Development Level

Tbio 10 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 2 | 239
abnormal behavior 1 | 298
abnormal posture 1 | 2
decreased circulating sodium l... 1 | 22
embryonic lethality prior to t... 1 | 278
increased circulating free fat... 1 | 20

Disease

ovarian cancer 7 | 8,520
lung cancer 5 | 4,740
Carcinoma 4 | 11,493
Multiple myeloma 4 | 1,332
Hereditary spherocytosis type 5 3 | 12
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
primitive neuroectodermal tumor 3 | 3,035
psoriasis 3 | 6,694
Cleft Palate 2 | 271
Congenital small ears 2 | 48
Decreased projection of maxilla 2 | 66
Deficiency of upper jaw bones 2 | 66
Downward slant of palpebral fissure 2 | 158
Hypoplasia of the maxilla 2 | 66
Hypoplastic mandible condyle 2 | 275
Hypotrophic maxilla 2 | 66
Kidney cancer 2 | 2,613
Mandibular hypoplasia 2 | 275
Maxillary retrognathia 2 | 66
Micrognathism 2 | 275
Retrusion of upper jaw bones 2 | 66
Treacher Collins syndrome 2 | 27
Uranostaphyloschisis 2 | 167
atypical teratoid / rhabdoid tumor 2 | 5,112
breast carcinoma 2 | 1,638
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
pediatric high grade glioma 2 | 1,064
Abnormal skeletal development 1 | 60
Abnormality of bone mineral density 1 | 5
Absent eyelashes 1 | 16
Acrocephalosyndactylia 1 | 17
Acrofacial dysostosis 1 | 8
Agenesis of teeth 1 | 21
Aplasia of eyelashes 1 | 16
Broad flat nasal bridge 1 | 236
CNS hypomyelination 1 | 17
Choanal Atresia 1 | 42
Ciliary Dyskinesia, Primary, 1 1 | 27
Coloboma of eyelid 1 | 15
Conductive hearing loss 1 | 123
Convex nasal bridge 1 | 57
Decreased projection of midface 1 | 105
Depressed cheekbone 1 | 22
Failure of development of eyelashes 1 | 16
Flattening of the zygomatic bone 1 | 22
Frontal bossing 1 | 157
Hypodontia 1 | 81
Hypomyelination 1 | 17
Hypomyelination-hypogonadotropic-hypogonadism-hypodontia syndrome 1 | 3
Hypoplasia of corpus callosum 1 | 90
Hypoplasia of the zygomatic bone 1 | 22
Hypotrophic cheekbone 1 | 22
Hypotrophic malar bone 1 | 129
Hypotrophic midface 1 | 105
Kidney hypertrophy 1 | 4
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Leukodystrophy 1 | 55
Leukodystrophy, Hypomyelinating, with Hypodontia and Hypogonadotropic Hypogonadism 1 | 3
Low Vision 1 | 174
Macrotia 1 | 87
Malar flattening 1 | 129
Malformed pinnae 1 | 37
Midface retrusion 1 | 105
Narrow internal auditory canal 1 | 8
Nasal bridge wide 1 | 236
Neoplasms, Experimental 1 | 40
Open Bite 1 | 21
Osteochondrodysplasias 1 | 72
Primary hypogonadism 1 | 37
Prominent nasal bridge 1 | 57
Reduced number of teeth 1 | 21
Retinitis pigmentosa 12 1 | 9
Retrognathia 1 | 54
Short palpebral fissure 1 | 38
Small cheekbone 1 | 22
Small midface 1 | 105
Stomach Neoplasms 1 | 300
Strabismus 1 | 270
Tremor 1 | 113
Visual Impairment 1 | 174
acute quadriplegic myopathy 1 | 1,158
astrocytoma 1 | 1,146
atypical teratoid/rhabdoid tumor 1 | 357
colon cancer 1 | 1,478
hepatocellular carcinoma 1 | 547
nasopharyngeal carcinoma 1 | 1,058
pancreatic carcinoma 1 | 562
posterior fossa group A ependymoma 1 | 468

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Enzyme 12 | 4,145

GO Component

DNA-directed RNA polymerase I ... 12 | 12
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

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