Development Level

Tbio 288 | 10,625
Tdark 68 | 7,003
Tchem 45 | 1,890
Tclin 8 | 602

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 30 | 633
decreased bone mineral content 8 | 157
decreased lean body mass 8 | 195
embryonic lethality prior to t... 8 | 187
decreased total body fat amoun... 7 | 186
decreased body weight 6 | 174
increased mean corpuscular hem... 6 | 93
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
decreased bone mineral density 5 | 126
decreased lumbar vertebrae num... 5 | 62
embryonic lethality prior to o... 5 | 148
increased circulating alkaline... 5 | 119
abnormal bone structure 4 | 131
abnormal head morphology 4 | 10
decreased body length 4 | 108
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
hyperactivity 4 | 108
hypoactivity 4 | 89
improved glucose tolerance 4 | 56
increased grip strength 4 | 83
increased leukocyte cell numbe... 4 | 37
increased mean corpuscular vol... 4 | 91
increased sacral vertebrae num... 4 | 62
prenatal lethality prior to he... 4 | 64
abnormal cranium morphology 3 | 32
abnormal embryo size 3 | 112
abnormal kidney morphology 3 | 30
abnormal lens morphology 3 | 73
abnormal limb bud morphology 3 | 15
abnormal spleen morphology 3 | 36
abnormal tail morphology 3 | 17
decreased basophil cell number 3 | 11
decreased circulating HDL chol... 3 | 77
decreased circulating serum al... 3 | 79
increased bone mineral density 3 | 52
increased circulating choleste... 3 | 53
increased lean body mass 3 | 107
increased or absent threshold ... 3 | 128
short tibia 3 | 82
vertebral fusion 3 | 23
abnormal bone mineralization 2 | 55
abnormal coat/ hair morphology 2 | 18
abnormal humerus morphology 2 | 11
abnormal joint morphology 2 | 14
abnormal pelvic girdle bone mo... 2 | 11
abnormal startle reflex 2 | 14
abnormal tail movements 2 | 12
abnormal vertebrae morphology 2 | 14
cataract 2 | 26
decreased circulating calcium ... 2 | 33
decreased circulating total pr... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased hematocrit 2 | 25
decreased mean corpuscular vol... 2 | 50
decreased startle reflex 2 | 48
edema 2 | 11
hemorrhage 2 | 12
hydrops fetalis 2 | 22
immune system phenotype 2 | 17
impaired glucose tolerance 2 | 52
increased NK cell number 2 | 19
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating glucose ... 2 | 16
increased circulating glycerol... 2 | 11
increased circulating iron lev... 2 | 25
increased fasted circulating g... 2 | 68
increased hematocrit 2 | 36
increased mean corpuscular hem... 2 | 25
increased prepulse inhibition 2 | 21
increased startle reflex 2 | 38
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal embryo turning 1 | 15
abnormal heart looping 1 | 2
abnormal heart morphology 1 | 51
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal testis morphology 1 | 30
convulsive seizures 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased red blood cell distr... 1 | 11
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
increased circulating creatini... 1 | 29
prenatal lethality 1 | 16
straub tail 1 | 26

Disease

ovarian cancer 253 | 8,484
osteosarcoma 220 | 7,933
medulloblastoma, large-cell 182 | 6,234
glioblastoma 161 | 5,572
psoriasis 154 | 6,685
atypical teratoid / rhabdoid tumor 128 | 4,369
lung cancer 125 | 4,466
Breast cancer 108 | 3,094
primitive neuroectodermal tumor 108 | 3,031
group 3 medulloblastoma 97 | 2,254
malignant mesothelioma 97 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 96 | 3,289
pediatric high grade glioma 85 | 2,712
oligodendroglioma 83 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 80 | 2,988
non-small cell lung cancer 75 | 2,798
invasive ductal carcinoma 72 | 2,950
ependymoma 71 | 2,514
posterior fossa group B ependymoma 66 | 1,530
Carcinoma 64 | 2,147
Pick disease 63 | 1,893
Cancer 61 | 2,346
adrenocortical carcinoma 61 | 1,427
lung adenocarcinoma 60 | 2,713
astrocytic glioma 58 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 56 | 2,956
colon cancer 55 | 1,475
pancreatic cancer 55 | 2,300
pilocytic astrocytoma 53 | 3,086
subependymal giant cell astrocytoma 51 | 2,287
ductal carcinoma in situ 48 | 1,745
adult high grade glioma 44 | 2,148
atypical teratoid/rhabdoid tumor 43 | 1,095
sonic hedgehog group medulloblastoma 43 | 1,482
ulcerative colitis 43 | 2,087
group 4 medulloblastoma 42 | 1,875
Multiple myeloma 41 | 1,327
astrocytoma 41 | 1,493
lung carcinoma 41 | 2,844
acute quadriplegic myopathy 40 | 1,157
breast carcinoma 40 | 1,614
medulloblastoma 39 | 1,524
posterior fossa group A ependymoma 38 | 1,511
nasopharyngeal carcinoma 35 | 1,056
pituitary cancer 35 | 1,972
Intellectual disability 34 | 573
diabetes mellitus 34 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,795
tuberculosis 34 | 1,557
Waldenstrons macroglobulinemia 31 | 765
juvenile dermatomyositis 30 | 1,189
Rheumatoid Arthritis 29 | 1,160
dermatomyositis 29 | 933
interstitial cystitis 28 | 2,299
tuberculosis and treatment for 6 months 28 | 686
Atopic dermatitis 27 | 944
Microcephaly 27 | 149
chronic rhinosinusitis 27 | 512
primary pancreatic ductal adenocarcinoma 27 | 1,271
progressive supranuclear palsy 27 | 674
active Crohn's disease 26 | 918
Ciliopathy 24 | 57
Joubert syndrome 23 | 61
Obesity 23 | 616
Polydactyly 22 | 93
non primary Sjogren syndrome sicca 22 | 840
Amyotrophic Lateral Sclerosis 21 | 431
Nephronophthisis 21 | 74
Retinitis pigmentosa 20 | 153
acute myeloid leukemia 20 | 780
cystic fibrosis 20 | 1,665
esophageal adenocarcinoma 20 | 737
hepatocellular carcinoma 20 | 532
Bardet-Biedl Syndrome 19 | 40
Endometriosis 19 | 535
IGA Glomerulonephritis 18 | 454
aldosterone-producing adenoma 17 | 664
gastric cancer 17 | 430
gastric carcinoma 17 | 832
pancreatic carcinoma 17 | 567
spina bifida 17 | 1,064
Meckel syndrome 16 | 48
Neurodegenerative disease 16 | 383
Prostatic Neoplasms 16 | 471
Schizophrenia 16 | 501
primary Sjogren syndrome 16 | 789
Asphyxiating thoracic dystrophy 15 | 32
hereditary spastic paraplegia 15 | 313
cutaneous lupus erythematosus 14 | 1,056
Down syndrome 13 | 548
Mammary Neoplasms 13 | 410
Alzheimer's disease 12 | 644
Senior-Loken syndrome 12 | 21
Fundus dystrophy 11 | 77
Parkinson's disease 11 | 364
active ulcerative colitis 11 | 477
cystic fibrosis and chronic rhinosinusitis 11 | 213
Crohn's disease 10 | 304
Duchenne muscular dystrophy 10 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499

Tissue

Blood and immune system 409 | 17,995
Cardiovascular System 408 | 17,958
Endocrine System 408 | 18,512
Female tissues 408 | 18,647
Nervous System 408 | 18,561
Digestive Tract 407 | 18,473
Liver and Pancreas 407 | 18,136
Male tissues 406 | 17,969
Urinary Tract 406 | 18,444
Respiratory system 403 | 17,484
Skin and soft tissues 403 | 18,115

Target Family

Non-IDG 290 | 11,971
Enzyme 69 | 4,146
Kinase 32 | 634
Transcription Factor 10 | 1,400
Epigenetic 4 | 242
Transporter 3 | 473
Ion Channel 1 | 341

GO Component

centrosome 409 | 409
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Coiled-coil domain-containing protein 15 CCDC15 Tdark Non-IDG 0.00000 53
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Ankyrin repeat domain-containing protein 26 ANKRD26 Tbio Non-IDG -1.28843 22.9 87
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
MAP7 domain-containing protein 3 MAP7D3 Tbio Non-IDG -0.92082 8.05 8
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.02867 11.1 125
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.65303 525.6 142