Development Level

Tbio 88 | 11,651
Tchem 12 | 1,388
Tclin 11 | 612
Tdark 8 | 6,593

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 4 | 499
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
increased startle reflex 3 | 112
abnormal bone mineralization 2 | 38
abnormal tail morphology 2 | 25
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral content 2 | 151
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased neutrophil cell numb... 2 | 42
decreased vertical activity 2 | 208
edema 2 | 59
embryonic lethality prior to t... 2 | 278
hypoactivity 2 | 132
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased heart rate 2 | 23
increased heart weight 2 | 62
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal limb morphology 1 | 13
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal urinary bladder morph... 1 | 11
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cyanosis 1 | 7
decreased NK cell number 1 | 2
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased heart rate variabili... 1 | 13
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
female infertility 1 | 60
hemorrhage 1 | 23
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating triglyce... 1 | 42
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
male infertility 1 | 123
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
respiratory system phenotype 1 | 2
short tibia 1 | 97
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
shortened RR interval 1 | 17
shortened ST segment 1 | 10
syndactyly 1 | 23
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 91 | 11,493
ovarian cancer 63 | 8,520
psoriasis 57 | 6,694
medulloblastoma, large-cell 50 | 6,241
atypical teratoid / rhabdoid tumor 48 | 5,112
glioblastoma 48 | 5,792
lung cancer 43 | 4,740
ependymoma 41 | 4,679
osteosarcoma 41 | 7,950
Breast cancer 40 | 3,578
adult high grade glioma 36 | 3,801
lung adenocarcinoma 36 | 2,716
primitive neuroectodermal tumor 35 | 3,035
pancreatic cancer 34 | 2,398
Kidney cancer 33 | 2,613
group 3 medulloblastoma 32 | 4,104
invasive ductal carcinoma 31 | 2,951
non-small cell lung cancer 31 | 2,890
colon cancer 30 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,291
malignant mesothelioma 30 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
oligodendroglioma 28 | 2,850
Astrocytoma, Pilocytic 27 | 3,081
lung carcinoma 27 | 2,843
acute quadriplegic myopathy 26 | 1,158
Cardiomyopathy 25 | 116
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
astrocytic glioma 23 | 2,597
Autosomal recessive predisposition 22 | 1,442
Liver cancer 21 | 604
pituitary cancer 20 | 1,972
subependymal giant cell astrocytoma 20 | 2,287
Cancer 19 | 2,499
Dilated cardiomyopathy 19 | 56
Myopathy 19 | 185
Pick disease 18 | 1,894
breast carcinoma 18 | 1,638
ductal carcinoma in situ 18 | 1,745
Familial isolated dilated cardiomyopathy 17 | 41
LEFT VENTRICULAR NONCOMPACTION 10 17 | 40
LEFT VENTRICULAR NONCOMPACTION 8 17 | 40
adrenocortical carcinoma 17 | 1,428
tuberculosis 17 | 2,010
Cardiomyopathy, Dilated 16 | 83
Hypertrophic Cardiomyopathy 16 | 117
cystic fibrosis 16 | 1,696
group 4 medulloblastoma 16 | 1,855
Endometrial cancer 15 | 311
Creatine phosphokinase serum increased 14 | 110
Elevated creatine kinase 14 | 110
Heart disease 14 | 306
Skin cancer 14 | 469
spina bifida 14 | 1,074
Atrial Fibrillation 13 | 124
Melanoma 13 | 711
active ulcerative colitis 13 | 764
diabetes mellitus 13 | 1,728
ulcerative colitis 13 | 1,819
Duchenne muscular dystrophy 12 | 601
Intellectual disability 12 | 1,016
Muscular dystrophy 12 | 75
juvenile dermatomyositis 12 | 1,187
primary pancreatic ductal adenocarcinoma 12 | 1,109
Cardiac Arrhythmia 11 | 103
Dull intelligence 11 | 645
Epilepsy 11 | 792
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Muscle biopsy shows dystrophic changes 11 | 39
Poor school performance 11 | 645
Schizophrenia 11 | 1,160
Seizures 11 | 596
active Crohn's disease 11 | 922
astrocytoma 11 | 1,146
interstitial cystitis 11 | 2,312
Atopic dermatitis 10 | 952
Congestive heart failure 10 | 113
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 510
dermatomyositis 10 | 966
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Adult onset 9 | 82
Bipolar Disorder 9 | 666
Cardiomyopathies 9 | 110
EMG: myopathic abnormalities 9 | 22
Heart failure 9 | 162
Renal Cell Carcinoma 9 | 214
Slow progression 9 | 89
Syncope 9 | 22
gastric carcinoma 9 | 807
hereditary spastic paraplegia 9 | 318
medulloblastoma 9 | 720
nasopharyngeal carcinoma 9 | 1,058
pediatric high grade glioma 9 | 1,064
Cognitive delay 8 | 608
Global developmental delay 8 | 608
Hypertension 8 | 396
Mental and motor retardation 8 | 608
Status Epilepticus 8 | 98

Tissue

Endocrine System 118 | 18,159
Female tissues 117 | 17,400
Digestive Tract 116 | 17,369
Blood and immune system 114 | 16,909
Male tissues 114 | 17,142
Skin and soft tissues 114 | 17,230
Urinary Tract 114 | 16,678
Liver and Pancreas 113 | 16,750
Nervous System 112 | 16,725
Cardiovascular System 110 | 15,192
Respiratory system 109 | 16,393

Target Family

Non-IDG 81 | 12,091
Enzyme 18 | 4,145
Ion Channel 10 | 344
Transporter 4 | 473
Kinase 3 | 634
Epigenetic 2 | 242
GPCR 1 | 408

GO Component

Z disc 119 | 119
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Potassium voltage-gated channel subfamily E member 1 KCNE1 Tbio Ion Channel -2.67495 441.7 193
Integrin beta-1-binding protein 2 ITGB1BP2 Tbio Non-IDG -1.09897 15.9 165
Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D Tclin Ion Channel -2.43448 273.2 215
Four and a half LIM domains protein 3 FHL3 Tbio Non-IDG -0.71819 5.67 103
E3 ubiquitin-protein ligase CHIP STUB1 Tbio Enzyme -2.96877 926.8 351
Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C Tclin Ion Channel -2.75188 537.5 330
Homer protein homolog 1 HOMER1 Tbio Non-IDG -2.45026 285.7 241
F-box and leucine-rich protein 22 FBXL22 Tdark Non-IDG 0.29 0.26 33
Protein AHNAK2 AHNAK2 Tbio Non-IDG -0.78071 6.06 78