Development Level

Tbio 344 | 11,445
Tclin 68 | 613
Tchem 48 | 1,598
Tdark 42 | 6,588

Collection

RFA-RM-18-021 20 | 328
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 32 | 979
preweaning lethality, incomple... 19 | 499
abnormal behavior 11 | 298
increased total body fat amoun... 11 | 134
decreased total body fat amoun... 10 | 207
decreased vertical activity 10 | 208
enlarged heart 9 | 210
decreased lean body mass 8 | 135
abnormal heart morphology 7 | 162
decreased body weight 7 | 161
decreased lymphocyte cell numb... 7 | 83
hyperactivity 7 | 148
increased lean body mass 7 | 172
decreased bone mineral content 6 | 151
decreased circulating choleste... 6 | 93
increased circulating alkaline... 6 | 122
abnormal bone structure 5 | 187
decreased circulating HDL chol... 5 | 68
embryonic lethality prior to t... 5 | 278
increased mean corpuscular vol... 5 | 92
increased or absent threshold ... 5 | 101
abnormal behavioral response t... 4 | 66
abnormal embryo size 4 | 220
abnormal locomotor behavior 4 | 24
abnormal seminal vesicle morph... 4 | 114
abnormal skin morphology 4 | 50
abnormal sleep behavior 4 | 70
abnormal testis morphology 4 | 43
decreased grip strength 4 | 116
decreased startle reflex 4 | 75
hemorrhage 4 | 23
hypoactivity 4 | 132
impaired glucose tolerance 4 | 75
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
increased circulating chloride... 4 | 41
increased fasted circulating g... 4 | 76
increased startle reflex 4 | 112
prenatal lethality prior to he... 4 | 87
short tibia 4 | 97
small testis 4 | 58
tremors 4 | 39
abnormal cornea morphology 3 | 31
abnormal epididymis morphology 3 | 42
abnormal eye morphology 3 | 68
abnormal gait 3 | 69
abnormal retina morphology 3 | 71
abnormal spleen morphology 3 | 55
decreased bone mineral density 3 | 126
decreased fasted circulating g... 3 | 65
decreased heart weight 3 | 27
decreased mean corpuscular vol... 3 | 79
edema 3 | 59
embryonic lethality prior to o... 3 | 239
improved glucose tolerance 3 | 79
increased circulating amylase ... 3 | 25
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
limb grasping 3 | 41
small superior vagus ganglion 3 | 74
abnormal bone mineralization 2 | 38
abnormal brain morphology 2 | 13
abnormal cecum morphology 2 | 7
abnormal coat-hair pigmentatio... 2 | 64
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal head morphology 2 | 10
abnormal joint morphology 2 | 23
abnormal kidney morphology 2 | 65
abnormal liver morphology 2 | 17
abnormal neural tube closure 2 | 46
abnormal vitreous body morphol... 2 | 10
absent vibrissae 2 | 12
brachydactyly 2 | 19
convulsive seizures 2 | 13
decreased body length 2 | 101
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased circulating phosphat... 2 | 27
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased exploration in new e... 2 | 11
decreased neutrophil cell numb... 2 | 42
decreased pulmonary respirator... 2 | 5
decreased red blood cell distr... 2 | 41
enlarged stomach 2 | 2
hydroencephaly 2 | 14
hydrometra 2 | 53
increased body weight 2 | 25
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased red blood cell distr... 2 | 34
pale yolk sac 2 | 25
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
small thymus 2 | 16
syndactyly 2 | 23

Disease

Carcinoma 376 | 11,493
medulloblastoma, large-cell 278 | 6,241
glioblastoma 262 | 5,792
atypical teratoid / rhabdoid tumor 248 | 5,112
ependymoma 226 | 4,679
ovarian cancer 216 | 8,520
osteosarcoma 214 | 7,950
adult high grade glioma 203 | 3,801
psoriasis 201 | 6,694
Astrocytoma, Pilocytic 183 | 3,081
group 3 medulloblastoma 177 | 4,104
primitive neuroectodermal tumor 167 | 3,035
oligodendroglioma 162 | 2,850
astrocytic glioma 147 | 2,597
Kidney cancer 133 | 2,613
lung carcinoma 133 | 2,843
lung cancer 128 | 4,740
subependymal giant cell astrocytoma 122 | 2,287
Schizophrenia 120 | 1,160
Pick disease 105 | 1,894
Breast cancer 101 | 3,578
malignant mesothelioma 98 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 96 | 3,291
interstitial cystitis 91 | 2,312
non-small cell lung cancer 88 | 2,890
pituitary cancer 87 | 1,972
invasive ductal carcinoma 86 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 85 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 82 | 2,955
pancreatic cancer 73 | 2,398
Bipolar Disorder 72 | 666
lung adenocarcinoma 71 | 2,716
Epilepsy 67 | 792
Cancer 65 | 2,499
Intellectual disability 56 | 1,016
cystic fibrosis 56 | 1,696
ductal carcinoma in situ 56 | 1,745
group 4 medulloblastoma 55 | 1,855
breast carcinoma 51 | 1,638
Autistic Disorder 49 | 364
tuberculosis 48 | 2,010
colon cancer 46 | 1,478
spina bifida 46 | 1,074
ulcerative colitis 45 | 1,819
Autosomal recessive predisposition 43 | 1,442
Liver cancer 43 | 604
Alcoholic Intoxication, Chronic 41 | 289
General anesthesia 40 | 53
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,962
Alzheimer's disease 39 | 658
primary pancreatic ductal adenocarcinoma 38 | 1,109
Melanoma 37 | 711
Parkinson's disease 37 | 392
diabetes mellitus 37 | 1,728
Depressive disorder 36 | 409
Rheumatoid arthritis 36 | 1,191
pediatric high grade glioma 35 | 1,064
Mental Depression 34 | 333
astrocytoma 33 | 1,146
medulloblastoma 33 | 720
Seizures 31 | 596
acute quadriplegic myopathy 31 | 1,158
adrenocortical carcinoma 31 | 1,428
non primary Sjogren syndrome sicca 30 | 891
Major Depressive Disorder 29 | 301
Skin cancer 29 | 469
cutaneous lupus erythematosus 29 | 1,057
juvenile dermatomyositis 28 | 1,187
Muscle hypotonia 27 | 571
Neurodegenerative disease 27 | 414
esophageal adenocarcinoma 27 | 737
gastric carcinoma 27 | 807
Down syndrome 26 | 499
active Crohn's disease 26 | 922
Tonic-clonic epilepsy 25 | 47
Amyotrophic lateral sclerosis 24 | 451
nasopharyngeal carcinoma 24 | 1,058
Cognitive delay 23 | 608
Dull intelligence 23 | 645
Global developmental delay 23 | 608
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental and motor retardation 23 | 608
Mental deficiency 23 | 645
Poor school performance 23 | 645
active ulcerative colitis 22 | 764
dermatomyositis 22 | 966
Anxiety 21 | 136
Unipolar Depression 21 | 250
Cocaine-Related Disorders 20 | 92
Local anesthesia 20 | 40
Mood Disorders 20 | 184
Toxic encephalopathy 20 | 141
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 510
Alcohol dependence 19 | 107
Atopic dermatitis 19 | 952
Duchenne muscular dystrophy 19 | 601
Multiple myeloma 19 | 1,332
Obesity 19 | 678
acute myeloid leukemia 19 | 783

Tissue

Endocrine System 491 | 18,159
Digestive Tract 480 | 17,369
Nervous System 479 | 16,725
Female tissues 477 | 17,400
Skin and soft tissues 474 | 17,230
Male tissues 471 | 17,142
Blood and immune system 455 | 16,909
Urinary Tract 455 | 16,678
Liver and Pancreas 451 | 16,750
Respiratory system 437 | 16,393
Cardiovascular System 399 | 15,192

Target Family

Non-IDG 317 | 12,091
Ion Channel 75 | 344
Enzyme 54 | 4,145
Kinase 17 | 634
GPCR 15 | 408
Transporter 15 | 473
Transcription Factor 7 | 1,400
Epigenetic 2 | 242

GO Component

cell junction 502 | 502
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
Neuromodulin GAP43 Tbio Non-IDG -2.93905 762.9 597
Proline-rich transmembrane protein 1 PRRT1 Tbio Non-IDG -1.33375 18.2 68
Potassium voltage-gated channel subfamily C member 2 KCNC2 Tclin Ion Channel -1.45272 28.7 178
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
Calcium-dependent secretion activator 2 CADPS2 Tbio Non-IDG -1.18033 15.0 36
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Endophilin-A2 SH3GL1 Tbio Non-IDG -2.15479 134.2 257
Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 Tclin Ion Channel -0.98683 8.48 87
Myocardial zonula adherens protein POLR2M Tbio Non-IDG -1.87592 70.6 20