Development Level

Tbio 681 | 11,651
Tdark 105 | 6,593
Tchem 87 | 1,388
Tclin 31 | 612

Collection

RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Target... 6 | 125
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 68 | 979
preweaning lethality, incomple... 32 | 499
embryonic lethality prior to t... 21 | 278
abnormal embryo size 19 | 220
decreased total body fat amoun... 15 | 207
abnormal bone structure 14 | 187
embryonic lethality prior to o... 14 | 239
decreased circulating serum al... 12 | 82
abnormal behavior 11 | 298
decreased body weight 10 | 161
embryonic growth retardation 10 | 106
decreased bone mineral content 9 | 151
decreased lean body mass 9 | 135
increased mean corpuscular vol... 9 | 92
short tibia 9 | 97
abnormal testis morphology 8 | 43
decreased circulating triglyce... 8 | 79
decreased vertical activity 8 | 208
enlarged heart 8 | 210
hypoactivity 8 | 132
increased lean body mass 8 | 172
increased total body fat amoun... 8 | 134
decreased circulating choleste... 7 | 93
decreased circulating glucose ... 7 | 126
decreased grip strength 7 | 116
impaired glucose tolerance 7 | 75
increased circulating alkaline... 7 | 122
increased startle reflex 7 | 112
small testis 7 | 58
abnormal heart morphology 6 | 162
abnormal kidney morphology 6 | 65
decreased erythrocyte cell num... 6 | 62
edema 6 | 59
hyperactivity 6 | 148
increased bone mineral content 6 | 108
increased fasted circulating g... 6 | 76
increased mean corpuscular hem... 6 | 96
abnormal gait 5 | 69
abnormal lens morphology 5 | 81
abnormal seminal vesicle morph... 5 | 114
decreased blood urea nitrogen ... 5 | 51
decreased body length 5 | 101
decreased bone mineral density 5 | 126
decreased circulating HDL chol... 5 | 68
decreased circulating total pr... 5 | 49
decreased eosinophil cell numb... 5 | 24
improved glucose tolerance 5 | 79
increased blood urea nitrogen ... 5 | 48
increased mean corpuscular hem... 5 | 36
increased mean platelet volume 5 | 45
increased or absent threshold ... 5 | 101
abnormal cranium morphology 4 | 36
abnormal joint morphology 4 | 23
abnormal limb morphology 4 | 13
abnormal neural tube closure 4 | 46
abnormal sleep behavior 4 | 70
abnormal tail morphology 4 | 25
cataract 4 | 92
decreased circulating alanine ... 4 | 47
decreased circulating amylase ... 4 | 28
decreased circulating calcium ... 4 | 36
decreased circulating creatini... 4 | 39
decreased circulating fructosa... 4 | 30
decreased circulating insulin ... 4 | 76
female infertility 4 | 60
increased circulating HDL chol... 4 | 80
increased circulating choleste... 4 | 66
increased heart weight 4 | 62
limb grasping 4 | 41
male infertility 4 | 123
persistence of hyaloid vascula... 4 | 33
prolonged QT interval 4 | 38
small superior vagus ganglion 4 | 74
syndactyly 4 | 23
thrombocytosis 4 | 27
abnormal cornea morphology 3 | 31
abnormal embryo turning 3 | 31
abnormal epididymis morphology 3 | 42
abnormal head morphology 3 | 10
abnormal limb bud morphology 3 | 17
abnormal locomotor behavior 3 | 24
abnormal skin morphology 3 | 50
brachydactyly 3 | 19
decreased circulating LDL chol... 3 | 38
decreased circulating alkaline... 3 | 46
decreased circulating magnesiu... 3 | 13
decreased hemoglobin content 3 | 68
enlarged epididymis 3 | 31
hemorrhage 3 | 23
hydrometra 3 | 53
impaired pupillary reflex 3 | 26
increased body weight 3 | 25
increased bone mineral density 3 | 72
increased circulating iron lev... 3 | 30
increased circulating serum al... 3 | 22
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 28
increased monocyte cell number 3 | 63
prenatal lethality 3 | 28
prolonged ST segment 3 | 36

Disease

Carcinoma 581 | 11,493
ovarian cancer 499 | 8,520
osteosarcoma 438 | 7,950
psoriasis 372 | 6,694
medulloblastoma, large-cell 330 | 6,241
glioblastoma 329 | 5,792
atypical teratoid / rhabdoid tumor 276 | 5,112
ependymoma 262 | 4,679
lung cancer 256 | 4,740
Breast cancer 210 | 3,578
Cancer 198 | 2,499
malignant mesothelioma 197 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 196 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 193 | 3,291
Astrocytoma, Pilocytic 189 | 3,081
adult high grade glioma 186 | 3,801
group 3 medulloblastoma 177 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 177 | 2,989
invasive ductal carcinoma 171 | 2,951
oligodendroglioma 160 | 2,850
non-small cell lung cancer 157 | 2,890
Kidney cancer 155 | 2,613
lung adenocarcinoma 154 | 2,716
tuberculosis 151 | 2,010
diabetes mellitus 146 | 1,728
lung carcinoma 142 | 2,843
astrocytic glioma 139 | 2,597
pancreatic cancer 139 | 2,398
primitive neuroectodermal tumor 138 | 3,035
subependymal giant cell astrocytoma 130 | 2,287
interstitial cystitis 120 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 119 | 1,962
group 4 medulloblastoma 114 | 1,855
Pick disease 113 | 1,894
Autosomal recessive predisposition 106 | 1,442
dermatomyositis 105 | 966
Rheumatoid arthritis 102 | 1,191
pituitary cancer 100 | 1,972
breast carcinoma 96 | 1,638
ulcerative colitis 96 | 1,819
Multiple myeloma 95 | 1,332
ductal carcinoma in situ 94 | 1,745
colon cancer 92 | 1,478
cystic fibrosis 89 | 1,696
astrocytoma 88 | 1,146
adrenocortical carcinoma 83 | 1,428
Intellectual disability 81 | 1,016
juvenile dermatomyositis 78 | 1,187
acute quadriplegic myopathy 76 | 1,158
pediatric high grade glioma 75 | 1,064
Ankylosing spondylitis 74 | 140
Arthritis 74 | 290
Behcet's disease 70 | 89
Schizophrenia 70 | 1,160
spina bifida 68 | 1,074
Hypersensitivity reaction type II disease 67 | 253
Alzheimer's disease 66 | 658
Acquired immunodeficiency syndrome 63 | 197
Epilepsy 63 | 792
Dull intelligence 62 | 645
Low intelligence 62 | 645
Mental Retardation 62 | 645
Mental deficiency 62 | 645
Poor school performance 62 | 645
Uveitis 62 | 103
active Crohn's disease 62 | 922
cutaneous lupus erythematosus 62 | 1,057
non primary Sjogren syndrome sicca 60 | 891
primary pancreatic ductal adenocarcinoma 60 | 1,109
Juvenile rheumatoid arthritis 59 | 111
gastric carcinoma 58 | 807
active ulcerative colitis 57 | 764
Herpes zoster 56 | 68
Human immunodeficiency virus infectious disease 56 | 138
Seizures 56 | 596
Stevens-Johnson syndrome 52 | 92
Kidney disease 51 | 430
Multiple Sclerosis 51 | 540
esophageal adenocarcinoma 51 | 737
Liver Cirrhosis, Experimental 49 | 769
Psoriatic arthritis 49 | 86
Short stature 49 | 531
Cognitive delay 48 | 608
Global developmental delay 48 | 608
Mental and motor retardation 48 | 608
nasopharyngeal carcinoma 48 | 1,058
Down syndrome 45 | 499
Neurodegenerative disease 44 | 414
pancreatic carcinoma 44 | 562
Bipolar Disorder 43 | 666
Dermatitis 43 | 157
Liver cancer 43 | 604
Muscle hypotonia 43 | 571
Duchenne muscular dystrophy 42 | 601
Melanoma 42 | 711
progressive supranuclear palsy 42 | 676
Obesity 41 | 678
Synovitis 38 | 78
aldosterone-producing adenoma 37 | 665
primary Sjogren syndrome 37 | 735

Tissue

Endocrine System 820 | 18,159
Digestive Tract 804 | 17,369
Nervous System 804 | 16,725
Female tissues 803 | 17,400
Male tissues 803 | 17,142
Skin and soft tissues 803 | 17,230
Urinary Tract 799 | 16,678
Liver and Pancreas 798 | 16,750
Blood and immune system 797 | 16,909
Respiratory system 782 | 16,393
Cardiovascular System 758 | 15,192

Target Family

Non-IDG 526 | 12,091
Enzyme 233 | 4,145
Kinase 42 | 634
Transporter 41 | 473
Transcription Factor 23 | 1,400
Ion Channel 16 | 344
GPCR 12 | 408
Epigenetic 9 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GO Component

Golgi apparatus 904 | 904
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
UPF0577 protein KIAA1324 KIAA1324 Tbio Non-IDG -1.30268 19.8 137
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0