Development Level

Tbio 69 | 10,625
Tdark 17 | 7,003
Tchem 13 | 1,890
Tclin 1 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 633
decreased lean body mass 4 | 195
decreased bone mineral content 3 | 157
decreased total body fat amoun... 3 | 186
hyperactivity 3 | 108
increased grip strength 3 | 83
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal coat- hair morphology 2 | 18
abnormal retina morphology 2 | 100
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 121
decreased grip strength 2 | 123
decreased mean corpuscular hem... 2 | 34
embryonic lethality prior to t... 2 | 187
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal coat appearance 1 | 25
abnormal coat-hair pigmentatio... 1 | 54
abnormal craniofacial morpholo... 1 | 12
abnormal defecation 1 | 1
abnormal gait 1 | 51
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal startle reflex 1 | 14
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased circulating serum al... 1 | 79
decreased heart weight 1 | 44
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
female infertility 1 | 34
fused cornea and lens 1 | 4
hypoactivity 1 | 89
impaired pupillary reflex 1 | 14
increased bone mineral density 1 | 52
increased circulating amylase ... 1 | 13
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased fasted circulating g... 1 | 68
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
prolonged QRS complex duration 1 | 2
short tibia 1 | 82

Disease

ovarian cancer 63 | 8,491
osteosarcoma 59 | 7,933
medulloblastoma, large-cell 52 | 6,234
psoriasis 46 | 6,685
glioblastoma 38 | 5,572
primitive neuroectodermal tumor 32 | 3,031
atypical teratoid / rhabdoid tumor 31 | 4,369
lung cancer 29 | 4,473
group 3 medulloblastoma 28 | 2,254
Breast cancer 27 | 3,098
pediatric high grade glioma 27 | 2,712
malignant mesothelioma 26 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,289
non-small cell lung cancer 23 | 2,798
Carcinoma 22 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
oligodendroglioma 22 | 2,849
Cancer 21 | 2,346
invasive ductal carcinoma 21 | 2,950
lung adenocarcinoma 20 | 2,714
ependymoma 18 | 2,514
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
Rheumatoid Arthritis 15 | 1,170
astrocytic glioma 15 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,956
acute quadriplegic myopathy 14 | 1,157
adrenocortical carcinoma 14 | 1,427
nasopharyngeal carcinoma 13 | 1,056
pituitary cancer 13 | 1,972
adult high grade glioma 12 | 2,148
colon cancer 12 | 1,475
juvenile dermatomyositis 12 | 1,189
pilocytic astrocytoma 12 | 3,086
Waldenstrons macroglobulinemia 11 | 764
atypical teratoid/rhabdoid tumor 11 | 1,095
diabetes mellitus 11 | 1,663
group 4 medulloblastoma 11 | 1,875
Intellectual disability 10 | 573
Pick disease 10 | 1,893
breast carcinoma 10 | 1,614
ductal carcinoma in situ 10 | 1,745
medulloblastoma 10 | 1,524
sonic hedgehog group medulloblastoma 10 | 1,482
astrocytoma 9 | 1,493
dermatomyositis 9 | 966
posterior fossa group A ependymoma 9 | 1,511
subependymal giant cell astrocytoma 9 | 2,287
Multiple myeloma 8 | 1,327
ulcerative colitis 8 | 2,087
Atopic dermatitis 7 | 944
Down syndrome 7 | 548
pancreatic cancer 7 | 2,300
Endometriosis 6 | 535
IGA Glomerulonephritis 6 | 454
Mammary Neoplasms 6 | 410
spina bifida 6 | 1,064
Adenoid Cystic Carcinoma 5 | 99
Cornelia de Lange syndrome 5 | 21
aldosterone-producing adenoma 5 | 664
gastric carcinoma 5 | 832
lung carcinoma 5 | 2,844
non primary Sjogren syndrome sicca 5 | 840
primary Sjogren syndrome 5 | 788
progressive supranuclear palsy 5 | 674
Alzheimer's disease 4 | 644
Autistic Disorder 4 | 320
Bloom syndrome 4 | 30
Gaucher disease type 1 4 | 171
Myeloid Leukemia 4 | 19
Rothmund-Thomson syndrome 4 | 22
Seckel syndrome 4 | 35
Sotos syndrome 4 | 15
acute myeloid leukemia 4 | 785
esophageal adenocarcinoma 4 | 737
gastric cancer 4 | 436
inflammatory breast cancer 4 | 404
interstitial cystitis 4 | 2,299
tuberculosis and treatment for 6 months 4 | 686
Acquired metabolic disease 3 | 267
Amyotrophic Lateral Sclerosis 3 | 432
Arthritis 3 | 248
Ataxia telangiectasia 3 | 32
Baller-Gerold syndrome 3 | 14
Bipolar Disorder 3 | 266
Infertility 3 | 163
Microcephaly 3 | 149
Neoplastic Cell Transformation 3 | 81
Nijmegen breakage syndrome 3 | 23
Prostate cancer 3 | 172
RAPADILINO syndrome 3 | 7
Roberts syndrome 3 | 16
Schizophrenia 3 | 503
Vascular disease 3 | 281
Werner syndrome 3 | 29
Wolf-Hirschhorn syndrome 3 | 32
active Crohn's disease 3 | 918
chronic lymphocytic leukemia 3 | 244
cystic fibrosis 3 | 1,670
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271

Tissue

Digestive Tract 97 | 18,472
Endocrine System 97 | 18,511
Nervous System 97 | 18,560
Blood and immune system 96 | 17,994
Female tissues 96 | 18,646
Liver and Pancreas 96 | 18,135
Urinary Tract 96 | 18,443
Cardiovascular System 95 | 17,957
Male tissues 95 | 17,968
Skin and soft tissues 95 | 18,114
Respiratory system 94 | 17,483

Target Family

Non-IDG 52 | 11,969
Enzyme 19 | 4,146
Epigenetic 13 | 242
Transcription Factor 8 | 1,400
TF/Epigenetic 5 | 38
Kinase 3 | 634

GO Component

chromosome 100 | 100
nucleus 5,106 | 5,106
cytoplasm 4,984 | 4,984
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,264 | 3,264
extracellular exosome 2,757 | 2,757
nucleoplasm 2,716 | 2,716
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 536 | 536
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
THAP domain-containing protein 7 THAP7 Tbio Transcription Factor -0.07311 1.18 14
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
UV-stimulated scaffold protein A UVSSA Tbio Non-IDG -0.81845 7.77 23
Histone-lysine N-methyltransferase NSD3 NSD3 Tbio Epigenetic -1.29117 15.4 192
NSFL1 cofactor p47 NSFL1C Tbio Non-IDG -0.96009 8.42 54
Denticleless protein homolog DTL Tbio Non-IDG -1.60626 45.3 123
Nucleolar and spindle-associated protein 1 NUSAP1 Tbio Non-IDG -1.40363 27.5 164
Putative high mobility group protein B1-like 1 HMGB1P1 Tdark Non-IDG -2.99651 1948.8 0
Histone-lysine N-methyltransferase SETDB2 SETDB2 Tbio TF/Epigenetic -0.96080 10.8 171
Probable histone-lysine N-methyltransferase PRDM7 PRDM7 Tdark Epigenetic -0.37312 2.69 22