Development Level

Tbio 4 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
decreased bone mineral content 1 | 151
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 6 | 8,520
Cancer 5 | 2,499
glioblastoma 5 | 5,792
Autoimmune lymphoproliferative syndrome 4 | 11
lung cancer 4 | 4,740
lung carcinoma 4 | 2,843
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Breast cancer 3 | 3,578
Carcinoma 3 | 11,493
Splenomegaly 3 | 190
atypical teratoid / rhabdoid tumor 3 | 5,112
cutaneous lupus erythematosus 3 | 1,057
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
Anti-nuclear factor positive 2 | 18
Antiphospholipid antibody positivity 2 | 4
Astrocytoma, Pilocytic 2 | 3,081
Autoimmune hemolytic anemia 2 | 31
Autoimmune neutropenia 2 | 5
Autoimmune thrombocytopenia 2 | 22
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Chronic noninfectious lymphadenopathy 2 | 6
Coombs positive hemolytic anemia 2 | 4
Defective lymphocyte apoptosis 2 | 4
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Elevated serum IgA 2 | 5
Eosinophilia 2 | 28
Follicular hyperplasia 2 | 4
Hepatomegaly 2 | 285
Idiopathic thrombocytopenia 2 | 22
Immune thrombocytopenic purpura 2 | 24
Increased IgM levels 2 | 16
Increased levels of IgG 2 | 4
Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors 2 | 3
Increased number of peripheral CD3+ T cells 2 | 3
Increased proportion of HLA DR+ and CD57+ T cells 2 | 3
Iron deficiency anemia 2 | 12
Lung Neoplasms 2 | 232
Melanoma 2 | 711
Nephritis 2 | 51
Neutrophil antibody positive 2 | 3
Platelet antibody positive 2 | 4
Reduced delayed hypersensitivity 2 | 4
Rheumatoid factor positive (finding) 2 | 3
Sensorineural Hearing Loss (disorder) 2 | 284
Short stature 2 | 531
Skin Neoplasms 2 | 69
Smooth muscle antibodies positive 2 | 3
Somatic mutation 2 | 61
Stomach Neoplasms 2 | 300
Urticaria 2 | 67
Vasculitis 2 | 80
colon cancer 2 | 1,478
ependymoma 2 | 4,679
group 3 medulloblastoma 2 | 4,104
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
subependymal giant cell astrocytoma 2 | 2,287
Acne 1 | 52
Acute Lung Injury 1 | 22
Amyotrophic lateral sclerosis type 8 1 | 10
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Aphthous stomatitis 1 | 16
Apraxias 1 | 27
Autoimmune lymphoproliferative syndrome type 2B 1 | 9
Behcet Syndrome 1 | 21
Behcet's syndrome 1 | 50
Carcinoma, squamous cell of head and neck 1 | 31
Decreased T cell activation 1 | 4
Diffuse large B-cell lymphoma 1 | 39
Edema 1 | 81
Gastric Cancer, Hereditary Diffuse 1 | 12
Gastrointestinal Hemorrhage 1 | 52
Hemiparesis 1 | 34
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Iridocyclitis 1 | 19
Joint swelling 1 | 26
Lymphoma, Extranodal NK-T-Cell 1 | 2
Lymphoma, Large B-Cell, Diffuse 1 | 34
Malaria, Falciparum 1 | 3
Malocclusion 1 | 57
Micronodular cirrhosis 1 | 12
Myasthenia gravis 1 | 23
Myocardial Reperfusion Injury 1 | 37
Neoplasm of stomach 1 | 11
Papule 1 | 43
Premature canities 1 | 24
Sparse scalp hair 1 | 42
Stomach Carcinoma 1 | 11
Stomach cancer 1 | 30
Subacute progressive viral hepatitis 1 | 9
esophageal cancer 1 | 22

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Non-IDG 4 | 12,091
Enzyme 2 | 4,145

GO Component

CD95 death-inducing signaling ... 6 | 6
nucleus 5,097 | 5,097
cytosol 4,834 | 4,834
plasma membrane 4,414 | 4,414
cytoplasm 4,094 | 4,094
integral component of membrane 3,665 | 3,665
nucleoplasm 2,996 | 2,996
extracellular exosome 2,767 | 2,767
membrane 1,917 | 1,917
extracellular region 1,833 | 1,833
integral component of plasma m... 1,418 | 1,418
extracellular space 1,380 | 1,380
mitochondrion 1,281 | 1,281
endoplasmic reticulum 938 | 938
Golgi apparatus 904 | 904
endoplasmic reticulum membrane 879 | 879
nucleolus 824 | 824
Golgi membrane 676 | 676
perinuclear region of cytoplas... 644 | 644
cell surface 608 | 608
intracellular membrane-bounded... 593 | 593
intracellular 566 | 566
protein complex 552 | 552
cell junction 502 | 502
mitochondrial inner membrane 432 | 432
centrosome 427 | 427
focal adhesion 387 | 387
nuclear speck 371 | 371
mitochondrial matrix 354 | 354
cytoskeleton 352 | 352
dendrite 330 | 330
neuronal cell body 325 | 325
lysosomal membrane 301 | 301
microtubule 298 | 298
apical plasma membrane 292 | 292
endoplasmic reticulum lumen 291 | 291
extracellular matrix 267 | 267
proteinaceous extracellular ma... 267 | 267
nuclear body 266 | 266
axon 250 | 250
external side of plasma membra... 247 | 247
endosome 239 | 239
nuclear membrane 239 | 239
neuron projection 235 | 235
early endosome 234 | 234
lysosome 222 | 222
cytoplasmic vesicle 217 | 217
membrane raft 215 | 215
postsynaptic membrane 210 | 210
early endosome membrane 203 | 203
postsynaptic density 202 | 202
endosome membrane 197 | 197
actin cytoskeleton 196 | 196
basolateral plasma membrane 184 | 184
nuclear chromatin 184 | 184
blood microparticle 175 | 175
synapse 172 | 172
transcription factor complex 172 | 172
cilium 171 | 171
lamellipodium 168 | 168
mitochondrial outer membrane 163 | 163
nuclear envelope 160 | 160
microtubule organizing center 153 | 153
cell-cell junction 149 | 149
myelin sheath 144 | 144
midbody 141 | 141
phagocytic vesicle membrane 138 | 138
recycling endosome membrane 138 | 138
microtubule cytoskeleton 134 | 134
vesicle 134 | 134
cytoplasmic vesicle membrane 133 | 133
ER to Golgi transport vesicle ... 132 | 132
receptor complex 132 | 132
trans-Golgi network 131 | 131
fibrillar center 128 | 128
centriole 124 | 124
ficolin-1-rich granule lumen 124 | 124
late endosome membrane 122 | 122
intracellular ribonucleoprotei... 121 | 121
Z disc 119 | 119
bicellular tight junction 119 | 119
late endosome 119 | 119
cell cortex 118 | 118
dendritic spine 118 | 118
growth cone 116 | 116
secretory granule lumen 116 | 116
spindle 116 | 116
spindle pole 115 | 115
chromosome 114 | 114
perikaryon 114 | 114
recycling endosome 109 | 109
anchored component of membrane 108 | 108
endomembrane system 108 | 108
integral component of lumenal ... 108 | 108
ciliary basal body 105 | 105
nuclear matrix 105 | 105
integral component of endoplas... 103 | 103
secretory granule membrane 103 | 103
Golgi lumen 101 | 101
melanosome 101 | 101
ubiquitin ligase complex 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
FAS-associated factor 1 FAF1 Tbio Non-IDG -1.71858 56.5 209
Caspase-8 CASP8 Tchem Enzyme -3.54224 3121.4 1045
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.32299 2090.2 2060
CASP8 and FADD-like apoptosis regulator CFLAR Tbio Non-IDG -2.89793 871.7 683
Caspase-10 CASP10 Tchem Enzyme -1.97653 89.1 457
FAS-associated death domain protein FADD Tbio Non-IDG -2.70083 469.8 708