Development Level

Tbio 170 | 10,625
Tchem 60 | 1,890
Tclin 33 | 602
Tdark 14 | 7,003

Collection

Eligible Ion Channel Proteins 3 | 117
Eligible non-olfactory GPCR Proteins 2 | 143
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 13 | 633
decreased total body fat amoun... 8 | 186
decreased body weight 6 | 174
decreased bone mineral content 6 | 157
decreased grip strength 6 | 123
decreased lean body mass 6 | 195
increased blood urea nitrogen ... 6 | 44
increased grip strength 6 | 83
increased or absent threshold ... 6 | 128
abnormal behavior 5 | 226
abnormal bone structure 5 | 131
decreased circulating triglyce... 5 | 83
hypoactivity 5 | 89
abnormal retinal pigmentation 4 | 61
abnormal seminal vesicle morph... 4 | 47
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased circulating choleste... 4 | 85
increased body weight 4 | 42
increased circulating alkaline... 4 | 119
short tibia 4 | 82
abnormal kidney morphology 3 | 30
abnormal pelvic girdle bone mo... 3 | 11
abnormal retina morphology 3 | 100
abnormal vibrissa morphology 3 | 17
decreased body length 3 | 108
decreased circulating amylase ... 3 | 24
decreased circulating free fat... 3 | 39
decreased leukocyte cell numbe... 3 | 54
decreased startle reflex 3 | 48
embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
enlarged heart 3 | 111
increased B cell number 3 | 23
increased mean corpuscular vol... 3 | 91
persistence of hyaloid vascula... 3 | 22
preweaning lethality, incomple... 3 | 260
trunk curl 3 | 15
abnormal bone mineralization 2 | 55
abnormal lens morphology 2 | 73
abnormal respiratory quotient 2 | 9
absent vibrissae 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased caudal vertebrae num... 2 | 49
decreased circulating chloride... 2 | 32
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased eosinophil cell numb... 2 | 41
decreased granulocyte number 2 | 8
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased pre-pro B cell numbe... 2 | 2
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
impaired righting response 2 | 19
increased bone mineral content 2 | 92
increased caudal vertebrae num... 2 | 8
increased circulating iron lev... 2 | 25
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 68
increased plasma cell number 2 | 5
stereotypic behavior 2 | 3
abnormal coat appearance 1 | 25
abnormal cornea morphology 1 | 24
abnormal ear morphology 1 | 5
abnormal heart morphology 1 | 51
abnormal locomotor activation 1 | 26
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal thoracic vertebrae mo... 1 | 16
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased NK cell number 1 | 16
decreased blood urea nitrogen ... 1 | 31
decreased circulating calcium ... 1 | 33
decreased effector memory CD8-... 1 | 24
decreased gamma-delta T cell n... 1 | 18
decreased neutrophil cell numb... 1 | 37
decreased vertical activity 1 | 22
enlarged heart atrium 1 | 2
female infertility 1 | 34
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 29
increased circulating triglyce... 1 | 24
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased startle reflex 1 | 38
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
shortened PQ interval 1 | 6
shortened ST segment 1 | 9
vertebral fusion 1 | 23

Disease

ovarian cancer 133 | 8,484
psoriasis 128 | 6,685
osteosarcoma 124 | 7,933
medulloblastoma, large-cell 105 | 6,234
glioblastoma 94 | 5,572
lung cancer 91 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 79 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 76 | 2,956
lung adenocarcinoma 76 | 2,713
Breast cancer 74 | 3,094
non-small cell lung cancer 73 | 2,798
malignant mesothelioma 72 | 3,162
invasive ductal carcinoma 71 | 2,950
Cancer 68 | 2,346
pancreatic cancer 67 | 2,300
interstitial cystitis 66 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 66 | 2,988
Carcinoma 65 | 2,147
atypical teratoid / rhabdoid tumor 65 | 4,369
pilocytic astrocytoma 64 | 3,086
lung carcinoma 58 | 2,844
pituitary cancer 55 | 1,972
pediatric high grade glioma 54 | 2,712
cystic fibrosis 53 | 1,665
ductal carcinoma in situ 53 | 1,745
oligodendroglioma 52 | 2,849
ulcerative colitis 50 | 2,087
ependymoma 48 | 2,514
subependymal giant cell astrocytoma 47 | 2,287
primitive neuroectodermal tumor 45 | 3,031
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
astrocytic glioma 36 | 2,241
breast carcinoma 36 | 1,614
colon cancer 36 | 1,475
diabetes mellitus 35 | 1,663
spina bifida 35 | 1,064
Kidney disease 34 | 396
adult high grade glioma 34 | 2,148
group 4 medulloblastoma 32 | 1,875
Hypertension 31 | 287
esophageal adenocarcinoma 31 | 737
group 3 medulloblastoma 31 | 2,254
posterior fossa group A ependymoma 31 | 1,511
nasopharyngeal carcinoma 30 | 1,056
Pick disease 29 | 1,893
primary pancreatic ductal adenocarcinoma 29 | 1,271
tuberculosis 29 | 1,557
posterior fossa group B ependymoma 28 | 1,530
astrocytoma 27 | 1,493
adrenocortical carcinoma 26 | 1,427
nephrosclerosis 25 | 329
Prostatic Neoplasms 24 | 471
active Crohn's disease 24 | 918
atypical teratoid/rhabdoid tumor 24 | 1,095
sonic hedgehog group medulloblastoma 24 | 1,482
Mammary Neoplasms 23 | 410
Rheumatoid Arthritis 23 | 1,160
gastric carcinoma 23 | 832
cutaneous lupus erythematosus 22 | 1,056
medulloblastoma 22 | 1,524
Down syndrome 19 | 548
acute quadriplegic myopathy 19 | 1,157
fibroadenoma 19 | 557
juvenile dermatomyositis 19 | 1,189
Diarrhea 18 | 155
Endometriosis 18 | 535
Hypertensive disease 18 | 193
active ulcerative colitis 17 | 477
aldosterone-producing adenoma 17 | 664
dermatomyositis 17 | 933
Multiple myeloma 16 | 1,327
Obesity 16 | 616
chronic rhinosinusitis 16 | 512
Atopic dermatitis 15 | 944
Atherosclerosis 14 | 275
Coronary artery disease 14 | 240
Schizophrenia 14 | 501
non primary Sjogren syndrome sicca 14 | 840
progressive supranuclear palsy 14 | 674
urothelial carcinoma 14 | 318
Cholestasis 13 | 93
Duchenne muscular dystrophy 13 | 602
Epilepsy 13 | 346
Heart disease 13 | 279
Nonsyndromic deafness 13 | 121
Metabolic acidosis 12 | 49
Osteoporosis 12 | 257
acute myeloid leukemia 12 | 780
glioblastoma multiforme 12 | 347
Atrial Fibrillation 11 | 110
Autistic Disorder 11 | 320
Cerebrovascular disease 11 | 231
Kidney cancer 11 | 118
Neurodegenerative disease 11 | 383
Sensorineural hearing loss 11 | 107
Vascular disease 11 | 281
Waldenstrons macroglobulinemia 11 | 765
mucosa-associated lymphoid tissue lymphoma 11 | 480
non-small cell lung carcinoma 11 | 413
primary Sjogren syndrome 11 | 789

Tissue

Digestive Tract 275 | 18,473
Nervous System 275 | 18,561
Endocrine System 274 | 18,512
Female tissues 274 | 18,647
Urinary Tract 274 | 18,444
Liver and Pancreas 272 | 18,136
Skin and soft tissues 272 | 18,115
Cardiovascular System 270 | 17,958
Blood and immune system 269 | 17,995
Male tissues 267 | 17,969
Respiratory system 265 | 17,484

Target Family

Non-IDG 129 | 11,971
Transporter 62 | 473
Enzyme 36 | 4,146
Ion Channel 20 | 341
Kinase 19 | 634
GPCR 11 | 406

GO Component

apical plasma membrane 277 | 277
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
N-acetylated-alpha-linked acidic dipeptidase-like protein NAALADL1 Tbio Enzyme -1.30374 25.3 78
Equilibrative nucleoside transporter 4 SLC29A4 Tbio Transporter -1.79381 73.1 189
Sodium/hydrogen exchanger 4 SLC9A4 Tdark Transporter -1.25841 17.4 6
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Ileal sodium/bile acid cotransporter SLC10A2 Tchem Transporter -2.60727 417.5 121
Otoancorin OTOA Tdark Non-IDG -1.29628 19.3 48
Solute carrier family 26 member 9 SLC26A9 Tbio Transporter -1.20448 19.3 27
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102