Development Level

Tbio 50 | 11,445
Tchem 15 | 1,598
Tclin 5 | 613
Tdark 2 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
preweaning lethality, complete... 4 | 979
decreased grip strength 3 | 116
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal retina morphology 2 | 71
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
enlarged heart 2 | 210
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating unsatura... 1 | 2
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
enlarged kidney 1 | 14
hyperactivity 1 | 148
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased vertical activity 1 | 24
limb grasping 1 | 41
mammalian phenotype 1 | 17
premature death 1 | 5
small testis 1 | 58
stereotypic behavior 1 | 3
thin ventricular wall 1 | 24
tremors 1 | 39
trunk curl 1 | 16

Disease

Carcinoma 54 | 11,493
ovarian cancer 43 | 8,520
osteosarcoma 42 | 7,950
psoriasis 42 | 6,694
lung cancer 35 | 4,740
ependymoma 31 | 4,679
glioblastoma 29 | 5,792
Breast cancer 28 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
medulloblastoma, large-cell 26 | 6,241
atypical teratoid / rhabdoid tumor 24 | 5,112
malignant mesothelioma 23 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
lung adenocarcinoma 22 | 2,716
Cancer 20 | 2,499
interstitial cystitis 20 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
invasive ductal carcinoma 20 | 2,951
group 3 medulloblastoma 18 | 4,104
lung carcinoma 18 | 2,843
pancreatic cancer 18 | 2,398
Astrocytoma, Pilocytic 17 | 3,081
Kidney cancer 17 | 2,613
adult high grade glioma 17 | 3,801
oligodendroglioma 17 | 2,850
Schizophrenia 16 | 1,160
astrocytic glioma 16 | 2,597
non-small cell lung cancer 16 | 2,890
pituitary cancer 16 | 1,972
primitive neuroectodermal tumor 14 | 3,035
diabetes mellitus 13 | 1,728
tuberculosis 13 | 2,010
ulcerative colitis 13 | 1,819
Autosomal recessive predisposition 12 | 1,442
breast carcinoma 12 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
ductal carcinoma in situ 11 | 1,745
subependymal giant cell astrocytoma 11 | 2,287
colon cancer 10 | 1,478
primary pancreatic ductal adenocarcinoma 10 | 1,109
Alzheimer's disease 9 | 658
Down syndrome 9 | 499
Kidney disease 9 | 430
Pick disease 9 | 1,894
acute quadriplegic myopathy 9 | 1,158
cystic fibrosis 9 | 1,696
group 4 medulloblastoma 9 | 1,855
juvenile dermatomyositis 9 | 1,187
Duchenne muscular dystrophy 8 | 601
Intellectual disability 8 | 1,016
Liver Cirrhosis, Experimental 8 | 769
Liver cancer 8 | 604
Rheumatoid arthritis 8 | 1,191
adrenocortical carcinoma 8 | 1,428
esophageal adenocarcinoma 8 | 737
gastric carcinoma 8 | 807
spina bifida 8 | 1,074
Melanoma 7 | 711
Neurodegenerative disease 7 | 414
Osteoporosis 7 | 363
Vascular disease 7 | 319
chronic rhinosinusitis 7 | 512
Cerebrovascular disease 6 | 238
Hypertension 6 | 396
Hypertensive disease 6 | 292
Skin cancer 6 | 469
astrocytoma 6 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
cutaneous lupus erythematosus 6 | 1,057
gastric cancer 6 | 459
hepatocellular carcinoma 6 | 547
mucosa-associated lymphoid tissue lymphoma 6 | 484
pediatric high grade glioma 6 | 1,064
sonic hedgehog group medulloblastoma 6 | 467
Anemia 5 | 365
Atherosclerosis 5 | 291
Atopic dermatitis 5 | 952
Becker muscular dystrophy 5 | 191
Cognitive delay 5 | 608
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Heart disease 5 | 306
Liver carcinoma 5 | 240
Low intelligence 5 | 645
Mental Depression 5 | 333
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Obesity 5 | 678
Poor school performance 5 | 645
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
dermatomyositis 5 | 966
medulloblastoma 5 | 720
pancreatic carcinoma 5 | 562
urothelial carcinoma 5 | 318
Bipolar Disorder 4 | 666
Depressive disorder 4 | 409
Multiple myeloma 4 | 1,332
nephrosclerosis 4 | 333

Tissue

Endocrine System 70 | 18,159
Urinary Tract 70 | 16,678
Digestive Tract 69 | 17,369
Liver and Pancreas 69 | 16,750
Male tissues 69 | 17,142
Skin and soft tissues 69 | 17,230
Blood and immune system 68 | 16,909
Female tissues 68 | 17,400
Nervous System 68 | 16,725
Respiratory system 66 | 16,393
Cardiovascular System 65 | 15,192

Target Family

Non-IDG 46 | 12,091
Enzyme 14 | 4,145
GPCR 4 | 408
Transporter 4 | 473
Ion Channel 3 | 344
Kinase 1 | 634

GO Component

apical part of cell 72 | 72
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Harmonin USH1C Tbio Non-IDG -2.10689 124.7 188
Moesin MSN Tbio Non-IDG -2.61389 361.7 550
Anion exchange protein 4 SLC4A9 Tbio Transporter -1.76538 50.3 91
Aquaporin-1 AQP1 Tbio Non-IDG -3.08125 1107.4 374
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.13751 1324.4 108
Nuclear mitotic apparatus protein 1 NUMA1 Tbio Non-IDG -2.76544 575.8 235
Na(+)/H(+) exchange regulatory cofactor NHE-RF4 PDZD3 Tbio Non-IDG -0.76581 6.17 121
Mitochondrial uncoupling protein 4 SLC25A27 Tbio Transporter -1.53936 38.0 51
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90