Development Level

Tbio 10,196 | 10,625
Tdark 5,382 | 7,003
Tchem 1,836 | 1,890
Tclin 577 | 602

Collection

Eligible Kinase Proteins 129 | 134
Eligible Ion Channel Proteins 108 | 117
Eligible non-olfactory GPCR Proteins 94 | 145

IMPC Term

preweaning lethality, complete... 622 | 633
preweaning lethality, incomple... 254 | 260
abnormal behavior 219 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 183 | 187
decreased total body fat amoun... 180 | 186
decreased body weight 172 | 174
decreased bone mineral content 155 | 157
embryonic lethality prior to o... 147 | 148
abnormal bone structure 129 | 131
decreased bone mineral density 125 | 126
increased or absent threshold ... 125 | 128
decreased grip strength 119 | 123
increased circulating alkaline... 115 | 119
decreased circulating glucose ... 112 | 121
abnormal embryo size 109 | 112
decreased body length 107 | 108
enlarged heart 103 | 111
hyperactivity 103 | 108
increased lean body mass 103 | 107
abnormal retina morphology 98 | 100
increased bone mineral content 92 | 92
increased mean corpuscular hem... 90 | 93
increased mean corpuscular vol... 89 | 91
hypoactivity 84 | 89
decreased circulating choleste... 82 | 85
short tibia 82 | 82
decreased circulating triglyce... 81 | 83
increased grip strength 81 | 83
decreased circulating serum al... 76 | 79
decreased circulating HDL chol... 75 | 77
abnormal lens morphology 71 | 73
decreased circulating insulin ... 71 | 75
increased circulating sodium l... 68 | 71
increased fasted circulating g... 66 | 68
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
prenatal lethality prior to he... 62 | 64
male infertility 61 | 62
increased sacral vertebrae num... 60 | 62
abnormal retinal pigmentation 59 | 61
decreased lumbar vertebrae num... 59 | 62
decreased rib number 58 | 59
increased total body fat amoun... 57 | 57
abnormal bone mineralization 54 | 55
improved glucose tolerance 54 | 56
decreased circulating alanine ... 53 | 53
decreased leukocyte cell numbe... 53 | 54
increased exploration in new e... 53 | 56
abnormal coat/hair pigmentatio... 52 | 54
decreased hemoglobin content 52 | 53
increased bone mineral density 52 | 52
increased circulating choleste... 52 | 53
abnormal behavioral response t... 51 | 52
decreased prepulse inhibition 51 | 52
decreased mean corpuscular vol... 50 | 50
impaired glucose tolerance 50 | 52
decreased fasted circulating g... 48 | 49
abnormal gait 47 | 51
decreased caudal vertebrae num... 47 | 49
decreased startle reflex 46 | 48
thrombocytopenia 46 | 46
abnormal heart morphology 45 | 51
decreased heart weight 44 | 44
abnormal seminal vesicle morph... 43 | 47
decreased erythrocyte cell num... 43 | 43
increased blood urea nitrogen ... 42 | 44
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
increased body weight 41 | 42
increased circulating chloride... 41 | 43
increased hemoglobin content 41 | 45
increased rib number 40 | 41
decreased eosinophil cell numb... 39 | 41
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
decreased circulating free fat... 37 | 39
decreased circulating LDL chol... 36 | 37
decreased neutrophil cell numb... 36 | 37
increased leukocyte cell numbe... 36 | 37
small testis 36 | 37
abnormal neural tube closure 35 | 37
abnormal spleen morphology 35 | 36
cardiovascular system phenotyp... 35 | 35
decreased mean corpuscular hem... 34 | 34
increased heart weight 34 | 37
increased hematocrit 34 | 36
tremors 34 | 34
female infertility 33 | 34
abnormal cranium morphology 32 | 32
decreased circulating calcium ... 32 | 33
decreased circulating chloride... 32 | 32
limb grasping 32 | 35
decreased T cell number 31 | 31
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
abnormal epididymis morphology 30 | 31
abnormal kidney morphology 30 | 30
abnormal testis morphology 30 | 30
decreased blood urea nitrogen ... 30 | 31

Disease

ovarian cancer 8,302 | 8,492
osteosarcoma 7,716 | 7,933
psoriasis 6,321 | 6,685
medulloblastoma, large-cell 6,063 | 6,234
glioblastoma 5,458 | 5,572
lung cancer 4,410 | 4,473
atypical teratoid / rhabdoid tumor 4,261 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,234 | 3,289
malignant mesothelioma 3,123 | 3,163
Breast cancer 3,052 | 3,099
pilocytic astrocytoma 3,010 | 3,086
primitive neuroectodermal tumor 2,972 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,936 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,903 | 2,956
invasive ductal carcinoma 2,891 | 2,950
oligodendroglioma 2,791 | 2,849
lung carcinoma 2,760 | 2,844
non-small cell lung cancer 2,749 | 2,798
pediatric high grade glioma 2,660 | 2,712
lung adenocarcinoma 2,636 | 2,714
ependymoma 2,468 | 2,514
Cancer 2,268 | 2,346
pancreatic cancer 2,249 | 2,300
subependymal giant cell astrocytoma 2,237 | 2,287
interstitial cystitis 2,227 | 2,299
group 3 medulloblastoma 2,202 | 2,254
astrocytic glioma 2,191 | 2,241
adult high grade glioma 2,071 | 2,148
Carcinoma 2,065 | 2,147
ulcerative colitis 2,044 | 2,087
pituitary cancer 1,915 | 1,972
Pick disease 1,867 | 1,893
group 4 medulloblastoma 1,831 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,777 | 1,795
ductal carcinoma in situ 1,716 | 1,745
cystic fibrosis 1,635 | 1,670
breast carcinoma 1,581 | 1,614
tuberculosis 1,531 | 1,563
diabetes mellitus 1,505 | 1,663
medulloblastoma 1,486 | 1,524
astrocytoma 1,478 | 1,493
posterior fossa group A ependymoma 1,472 | 1,511
posterior fossa group B ependymoma 1,471 | 1,530
colon cancer 1,451 | 1,475
sonic hedgehog group medulloblastoma 1,445 | 1,482
adrenocortical carcinoma 1,404 | 1,427
Multiple myeloma 1,320 | 1,328
primary pancreatic ductal adenocarcinoma 1,247 | 1,271
juvenile dermatomyositis 1,174 | 1,189
acute quadriplegic myopathy 1,145 | 1,157
Rheumatoid Arthritis 1,139 | 1,171
atypical teratoid/rhabdoid tumor 1,070 | 1,095
spina bifida 1,046 | 1,064
cutaneous lupus erythematosus 1,034 | 1,056
nasopharyngeal carcinoma 1,021 | 1,056
dermatomyositis 957 | 967
Atopic dermatitis 917 | 944
active Crohn's disease 893 | 918
non primary Sjogren syndrome sicca 821 | 840
gastric carcinoma 817 | 832
primary Sjogren syndrome 773 | 789
acute myeloid leukemia 770 | 785
Waldenstrons macroglobulinemia 761 | 765
esophageal adenocarcinoma 727 | 737
tuberculosis and treatment for 6 months 679 | 686
progressive supranuclear palsy 665 | 674
aldosterone-producing adenoma 651 | 664
Alzheimer's disease 628 | 644
Duchenne muscular dystrophy 595 | 602
Obesity 587 | 616
Intellectual disability 557 | 573
pancreatic carcinoma 549 | 567
fibroadenoma 546 | 557
hepatocellular carcinoma 546 | 550
Down syndrome 540 | 548
Endometriosis 522 | 535
chronic rhinosinusitis 497 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 499
Schizophrenia 486 | 503
Multiple Sclerosis 467 | 498
Prostatic Neoplasms 465 | 471
mucosa-associated lymphoid tissue lymphoma 461 | 480
active ulcerative colitis 458 | 477
IGA Glomerulonephritis 450 | 454
gastric cancer 430 | 436
Amyotrophic Lateral Sclerosis 427 | 432
Mammary Neoplasms 400 | 410
inflammatory breast cancer 394 | 404
non-small cell lung carcinoma 388 | 413
Kidney disease 383 | 397
Neurodegenerative disease 376 | 383
sarcoidosis 359 | 368
Parkinson's disease 351 | 364
Asthma 341 | 349
glioblastoma multiforme 339 | 347
Epilepsy 334 | 346
Polycystic Ovary Syndrome 325 | 335
nephrosclerosis 325 | 329
tuberculosis and treatment for 3 months 315 | 327
urothelial carcinoma 311 | 318

Tissue

Female tissues 17,194 | 18,647
Nervous System 17,171 | 18,561
Endocrine System 17,139 | 18,512
Digestive Tract 17,135 | 18,473
Urinary Tract 17,083 | 18,444
Liver and Pancreas 16,970 | 18,136
Skin and soft tissues 16,889 | 18,115
Male tissues 16,875 | 17,969
Blood and immune system 16,850 | 17,995
Cardiovascular System 16,850 | 17,958
Respiratory system 16,528 | 17,484

Target Family

Non-IDG 10,673 | 11,969
Enzyme 3,921 | 4,146
Transcription Factor 1,265 | 1,400
Kinase 620 | 634
Transporter 447 | 473
GPCR 330 | 408
Ion Channel 319 | 341
Epigenetic 237 | 242
oGPCR 97 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 34 | 38

Data Source

UniProt Tissue 17,991 | 17,991
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24