Development Level

Tbio 81 | 11,651
Tdark 17 | 6,593
Tchem 15 | 1,388
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 5 | 499
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
increased startle reflex 4 | 112
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
thrombocytopenia 3 | 56
decreased basophil cell number 2 | 16
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
impaired pupillary reflex 2 | 26
increased lean body mass 2 | 172
persistence of hyaloid vascula... 2 | 33
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal defecation 1 | 1
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal locomotor activation 1 | 16
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal spinal cord morpholog... 1 | 9
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
cataract 1 | 92
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased kidney weight 1 | 1
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased CD4-positive, alpha ... 1 | 4
increased anti-nuclear antigen... 1 | 19
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatine... 1 | 5
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased fluid intake 1 | 1
increased heart rate 1 | 23
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
male infertility 1 | 123
prolonged QRS complex duration 1 | 8
shortened RR interval 1 | 17
small spleen 1 | 19
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 92 | 11,493
ovarian cancer 71 | 8,520
osteosarcoma 66 | 7,950
medulloblastoma, large-cell 57 | 6,241
psoriasis 52 | 6,694
atypical teratoid / rhabdoid tumor 45 | 5,112
group 3 medulloblastoma 44 | 4,104
glioblastoma 41 | 5,792
Breast cancer 36 | 3,578
primitive neuroectodermal tumor 35 | 3,035
adult high grade glioma 33 | 3,801
lung cancer 32 | 4,740
ependymoma 31 | 4,679
malignant mesothelioma 31 | 3,232
Kidney cancer 30 | 2,613
Cancer 26 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
oligodendroglioma 26 | 2,850
non-small cell lung cancer 25 | 2,890
invasive ductal carcinoma 22 | 2,951
lung adenocarcinoma 21 | 2,716
astrocytic glioma 20 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Rheumatoid arthritis 18 | 1,191
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
Intellectual disability 17 | 1,016
group 4 medulloblastoma 16 | 1,855
pituitary cancer 16 | 1,972
Astrocytoma, Pilocytic 15 | 3,081
adrenocortical carcinoma 15 | 1,428
acute quadriplegic myopathy 14 | 1,158
juvenile dermatomyositis 14 | 1,187
Pick disease 13 | 1,894
nasopharyngeal carcinoma 13 | 1,058
pediatric high grade glioma 13 | 1,064
subependymal giant cell astrocytoma 13 | 2,287
Waldenstrons macroglobulinemia 12 | 765
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
colon cancer 11 | 1,478
diabetes mellitus 11 | 1,728
ductal carcinoma in situ 11 | 1,745
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Short stature 10 | 531
breast carcinoma 10 | 1,638
dermatomyositis 10 | 966
Delayed bone age 9 | 136
Schizophrenia 9 | 1,160
Small head 9 | 374
ulcerative colitis 9 | 1,819
Fetal Growth Retardation 8 | 189
Hypoplastic mandible condyle 8 | 275
Infant, Small for Gestational Age 8 | 176
Intrauterine retardation 8 | 176
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Multiple myeloma 8 | 1,332
astrocytoma 8 | 1,146
Alzheimer's disease 7 | 658
Atopic dermatitis 7 | 952
Bilateral fifth finger clinodactyly 7 | 110
Blepharoptosis 7 | 231
Breast Neoplasms 7 | 445
Cryptorchidism 7 | 296
Curvature of little finger 7 | 110
Down syndrome 7 | 499
Downward slant of palpebral fissure 7 | 158
Mammary Neoplasms 7 | 425
Penile hypospadias 7 | 106
lung carcinoma 7 | 2,843
pancreatic cancer 7 | 2,398
spina bifida 7 | 1,074
Adenoid Cystic Carcinoma 6 | 99
Attention deficit hyperactivity disorder 6 | 278
Bipolar Disorder 6 | 666
Byzanthine arch palate 6 | 194
Carcinoma, Adenoid Cystic 6 | 99
Endometriosis 6 | 540
Epilepsy 6 | 792
Failure to gain weight 6 | 365
Liver cancer 6 | 604
Pediatric failure to thrive 6 | 365
Seizures 6 | 596
progressive supranuclear palsy 6 | 676
Autistic Disorder 5 | 364
Feeding difficulties in infancy 5 | 175
Gastroesophageal reflux disease 5 | 110
Gaucher disease type 1 5 | 180
Heartburn 5 | 78
acute myeloid leukemia 5 | 783
aldosterone-producing adenoma 5 | 665
gastric carcinoma 5 | 807
medulloblastoma 5 | 720
primary Sjogren syndrome 5 | 735

Tissue

Endocrine System 112 | 18,159
Blood and immune system 109 | 16,909
Skin and soft tissues 109 | 17,230
Female tissues 108 | 17,400
Liver and Pancreas 108 | 16,750
Male tissues 108 | 17,142
Nervous System 108 | 16,725
Digestive Tract 107 | 17,369
Urinary Tract 107 | 16,678
Respiratory system 105 | 16,393
Cardiovascular System 104 | 15,192

Target Family

Non-IDG 59 | 12,091
Enzyme 20 | 4,145
Epigenetic 15 | 242
Transcription Factor 9 | 1,400
Kinase 6 | 634
TF/Epigenetic 5 | 38

GO Component

chromosome 114 | 114
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific NSD1 Tbio Epigenetic -2.16239 142.5 123
GTP-binding protein 10 GTPBP10 Tdark Non-IDG -0.23899 1.73 121
RCC1 domain-containing protein 1 RCCD1 Tdark Non-IDG -0.97968 9.71 12
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.24186 173.0 274
Proline-rich protein 14 PRR14 Tbio Non-IDG -0.76170 6.46 60
Histone-lysine N-methyltransferase SETDB2 SETDB2 Tbio TF/Epigenetic -1.05387 12.8 177
Ubiquitin carboxyl-terminal hydrolase 7 USP7 Tchem Enzyme -2.26799 196.6 427
Denticleless protein homolog DTL Tbio Non-IDG -1.63065 50.0 160
Nucleolar and spindle-associated protein 1 NUSAP1 Tbio Non-IDG -1.48322 31.1 179
NSFL1 cofactor p47 NSFL1C Tbio Non-IDG -1.01934 9.42 65