Development Level

Tbio 402 | 11,445
Tchem 108 | 1,598
Tclin 67 | 613
Tdark 31 | 6,588

Collection

GPCR: IDG Consortium (Targets) 4 | 126
GPCR: IDG Consortium (Complete... 2 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 28 | 979
preweaning lethality, incomple... 20 | 499
decreased vertical activity 14 | 208
enlarged heart 12 | 210
decreased lean body mass 11 | 135
abnormal bone structure 10 | 187
decreased total body fat amoun... 10 | 207
embryonic lethality prior to t... 9 | 278
abnormal heart morphology 8 | 162
increased total body fat amoun... 8 | 134
increased lean body mass 7 | 172
increased mean corpuscular vol... 7 | 92
abnormal eye morphology 6 | 68
decreased body weight 6 | 161
decreased bone mineral content 6 | 151
decreased grip strength 6 | 116
impaired glucose tolerance 6 | 75
increased circulating choleste... 6 | 66
increased heart weight 6 | 62
tremors 6 | 39
abnormal embryo size 5 | 220
abnormal seminal vesicle morph... 5 | 114
decreased bone mineral density 5 | 126
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
embryonic lethality prior to o... 5 | 239
improved glucose tolerance 5 | 79
increased bone mineral content 5 | 108
short tibia 5 | 97
small superior vagus ganglion 5 | 74
abnormal behavior 4 | 298
abnormal gait 4 | 69
decreased circulating alkaline... 4 | 46
decreased circulating insulin ... 4 | 76
decreased heart weight 4 | 27
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular hem... 4 | 50
decreased mean corpuscular vol... 4 | 79
edema 4 | 59
hyperactivity 4 | 148
increased circulating HDL chol... 4 | 80
increased leukocyte cell numbe... 4 | 47
increased startle reflex 4 | 112
abnormal coat appearance 3 | 31
abnormal epididymis morphology 3 | 42
abnormal kidney morphology 3 | 65
abnormal lung morphology 3 | 26
abnormal optic disc morphology 3 | 10
abnormal testis morphology 3 | 43
abnormal vibrissa morphology 3 | 25
cardiovascular system phenotyp... 3 | 36
cataract 3 | 92
decreased body length 3 | 101
decreased cardiac muscle contr... 3 | 11
decreased circulating glucose ... 3 | 126
decreased eosinophil cell numb... 3 | 24
decreased fasted circulating g... 3 | 65
decreased mean corpuscular hem... 3 | 31
decreased prepulse inhibition 3 | 82
decreased startle reflex 3 | 75
decreased threshold for audito... 3 | 26
increased circulating alkaline... 3 | 122
increased circulating amylase ... 3 | 25
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 42
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 96
increased or absent threshold ... 3 | 101
limb grasping 3 | 41
pale yolk sac 3 | 25
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal limb bud morphology 2 | 17
abnormal liver morphology 2 | 17
abnormal locomotor behavior 2 | 24
abnormal sleep behavior 2 | 70
absent startle reflex 2 | 24
anophthalmia 2 | 33
decreased circulating bilirubi... 2 | 19
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased pulmonary respirator... 2 | 5
decreased red blood cell distr... 2 | 41
hypoactivity 2 | 132
increased body weight 2 | 25
increased circulating bilirubi... 2 | 16
increased circulating iron lev... 2 | 30
increased eosinophil cell numb... 2 | 11
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased prepulse inhibition 2 | 32
microphthalmia 2 | 26
pallor 2 | 34
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87

Disease

Carcinoma 398 | 11,493
psoriasis 301 | 6,694
Cancer 282 | 2,499
ovarian cancer 278 | 8,520
osteosarcoma 254 | 7,950
glioblastoma 227 | 5,792
medulloblastoma, large-cell 208 | 6,241
lung cancer 205 | 4,740
atypical teratoid / rhabdoid tumor 180 | 5,112
lung carcinoma 176 | 2,843
ependymoma 174 | 4,679
Astrocytoma, Pilocytic 167 | 3,081
Breast cancer 165 | 3,578
invasive ductal carcinoma 160 | 2,951
malignant mesothelioma 156 | 3,232
diabetes mellitus 154 | 1,728
adult high grade glioma 152 | 3,801
non-small cell lung cancer 149 | 2,890
interstitial cystitis 147 | 2,312
pancreatic cancer 142 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 141 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 141 | 3,291
lung adenocarcinoma 141 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 137 | 2,989
tuberculosis 126 | 2,010
group 3 medulloblastoma 119 | 4,104
ulcerative colitis 119 | 1,819
Kidney cancer 111 | 2,613
subependymal giant cell astrocytoma 105 | 2,287
Rheumatoid arthritis 103 | 1,191
cystic fibrosis 103 | 1,696
oligodendroglioma 99 | 2,850
Hypersensitivity reaction type II disease 98 | 253
pituitary cancer 96 | 1,972
Arthritis 92 | 290
primitive neuroectodermal tumor 89 | 3,035
astrocytic glioma 88 | 2,597
Schizophrenia 87 | 1,160
ductal carcinoma in situ 86 | 1,745
dermatomyositis 84 | 966
pancreatic ductal adenocarcinoma liver metastasis 83 | 1,962
group 4 medulloblastoma 80 | 1,855
breast carcinoma 79 | 1,638
Ankylosing spondylitis 78 | 140
Autosomal recessive predisposition 74 | 1,442
Kidney disease 73 | 430
adrenocortical carcinoma 73 | 1,428
cutaneous lupus erythematosus 73 | 1,057
Behcet's disease 72 | 89
colon cancer 72 | 1,478
Liver Cirrhosis, Experimental 71 | 769
Multiple Sclerosis 70 | 540
esophageal adenocarcinoma 70 | 737
Human immunodeficiency virus infectious disease 68 | 138
primary pancreatic ductal adenocarcinoma 67 | 1,109
Juvenile rheumatoid arthritis 66 | 111
Uveitis 66 | 103
Acquired immunodeficiency syndrome 65 | 197
Herpes zoster 58 | 68
Atopic dermatitis 57 | 952
juvenile dermatomyositis 57 | 1,187
Anemia 56 | 365
astrocytoma 55 | 1,146
Alzheimer's disease 54 | 658
Psoriatic arthritis 54 | 86
Duchenne muscular dystrophy 52 | 601
Stevens-Johnson syndrome 52 | 92
Liver disease 51 | 237
gastric carcinoma 51 | 807
nasopharyngeal carcinoma 51 | 1,058
Bipolar Disorder 50 | 666
Atherosclerosis 49 | 291
Dermatitis 49 | 157
Multiple myeloma 49 | 1,332
Coronary artery disease 47 | 268
Pick disease 47 | 1,894
Hypertension 44 | 396
Cerebrovascular disease 43 | 238
Down syndrome 43 | 499
active Crohn's disease 43 | 922
pediatric high grade glioma 43 | 1,064
Synovitis 42 | 78
acute quadriplegic myopathy 42 | 1,158
fibroadenoma 42 | 559
Melanoma 41 | 711
Vascular disease 41 | 319
spina bifida 41 | 1,074
Behcet's syndrome 40 | 50
Epilepsy 40 | 792
Nephritis 39 | 51
active ulcerative colitis 39 | 764
primary Sjogren syndrome 38 | 735
Obesity 37 | 678
Prostatic Neoplasms 37 | 495
Takayasu's arteritis 37 | 53
drug-induced hepatitis 37 | 44
Asthma 36 | 385
Congenital adrenal hyperplasia 36 | 73
Endometriosis 36 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 36 | 510

Tissue

Endocrine System 513 | 18,159
Male tissues 511 | 17,142
Digestive Tract 503 | 17,369
Female tissues 494 | 17,400
Skin and soft tissues 490 | 17,230
Liver and Pancreas 484 | 16,750
Urinary Tract 484 | 16,678
Blood and immune system 479 | 16,909
Nervous System 476 | 16,725
Respiratory system 474 | 16,393
Cardiovascular System 434 | 15,192

Target Family

Non-IDG 424 | 12,091
Enzyme 80 | 4,145
GPCR 36 | 408
Ion Channel 26 | 344
Kinase 21 | 634
Transporter 19 | 473
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

GO Component

cell surface 608 | 608
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Neuroplastin NPTN Tbio Non-IDG -2.31075 211.6 201
Transient receptor potential cation channel subfamily V member 2 TRPV2 Tchem Ion Channel -2.28525 197.9 203
Hedgehog-interacting protein HHIP Tbio Non-IDG -1.83526 65.4 193
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
Neurexin-1 NRXN1 Tbio Non-IDG -1.88807 125.1 174
A disintegrin and metalloproteinase with thrombospondin motifs 7 ADAMTS7 Tbio Enzyme -1.43732 33.7 98
Tetraspanin-32 TSPAN32 Tbio Non-IDG -0.97140 8.31 153
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Atrial natriuretic peptide-converting enzyme CORIN Tbio Non-IDG -2.14443 144.4 221