Development Level

Tbio 10,957 | 11,445
Tdark 4,891 | 6,588
Tchem 1,552 | 1,598
Tclin 589 | 613

Collection

RFA-RM-18-021 291 | 328
Kinase: IDG Consortium (Target... 119 | 125
Ion Channel: IDG Consortium (T... 94 | 99
GPCR: IDG Consortium (Targets) 86 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 963 | 979
preweaning lethality, incomple... 482 | 499
abnormal behavior 285 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 215 | 220
decreased total body fat amoun... 200 | 207
decreased vertical activity 197 | 208
enlarged heart 197 | 210
abnormal bone structure 184 | 187
increased lean body mass 168 | 172
decreased body weight 159 | 161
abnormal heart morphology 152 | 162
decreased bone mineral content 146 | 151
hyperactivity 142 | 148
decreased lean body mass 134 | 135
increased total body fat amoun... 132 | 134
hypoactivity 124 | 132
decreased bone mineral density 123 | 126
male infertility 119 | 123
decreased circulating glucose ... 118 | 126
increased circulating alkaline... 117 | 122
decreased grip strength 111 | 116
increased startle reflex 111 | 112
abnormal seminal vesicle morph... 109 | 114
embryonic growth retardation 104 | 106
increased bone mineral content 104 | 108
decreased body length 100 | 101
increased or absent threshold ... 98 | 101
short tibia 95 | 97
decreased circulating choleste... 91 | 93
increased mean corpuscular hem... 91 | 96
cataract 89 | 92
increased mean corpuscular vol... 88 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 81 | 83
abnormal lens morphology 80 | 81
decreased circulating triglyce... 79 | 79
decreased prepulse inhibition 79 | 82
increased circulating HDL chol... 78 | 80
decreased circulating serum al... 77 | 82
decreased mean corpuscular vol... 77 | 79
decreased circulating insulin ... 74 | 76
improved glucose tolerance 74 | 79
impaired glucose tolerance 73 | 75
small superior vagus ganglion 73 | 74
decreased startle reflex 72 | 75
increased bone mineral density 72 | 72
increased fasted circulating g... 72 | 76
decreased leukocyte cell numbe... 71 | 73
abnormal retina morphology 70 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 67 | 68
decreased circulating HDL chol... 67 | 68
increased circulating sodium l... 67 | 71
abnormal behavioral response t... 66 | 66
abnormal kidney morphology 65 | 65
decreased hemoglobin content 65 | 68
abnormal gait 64 | 69
increased circulating choleste... 64 | 66
decreased fasted circulating g... 63 | 65
abnormal coat-hair pigmentatio... 61 | 64
decreased erythrocyte cell num... 60 | 62
increased monocyte cell number 60 | 63
increased heart weight 58 | 62
small testis 57 | 58
edema 56 | 59
thrombocytopenia 56 | 56
female infertility 55 | 60
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
abnormal skin morphology 48 | 50
decreased blood urea nitrogen ... 48 | 51
decreased circulating alanine ... 47 | 47
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 47 | 50
increased blood urea nitrogen ... 46 | 48
increased leukocyte cell numbe... 46 | 47
decreased circulating alkaline... 45 | 46
increased neutrophil cell numb... 45 | 46
abnormal neural tube closure 44 | 46
decreased hematocrit 44 | 46
increased hematocrit 44 | 46
increased mean platelet volume 44 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 40 | 42
decreased red blood cell distr... 40 | 41
enlarged spleen 40 | 41
increased circulating chloride... 39 | 41
increased circulating triglyce... 39 | 42
increased grip strength 39 | 41
increased hemoglobin content 39 | 45
limb grasping 39 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
decreased circulating LDL chol... 37 | 38
decreased circulating creatini... 37 | 39
increased erythrocyte cell num... 37 | 39

Disease

Carcinoma 10,798 | 11,493
ovarian cancer 8,324 | 8,520
osteosarcoma 7,721 | 7,950
psoriasis 6,320 | 6,694
medulloblastoma, large-cell 6,066 | 6,241
glioblastoma 5,668 | 5,792
atypical teratoid / rhabdoid tumor 4,988 | 5,112
lung cancer 4,648 | 4,740
ependymoma 4,565 | 4,679
group 3 medulloblastoma 4,011 | 4,104
adult high grade glioma 3,689 | 3,801
Breast cancer 3,511 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,236 | 3,291
malignant mesothelioma 3,189 | 3,232
Astrocytoma, Pilocytic 3,002 | 3,081
primitive neuroectodermal tumor 2,975 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,937 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,902 | 2,955
invasive ductal carcinoma 2,891 | 2,951
non-small cell lung cancer 2,835 | 2,890
oligodendroglioma 2,791 | 2,850
lung carcinoma 2,759 | 2,843
lung adenocarcinoma 2,635 | 2,716
astrocytic glioma 2,540 | 2,597
Kidney cancer 2,534 | 2,613
Cancer 2,414 | 2,499
pancreatic cancer 2,342 | 2,398
subependymal giant cell astrocytoma 2,237 | 2,287
interstitial cystitis 2,232 | 2,312
tuberculosis 1,967 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,942 | 1,962
pituitary cancer 1,914 | 1,972
Pick disease 1,868 | 1,894
group 4 medulloblastoma 1,815 | 1,855
ulcerative colitis 1,772 | 1,819
ductal carcinoma in situ 1,715 | 1,745
cystic fibrosis 1,661 | 1,696
breast carcinoma 1,605 | 1,638
diabetes mellitus 1,565 | 1,728
colon cancer 1,451 | 1,478
adrenocortical carcinoma 1,405 | 1,428
Autosomal recessive predisposition 1,400 | 1,442
Multiple myeloma 1,320 | 1,332
juvenile dermatomyositis 1,172 | 1,187
Rheumatoid arthritis 1,159 | 1,191
acute quadriplegic myopathy 1,146 | 1,158
astrocytoma 1,136 | 1,146
Schizophrenia 1,121 | 1,160
primary pancreatic ductal adenocarcinoma 1,085 | 1,109
spina bifida 1,053 | 1,074
pediatric high grade glioma 1,044 | 1,064
cutaneous lupus erythematosus 1,034 | 1,057
nasopharyngeal carcinoma 1,022 | 1,058
Intellectual disability 989 | 1,016
dermatomyositis 956 | 966
Atopic dermatitis 925 | 952
active Crohn's disease 897 | 922
non primary Sjogren syndrome sicca 871 | 891
gastric carcinoma 791 | 807
Epilepsy 775 | 792
acute myeloid leukemia 769 | 783
Waldenstrons macroglobulinemia 761 | 765
Liver Cirrhosis, Experimental 758 | 769
active ulcerative colitis 740 | 764
esophageal adenocarcinoma 727 | 737
primary Sjogren syndrome 720 | 735
medulloblastoma 691 | 720
Melanoma 677 | 711
progressive supranuclear palsy 667 | 676
aldosterone-producing adenoma 651 | 665
Obesity 646 | 678
Alzheimer's disease 642 | 658
Bipolar Disorder 642 | 666
Dull intelligence 633 | 645
Low intelligence 633 | 645
Mental Retardation 633 | 645
Mental deficiency 633 | 645
Poor school performance 633 | 645
Cognitive delay 600 | 608
Global developmental delay 600 | 608
Mental and motor retardation 600 | 608
Duchenne muscular dystrophy 594 | 601
Seizures 587 | 596
Liver cancer 574 | 604
Muscle hypotonia 563 | 571
fibroadenoma 548 | 559
pancreatic carcinoma 544 | 562
hepatocellular carcinoma 543 | 547
Endometriosis 527 | 540
Short stature 515 | 531
Multiple Sclerosis 510 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 503 | 510
chronic rhinosinusitis 497 | 512
Down syndrome 493 | 499
Prostatic Neoplasms 489 | 495
mucosa-associated lymphoid tissue lymphoma 465 | 484
sonic hedgehog group medulloblastoma 458 | 467
posterior fossa group A ependymoma 454 | 468
gastric cancer 453 | 459
Skin cancer 447 | 469

Tissue

Endocrine System 16,934 | 18,159
Female tissues 16,457 | 17,400
Digestive Tract 16,442 | 17,369
Skin and soft tissues 16,336 | 17,230
Male tissues 16,253 | 17,142
Blood and immune system 16,065 | 16,909
Liver and Pancreas 15,965 | 16,750
Nervous System 15,932 | 16,725
Urinary Tract 15,930 | 16,678
Respiratory system 15,687 | 16,393
Cardiovascular System 14,666 | 15,192

Target Family

Non-IDG 10,669 | 12,091
Enzyme 3,920 | 4,145
Transcription Factor 1,265 | 1,400
Kinase 620 | 634
Transporter 447 | 473
GPCR 330 | 408
Ion Channel 322 | 344
Epigenetic 237 | 242
oGPCR 97 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 34 | 38

Data Source

UniProt Tissue 17,989 | 17,989
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Putative homeobox protein Meis3-like 2 MEIS3P2 Tdark Non-IDG 0.00000 0
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22