Development Level

Tbio 312 | 11,178
Tdark 64 | 6,569
Tchem 44 | 1,885
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Comple... 4 | 37
Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 49 | 979
preweaning lethality, incomple... 14 | 499
embryonic lethality prior to t... 12 | 278
abnormal behavior 10 | 298
abnormal embryo size 10 | 220
decreased total body fat amoun... 9 | 207
embryonic lethality prior to o... 9 | 239
decreased vertical activity 8 | 208
decreased bone mineral content 7 | 151
hypoactivity 7 | 132
decreased body length 6 | 101
decreased body weight 6 | 161
decreased lean body mass 6 | 135
impaired glucose tolerance 6 | 75
male infertility 6 | 123
prenatal lethality prior to he... 6 | 87
abnormal heart morphology 5 | 162
increased bone mineral density 5 | 72
abnormal bone structure 4 | 187
abnormal craniofacial morpholo... 4 | 33
abnormal head morphology 4 | 10
abnormal kidney morphology 4 | 65
abnormal spleen morphology 4 | 55
abnormal tail morphology 4 | 25
decreased circulating choleste... 4 | 93
decreased grip strength 4 | 116
edema 4 | 59
enlarged heart 4 | 210
improved glucose tolerance 4 | 79
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
increased or absent threshold ... 4 | 101
prenatal lethality 4 | 28
small testis 4 | 58
abnormal cranium morphology 3 | 36
abnormal lens morphology 3 | 81
abnormal limb morphology 3 | 13
abnormal seminal vesicle morph... 3 | 114
abnormal sleep behavior 3 | 70
abnormal testis morphology 3 | 43
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 76
decreased startle reflex 3 | 75
embryonic growth retardation 3 | 106
hemorrhage 3 | 23
increased circulating HDL chol... 3 | 80
increased circulating alkaline... 3 | 122
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal body wall morphology 2 | 9
abnormal coat- hair morphology 2 | 19
abnormal embryo turning 2 | 31
abnormal facial morphology 2 | 17
abnormal joint morphology 2 | 23
abnormal locomotor behavior 2 | 24
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal pancreas morphology 2 | 13
abnormal placenta size 2 | 20
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal skin morphology 2 | 50
abnormal startle reflex 2 | 15
convulsive seizures 2 | 13
decreased basophil cell number 2 | 16
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating calcium ... 2 | 36
decreased circulating glucose ... 2 | 126
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased red blood cell distr... 2 | 41
enlarged lymph nodes 2 | 37
enlarged spleen 2 | 41
hyperactivity 2 | 148
increased body length 2 | 32
increased circulating chloride... 2 | 41
increased circulating glucose ... 2 | 24
increased grip strength 2 | 41
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 36
increased monocyte cell number 2 | 63
increased prepulse inhibition 2 | 32
microphthalmia 2 | 26
protruding tongue 2 | 3
short tibia 2 | 97
tremors 2 | 39
vertebral fusion 2 | 23

Disease

Carcinoma 301 | 11,192
ovarian cancer 257 | 8,297
osteosarcoma 228 | 7,766
medulloblastoma, large-cell 189 | 6,086
glioblastoma 167 | 5,635
atypical teratoid / rhabdoid tumor 162 | 4,971
psoriasis 156 | 6,514
ependymoma 148 | 4,559
group 3 medulloblastoma 147 | 4,002
lung cancer 137 | 4,607
Breast cancer 114 | 3,469
primitive neuroectodermal tumor 106 | 2,957
adult high grade glioma 105 | 3,701
malignant mesothelioma 105 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 101 | 3,204
Kidney cancer 86 | 2,548
intraductal papillary-mucinous carcinoma (IPMC) 84 | 2,902
oligodendroglioma 83 | 2,768
invasive ductal carcinoma 74 | 2,867
non-small cell lung cancer 74 | 2,799
Cancer 65 | 2,388
astrocytic glioma 64 | 2,530
adrenocortical carcinoma 61 | 1,385
Intellectual disability 60 | 998
Pick disease 60 | 1,856
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,872
Astrocytoma, Pilocytic 59 | 3,006
pancreatic cancer 58 | 2,322
lung adenocarcinoma 57 | 2,627
Autosomal recessive predisposition 55 | 1,407
subependymal giant cell astrocytoma 53 | 2,230
colon cancer 52 | 1,428
ductal carcinoma in situ 49 | 1,686
breast carcinoma 44 | 1,589
Multiple myeloma 42 | 1,296
tuberculosis 42 | 1,963
Dull intelligence 40 | 634
Low intelligence 40 | 634
Mental Retardation 40 | 634
Mental deficiency 40 | 634
Poor school performance 40 | 634
acute quadriplegic myopathy 40 | 1,133
lung carcinoma 40 | 2,755
Cognitive delay 38 | 596
Global developmental delay 38 | 596
Mental and motor retardation 38 | 596
group 4 medulloblastoma 38 | 1,806
Short stature 36 | 514
astrocytoma 36 | 1,113
diabetes mellitus 36 | 1,683
interstitial cystitis 34 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,911
pituitary cancer 34 | 1,915
Atopic dermatitis 33 | 915
Schizophrenia 33 | 1,136
nasopharyngeal carcinoma 33 | 1,024
ulcerative colitis 33 | 1,765
juvenile dermatomyositis 32 | 1,147
Rheumatoid arthritis 31 | 1,156
Small head 31 | 366
Waldenstrons macroglobulinemia 31 | 742
dermatomyositis 31 | 941
Ciliopathy 30 | 71
pediatric high grade glioma 30 | 1,035
Obesity 28 | 655
chronic rhinosinusitis 28 | 505
progressive supranuclear palsy 28 | 656
Joubert syndrome 27 | 66
Microcephaly 27 | 166
Polydactyly 27 | 106
active Crohn's disease 26 | 882
non primary Sjogren syndrome sicca 26 | 861
Endometriosis 24 | 521
Nystagmus 24 | 309
Retinitis Pigmentosa 24 | 223
Bardet-Biedl syndrome 23 | 51
medulloblastoma 23 | 702
primary pancreatic ductal adenocarcinoma 23 | 1,071
Amyotrophic lateral sclerosis 22 | 437
Nephronophthisis 22 | 79
cystic fibrosis 22 | 1,629
gastric cancer 22 | 445
hepatocellular carcinoma 22 | 536
Epilepsy 20 | 775
acute myeloid leukemia 20 | 760
posterior fossa group B ependymoma 20 | 406
tuberculosis and treatment for 6 months 20 | 399
Seizures 19 | 584
esophageal adenocarcinoma 19 | 696
primary Sjogren syndrome 19 | 710
Bipolar Disorder 18 | 646
Cerebellar Ataxia 18 | 302
Neurodegenerative disease 18 | 402
active ulcerative colitis 18 | 736
Cataract 17 | 290
Retinal Degeneration 17 | 103
cutaneous lupus erythematosus 17 | 1,016
spina bifida 17 | 1,053
Fetal Growth Retardation 16 | 186
Hypertensive disease 16 | 278

Tissue

Endocrine System 424 | 18,159
Female tissues 423 | 17,400
Male tissues 423 | 17,142
Skin and soft tissues 422 | 17,230
Blood and immune system 421 | 16,909
Digestive Tract 421 | 17,369
Liver and Pancreas 420 | 16,750
Respiratory system 420 | 16,393
Urinary Tract 420 | 16,678
Nervous System 419 | 16,725
Cardiovascular System 408 | 15,192

Target Family

Non-IDG 317 | 12,091
Enzyme 64 | 4,145
Kinase 28 | 634
Transcription Factor 12 | 1,400
Epigenetic 4 | 242
Ion Channel 1 | 344
Transporter 1 | 473

GO Component

centrosome 427 | 427
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
Centrobin CNTROB Tbio Non-IDG -1.31192 23.3 151
Serine/threonine-protein kinase greatwall MASTL Tbio Kinase -2.17166 152.5 259
Centriole, cilia and spindle-associated protein CCSAP Tbio Non-IDG -1.93256 89.5 55
Pleckstrin homology domain-containing family A member 7 PLEKHA7 Tbio Non-IDG -0.97160 13.3 46
E3 ubiquitin-protein ligase UBR4 UBR4 Tbio Enzyme -1.10111 13.3 76
Serine/threonine-protein kinase BRSK1 BRSK1 Tchem Kinase -1.44039 28.9 301
Protein SFI1 homolog SFI1 Tdark Non-IDG -1.48977 32.1 21
Cytoskeleton-associated protein 5 CKAP5 Tbio Non-IDG -2.12618 129.3 77
Centrosomal protein of 192 kDa CEP192 Tbio Non-IDG -1.15560 13.3 34