Development Level

Tbio 280 | 10,625
Tclin 66 | 602
Tdark 54 | 7,003
Tchem 51 | 1,890

Collection

Eligible Ion Channel Proteins 24 | 117
Eligible non-olfactory GPCR Proteins 3 | 143
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 21 | 633
preweaning lethality, incomple... 11 | 260
abnormal behavior 8 | 226
decreased body weight 8 | 174
decreased grip strength 8 | 123
decreased bone mineral content 7 | 157
decreased circulating choleste... 7 | 85
decreased lean body mass 7 | 195
decreased total body fat amoun... 7 | 186
decreased circulating HDL chol... 6 | 77
abnormal bone structure 5 | 131
increased lean body mass 5 | 107
abnormal embryo size 4 | 112
embryonic lethality prior to o... 4 | 148
enlarged heart 4 | 111
increased circulating alkaline... 4 | 119
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
increased total body fat amoun... 4 | 57
short tibia 4 | 82
tremors 4 | 34
abnormal gait 3 | 51
abnormal heart morphology 3 | 51
abnormal locomotor activation 3 | 26
abnormal retina morphology 3 | 100
abnormal skin morphology 3 | 23
decreased bone mineral density 3 | 126
decreased fasted circulating g... 3 | 49
embryonic lethality prior to t... 3 | 187
hemorrhage 3 | 12
hyperactivity 3 | 108
hypoactivity 3 | 89
impaired glucose tolerance 3 | 52
increased bone mineral content 3 | 92
increased or absent threshold ... 3 | 128
increased vertical activity 3 | 18
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
abnormal coat/hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal eye morphology 2 | 38
abnormal head morphology 2 | 10
abnormal heart left ventricle ... 2 | 20
abnormal neural tube closure 2 | 37
abnormal retinal pigmentation 2 | 61
abnormal tail morphology 2 | 17
cyanosis 2 | 6
decreased circulating alkaline... 2 | 41
decreased circulating chloride... 2 | 32
decreased effector memory CD8-... 2 | 24
decreased exploration in new e... 2 | 9
decreased heart weight 2 | 44
decreased mean corpuscular vol... 2 | 50
decreased pulmonary respirator... 2 | 4
decreased vertical activity 2 | 22
enlarged stomach 2 | 2
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating phosphat... 2 | 24
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 68
increased grip strength 2 | 83
increased mean corpuscular hem... 2 | 25
increased startle reflex 2 | 38
lethargy 2 | 5
limb grasping 2 | 35
pale yolk sac 2 | 12
persistence of hyaloid vascula... 2 | 22
shortened RR interval 2 | 19
small thymus 2 | 11
straub tail 2 | 26
thrombocytopenia 2 | 46
abnormal QRS complex 1 | 25
abnormal eye size 1 | 11
abnormal limb bud morphology 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased CD4-positive, alpha ... 1 | 19
decreased basophil cell number 1 | 11
decreased circulating creatini... 1 | 31
decreased circulating sodium l... 1 | 18
decreased gamma-delta T cell n... 1 | 18
decreased mean corpuscular hem... 1 | 34
hydrops fetalis 1 | 22
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating glycerol... 1 | 11
increased sacral vertebrae num... 1 | 62
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9
trunk curl 1 | 15

Disease

medulloblastoma, large-cell 255 | 6,234
glioblastoma 230 | 5,572
atypical teratoid / rhabdoid tumor 201 | 4,369
ovarian cancer 193 | 8,484
osteosarcoma 189 | 7,933
psoriasis 183 | 6,685
pilocytic astrocytoma 175 | 3,086
primitive neuroectodermal tumor 162 | 3,031
oligodendroglioma 156 | 2,849
pediatric high grade glioma 132 | 2,712
lung carcinoma 119 | 2,844
subependymal giant cell astrocytoma 113 | 2,287
Carcinoma 111 | 2,147
ependymoma 108 | 2,514
lung cancer 102 | 4,466
Pick disease 101 | 1,893
astrocytic glioma 98 | 2,241
malignant mesothelioma 91 | 3,162
medulloblastoma 91 | 1,524
adult high grade glioma 89 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 84 | 3,289
pituitary cancer 77 | 1,972
Breast cancer 76 | 3,094
astrocytoma 75 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 74 | 2,988
posterior fossa group A ependymoma 74 | 1,511
invasive ductal carcinoma 73 | 2,950
interstitial cystitis 72 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 71 | 2,956
non-small cell lung cancer 68 | 2,798
lung adenocarcinoma 66 | 2,713
Schizophrenia 64 | 501
group 3 medulloblastoma 59 | 2,254
Epilepsy 57 | 346
group 4 medulloblastoma 57 | 1,875
posterior fossa group B ependymoma 56 | 1,530
sonic hedgehog group medulloblastoma 52 | 1,482
cystic fibrosis 51 | 1,665
ductal carcinoma in situ 51 | 1,745
pancreatic cancer 48 | 2,300
Cancer 47 | 2,346
Autistic Disorder 44 | 320
breast carcinoma 41 | 1,614
General anesthesia 40 | 53
colon cancer 40 | 1,475
atypical teratoid/rhabdoid tumor 39 | 1,095
ulcerative colitis 38 | 2,087
spina bifida 37 | 1,064
Alzheimer's disease 36 | 644
Intellectual disability 36 | 573
tuberculosis 36 | 1,557
Parkinson's disease 35 | 364
primary pancreatic ductal adenocarcinoma 32 | 1,271
acute quadriplegic myopathy 31 | 1,157
diabetes mellitus 31 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,795
Rheumatoid Arthritis 28 | 1,160
Down syndrome 26 | 548
juvenile dermatomyositis 26 | 1,189
Tonic-clonic epilepsy 25 | 47
adrenocortical carcinoma 25 | 1,427
non primary Sjogren syndrome sicca 25 | 840
Bipolar Disorder 24 | 266
Neurodegenerative disease 23 | 383
cutaneous lupus erythematosus 23 | 1,056
gastric carcinoma 22 | 832
Multiple myeloma 21 | 1,327
Amyotrophic Lateral Sclerosis 20 | 431
Local anesthesia 20 | 40
Alcohol dependence 19 | 107
Nicotine dependence 19 | 53
active Crohn's disease 19 | 918
Cocaine-Related Disorders 18 | 88
Obesity 18 | 616
Toxic encephalopathy 18 | 131
dermatomyositis 18 | 933
esophageal adenocarcinoma 18 | 737
progressive supranuclear palsy 18 | 674
Duchenne muscular dystrophy 17 | 602
acute myeloid leukemia 17 | 780
aldosterone-producing adenoma 17 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 17 | 499
Anxiety 16 | 24
Insomnia 16 | 20
Neuropathy 16 | 210
active ulcerative colitis 16 | 477
Irritable bowel syndrome 15 | 59
Lennox-Gastaut syndrome 15 | 34
Tetanus 15 | 66
glioblastoma multiforme 15 | 347
Cerebrovascular disease 14 | 231
Major Depressive Disorder 14 | 106
Multiple Sclerosis 14 | 498
Seizures 14 | 95
Simple partial seizure 14 | 26
mucosa-associated lymphoid tissue lymphoma 14 | 480
nasopharyngeal carcinoma 14 | 1,056
Atopic dermatitis 13 | 944
Migraine Prevention 13 | 22
fibroadenoma 13 | 557

Tissue

Female tissues 449 | 18,647
Digestive Tract 448 | 18,473
Nervous System 447 | 18,561
Endocrine System 446 | 18,512
Liver and Pancreas 446 | 18,136
Urinary Tract 445 | 18,444
Blood and immune system 443 | 17,995
Cardiovascular System 441 | 17,958
Male tissues 441 | 17,969
Skin and soft tissues 441 | 18,115
Respiratory system 437 | 17,484

Target Family

Non-IDG 281 | 11,971
Ion Channel 73 | 341
Enzyme 48 | 4,146
Kinase 17 | 634
GPCR 15 | 406
Transporter 10 | 473
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

GO Component

cell junction 451 | 451
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.89749 80.7 139
Cytoplasmic polyadenylation element-binding protein 1 CPEB1 Tbio Non-IDG -2.20580 171.1 185
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Keratinocyte differentiation factor 1 KDF1 Tbio Non-IDG -0.24304 2.16 71
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.23749 17.4 128
ERC protein 2 ERC2 Tbio Non-IDG -1.59613 39.1 32