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Target Filters...

Development Level

Tbio 80 | 11,651
Tchem 16 | 1,388
Tdark 3 | 6,593
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 4 | 499
abnormal tail morphology 3 | 25
decreased mean corpuscular vol... 3 | 79
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
decreased bone mineral content 2 | 151
decreased circulating triglyce... 2 | 79
increased blood urea nitrogen ... 2 | 48
increased lean body mass 2 | 172
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal neural tube closure 1 | 46
abnormal skin coloration 1 | 25
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cataract 1 | 92
cleft palate 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body weight 1 | 25
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating triglyce... 1 | 42
increased neutrophil cell numb... 1 | 46
increased total body fat amoun... 1 | 134
mydriasis 1 | 6
premature death 1 | 5
small adrenal glands 1 | 16
small heart 1 | 10
small kidney 1 | 16
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 68 | 11,493
psoriasis 54 | 6,694
ovarian cancer 46 | 8,520
Cancer 40 | 2,499
osteosarcoma 36 | 7,950
lung cancer 34 | 4,740
Breast cancer 31 | 3,578
glioblastoma 28 | 5,792
lung adenocarcinoma 27 | 2,716
medulloblastoma, large-cell 27 | 6,241
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
pancreatic cancer 26 | 2,398
atypical teratoid / rhabdoid tumor 25 | 5,112
lung carcinoma 25 | 2,843
invasive ductal carcinoma 24 | 2,951
cystic fibrosis 23 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
Astrocytoma, Pilocytic 21 | 3,081
non-small cell lung cancer 21 | 2,890
adult high grade glioma 20 | 3,801
breast carcinoma 20 | 1,638
diabetes mellitus 20 | 1,728
ependymoma 20 | 4,679
pituitary cancer 20 | 1,972
malignant mesothelioma 19 | 3,232
Autosomal recessive predisposition 18 | 1,442
ductal carcinoma in situ 18 | 1,745
group 3 medulloblastoma 18 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
ulcerative colitis 16 | 1,819
oligodendroglioma 15 | 2,850
interstitial cystitis 14 | 2,312
primary pancreatic ductal adenocarcinoma 14 | 1,109
Atherosclerosis 13 | 291
Kidney cancer 13 | 2,613
adrenocortical carcinoma 12 | 1,428
Atopic dermatitis 11 | 952
Osteoporosis 11 | 363
colon cancer 11 | 1,478
esophageal adenocarcinoma 11 | 737
Liver cancer 10 | 604
Schizophrenia 10 | 1,160
active ulcerative colitis 10 | 764
astrocytic glioma 10 | 2,597
nasopharyngeal carcinoma 10 | 1,058
primitive neuroectodermal tumor 10 | 3,035
sonic hedgehog group medulloblastoma 10 | 467
Kidney disease 9 | 430
Rheumatoid arthritis 9 | 1,191
astrocytoma 9 | 1,146
cutaneous lupus erythematosus 9 | 1,057
fibroadenoma 9 | 559
Alzheimer's disease 8 | 658
Cerebrovascular disease 8 | 238
Duchenne muscular dystrophy 8 | 601
Hypertension 8 | 396
Pick disease 8 | 1,894
gastric carcinoma 8 | 807
group 4 medulloblastoma 8 | 1,855
spina bifida 8 | 1,074
subependymal giant cell astrocytoma 8 | 2,287
Asthma 7 | 385
Bipolar Disorder 7 | 666
Broad flat nasal bridge 7 | 236
Cleft Palate 7 | 271
Hypertensive disease 7 | 292
Large intestine cancer 7 | 126
Nasal bridge wide 7 | 236
Obesity 7 | 678
Prostatic Neoplasms 7 | 495
Short stature 7 | 531
active Crohn's disease 7 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 510
dermatomyositis 7 | 966
non primary Sjogren syndrome sicca 7 | 891
tuberculosis 7 | 2,010
Adenoma 6 | 167
Arthritis 6 | 290
Cognitive delay 6 | 608
Crohn's disease 6 | 321
Cryptorchidism 6 | 296
Down syndrome 6 | 499
Global developmental delay 6 | 608
Hypoplastic mandible condyle 6 | 275
Intellectual disability 6 | 1,016
Liver Cirrhosis, Experimental 6 | 769
Liver disease 6 | 237
Mandibular hypoplasia 6 | 275
Melanoma 6 | 711
Mental and motor retardation 6 | 608
Micrognathism 6 | 275
Myopia 6 | 176
Thrombosis 6 | 46
Vascular disease 6 | 319
juvenile dermatomyositis 6 | 1,187
limb girdle muscular dystrophy 2A 6 | 213
pediatric high grade glioma 6 | 1,064
periodontitis 5 | 293
urothelial carcinoma 5 | 318

Tissue

Digestive Tract 95 | 17,369
Female tissues 92 | 17,400
Skin and soft tissues 92 | 17,230
Endocrine System 89 | 18,159
Blood and immune system 86 | 16,909
Liver and Pancreas 85 | 16,750
Urinary Tract 85 | 16,678
Male tissues 84 | 17,142
Respiratory system 82 | 16,393
Nervous System 79 | 16,725
Cardiovascular System 63 | 15,192

Target Family

Non-IDG 81 | 12,091
Enzyme 19 | 4,145
Transcription Factor 1 | 1,400

GO Component

Golgi lumen 101 | 101
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Osteomodulin OMD Tbio Non-IDG -2.36749 234.5 121
Inositol monophosphatase 3 IMPAD1 Tdark Enzyme -0.78606 4.97 79
Defensin-5 DEFA5 Tbio Non-IDG -1.93853 88.3 171
Defensin-6 DEFA6 Tbio Non-IDG -1.25739 19.3 70
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222