
Female tissues 39 | 17,400
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Liver and Pancreas 38 | 16,750
Urinary Tract 38 | 16,678
Cardiovascular System 36 | 15,192

Target Family

Non-IDG 19 | 12,091
Enzyme 15 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
Kinase 1 | 634

GO Component

chromosome, telomeric region 42 | 42
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Telomerase protein component 1 TEP1 Tbio Enzyme -1.74492 50.6 71
Meiotic recombination protein SPO11 SPO11 Tbio Non-IDG -2.33263 208.9 148
DPY30 domain-containing protein 1 DYDC1 Tbio Non-IDG -0.70377 5.09 133
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
Telomerase-binding protein EST1A SMG6 Tbio Enzyme -1.48788 32.6 37
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Telomere repeats-binding bouquet formation protein 1 TERB1 Tdark Transcription Factor -0.45230 3.56 26
Regulator of telomere elongation helicase 1 RTEL1 Tbio Enzyme -2.66156 233.0 85
Telomeric repeat-binding factor 2-interacting protein 1 TERF2IP Tchem Non-IDG -0.75509 5.75 308
Structural maintenance of chromosomes protein 6 SMC6 Tbio Non-IDG -1.42371 20.0 115