Development Level

Tbio 71 | 11,445
Tchem 20 | 1,598
Tdark 3 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 2 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 9 | 499
abnormal embryo size 3 | 220
decreased circulating glucose ... 3 | 126
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
increased body length 2 | 32
increased bone mineral content 2 | 108
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal heart left ventricle ... 1 | 16
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal social-conspecific in... 1 | 3
abnormal spinal cord morpholog... 1 | 9
abnormal urinary bladder morph... 1 | 11
abnormal vitreous body morphol... 1 | 10
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased fasted circulating g... 1 | 65
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased prepulse inhibition 1 | 82
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
edema 1 | 59
enlarged epididymis 1 | 31
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased heart rate 1 | 23
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
pallor 1 | 34
shortened RR interval 1 | 17
small testis 1 | 58
tremors 1 | 39

Disease

Carcinoma 76 | 11,493
ovarian cancer 58 | 8,520
osteosarcoma 56 | 7,950
medulloblastoma, large-cell 46 | 6,241
Cancer 45 | 2,499
psoriasis 44 | 6,694
glioblastoma 42 | 5,792
lung cancer 40 | 4,740
atypical teratoid / rhabdoid tumor 33 | 5,112
Breast cancer 31 | 3,578
malignant mesothelioma 27 | 3,232
group 3 medulloblastoma 24 | 4,104
adult high grade glioma 23 | 3,801
primitive neuroectodermal tumor 23 | 3,035
ependymoma 22 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
Kidney cancer 19 | 2,613
Pick disease 17 | 1,894
Rheumatoid arthritis 17 | 1,191
Waldenstrons macroglobulinemia 17 | 765
pancreatic cancer 17 | 2,398
subependymal giant cell astrocytoma 17 | 2,287
Intellectual disability 16 | 1,016
astrocytic glioma 16 | 2,597
juvenile dermatomyositis 16 | 1,187
non-small cell lung cancer 16 | 2,890
pituitary cancer 16 | 1,972
intraductal papillary-mucinous adenoma (IPMA) 15 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
oligodendroglioma 15 | 2,850
Astrocytoma, Pilocytic 14 | 3,081
Multiple myeloma 14 | 1,332
diabetes mellitus 14 | 1,728
tuberculosis 14 | 2,010
ulcerative colitis 14 | 1,819
dermatomyositis 13 | 966
group 4 medulloblastoma 13 | 1,855
acute quadriplegic myopathy 12 | 1,158
invasive ductal carcinoma 12 | 2,951
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
breast carcinoma 11 | 1,638
pediatric high grade glioma 11 | 1,064
Short stature 10 | 531
Small head 10 | 374
Amyotrophic lateral sclerosis 9 | 451
Autosomal recessive predisposition 9 | 1,442
Prostatic Neoplasms 9 | 495
primary Sjogren syndrome 9 | 735
Parkinson's disease 8 | 392
Schizophrenia 8 | 1,160
adrenocortical carcinoma 8 | 1,428
colon cancer 8 | 1,478
lung adenocarcinoma 8 | 2,716
lung carcinoma 8 | 2,843
Breast Neoplasms 7 | 445
Cognitive delay 7 | 608
Epilepsy 7 | 792
Global developmental delay 7 | 608
Hypoplastic mandible condyle 7 | 275
Lymphoma 7 | 81
Mammary Neoplasms 7 | 425
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Obesity 7 | 678
Pancreatic Neoplasm 7 | 85
Renal Cell Carcinoma 7 | 214
Thrombocytopenia 7 | 197
acute myeloid leukemia 7 | 783
astrocytoma 7 | 1,146
cutaneous lupus erythematosus 7 | 1,057
interstitial cystitis 7 | 2,312
medulloblastoma 7 | 720
progressive supranuclear palsy 7 | 676
Ataxia telangiectasia 6 | 34
Carcinoma, Hepatocellular 6 | 228
Chronic Lymphocytic Leukemia 6 | 262
Glioma 6 | 74
Hereditary Breast and Ovarian Cancer Syndrome 6 | 14
Leukemia 6 | 104
Liver cancer 6 | 604
Liver carcinoma 6 | 240
Multiple Sclerosis 6 | 540
Muscle hypotonia 6 | 571
Nijmegen breakage syndrome 6 | 24
Pancreatic Neoplasms 6 | 85
aldosterone-producing adenoma 6 | 665
non primary Sjogren syndrome sicca 6 | 891
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109
Alzheimer's disease 5 | 658
Endometriosis 5 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
cystic fibrosis 5 | 1,696
ductal carcinoma in situ 5 | 1,745
spina bifida 5 | 1,074

Tissue

Endocrine System 94 | 18,159
Blood and immune system 93 | 16,909
Digestive Tract 93 | 17,369
Female tissues 93 | 17,400
Nervous System 93 | 16,725
Liver and Pancreas 92 | 16,750
Male tissues 92 | 17,142
Respiratory system 92 | 16,393
Skin and soft tissues 92 | 17,230
Urinary Tract 92 | 16,678
Cardiovascular System 91 | 15,192

Target Family

Non-IDG 47 | 12,091
Enzyme 17 | 4,145
Transcription Factor 15 | 1,400
Kinase 11 | 634
Epigenetic 2 | 242
TF/Epigenetic 2 | 38
Nuclear Receptor 1 | 48

GO Component

PML body 95 | 95
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CASP8-associated protein 2 CASP8AP2 Tbio Non-IDG 0.00000 0
G/T mismatch-specific thymine DNA glycosylase TDG Tbio Enzyme -2.46252 297.6 225
MAP kinase-interacting serine/threonine-protein kinase 2 MKNK2 Tchem Kinase -1.32729 19.5 234
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
E3 SUMO-protein ligase ZNF451 ZNF451 Tbio Transcription Factor -2.42090 254.4 71
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
Nuclear receptor subfamily 2 group C member 1 NR2C1 Tbio Nuclear Receptor -1.39182 24.4 294
Regulator of G-protein signaling 14 RGS14 Tbio Non-IDG -1.61170 43.9 233
Structural maintenance of chromosomes protein 6 SMC6 Tbio Non-IDG -1.42371 20.0 115
A-kinase anchor protein 8-like AKAP8L Tbio Enzyme -1.03730 13.2 140