Development Level

Tbio 622 | 10,625
Tchem 107 | 1,890
Tdark 104 | 7,003
Tclin 31 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 3 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 48 | 633
preweaning lethality, incomple... 17 | 260
decreased total body fat amoun... 15 | 186
decreased body weight 13 | 174
decreased lean body mass 13 | 195
embryonic lethality prior to t... 13 | 187
abnormal behavior 10 | 226
abnormal bone structure 9 | 131
abnormal embryo size 9 | 112
decreased bone mineral content 9 | 157
increased bone mineral content 9 | 92
increased mean corpuscular hem... 8 | 93
decreased circulating serum al... 7 | 79
decreased grip strength 7 | 123
hyperactivity 7 | 108
increased circulating alkaline... 7 | 119
increased lean body mass 7 | 107
increased mean corpuscular vol... 7 | 91
abnormal limb bud morphology 6 | 15
decreased body length 6 | 108
decreased circulating triglyce... 6 | 83
abnormal lens morphology 5 | 73
abnormal neural tube closure 5 | 37
decreased bone mineral density 5 | 126
decreased circulating insulin ... 5 | 75
embryonic lethality prior to o... 5 | 148
hemorrhage 5 | 12
hypoactivity 5 | 89
impaired glucose tolerance 5 | 52
increased blood urea nitrogen ... 5 | 44
increased fasted circulating g... 5 | 68
increased or absent threshold ... 5 | 128
abnormal gait 4 | 51
abnormal head morphology 4 | 10
abnormal limb morphology 4 | 7
abnormal retina morphology 4 | 100
abnormal tail morphology 4 | 17
abnormal testis morphology 4 | 30
decreased circulating LDL chol... 4 | 37
decreased circulating choleste... 4 | 85
decreased circulating glucose ... 4 | 121
decreased lumbar vertebrae num... 4 | 62
increased circulating HDL chol... 4 | 63
male infertility 4 | 62
short tibia 4 | 82
straub tail 4 | 26
abnormal bone mineralization 3 | 55
abnormal cranium morphology 3 | 32
abnormal facial morphology 3 | 9
decreased circulating HDL chol... 3 | 77
decreased circulating alanine ... 3 | 53
decreased circulating fructosa... 3 | 31
decreased eosinophil cell numb... 3 | 41
decreased erythrocyte cell num... 3 | 43
decreased leukocyte cell numbe... 3 | 54
decreased prepulse inhibition 3 | 52
decreased rib number 3 | 59
edema 3 | 11
female infertility 3 | 34
improved glucose tolerance 3 | 56
increased bone mineral density 3 | 52
increased circulating calcium ... 3 | 32
increased circulating serum al... 3 | 25
increased circulating sodium l... 3 | 71
increased erythrocyte cell num... 3 | 26
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 25
increased sacral vertebrae num... 3 | 62
limb grasping 3 | 35
persistence of hyaloid vascula... 3 | 22
small testis 3 | 37
thrombocytosis 3 | 23
abnormal body wall morphology 2 | 7
abnormal coat/hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal epididymis morphology 2 | 31
abnormal kidney morphology 2 | 30
abnormal locomotor activation 2 | 26
abnormal retinal pigmentation 2 | 61
abnormal rib morphology 2 | 28
anophthalmia 2 | 20
cardiovascular system phenotyp... 2 | 35
decreased blood urea nitrogen ... 2 | 31
decreased circulating calcium ... 2 | 33
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
decreased startle reflex 2 | 48
decreased total retina thickne... 2 | 20
dilated heart left ventricle 2 | 10
embryonic growth retardation 2 | 28
impaired righting response 2 | 19
increased body weight 2 | 42
increased circulating bilirubi... 2 | 16
increased circulating choleste... 2 | 53
increased mean platelet volume 2 | 19
increased total body fat amoun... 2 | 57
prenatal lethality prior to he... 2 | 64

Disease

ovarian cancer 486 | 8,484
osteosarcoma 402 | 7,933
psoriasis 349 | 6,685
medulloblastoma, large-cell 317 | 6,234
glioblastoma 311 | 5,572
lung cancer 238 | 4,466
atypical teratoid / rhabdoid tumor 229 | 4,369
Cancer 194 | 2,346
malignant mesothelioma 193 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 186 | 3,289
pilocytic astrocytoma 181 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 180 | 2,956
invasive ductal carcinoma 178 | 2,950
Breast cancer 172 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 164 | 2,988
oligodendroglioma 160 | 2,849
pediatric high grade glioma 154 | 2,712
lung adenocarcinoma 152 | 2,713
diabetes mellitus 148 | 1,663
non-small cell lung cancer 148 | 2,798
lung carcinoma 146 | 2,844
ependymoma 145 | 2,514
primitive neuroectodermal tumor 138 | 3,031
pancreatic cancer 134 | 2,300
subependymal giant cell astrocytoma 128 | 2,287
astrocytoma 121 | 1,493
ulcerative colitis 112 | 2,087
interstitial cystitis 111 | 2,299
group 4 medulloblastoma 109 | 1,875
Carcinoma 108 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 108 | 1,795
Pick disease 107 | 1,893
astrocytic glioma 103 | 2,241
ductal carcinoma in situ 102 | 1,745
adult high grade glioma 101 | 2,148
pituitary cancer 101 | 1,972
Multiple myeloma 98 | 1,327
breast carcinoma 97 | 1,614
Rheumatoid Arthritis 94 | 1,160
colon cancer 93 | 1,475
tuberculosis 90 | 1,557
cystic fibrosis 85 | 1,665
group 3 medulloblastoma 83 | 2,254
adrenocortical carcinoma 82 | 1,427
posterior fossa group B ependymoma 82 | 1,530
juvenile dermatomyositis 81 | 1,189
medulloblastoma 78 | 1,524
Ankylosing spondylitis 73 | 138
posterior fossa group A ependymoma 71 | 1,511
primary pancreatic ductal adenocarcinoma 70 | 1,271
Arthritis 69 | 248
acute quadriplegic myopathy 69 | 1,157
Hypersensitivity reaction type II disease 67 | 235
dermatomyositis 67 | 933
cutaneous lupus erythematosus 63 | 1,056
spina bifida 63 | 1,064
Acquired immunodeficiency syndrome 62 | 164
sonic hedgehog group medulloblastoma 62 | 1,482
Uveitis 61 | 103
Alzheimer's disease 60 | 644
active Crohn's disease 60 | 918
Juvenile rheumatoid arthritis 58 | 104
Behcet's disease 57 | 74
non primary Sjogren syndrome sicca 51 | 840
gastric carcinoma 50 | 832
Psoriatic arthritis 49 | 83
esophageal adenocarcinoma 49 | 737
nasopharyngeal carcinoma 49 | 1,056
Kidney disease 48 | 396
atypical teratoid/rhabdoid tumor 45 | 1,095
Multiple Sclerosis 44 | 498
tuberculosis and treatment for 6 months 44 | 686
Down syndrome 43 | 548
Duchenne muscular dystrophy 43 | 602
pancreatic carcinoma 43 | 567
Intellectual disability 42 | 573
Neurodegenerative disease 42 | 383
primary Sjogren syndrome 42 | 789
progressive supranuclear palsy 41 | 674
Stevens-Johnson syndrome 40 | 78
Waldenstrons macroglobulinemia 39 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 39 | 499
aldosterone-producing adenoma 38 | 664
Atopic dermatitis 37 | 944
Liver disease 37 | 219
active ulcerative colitis 37 | 477
Congenital adrenal hyperplasia 36 | 74
IGA Glomerulonephritis 36 | 454
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
acute myeloid leukemia 34 | 780
fibroadenoma 33 | 557
Schizophrenia 32 | 501
gastric cancer 31 | 430
hepatocellular carcinoma 29 | 532
Amyotrophic Lateral Sclerosis 28 | 431
Parkinson's disease 28 | 364
Prostatic Neoplasms 28 | 471
hereditary spastic paraplegia 28 | 313
mucosa-associated lymphoid tissue lymphoma 28 | 480

Tissue

Liver and Pancreas 794 | 18,136
Nervous System 794 | 18,561
Digestive Tract 793 | 18,473
Endocrine System 792 | 18,512
Female tissues 792 | 18,647
Male tissues 792 | 17,969
Urinary Tract 790 | 18,444
Blood and immune system 789 | 17,995
Cardiovascular System 788 | 17,958
Respiratory system 781 | 17,484
Skin and soft tissues 776 | 18,115

Target Family

Non-IDG 513 | 11,971
Enzyme 212 | 4,146
Kinase 40 | 634
Transporter 37 | 473
Transcription Factor 26 | 1,400
Ion Channel 13 | 341
GPCR 11 | 406
Epigenetic 9 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

GO Component

Golgi apparatus 864 | 864
nucleus 5,107 | 5,107
cytoplasm 4,985 | 4,985
plasma membrane 4,118 | 4,118
integral component of membrane 3,679 | 3,679
cytosol 3,265 | 3,265
extracellular exosome 2,758 | 2,758
nucleoplasm 2,717 | 2,717
membrane 1,906 | 1,906
extracellular region 1,493 | 1,493
integral component of plasma m... 1,406 | 1,406
extracellular space 1,304 | 1,304
mitochondrion 1,231 | 1,231
endoplasmic reticulum 859 | 859
endoplasmic reticulum membrane 848 | 848
nucleolus 815 | 815
Golgi membrane 659 | 659
perinuclear region of cytoplas... 611 | 611
cell surface 594 | 594
intracellular 548 | 548
intracellular membrane-bounded... 537 | 537
cell junction 451 | 451
mitochondrial inner membrane 425 | 425
centrosome 409 | 409
focal adhesion 383 | 383
protein complex 355 | 355
cytoskeleton 343 | 343
dendrite 329 | 329
mitochondrial matrix 322 | 322
cell-cell adherens junction 307 | 307
neuronal cell body 303 | 303
microtubule 294 | 294
lysosomal membrane 278 | 278
apical plasma membrane 277 | 277
proteinaceous extracellular ma... 244 | 244
neuron projection 229 | 229
nuclear membrane 218 | 218
early endosome 217 | 217
axon 214 | 214
lysosome 210 | 210
endosome 208 | 208
actin cytoskeleton 205 | 205
external side of plasma membra... 205 | 205
postsynaptic membrane 204 | 204
extracellular matrix 198 | 198
nuclear speck 197 | 197
membrane raft 196 | 196
endoplasmic reticulum lumen 192 | 192
transcription factor complex 184 | 184
endosome membrane 182 | 182
early endosome membrane 180 | 180
basolateral plasma membrane 174 | 174
nuclear chromatin 169 | 169
synapse 166 | 166
cell-cell junction 161 | 161
nuclear envelope 156 | 156
lamellipodium 153 | 153
mitochondrial outer membrane 148 | 148
blood microparticle 147 | 147
myelin sheath 144 | 144
postsynaptic density 144 | 144
cytoplasmic vesicle 143 | 143
microtubule organizing center 137 | 137
cytoplasmic, membrane-bounded ... 132 | 132
ER to Golgi transport vesicle ... 131 | 131
microtubule cytoskeleton 127 | 127
receptor complex 127 | 127
phagocytic vesicle membrane 126 | 126
cytoplasmic vesicle membrane 125 | 125
midbody 125 | 125
trans-Golgi network 124 | 124
cell cortex 119 | 119
cilium 118 | 118
late endosome 116 | 116
spindle 116 | 116
intracellular ribonucleoprotei... 114 | 114
vesicle 112 | 112
Z disc 110 | 110
bicellular tight junction 110 | 110
anchored component of membrane 109 | 109
growth cone 109 | 109
integral component of lumenal ... 108 | 108
late endosome membrane 107 | 107
endomembrane system 106 | 106
centriole 105 | 105
recycling endosome 104 | 104
spindle pole 104 | 104
perikaryon 103 | 103
integral component of endoplas... 101 | 101
intermediate filament 101 | 101
melanosome 101 | 101
chromosome 100 | 100
dendritic spine 99 | 99
ubiquitin ligase complex 99 | 99
peroxisome 98 | 98
nuclear matrix 97 | 97
PML body 94 | 94
Golgi lumen 93 | 93
keratin filament 93 | 93
trans-Golgi network membrane 92 | 92

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Monocarboxylate transporter 13 SLC16A13 Tdark Transporter -0.40437 1.87 71
HLA class I histocompatibility antigen, Cw-5 alpha chain HLA-C Tbio Non-IDG 777.4 0
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Interleukin-15 IL15 Tbio Non-IDG -3.01964 1248.2 612
Dymeclin DYM Tbio Non-IDG -1.45800 31.6 59
HLA class I histocompatibility antigen, B-27 alpha chain HLA-B Tbio Non-IDG 1568.8 0