Development Level

Tbio 157 | 11,651
Tdark 20 | 6,593
Tchem 15 | 1,388
Tclin 4 | 612

Collection

RFA-RM-18-021 4 | 328
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 11 | 499
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
decreased body weight 5 | 161
decreased vertical activity 5 | 208
increased lean body mass 5 | 172
abnormal sleep behavior 4 | 70
embryonic lethality prior to o... 4 | 239
improved glucose tolerance 4 | 79
decreased caudal vertebrae num... 3 | 53
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
hyperactivity 3 | 148
increased body weight 3 | 25
increased startle reflex 3 | 112
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal coat-hair pigmentatio... 2 | 64
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
abnormal retinal inner nuclear... 2 | 8
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased circulating creatini... 2 | 38
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased red blood cell distr... 2 | 34
male infertility 2 | 123
prenatal lethality 2 | 28
abnormal allantois morphology 1 | 8
abnormal behavioral response t... 1 | 66
abnormal chorioallantoic fusio... 1 | 8
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal liver morphology 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
absent startle reflex 1 | 24
absent teeth 1 | 3
brachydactyly 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired righting response 1 | 26
increased circulating chloride... 1 | 41
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
microphthalmia 1 | 26
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
shortened PQ interval 1 | 7
small superior vagus ganglion 1 | 74
small testis 1 | 58
small thymus 1 | 16
syndactyly 1 | 23
thin ventricular wall 1 | 24
vertebral fusion 1 | 23

Disease

Carcinoma 149 | 11,493
osteosarcoma 112 | 7,950
ovarian cancer 109 | 8,519
glioblastoma 94 | 5,792
medulloblastoma, large-cell 86 | 6,241
atypical teratoid / rhabdoid tumor 81 | 5,112
psoriasis 80 | 6,694
ependymoma 71 | 4,679
lung cancer 71 | 4,740
Breast cancer 61 | 3,577
Astrocytoma, Pilocytic 60 | 3,081
group 3 medulloblastoma 59 | 4,104
pancreatic cancer 58 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,290
primitive neuroectodermal tumor 55 | 3,035
malignant mesothelioma 54 | 3,232
adult high grade glioma 53 | 3,801
invasive ductal carcinoma 53 | 2,950
Kidney cancer 50 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,954
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,988
Cancer 43 | 2,499
non-small cell lung cancer 43 | 2,890
oligodendroglioma 43 | 2,850
astrocytic glioma 39 | 2,597
lung adenocarcinoma 38 | 2,716
lung carcinoma 37 | 2,843
tuberculosis 36 | 2,010
colon cancer 33 | 1,478
group 4 medulloblastoma 31 | 1,855
breast carcinoma 30 | 1,637
pituitary cancer 30 | 1,972
subependymal giant cell astrocytoma 30 | 2,287
interstitial cystitis 29 | 2,312
primary pancreatic ductal adenocarcinoma 29 | 1,108
juvenile dermatomyositis 28 | 1,187
ductal carcinoma in situ 27 | 1,744
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
ulcerative colitis 25 | 1,819
adrenocortical carcinoma 24 | 1,428
cystic fibrosis 24 | 1,695
diabetes mellitus 24 | 1,728
pediatric high grade glioma 24 | 1,064
Autosomal recessive predisposition 23 | 1,442
Schizophrenia 23 | 1,160
acute quadriplegic myopathy 23 | 1,158
spina bifida 23 | 1,074
dermatomyositis 22 | 966
Duchenne muscular dystrophy 19 | 601
Pick disease 18 | 1,894
Rheumatoid arthritis 18 | 1,191
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 510
Bipolar Disorder 17 | 666
Liver Cirrhosis, Experimental 17 | 769
Waldenstrons macroglobulinemia 17 | 765
astrocytoma 17 | 1,146
Multiple myeloma 16 | 1,332
Alzheimer's disease 15 | 658
Liver cancer 15 | 604
cutaneous lupus erythematosus 15 | 1,057
aldosterone-producing adenoma 14 | 665
nasopharyngeal carcinoma 14 | 1,058
non primary Sjogren syndrome sicca 14 | 891
Amyotrophic lateral sclerosis 13 | 451
esophageal adenocarcinoma 13 | 737
medulloblastoma 13 | 720
Atopic dermatitis 12 | 952
Intellectual disability 12 | 1,016
fibroadenoma 12 | 559
hereditary spastic paraplegia 12 | 318
pancreatic carcinoma 12 | 562
Acquired scoliosis 11 | 281
Blepharoptosis 11 | 231
Curvature of spine 11 | 282
Down syndrome 11 | 499
gastric carcinoma 11 | 807
hepatocellular carcinoma 11 | 547
primary Sjogren syndrome 11 | 735
Breast Neoplasms 10 | 445
Byzanthine arch palate 10 | 194
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Muscle hypotonia 10 | 571
Poor school performance 10 | 645
Short stature 10 | 531
gastric cancer 10 | 459
progressive supranuclear palsy 10 | 676
Infantile onset 9 | 238
Mammary Neoplasms 9 | 425
Skin cancer 9 | 469
active Crohn's disease 9 | 922
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Hypoplastic mandible condyle 8 | 275
Mandibular hypoplasia 8 | 275
Mental and motor retardation 8 | 608
Micrognathism 8 | 275
Prostatic Neoplasms 8 | 495

Tissue

Endocrine System 196 | 18,159
Blood and immune system 194 | 16,909
Female tissues 194 | 17,400
Liver and Pancreas 194 | 16,750
Skin and soft tissues 194 | 17,230
Male tissues 193 | 17,142
Digestive Tract 192 | 17,369
Urinary Tract 192 | 16,678
Nervous System 191 | 16,725
Respiratory system 190 | 16,393
Cardiovascular System 182 | 15,192

Target Family

Non-IDG 142 | 12,091
Enzyme 26 | 4,145
Kinase 12 | 634
Transcription Factor 7 | 1,400
Ion Channel 4 | 344
GPCR 2 | 408
Transporter 2 | 473
Nuclear Receptor 1 | 48

GO Component

actin cytoskeleton 196 | 196
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Actin filament-associated protein 1 AFAP1 Tbio Non-IDG -1.89567 70.0 314
Integrator complex subunit 6 INTS6 Tbio Non-IDG -2.07240 118.9 80
Neuropeptide FF receptor 2 NPFFR2 Tchem GPCR -1.63803 38.0 161
Chloride intracellular channel protein 4 CLIC4 Tbio Ion Channel -1.81713 70.5 221
Cdc42 effector protein 3 CDC42EP3 Tbio Non-IDG -1.57638 37.5 124
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
Serine/threonine-protein kinase 17B STK17B Tchem Kinase -1.26923 26.6 344
Usher syndrome type-1G protein USH1G Tbio Non-IDG -1.64281 40.2 24
Amyloid-beta A4 precursor protein-binding family B member 3 APBB3 Tdark Non-IDG -0.61314 4.42 111