Development Level

Tbio 116 | 11,651
Tchem 22 | 1,388
Tclin 8 | 612
Tdark 3 | 6,593

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 17 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 5 | 220
preweaning lethality, incomple... 5 | 499
abnormal behavior 4 | 298
abnormal retina morphology 4 | 71
decreased vertical activity 4 | 208
increased blood urea nitrogen ... 4 | 48
abnormal eye morphology 3 | 68
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
abnormal pericardium morpholog... 3 | 26
cataract 3 | 92
decreased grip strength 3 | 116
decreased total body fat amoun... 3 | 207
increased circulating alkaline... 3 | 122
abnormal bone structure 2 | 187
abnormal neural tube closure 2 | 46
abnormal tail movements 2 | 12
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
hyperactivity 2 | 148
increased bone mineral density 2 | 72
increased heart weight 2 | 62
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
male infertility 2 | 123
mammalian phenotype 2 | 17
pale yolk sac 2 | 25
persistence of hyaloid vascula... 2 | 33
prolonged ST segment 2 | 36
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart looping 1 | 5
abnormal left-right axis patte... 1 | 2
abnormal midbrain development 1 | 20
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal pharyngeal arch morph... 1 | 8
abnormal response to new envir... 1 | 10
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal somite shape 1 | 5
abnormal startle reflex 1 | 15
abnormal tail bud morphology 1 | 8
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 19
decreased circulating serum al... 1 | 82
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
dilated heart left ventricle 1 | 11
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased startle reflex 1 | 112
increased vertical activity 1 | 24
microphthalmia 1 | 26
premature death 1 | 5
prenatal lethality 1 | 28
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 117 | 11,493
ovarian cancer 93 | 8,520
osteosarcoma 86 | 7,950
psoriasis 84 | 6,694
medulloblastoma, large-cell 76 | 6,241
glioblastoma 73 | 5,792
atypical teratoid / rhabdoid tumor 69 | 5,112
lung cancer 60 | 4,740
ependymoma 55 | 4,679
Cancer 53 | 2,499
non-small cell lung cancer 53 | 2,890
Breast cancer 47 | 3,578
lung adenocarcinoma 47 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 46 | 2,989
Kidney cancer 45 | 2,613
group 3 medulloblastoma 45 | 4,104
invasive ductal carcinoma 44 | 2,951
malignant mesothelioma 44 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,291
adult high grade glioma 42 | 3,801
interstitial cystitis 38 | 2,312
lung carcinoma 38 | 2,843
pancreatic cancer 35 | 2,398
oligodendroglioma 34 | 2,850
primitive neuroectodermal tumor 34 | 3,035
Astrocytoma, Pilocytic 33 | 3,081
astrocytic glioma 33 | 2,597
breast carcinoma 31 | 1,638
pituitary cancer 28 | 1,972
ductal carcinoma in situ 25 | 1,745
cystic fibrosis 23 | 1,696
subependymal giant cell astrocytoma 23 | 2,287
ulcerative colitis 23 | 1,819
Autosomal recessive predisposition 22 | 1,442
spina bifida 22 | 1,074
Liver Cirrhosis, Experimental 20 | 769
diabetes mellitus 20 | 1,728
group 4 medulloblastoma 20 | 1,855
pediatric high grade glioma 20 | 1,064
primary pancreatic ductal adenocarcinoma 20 | 1,109
tuberculosis 20 | 2,010
cutaneous lupus erythematosus 19 | 1,057
juvenile dermatomyositis 19 | 1,187
Pick disease 18 | 1,894
Rheumatoid arthritis 16 | 1,191
Schizophrenia 16 | 1,160
astrocytoma 16 | 1,146
Breast Neoplasms 15 | 445
Obesity 15 | 678
adrenocortical carcinoma 15 | 1,428
colon cancer 15 | 1,478
Bipolar Disorder 14 | 666
Intellectual disability 14 | 1,016
Mammary Neoplasms 14 | 425
esophageal adenocarcinoma 14 | 737
gastric carcinoma 14 | 807
primary Sjogren syndrome 14 | 735
Atopic dermatitis 13 | 952
acute myeloid leukemia 13 | 783
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
Multiple myeloma 12 | 1,332
dermatomyositis 12 | 966
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Alzheimer's disease 11 | 658
Dull intelligence 11 | 645
Kidney disease 11 | 430
Liver cancer 11 | 604
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 510
medulloblastoma 11 | 720
Epilepsy 10 | 792
Infantile onset 10 | 238
Melanoma 10 | 711
fibroadenoma 10 | 559
Endometrial cancer 9 | 311
Multiple Sclerosis 9 | 540
Prostatic Neoplasms 9 | 495
Skin cancer 9 | 469
active Crohn's disease 9 | 922
nephrosclerosis 9 | 333
posterior fossa group A ependymoma 9 | 468
Nystagmus 8 | 317
Osteoporosis 8 | 363
Renal Cell Carcinoma 8 | 214
Waldenstrons macroglobulinemia 8 | 765
aldosterone-producing adenoma 8 | 665
nasopharyngeal carcinoma 8 | 1,058
progressive supranuclear palsy 8 | 676
Duchenne muscular dystrophy 7 | 601
Muscle hypotonia 7 | 571
Short stature 7 | 531
Splenomegaly 7 | 190
acute quadriplegic myopathy 7 | 1,158
pancreatic carcinoma 7 | 562

Tissue

Digestive Tract 146 | 17,369
Blood and immune system 145 | 16,909
Endocrine System 145 | 18,159
Nervous System 145 | 16,725
Male tissues 144 | 17,142
Skin and soft tissues 144 | 17,230
Urinary Tract 144 | 16,678
Female tissues 143 | 17,400
Liver and Pancreas 142 | 16,750
Respiratory system 141 | 16,393
Cardiovascular System 139 | 15,192

Target Family

Non-IDG 102 | 12,091
Kinase 19 | 634
Enzyme 17 | 4,145
GPCR 4 | 408
Ion Channel 4 | 344
Transporter 2 | 473
Transcription Factor 1 | 1,400

GO Component

cell-cell junction 149 | 149
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Chloride intracellular channel protein 4 CLIC4 Tbio Ion Channel -1.81713 70.5 221
Src kinase-associated phosphoprotein 1 SKAP1 Tbio Enzyme -1.31527 25.2 175
Talin-1 TLN1 Tbio Non-IDG -1.94109 90.0 426
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Pleckstrin homology domain-containing family G member 5 PLEKHG5 Tbio Non-IDG -2.19698 161.7 100
Protein kinase C and casein kinase substrate in neurons protein 2 PACSIN2 Tbio Enzyme -1.38534 27.2 135