Development Level

Tbio 361 | 10,625
Tchem 125 | 1,890
Tclin 63 | 602
Tdark 45 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 4 | 143
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 18 | 633
preweaning lethality, incomple... 15 | 260
decreased total body fat amoun... 10 | 186
decreased bone mineral density 9 | 126
decreased grip strength 9 | 123
decreased lean body mass 9 | 195
decreased bone mineral content 8 | 157
enlarged heart 8 | 111
abnormal bone structure 7 | 131
decreased body weight 7 | 174
embryonic lethality prior to t... 7 | 187
abnormal behavior 6 | 226
impaired glucose tolerance 6 | 52
increased lean body mass 6 | 107
increased or absent threshold ... 6 | 128
tremors 6 | 34
abnormal eye morphology 5 | 38
abnormal gait 5 | 51
decreased circulating choleste... 5 | 85
embryonic lethality prior to o... 5 | 148
hyperactivity 5 | 108
increased mean corpuscular vol... 5 | 91
abnormal heart morphology 4 | 51
abnormal locomotor activation 4 | 26
abnormal seminal vesicle morph... 4 | 47
decreased body length 4 | 108
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
decreased circulating alkaline... 4 | 41
decreased circulating glucose ... 4 | 121
decreased circulating insulin ... 4 | 75
decreased leukocyte cell numbe... 4 | 54
hydrops fetalis 4 | 22
improved glucose tolerance 4 | 56
increased body weight 4 | 42
increased bone mineral content 4 | 92
increased leukocyte cell numbe... 4 | 37
increased total body fat amoun... 4 | 57
short tibia 4 | 82
abnormal embryo size 3 | 112
abnormal vibrissa morphology 3 | 17
decreased eosinophil cell numb... 3 | 41
decreased fasted circulating g... 3 | 49
decreased heart weight 3 | 44
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
decreased monocyte cell number 3 | 28
decreased prepulse inhibition 3 | 52
decreased startle reflex 3 | 48
increased blood urea nitrogen ... 3 | 44
increased circulating alkaline... 3 | 119
increased grip strength 3 | 83
increased heart weight 3 | 37
increased mean corpuscular hem... 3 | 93
limb grasping 3 | 35
abnormal QRS complex 2 | 25
abnormal behavioral response t... 2 | 52
abnormal coat appearance 2 | 25
abnormal coat/hair pigmentatio... 2 | 54
abnormal coping response 2 | 12
abnormal epididymis morphology 2 | 31
abnormal heart left ventricle ... 2 | 20
abnormal kidney morphology 2 | 30
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
abnormal testis morphology 2 | 30
abnormal tooth morphology 2 | 24
absent startle reflex 2 | 15
cardiovascular system phenotyp... 2 | 35
decreased basophil cell number 2 | 11
decreased caudal vertebrae num... 2 | 49
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 19
decreased pulmonary respirator... 2 | 4
enlarged stomach 2 | 2
increased circulating HDL chol... 2 | 63
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating choleste... 2 | 53
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased fasted circulating g... 2 | 68
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 21
increased red blood cell distr... 2 | 21
increased sacral vertebrae num... 2 | 62
lethargy 2 | 5
male infertility 2 | 62
microphthalmia 2 | 15
small superior vagus ganglion 2 | 20
small testis 2 | 37
small thymus 2 | 11
straub tail 2 | 26
thrombocytopenia 2 | 46
decreased alpha-beta T cell nu... 1 | 12
increased circulating creatini... 1 | 29

Disease

psoriasis 295 | 6,685
ovarian cancer 271 | 8,484
Cancer 267 | 2,346
osteosarcoma 248 | 7,933
glioblastoma 207 | 5,572
medulloblastoma, large-cell 205 | 6,234
lung cancer 187 | 4,466
lung carcinoma 173 | 2,844
pilocytic astrocytoma 164 | 3,086
invasive ductal carcinoma 159 | 2,950
diabetes mellitus 148 | 1,663
atypical teratoid / rhabdoid tumor 146 | 4,369
non-small cell lung cancer 144 | 2,798
malignant mesothelioma 142 | 3,162
interstitial cystitis 141 | 2,299
lung adenocarcinoma 138 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 137 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 137 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 134 | 2,988
pancreatic cancer 133 | 2,300
Breast cancer 132 | 3,094
ulcerative colitis 128 | 2,087
pediatric high grade glioma 116 | 2,712
subependymal giant cell astrocytoma 104 | 2,287
cystic fibrosis 100 | 1,665
Carcinoma 98 | 2,147
Rheumatoid Arthritis 98 | 1,160
Hypersensitivity reaction type II disease 95 | 235
oligodendroglioma 94 | 2,849
pituitary cancer 94 | 1,972
group 4 medulloblastoma 90 | 1,875
Arthritis 88 | 248
primitive neuroectodermal tumor 88 | 3,031
ductal carcinoma in situ 87 | 1,745
tuberculosis 85 | 1,557
posterior fossa group A ependymoma 84 | 1,511
ependymoma 82 | 2,514
breast carcinoma 79 | 1,614
Ankylosing spondylitis 78 | 138
pancreatic ductal adenocarcinoma liver metastasis 76 | 1,795
astrocytic glioma 74 | 2,241
primary pancreatic ductal adenocarcinoma 72 | 1,271
adrenocortical carcinoma 71 | 1,427
adult high grade glioma 71 | 2,148
colon cancer 71 | 1,475
cutaneous lupus erythematosus 71 | 1,056
Multiple Sclerosis 70 | 498
Kidney disease 69 | 396
Uveitis 66 | 103
Juvenile rheumatoid arthritis 65 | 104
astrocytoma 65 | 1,493
esophageal adenocarcinoma 65 | 737
Acquired immunodeficiency syndrome 63 | 164
Behcet's disease 58 | 74
group 3 medulloblastoma 58 | 2,254
juvenile dermatomyositis 56 | 1,189
Atopic dermatitis 55 | 944
Psoriatic arthritis 54 | 83
gastric carcinoma 54 | 832
sonic hedgehog group medulloblastoma 50 | 1,482
Atherosclerosis 48 | 275
Duchenne muscular dystrophy 48 | 602
Liver disease 48 | 219
Multiple myeloma 48 | 1,327
Pick disease 48 | 1,893
dermatomyositis 48 | 933
nasopharyngeal carcinoma 48 | 1,056
Alzheimer's disease 47 | 644
Anemia 46 | 252
Down syndrome 43 | 548
active Crohn's disease 42 | 918
atypical teratoid/rhabdoid tumor 42 | 1,095
fibroadenoma 42 | 557
primary Sjogren syndrome 42 | 789
Cerebrovascular disease 41 | 231
Coronary artery disease 41 | 240
acute quadriplegic myopathy 40 | 1,157
posterior fossa group B ependymoma 40 | 1,530
Stevens-Johnson syndrome 39 | 78
spina bifida 39 | 1,064
Prostatic Neoplasms 37 | 471
Schizophrenia 37 | 501
Takayasu's arteritis 37 | 52
medulloblastoma 37 | 1,524
Congenital adrenal hyperplasia 36 | 74
Vascular disease 36 | 281
Asthma 35 | 349
Endometriosis 35 | 535
Retinal vasculitis 35 | 36
autosomal dominant Emery-Dreifuss muscular dystrophy 35 | 499
mucosa-associated lymphoid tissue lymphoma 34 | 480
pancreatic carcinoma 34 | 567
Hepatitis B 33 | 103
Hypertension 32 | 287
Mammary Neoplasms 32 | 410
Heart disease 31 | 279
Human immunodeficiency virus infectious disease 31 | 92
Obesity 31 | 616
IGA Glomerulonephritis 30 | 454
Leprosy 30 | 77

Tissue

Female tissues 514 | 18,647
Nervous System 513 | 18,561
Digestive Tract 512 | 18,473
Endocrine System 512 | 18,512
Urinary Tract 510 | 18,444
Liver and Pancreas 504 | 18,136
Male tissues 504 | 17,969
Cardiovascular System 500 | 17,958
Skin and soft tissues 499 | 18,115
Blood and immune system 494 | 17,995
Respiratory system 494 | 17,484

Target Family

Non-IDG 417 | 11,971
Enzyme 76 | 4,146
GPCR 34 | 406
Ion Channel 27 | 341
Kinase 19 | 634
Transporter 19 | 473
Nuclear Receptor 1 | 48
Transcription Factor 1 | 1,400

GO Component

cell surface 594 | 594
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Stereocilin STRC Tbio Non-IDG 35.9 7
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0