Development Level

Tbio 78 | 10,625
Tclin 13 | 602
Tchem 12 | 1,890
Tdark 7 | 7,003

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 9 | 633
decreased bone mineral content 4 | 157
decreased lean body mass 4 | 195
abnormal retina morphology 3 | 100
increased bone mineral density 3 | 52
abnormal bone mineralization 2 | 55
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal retinal pigmentation 2 | 61
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
increased body length 2 | 20
increased body weight 2 | 42
increased heart rate 2 | 17
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal retinal blood vessel ... 1 | 18
abnormal retinal outer nuclear... 1 | 5
abnormal rib morphology 1 | 28
abnormal startle reflex 1 | 14
abnormal thoracic vertebrae mo... 1 | 16
abnormal urinary bladder morph... 1 | 2
cardiovascular system phenotyp... 1 | 35
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating total pr... 1 | 41
decreased coping response 1 | 5
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased mature B cell number 1 | 25
decreased threshold for audito... 1 | 32
decreased vertical activity 1 | 22
edema 1 | 11
embryonic lethality prior to t... 1 | 187
female infertility 1 | 34
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
improved glucose tolerance 1 | 56
increased blood urea nitrogen ... 1 | 44
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
male infertility 1 | 62
prenatal lethality 1 | 16
short tibia 1 | 82
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened RR interval 1 | 19
shortened ST segment 1 | 9
thick ventricular wall 1 | 7
tremors 1 | 34

Disease

ovarian cancer 59 | 8,492
psoriasis 57 | 6,685
medulloblastoma, large-cell 49 | 6,234
glioblastoma 45 | 5,572
lung cancer 42 | 4,473
atypical teratoid / rhabdoid tumor 40 | 4,369
osteosarcoma 38 | 7,933
Carcinoma 34 | 2,147
primitive neuroectodermal tumor 33 | 3,031
lung adenocarcinoma 32 | 2,714
invasive ductal carcinoma 31 | 2,950
non-small cell lung cancer 31 | 2,798
Breast cancer 30 | 3,099
colon cancer 29 | 1,475
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,289
oligodendroglioma 28 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
pancreatic cancer 26 | 2,300
pilocytic astrocytoma 26 | 3,086
malignant mesothelioma 25 | 3,163
pediatric high grade glioma 25 | 2,712
acute quadriplegic myopathy 23 | 1,157
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
lung carcinoma 23 | 2,844
Cardiomyopathy 22 | 110
pituitary cancer 21 | 1,972
Myopathy 20 | 128
medulloblastoma 19 | 1,524
subependymal giant cell astrocytoma 19 | 2,287
Pick disease 18 | 1,893
adult high grade glioma 18 | 2,148
astrocytic glioma 18 | 2,241
ependymoma 18 | 2,514
cystic fibrosis 17 | 1,670
ductal carcinoma in situ 17 | 1,745
Dilated cardiomyopathy 16 | 51
Familial isolated dilated cardiomyopathy 16 | 41
adrenocortical carcinoma 16 | 1,427
astrocytoma 16 | 1,493
ulcerative colitis 16 | 2,087
Cancer 15 | 2,346
breast carcinoma 15 | 1,614
group 4 medulloblastoma 15 | 1,875
primary pancreatic ductal adenocarcinoma 15 | 1,271
posterior fossa group A ependymoma 14 | 1,511
sonic hedgehog group medulloblastoma 14 | 1,482
posterior fossa group B ependymoma 13 | 1,530
tuberculosis 13 | 1,563
Heart disease 12 | 279
Hypertrophic Cardiomyopathy 12 | 56
spina bifida 12 | 1,064
Cardiomyopathies 11 | 90
active Crohn's disease 11 | 918
group 3 medulloblastoma 11 | 2,254
Amyotrophic Lateral Sclerosis 10 | 432
Atopic dermatitis 10 | 944
Atrial Fibrillation 10 | 110
Cardiomyopathy, Hypertrophic, Familial 10 | 21
Duchenne muscular dystrophy 10 | 602
Kidney cancer 10 | 121
dermatomyositis 10 | 967
interstitial cystitis 10 | 2,299
juvenile dermatomyositis 10 | 1,189
Cardiomyopathy, Dilated 9 | 47
active ulcerative colitis 9 | 477
atypical teratoid/rhabdoid tumor 9 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 499
diabetes mellitus 9 | 1,663
gastric carcinoma 9 | 832
nasopharyngeal carcinoma 9 | 1,056
Heart conduction disease 8 | 65
Long QT syndrome 8 | 53
Renal Cell Carcinoma 8 | 199
Status Epilepticus 8 | 85
esophageal adenocarcinoma 8 | 737
hereditary spastic paraplegia 8 | 313
Down syndrome 7 | 548
Rheumatoid Arthritis 7 | 1,171
Schizophrenia 7 | 503
cutaneous lupus erythematosus 7 | 1,056
limb-girdle muscular dystrophy 7 | 36
Intellectual disability 6 | 573
Neurodegenerative disease 6 | 383
Neuropathy 6 | 210
Vascular disease 6 | 281
aldosterone-producing adenoma 6 | 664
chronic rhinosinusitis 6 | 512
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Alzheimer's disease 5 | 644
Asthma 5 | 349
Autistic Disorder 5 | 320
Brugada syndrome 5 | 26
Cerebrovascular disease 5 | 231
Hypertension 5 | 293
Multiple myeloma 5 | 1,328
Romano-Ward Syndrome 5 | 12
Waldenstrons macroglobulinemia 5 | 765
glioblastoma multiforme 5 | 347
pancreatic carcinoma 5 | 567
progressive supranuclear palsy 5 | 674

Tissue

Cardiovascular System 110 | 17,958
Digestive Tract 110 | 18,473
Endocrine System 110 | 18,512
Female tissues 110 | 18,647
Liver and Pancreas 110 | 18,136
Male tissues 110 | 17,969
Nervous System 110 | 18,561
Respiratory system 110 | 17,484
Skin and soft tissues 110 | 18,115
Urinary Tract 110 | 18,444
Blood and immune system 109 | 17,995

Target Family

Non-IDG 72 | 11,969
Enzyme 17 | 4,146
Ion Channel 12 | 341
Kinase 3 | 634
Transporter 3 | 473
Epigenetic 2 | 242
GPCR 1 | 408

GO Component

Z disc 110 | 110
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
Golgi apparatus 864 | 864
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ankyrin-2 ANK2 Tbio Non-IDG -2.04838 107.1 205
Beta-parvin PARVB Tbio Non-IDG -1.23257 16.7 66
BAG family molecular chaperone regulator 3 BAG3 Tbio Non-IDG -2.19746 181.8 254
Xin actin-binding repeat-containing protein 2 XIRP2 Tbio Non-IDG -0.90215 8.50 16
F-box and leucine-rich protein 22 FBXL22 Tdark Non-IDG 0.30 0.25 20
Junctophilin-1 JPH1 Tbio Non-IDG -1.75131 52.9 77
Sodium channel subunit beta-3 SCN3B Tbio Ion Channel -0.96474 9.44 51
Integrin beta-1-binding protein 2 ITGB1BP2 Tbio Non-IDG -1.09724 15.5 129
Palladin PALLD Tbio Non-IDG -2.69516 485.5 162
Muscle-related coiled-coil protein MURC Tbio Non-IDG -1.42436 31.1 59