Development Level

Tbio 118 | 10,625
Tchem 30 | 1,890
Tclin 8 | 602
Tdark 5 | 7,003

Collection

Eligible Kinase Proteins 1 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 12 | 633
preweaning lethality, incomple... 7 | 260
abnormal embryo size 5 | 112
embryonic lethality prior to o... 5 | 148
embryonic lethality prior to t... 5 | 187
abnormal retina morphology 4 | 100
decreased bone mineral content 4 | 157
decreased grip strength 4 | 123
increased blood urea nitrogen ... 4 | 44
decreased total body fat amoun... 3 | 186
increased or absent threshold ... 3 | 128
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal eye morphology 2 | 38
abnormal neural tube closure 2 | 37
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased lean body mass 2 | 195
increased circulating alkaline... 2 | 119
increased vertical activity 2 | 18
pale yolk sac 2 | 12
abnormal allantois morphology 1 | 3
abnormal behavioral response t... 1 | 52
abnormal cervical vertebrae mo... 1 | 4
abnormal coat appearance 1 | 25
abnormal coping response 1 | 12
abnormal embryo turning 1 | 15
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube morpholog... 1 | 8
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 11
abnormal respiratory quotient 1 | 9
abnormal response to new envir... 1 | 8
abnormal rib morphology 1 | 28
abnormal spinal cord morpholog... 1 | 8
abnormal startle reflex 1 | 14
abnormal tail bud morphology 1 | 6
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
cardiovascular system phenotyp... 1 | 35
craniofacial phenotype 1 | 9
decreased B cell number 1 | 30
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased circulating HDL chol... 1 | 77
decreased circulating bilirubi... 1 | 14
decreased circulating glycerol... 1 | 19
decreased fasted circulating g... 1 | 49
decreased kidney weight 1 | 7
decreased mature B cell number 1 | 25
decreased monocyte cell number 1 | 28
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
edema 1 | 11
embryonic growth retardation 1 | 28
herniated abdominal wall 1 | 4
hydrometra 1 | 13
hydrops fetalis 1 | 22
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased NK cell number 1 | 19
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
increased circulating total pr... 1 | 20
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
microphthalmia 1 | 15
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
premature death 1 | 5
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
short snout 1 | 4
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 102 | 8,484
osteosarcoma 94 | 7,933
psoriasis 90 | 6,685
medulloblastoma, large-cell 83 | 6,234
glioblastoma 77 | 5,572
atypical teratoid / rhabdoid tumor 62 | 4,369
lung cancer 59 | 4,466
non-small cell lung cancer 58 | 2,798
lung adenocarcinoma 54 | 2,713
Carcinoma 52 | 2,147
Cancer 50 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 50 | 2,988
invasive ductal carcinoma 48 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 47 | 3,289
Breast cancer 46 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,956
malignant mesothelioma 45 | 3,162
lung carcinoma 44 | 2,844
pediatric high grade glioma 44 | 2,712
interstitial cystitis 40 | 2,299
pancreatic cancer 39 | 2,300
pilocytic astrocytoma 38 | 3,086
oligodendroglioma 37 | 2,849
primitive neuroectodermal tumor 36 | 3,031
ependymoma 33 | 2,514
breast carcinoma 31 | 1,614
pituitary cancer 31 | 1,972
astrocytic glioma 30 | 2,241
ductal carcinoma in situ 30 | 1,745
group 4 medulloblastoma 30 | 1,875
posterior fossa group A ependymoma 26 | 1,511
primary pancreatic ductal adenocarcinoma 26 | 1,271
subependymal giant cell astrocytoma 26 | 2,287
ulcerative colitis 24 | 2,087
adult high grade glioma 23 | 2,148
cystic fibrosis 23 | 1,665
medulloblastoma 22 | 1,524
spina bifida 22 | 1,064
astrocytoma 21 | 1,493
juvenile dermatomyositis 20 | 1,189
tuberculosis 20 | 1,557
Pick disease 19 | 1,893
cutaneous lupus erythematosus 19 | 1,056
adrenocortical carcinoma 18 | 1,427
colon cancer 18 | 1,475
diabetes mellitus 17 | 1,663
sonic hedgehog group medulloblastoma 17 | 1,482
Rheumatoid Arthritis 16 | 1,160
atypical teratoid/rhabdoid tumor 16 | 1,095
group 3 medulloblastoma 16 | 2,254
Mammary Neoplasms 15 | 410
gastric carcinoma 15 | 832
posterior fossa group B ependymoma 15 | 1,530
Atopic dermatitis 14 | 944
Multiple myeloma 14 | 1,327
acute myeloid leukemia 14 | 780
dermatomyositis 14 | 933
primary Sjogren syndrome 14 | 789
esophageal adenocarcinoma 13 | 737
aldosterone-producing adenoma 12 | 664
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
Obesity 11 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 11 | 499
Multiple Sclerosis 10 | 498
fibroadenoma 10 | 557
Down syndrome 9 | 548
Intellectual disability 9 | 573
Kidney disease 9 | 396
Osteoporosis 9 | 257
Prostatic Neoplasms 9 | 471
Schizophrenia 9 | 501
Waldenstrons macroglobulinemia 9 | 765
active Crohn's disease 9 | 918
acute quadriplegic myopathy 9 | 1,157
nephrosclerosis 9 | 329
Alzheimer's disease 8 | 644
Duchenne muscular dystrophy 8 | 602
Renal Cell Carcinoma 8 | 199
nasopharyngeal carcinoma 8 | 1,056
progressive supranuclear palsy 8 | 674
Amyotrophic Lateral Sclerosis 7 | 431
Animal Mammary Neoplasms 7 | 136
Cardiomyopathy 7 | 110
Epilepsy 7 | 346
Gaucher disease type 1 7 | 171
Nephronophthisis 7 | 74
Polycystic Ovary Syndrome 7 | 332
pancreatic carcinoma 7 | 567
Colorectal Neoplasms 6 | 217
Diabetic Retinopathy 6 | 53
Liver disease 6 | 219
Parkinson's disease 6 | 364
Vascular disease 6 | 281
hereditary spastic paraplegia 6 | 313
urothelial carcinoma 6 | 318
Cerebrovascular disease 5 | 231
Endometriosis 5 | 535
chronic rhinosinusitis 5 | 512
gastric cancer 5 | 430
mucosa-associated lymphoid tissue lymphoma 5 | 480

Tissue

Blood and immune system 161 | 17,995
Cardiovascular System 160 | 17,958
Digestive Tract 160 | 18,473
Endocrine System 160 | 18,512
Female tissues 160 | 18,647
Liver and Pancreas 160 | 18,136
Urinary Tract 160 | 18,444
Male tissues 159 | 17,969
Nervous System 159 | 18,561
Respiratory system 159 | 17,484
Skin and soft tissues 159 | 18,115

Target Family

Non-IDG 110 | 11,971
Kinase 21 | 634
Enzyme 18 | 4,146
GPCR 4 | 406
Ion Channel 4 | 341
Transporter 3 | 473
Transcription Factor 1 | 1,400

GO Component

cell-cell junction 161 | 161
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Receptor-type tyrosine-protein phosphatase eta PTPRJ Tbio Enzyme -1.94494 110.6 235
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.59340 415.3 337
Fatty acid-binding protein, brain FABP7 Tchem Non-IDG -2.12234 145.0 346
WD repeat-containing protein 1 WDR1 Tbio Non-IDG -1.58081 43.3 85
Nephrocystin-4 NPHP4 Tbio Non-IDG -1.39275 26.0 48
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 Tbio Non-IDG -2.42637 343.3 423
Nephrocystin-1 NPHP1 Tbio Non-IDG -1.70748 50.8 88