Development Level

Tbio 10,696 | 11,178
Tdark 4,875 | 6,569
Tchem 1,830 | 1,885
Tclin 588 | 612

Collection

Kinase: IDG Consortium (Target... 119 | 125
Ion Channel: IDG Consortium (T... 94 | 99
GPCR: IDG Consortium (Targets) 86 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 963 | 979
preweaning lethality, incomple... 482 | 499
abnormal behavior 285 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 215 | 220
decreased total body fat amoun... 200 | 207
decreased vertical activity 197 | 208
enlarged heart 197 | 210
abnormal bone structure 184 | 187
increased lean body mass 168 | 172
decreased body weight 159 | 161
abnormal heart morphology 152 | 162
decreased bone mineral content 146 | 151
hyperactivity 142 | 148
decreased lean body mass 134 | 135
increased total body fat amoun... 132 | 134
hypoactivity 124 | 132
decreased bone mineral density 123 | 126
male infertility 119 | 123
decreased circulating glucose ... 118 | 126
increased circulating alkaline... 117 | 122
decreased grip strength 111 | 116
increased startle reflex 111 | 112
abnormal seminal vesicle morph... 109 | 114
embryonic growth retardation 104 | 106
increased bone mineral content 104 | 108
decreased body length 100 | 101
increased or absent threshold ... 98 | 101
short tibia 95 | 97
decreased circulating choleste... 91 | 93
increased mean corpuscular hem... 91 | 96
cataract 89 | 92
increased mean corpuscular vol... 88 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 81 | 83
abnormal lens morphology 80 | 81
decreased circulating triglyce... 79 | 79
decreased prepulse inhibition 79 | 82
increased circulating HDL chol... 78 | 80
decreased circulating serum al... 77 | 82
decreased mean corpuscular vol... 77 | 79
decreased circulating insulin ... 74 | 76
improved glucose tolerance 74 | 79
impaired glucose tolerance 73 | 75
small superior vagus ganglion 73 | 74
decreased startle reflex 72 | 75
increased bone mineral density 72 | 72
increased fasted circulating g... 72 | 76
decreased leukocyte cell numbe... 71 | 73
abnormal retina morphology 70 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 67 | 68
decreased circulating HDL chol... 67 | 68
increased circulating sodium l... 67 | 71
abnormal behavioral response t... 66 | 66
abnormal kidney morphology 65 | 65
decreased hemoglobin content 65 | 68
abnormal gait 64 | 69
increased circulating choleste... 64 | 66
decreased fasted circulating g... 63 | 65
abnormal coat-hair pigmentatio... 61 | 64
decreased erythrocyte cell num... 60 | 62
increased monocyte cell number 60 | 63
increased heart weight 58 | 62
small testis 57 | 58
edema 56 | 59
thrombocytopenia 56 | 56
female infertility 55 | 60
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
abnormal skin morphology 48 | 50
decreased blood urea nitrogen ... 48 | 51
decreased circulating alanine ... 47 | 47
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 47 | 50
increased blood urea nitrogen ... 46 | 48
increased leukocyte cell numbe... 46 | 47
decreased circulating alkaline... 45 | 46
increased neutrophil cell numb... 45 | 46
abnormal neural tube closure 44 | 46
decreased hematocrit 44 | 46
increased hematocrit 44 | 46
increased mean platelet volume 44 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 40 | 42
decreased red blood cell distr... 40 | 41
enlarged spleen 40 | 41
increased circulating chloride... 39 | 41
increased circulating triglyce... 39 | 42
increased grip strength 39 | 41
increased hemoglobin content 39 | 45
limb grasping 39 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
decreased circulating LDL chol... 37 | 38
decreased circulating creatini... 37 | 39
increased erythrocyte cell num... 37 | 39

Disease

Carcinoma 10,513 | 11,192
ovarian cancer 8,108 | 8,297
osteosarcoma 7,543 | 7,766
psoriasis 6,152 | 6,514
medulloblastoma, large-cell 5,917 | 6,086
glioblastoma 5,514 | 5,635
atypical teratoid / rhabdoid tumor 4,849 | 4,971
lung cancer 4,516 | 4,607
ependymoma 4,448 | 4,559
group 3 medulloblastoma 3,914 | 4,002
adult high grade glioma 3,591 | 3,701
Breast cancer 3,403 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,152 | 3,204
malignant mesothelioma 3,094 | 3,135
Astrocytoma, Pilocytic 2,928 | 3,006
primitive neuroectodermal tumor 2,900 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,851 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,821 | 2,872
invasive ductal carcinoma 2,811 | 2,867
non-small cell lung cancer 2,747 | 2,799
oligodendroglioma 2,711 | 2,768
lung carcinoma 2,672 | 2,755
lung adenocarcinoma 2,547 | 2,627
astrocytic glioma 2,475 | 2,530
Kidney cancer 2,472 | 2,548
Cancer 2,307 | 2,388
pancreatic cancer 2,267 | 2,322
subependymal giant cell astrocytoma 2,181 | 2,230
interstitial cystitis 2,161 | 2,237
tuberculosis 1,920 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,892 | 1,911
pituitary cancer 1,858 | 1,915
Pick disease 1,831 | 1,856
group 4 medulloblastoma 1,767 | 1,806
ulcerative colitis 1,719 | 1,765
ductal carcinoma in situ 1,657 | 1,686
cystic fibrosis 1,595 | 1,629
breast carcinoma 1,558 | 1,589
diabetes mellitus 1,520 | 1,683
colon cancer 1,401 | 1,428
Autosomal recessive predisposition 1,366 | 1,407
adrenocortical carcinoma 1,362 | 1,385
Multiple myeloma 1,284 | 1,296
juvenile dermatomyositis 1,132 | 1,147
Rheumatoid arthritis 1,125 | 1,156
acute quadriplegic myopathy 1,121 | 1,133
astrocytoma 1,104 | 1,113
Schizophrenia 1,097 | 1,136
primary pancreatic ductal adenocarcinoma 1,048 | 1,071
spina bifida 1,033 | 1,053
pediatric high grade glioma 1,016 | 1,035
cutaneous lupus erythematosus 994 | 1,016
nasopharyngeal carcinoma 990 | 1,024
Intellectual disability 971 | 998
dermatomyositis 931 | 941
Atopic dermatitis 890 | 915
active Crohn's disease 857 | 882
non primary Sjogren syndrome sicca 842 | 861
gastric carcinoma 766 | 781
Epilepsy 758 | 775
acute myeloid leukemia 746 | 760
Waldenstrons macroglobulinemia 738 | 742
Liver Cirrhosis, Experimental 722 | 733
active ulcerative colitis 712 | 736
primary Sjogren syndrome 695 | 710
esophageal adenocarcinoma 687 | 696
medulloblastoma 673 | 702
Melanoma 657 | 689
progressive supranuclear palsy 647 | 656
aldosterone-producing adenoma 633 | 646
Obesity 625 | 655
Alzheimer's disease 624 | 640
Bipolar Disorder 623 | 646
Dull intelligence 622 | 634
Low intelligence 622 | 634
Mental Retardation 622 | 634
Mental deficiency 622 | 634
Poor school performance 622 | 634
Cognitive delay 588 | 596
Global developmental delay 588 | 596
Mental and motor retardation 588 | 596
Duchenne muscular dystrophy 580 | 587
Seizures 575 | 584
Liver cancer 560 | 589
Muscle hypotonia 554 | 562
pancreatic carcinoma 537 | 555
hepatocellular carcinoma 532 | 536
fibroadenoma 528 | 538
Endometriosis 508 | 521
Short stature 499 | 514
Multiple Sclerosis 498 | 527
chronic rhinosinusitis 490 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 485 | 492
Down syndrome 474 | 480
Prostatic Neoplasms 466 | 472
mucosa-associated lymphoid tissue lymphoma 454 | 473
sonic hedgehog group medulloblastoma 450 | 459
posterior fossa group A ependymoma 442 | 456
gastric cancer 439 | 445
Skin cancer 431 | 451

Tissue

Endocrine System 16,934 | 18,159
Female tissues 16,457 | 17,400
Digestive Tract 16,442 | 17,369
Skin and soft tissues 16,336 | 17,230
Male tissues 16,253 | 17,142
Blood and immune system 16,065 | 16,909
Liver and Pancreas 15,965 | 16,750
Nervous System 15,932 | 16,725
Urinary Tract 15,930 | 16,678
Respiratory system 15,687 | 16,393
Cardiovascular System 14,666 | 15,192

Target Family

Non-IDG 10,669 | 12,091
Enzyme 3,920 | 4,145
Transcription Factor 1,265 | 1,400
Kinase 620 | 634
Transporter 447 | 473
GPCR 330 | 408
Ion Channel 322 | 344
Epigenetic 237 | 242
oGPCR 97 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 34 | 38

Data Source

UniProt Tissue 17,989 | 17,989
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116