Development Level

Tbio 67 | 11,445
Tdark 7 | 6,588
Tchem 2 | 1,598

IMPC Phenotype

abnormal coat-hair pigmentatio... 4 | 64
preweaning lethality, complete... 4 | 979
cataract 3 | 92
decreased body weight 3 | 161
increased fasted circulating g... 3 | 76
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
abnormal humerus morphology 2 | 11
abnormal lens morphology 2 | 81
abnormal spleen morphology 2 | 55
decreased bone mineral content 2 | 151
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
enlarged heart 2 | 210
increased heart weight 2 | 62
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal head size 1 | 6
abnormal incisor color 1 | 3
abnormal maxilla morphology 1 | 17
abnormal pelvic girdle bone mo... 1 | 12
abnormal placement of pupils 1 | 6
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
cleft palate 1 | 8
convulsive seizures 1 | 13
decreased body length 1 | 101
decreased body temperature 1 | 2
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
enlarged adrenal glands 1 | 3
enlarged kidney 1 | 14
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased hematocrit 1 | 46
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased vertical activity 1 | 24
irregularly shaped pupil 1 | 7
mammalian phenotype 1 | 17
mydriasis 1 | 6
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 60 | 11,493
ovarian cancer 52 | 8,520
glioblastoma 48 | 5,792
ependymoma 41 | 4,679
Astrocytoma, Pilocytic 40 | 3,081
Breast cancer 40 | 3,578
psoriasis 40 | 6,694
atypical teratoid / rhabdoid tumor 39 | 5,112
pancreatic cancer 38 | 2,398
Kidney cancer 34 | 2,613
medulloblastoma, large-cell 34 | 6,241
osteosarcoma 34 | 7,950
lung cancer 33 | 4,740
lung carcinoma 33 | 2,843
malignant mesothelioma 33 | 3,232
adult high grade glioma 32 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
invasive ductal carcinoma 30 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
lung adenocarcinoma 26 | 2,716
Duchenne muscular dystrophy 24 | 601
group 3 medulloblastoma 24 | 4,104
interstitial cystitis 24 | 2,312
cystic fibrosis 23 | 1,696
gastric carcinoma 23 | 807
non-small cell lung cancer 23 | 2,890
primary pancreatic ductal adenocarcinoma 22 | 1,109
primitive neuroectodermal tumor 22 | 3,035
juvenile dermatomyositis 21 | 1,187
pituitary cancer 21 | 1,972
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 510
breast carcinoma 20 | 1,638
oligodendroglioma 20 | 2,850
ulcerative colitis 20 | 1,819
Autosomal recessive predisposition 19 | 1,442
subependymal giant cell astrocytoma 19 | 2,287
ductal carcinoma in situ 18 | 1,745
Cancer 17 | 2,499
astrocytic glioma 17 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
adrenocortical carcinoma 16 | 1,428
Liver cancer 15 | 604
Becker muscular dystrophy 14 | 191
Myopia 14 | 176
nasopharyngeal carcinoma 14 | 1,058
Cataract 13 | 297
Liver Cirrhosis, Experimental 12 | 769
diabetes mellitus 12 | 1,728
esophageal adenocarcinoma 12 | 737
Melanoma 11 | 711
Skin cancer 11 | 469
cutaneous lupus erythematosus 11 | 1,057
limb girdle muscular dystrophy 2A 11 | 213
pediatric high grade glioma 11 | 1,064
Endometriosis 10 | 540
Lens Opacities 10 | 231
colon cancer 10 | 1,478
group 4 medulloblastoma 10 | 1,855
sonic hedgehog group medulloblastoma 10 | 467
Intellectual disability 9 | 1,016
acute quadriplegic myopathy 9 | 1,158
non primary Sjogren syndrome sicca 9 | 891
Atopic dermatitis 8 | 952
Endometrial cancer 8 | 311
Muscle hypotonia 8 | 571
active ulcerative colitis 8 | 764
dermatomyositis 8 | 966
Dull intelligence 7 | 645
Epidermolysis bullosa 7 | 21
Fraser syndrome 7 | 13
Glaucoma 7 | 239
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Short stature 7 | 531
interstitial lung disease 7 | 298
urothelial carcinoma 7 | 318
Atrophic scar 6 | 18
Hypoplastic mandible condyle 6 | 275
Keratoconus 6 | 113
Kidney disease 6 | 430
Mandibular hypoplasia 6 | 275
Micrognathism 6 | 275
Prostatic Neoplasms 6 | 495
Rheumatoid arthritis 6 | 1,191
Sensorineural Hearing Loss (disorder) 6 | 284
acute myeloid leukemia 6 | 783
astrocytoma 6 | 1,146
medulloblastoma 6 | 720
tuberculosis 6 | 2,010
Arthritis 5 | 290
Cognitive delay 5 | 608
Curvature of spine 5 | 282
Down syndrome 5 | 499
Mental and motor retardation 5 | 608
Pick disease 5 | 1,894
Vascular disease 5 | 319
fibroadenoma 5 | 559

Tissue

Endocrine System 75 | 18,159
Liver and Pancreas 74 | 16,750
Nervous System 74 | 16,725
Urinary Tract 74 | 16,678
Digestive Tract 73 | 17,369
Male tissues 73 | 17,142
Skin and soft tissues 73 | 17,230
Female tissues 72 | 17,400
Respiratory system 72 | 16,393
Blood and immune system 71 | 16,909
Cardiovascular System 68 | 15,192

Target Family

Non-IDG 66 | 12,091
Enzyme 8 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

GO Component

basement membrane 76 | 76
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
EGF-containing fibulin-like extracellular matrix protein 2 EFEMP2 Tbio Non-IDG -1.67314 52.3 243
A disintegrin and metalloproteinase with thrombospondin motifs 1 ADAMTS1 Tchem Enzyme -2.44459 279.8 227
Collagen alpha-1(XVIII) chain COL18A1 Tbio Non-IDG -3.18339 1561.4 433
Cystatin-C CST3 Tbio Non-IDG -3.52815 3278.8 866
Collagen alpha-1(IV) chain COL4A1 Tbio Non-IDG -2.28595 186.9 391
Collagen alpha-1(XXVIII) chain COL28A1 Tdark Non-IDG 0.78 0.10 6
Hemicentin-1 HMCN1 Tbio Non-IDG -1.25421 18.0 12
Collagen alpha-1(XVII) chain COL17A1 Tbio Non-IDG -2.75473 576.3 123
Lysyl oxidase homolog 1 LOXL1 Tbio Enzyme -2.55611 364.6 174
Laminin subunit beta-4 LAMB4 Tbio Non-IDG -0.78478 6.19 13