Development Level

Tbio 256 | 10,625
Tchem 43 | 1,890
Tclin 6 | 602
Tdark 2 | 7,003

Collection

Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 14 | 633
decreased lean body mass 8 | 195
preweaning lethality, incomple... 8 | 260
decreased total body fat amoun... 7 | 186
abnormal embryo size 6 | 112
decreased circulating HDL chol... 6 | 77
increased lean body mass 6 | 107
increased or absent threshold ... 6 | 128
decreased body weight 5 | 174
decreased circulating alanine ... 5 | 53
decreased bone mineral content 4 | 157
decreased circulating choleste... 4 | 85
decreased mean corpuscular vol... 4 | 50
embryonic lethality prior to t... 4 | 187
improved glucose tolerance 4 | 56
abnormal behavior 3 | 226
abnormal sleep behavior 3 | 63
decreased circulating LDL chol... 3 | 37
decreased fasted circulating g... 3 | 49
decreased mean corpuscular hem... 3 | 34
impaired glucose tolerance 3 | 52
increased bone mineral density 3 | 52
prenatal lethality prior to he... 3 | 64
abnormal bone structure 2 | 131
abnormal craniofacial morpholo... 2 | 12
abnormal head morphology 2 | 10
abnormal neural tube closure 2 | 37
abnormal pericardium morpholog... 2 | 11
abnormal retina morphology 2 | 100
abnormal vertebrae morphology 2 | 14
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lactate dehydrogenas... 2 | 14
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating phosphat... 2 | 24
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased hematocrit 2 | 36
increased mean corpuscular hem... 2 | 93
short tibia 2 | 82
shortened RR interval 2 | 19
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
absent pinna reflex 1 | 21
absent teeth 1 | 4
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased circulating bilirubi... 1 | 14
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased circulating amylase ... 1 | 13
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased erythrocyte cell num... 1 | 26
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased total body fat amoun... 1 | 57
prenatal lethality 1 | 16
shortened ST segment 1 | 9
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

ovarian cancer 203 | 8,484
osteosarcoma 160 | 7,933
psoriasis 144 | 6,685
glioblastoma 135 | 5,572
medulloblastoma, large-cell 129 | 6,234
lung cancer 122 | 4,466
atypical teratoid / rhabdoid tumor 111 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 93 | 3,289
pancreatic cancer 86 | 2,300
Cancer 83 | 2,346
Breast cancer 79 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 77 | 2,988
lung adenocarcinoma 74 | 2,713
pediatric high grade glioma 71 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 70 | 2,956
invasive ductal carcinoma 70 | 2,950
non-small cell lung cancer 69 | 2,798
ependymoma 68 | 2,514
malignant mesothelioma 64 | 3,162
Carcinoma 63 | 2,147
Multiple myeloma 63 | 1,327
pilocytic astrocytoma 62 | 3,086
oligodendroglioma 61 | 2,849
subependymal giant cell astrocytoma 56 | 2,287
astrocytoma 55 | 1,493
primary pancreatic ductal adenocarcinoma 55 | 1,271
primitive neuroectodermal tumor 55 | 3,031
spina bifida 53 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 51 | 1,795
dermatomyositis 50 | 933
group 4 medulloblastoma 50 | 1,875
Waldenstrons macroglobulinemia 49 | 765
interstitial cystitis 47 | 2,299
astrocytic glioma 45 | 2,241
lung carcinoma 45 | 2,844
diabetes mellitus 43 | 1,663
acute quadriplegic myopathy 42 | 1,157
ductal carcinoma in situ 41 | 1,745
breast carcinoma 40 | 1,614
Pick disease 39 | 1,893
pituitary cancer 38 | 1,972
tuberculosis 37 | 1,557
juvenile dermatomyositis 36 | 1,189
sonic hedgehog group medulloblastoma 36 | 1,482
Rheumatoid Arthritis 35 | 1,160
ulcerative colitis 35 | 2,087
adult high grade glioma 34 | 2,148
medulloblastoma 33 | 1,524
colon cancer 31 | 1,475
cystic fibrosis 31 | 1,665
esophageal adenocarcinoma 31 | 737
posterior fossa group A ependymoma 30 | 1,511
adrenocortical carcinoma 26 | 1,427
group 3 medulloblastoma 26 | 2,254
cutaneous lupus erythematosus 25 | 1,056
nasopharyngeal carcinoma 24 | 1,056
gastric carcinoma 23 | 832
Down syndrome 22 | 548
Alzheimer's disease 20 | 644
Amyotrophic Lateral Sclerosis 20 | 431
Duchenne muscular dystrophy 19 | 602
acute myeloid leukemia 19 | 780
posterior fossa group B ependymoma 19 | 1,530
Osteoporosis 18 | 257
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
tuberculosis and treatment for 6 months 18 | 686
Mammary Neoplasms 17 | 410
active Crohn's disease 16 | 918
atypical teratoid/rhabdoid tumor 16 | 1,095
hereditary spastic paraplegia 16 | 313
progressive supranuclear palsy 16 | 674
Atopic dermatitis 15 | 944
Neurodegenerative disease 15 | 383
active ulcerative colitis 15 | 477
Intellectual disability 14 | 573
Liver carcinoma 14 | 217
Prostatic Neoplasms 14 | 471
aldosterone-producing adenoma 14 | 664
non primary Sjogren syndrome sicca 14 | 840
primary Sjogren syndrome 14 | 789
IGA Glomerulonephritis 13 | 454
Neoplasm Invasiveness 13 | 127
gastric cancer 13 | 430
mucosa-associated lymphoid tissue lymphoma 13 | 480
pancreatic carcinoma 13 | 567
Animal Mammary Neoplasms 12 | 136
Schizophrenia 12 | 501
Mammary Neoplasms, Experimental 11 | 150
Neoplasm Metastasis 11 | 138
Obesity 11 | 616
Parkinson's disease 11 | 364
Stomach Neoplasms 11 | 282
non-small cell lung carcinoma 11 | 413
Cardiomyopathy 10 | 110
Disease Progression 10 | 125
Squamous cell carcinoma of esophagus 10 | 82
hepatocellular carcinoma 10 | 532
Crohn's disease 9 | 304
Vascular disease 9 | 281
fibroadenoma 9 | 557

Tissue

Blood and immune system 307 | 17,995
Cardiovascular System 307 | 17,958
Digestive Tract 307 | 18,473
Endocrine System 307 | 18,512
Female tissues 307 | 18,647
Liver and Pancreas 307 | 18,136
Male tissues 307 | 17,969
Nervous System 307 | 18,561
Respiratory system 307 | 17,484
Skin and soft tissues 307 | 18,115
Urinary Tract 307 | 18,444

Target Family

Non-IDG 239 | 11,971
Enzyme 43 | 4,146
Kinase 17 | 634
Transporter 3 | 473
GPCR 2 | 406
Epigenetic 1 | 242
Ion Channel 1 | 341
Transcription Factor 1 | 1,400

GO Component

cell-cell adherens junction 307 | 307
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Emerin EMD Tbio Non-IDG -2.77469 617.6 238
Neuroblast differentiation-associated protein AHNAK AHNAK Tbio Non-IDG -1.61845 51.3 82
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
Golgin subfamily A member 2 GOLGA2 Tbio Non-IDG -1.94177 80.5 168
Golgin subfamily A member 3 GOLGA3 Tbio Non-IDG -1.29668 20.3 130