Development Level

Tdark 36 | 6,593
Tbio 30 | 11,651
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
decreased circulating chloride... 2 | 30
decreased circulating creatini... 2 | 39
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
increased circulating chloride... 2 | 41
increased lean body mass 2 | 172
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal radius morphology 1 | 8
abnormal response to tactile s... 1 | 17
abnormal sleep behavior 1 | 70
abnormal vertebral arch morpho... 1 | 9
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased respiratory quotient 1 | 16
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart rate 1 | 23
increased heart weight 1 | 62
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small adrenal glands 1 | 16
small thymus 1 | 16

Disease

Carcinoma 47 | 11,493
ovarian cancer 33 | 8,520
medulloblastoma, large-cell 32 | 6,241
osteosarcoma 29 | 7,950
glioblastoma 26 | 5,792
atypical teratoid / rhabdoid tumor 23 | 5,112
ependymoma 19 | 4,679
oligodendroglioma 17 | 2,850
psoriasis 17 | 6,694
group 4 medulloblastoma 16 | 1,855
Astrocytoma, Pilocytic 15 | 3,081
adult high grade glioma 14 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
primitive neuroectodermal tumor 13 | 3,035
Breast cancer 12 | 3,578
group 3 medulloblastoma 12 | 4,104
invasive ductal carcinoma 12 | 2,951
malignant mesothelioma 12 | 3,232
lung cancer 11 | 4,740
astrocytic glioma 10 | 2,597
lung carcinoma 9 | 2,843
pancreatic cancer 9 | 2,398
subependymal giant cell astrocytoma 9 | 2,287
Kidney cancer 8 | 2,613
interstitial cystitis 8 | 2,312
pituitary cancer 8 | 1,972
tuberculosis 8 | 2,010
aldosterone-producing adenoma 7 | 665
ductal carcinoma in situ 7 | 1,745
ulcerative colitis 7 | 1,819
adrenocortical carcinoma 6 | 1,428
breast carcinoma 6 | 1,638
gastric carcinoma 6 | 807
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
pediatric high grade glioma 6 | 1,064
spina bifida 6 | 1,074
Multiple myeloma 5 | 1,332
diabetes mellitus 5 | 1,728
hepatocellular carcinoma 5 | 547
non-small cell lung cancer 5 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primary pancreatic ductal adenocarcinoma 5 | 1,109
sonic hedgehog group medulloblastoma 5 | 467
Acquired metabolic disease 4 | 336
Nemaline myopathy 4 | 17
Pick disease 4 | 1,894
Pseudohypoaldosteronism 4 | 23
gastric cancer 4 | 459
pancreatic carcinoma 4 | 562
primary Sjogren syndrome 4 | 735
sarcoidosis 4 | 370
tuberculosis and treatment for 6 months 4 | 409
Autosomal recessive predisposition 3 | 1,442
Cancer 3 | 2,499
Congenital myopathy 3 | 16
Multiple Sclerosis 3 | 540
Parkinson's disease 3 | 392
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
juvenile dermatomyositis 3 | 1,187
lung adenocarcinoma 3 | 2,716
nasopharyngeal carcinoma 3 | 1,058
Alzheimer's disease 2 | 658
Atopic dermatitis 2 | 952
Cardiovascular system disease 2 | 246
Centronuclear myopathy 2 | 27
Dystonia 2 | 164
Gaucher disease type 1 2 | 180
Hyperchloremia 2 | 2
Hyperchloremic metabolic acidosis 2 | 5
Hyperkalemia 2 | 17
Hypertension 2 | 396
Hypertensive disease 2 | 292
Increase in blood pressure 2 | 119
Intellectual disability 2 | 1,016
Kidney disease 2 | 430
Lipid metabolism disorder 2 | 114
Malaria 2 | 160
Mental Depression 2 | 333
Metabolic acidosis 2 | 90
Nemaline Myopathy, Childhood Onset 2 | 6
Orofacial cleft 2 | 54
Prostatic Neoplasms 2 | 495
Pseudohypoaldosteronism, type 2 2 | 4
Retinitis pigmentosa 11 2 | 59
Retinitis pigmentosa 42 2 | 9
Rheumatoid arthritis 2 | 1,191
Type 2 diabetes mellitus 2 | 272
active ulcerative colitis 2 | 764
chronic rhinosinusitis 2 | 512
cold-induced sweating syndrome 2 | 7
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
posterior fossa group A ependymoma 2 | 468
type II diabetes mellitus and post-ischemic heart failure 2 | 88
DOID:9917 1 | 31
Relapsing remitting multiple sclerosis 1 | 14

Tissue

Endocrine System 67 | 18,159
Nervous System 66 | 16,725
Skin and soft tissues 66 | 17,230
Male tissues 65 | 17,142
Digestive Tract 64 | 17,369
Blood and immune system 63 | 16,909
Female tissues 63 | 17,400
Liver and Pancreas 62 | 16,750
Respiratory system 62 | 16,393
Urinary Tract 62 | 16,678
Cardiovascular System 60 | 15,192

Target Family

Non-IDG 64 | 12,091
Transcription Factor 2 | 1,400
Enzyme 1 | 4,145

GO Component

Cul3-RING ubiquitin ligase com... 67 | 67
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
BTB/POZ domain-containing protein 18 BTBD18 Tdark Non-IDG -0.42597 2.79 11
Kelch-like protein 28 KLHL28 Tdark Non-IDG 0.00000 116
Kelch repeat and BTB domain-containing protein 7 KBTBD7 Tdark Non-IDG 0.14 0.94 89
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 TNFAIP1 Tbio Non-IDG -1.31215 21.6 197
Kelch-like protein 10 KLHL10 Tdark Non-IDG -0.66547 4.52 40
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 KCTD13 Tbio Non-IDG -0.89298 8.48 87
Kelch-like protein 26 KLHL26 Tdark Non-IDG 0.60 0.08 83
Kelch-like protein 18 KLHL18 Tdark Non-IDG 0.19 0.56 37
Kelch-like protein 33 KLHL33 Tdark Non-IDG 1.08 0.08 22
Kelch-like protein 12 KLHL12 Tbio Non-IDG -0.99873 10.5 240