Development Level

Tbio 1,352 | 11,445
Tchem 328 | 1,598
Tclin 154 | 613
Tdark 86 | 6,588

Collection

RFA-RM-18-021 23 | 328
Ion Channel: IDG Consortium (T... 15 | 99
Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Targets) 2 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 180 | 979
preweaning lethality, incomple... 67 | 499
embryonic lethality prior to t... 55 | 278
embryonic lethality prior to o... 51 | 239
abnormal embryo size 37 | 220
abnormal behavior 34 | 298
decreased total body fat amoun... 34 | 207
enlarged heart 33 | 210
decreased body weight 31 | 161
abnormal heart morphology 25 | 162
decreased vertical activity 25 | 208
increased lean body mass 24 | 172
decreased lean body mass 23 | 135
abnormal bone structure 22 | 187
increased startle reflex 22 | 112
decreased bone mineral content 21 | 151
decreased circulating glucose ... 20 | 126
hypoactivity 20 | 132
increased total body fat amoun... 20 | 134
decreased mean corpuscular vol... 17 | 79
hyperactivity 17 | 148
increased mean corpuscular vol... 17 | 92
abnormal seminal vesicle morph... 16 | 114
decreased bone mineral density 16 | 126
embryonic growth retardation 16 | 106
impaired glucose tolerance 16 | 75
male infertility 16 | 123
decreased body length 15 | 101
decreased circulating HDL chol... 15 | 68
increased bone mineral density 15 | 72
decreased circulating choleste... 14 | 93
decreased hemoglobin content 14 | 68
decreased lymphocyte cell numb... 14 | 83
increased bone mineral content 14 | 108
increased circulating alkaline... 14 | 122
abnormal lens morphology 13 | 81
abnormal retina morphology 13 | 71
increased heart weight 13 | 62
increased monocyte cell number 13 | 63
abnormal kidney morphology 12 | 65
cataract 12 | 92
decreased fasted circulating g... 12 | 65
decreased mean corpuscular hem... 12 | 50
increased circulating HDL chol... 12 | 80
increased mean corpuscular hem... 12 | 96
abnormal eye morphology 11 | 68
abnormal gait 11 | 69
decreased circulating insulin ... 11 | 76
decreased circulating triglyce... 11 | 79
decreased grip strength 11 | 116
edema 11 | 59
enlarged spleen 11 | 41
increased circulating choleste... 11 | 66
increased grip strength 11 | 41
increased neutrophil cell numb... 11 | 46
increased or absent threshold ... 11 | 101
persistence of hyaloid vascula... 11 | 33
prenatal lethality prior to he... 11 | 87
short tibia 11 | 97
small superior vagus ganglion 11 | 74
abnormal skin morphology 10 | 50
abnormal sleep behavior 10 | 70
abnormal spleen morphology 10 | 55
increased leukocyte cell numbe... 10 | 47
thrombocytopenia 10 | 56
abnormal neural tube closure 9 | 46
abnormal tooth morphology 9 | 24
decreased blood urea nitrogen ... 9 | 51
decreased circulating LDL chol... 9 | 38
decreased circulating serum al... 9 | 82
decreased erythrocyte cell num... 9 | 62
decreased leukocyte cell numbe... 9 | 73
decreased red blood cell distr... 9 | 41
increased circulating chloride... 9 | 41
increased circulating sodium l... 9 | 71
abnormal craniofacial morpholo... 8 | 33
abnormal embryo turning 8 | 31
decreased circulating alkaline... 8 | 46
decreased circulating iron lev... 8 | 32
decreased mean corpuscular hem... 8 | 31
decreased prepulse inhibition 8 | 82
increased hemoglobin content 8 | 45
increased lymphocyte cell numb... 8 | 32
increased mean corpuscular hem... 8 | 36
microphthalmia 8 | 26
abnormal bone mineralization 7 | 38
abnormal coat-hair pigmentatio... 7 | 64
abnormal epididymis morphology 7 | 42
cardiovascular system phenotyp... 7 | 36
decreased circulating amylase ... 7 | 28
decreased circulating total pr... 7 | 49
decreased hematocrit 7 | 46
decreased neutrophil cell numb... 7 | 42
decreased startle reflex 7 | 75
enlarged epididymis 7 | 31
enlarged lymph nodes 7 | 37
hydrometra 7 | 53
increased circulating triglyce... 7 | 42
increased mean platelet volume 7 | 45
limb grasping 7 | 41

Disease

Carcinoma 1,278 | 11,493
ovarian cancer 1,063 | 8,520
osteosarcoma 943 | 7,950
psoriasis 890 | 6,694
glioblastoma 779 | 5,792
medulloblastoma, large-cell 754 | 6,241
lung cancer 666 | 4,740
atypical teratoid / rhabdoid tumor 630 | 5,112
Cancer 617 | 2,499
ependymoma 546 | 4,679
Breast cancer 491 | 3,578
group 3 medulloblastoma 481 | 4,104
adult high grade glioma 461 | 3,801
malignant mesothelioma 461 | 3,232
invasive ductal carcinoma 427 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 394 | 3,291
non-small cell lung cancer 393 | 2,890
Astrocytoma, Pilocytic 390 | 3,081
Kidney cancer 382 | 2,613
primitive neuroectodermal tumor 370 | 3,035
lung adenocarcinoma 360 | 2,716
oligodendroglioma 355 | 2,850
lung carcinoma 354 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 349 | 2,989
pancreatic cancer 339 | 2,398
interstitial cystitis 333 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 328 | 2,955
subependymal giant cell astrocytoma 298 | 2,287
astrocytic glioma 293 | 2,597
tuberculosis 293 | 2,010
Autosomal recessive predisposition 280 | 1,442
diabetes mellitus 272 | 1,728
breast carcinoma 258 | 1,638
ductal carcinoma in situ 249 | 1,745
ulcerative colitis 249 | 1,819
pituitary cancer 247 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 246 | 1,962
Pick disease 234 | 1,894
Schizophrenia 228 | 1,160
group 4 medulloblastoma 227 | 1,855
colon cancer 221 | 1,478
Multiple myeloma 213 | 1,332
adrenocortical carcinoma 204 | 1,428
astrocytoma 204 | 1,146
cystic fibrosis 202 | 1,696
Rheumatoid arthritis 191 | 1,191
acute quadriplegic myopathy 186 | 1,158
juvenile dermatomyositis 183 | 1,187
Intellectual disability 171 | 1,016
dermatomyositis 164 | 966
cutaneous lupus erythematosus 163 | 1,057
pediatric high grade glioma 151 | 1,064
primary pancreatic ductal adenocarcinoma 150 | 1,109
Atopic dermatitis 141 | 952
Epilepsy 139 | 792
Waldenstrons macroglobulinemia 135 | 765
Obesity 134 | 678
nasopharyngeal carcinoma 133 | 1,058
spina bifida 133 | 1,074
primary Sjogren syndrome 128 | 735
Bipolar Disorder 125 | 666
Short stature 123 | 531
Dull intelligence 122 | 645
Low intelligence 122 | 645
Mental Retardation 122 | 645
Mental deficiency 122 | 645
Poor school performance 122 | 645
Liver Cirrhosis, Experimental 120 | 769
Cognitive delay 118 | 608
Global developmental delay 118 | 608
Mental and motor retardation 118 | 608
Seizures 118 | 596
gastric carcinoma 118 | 807
active Crohn's disease 116 | 922
non primary Sjogren syndrome sicca 113 | 891
Alzheimer's disease 112 | 658
acute myeloid leukemia 109 | 783
Breast Neoplasms 108 | 445
esophageal adenocarcinoma 108 | 737
medulloblastoma 108 | 720
Melanoma 107 | 711
Muscle hypotonia 104 | 571
Mammary Neoplasms 102 | 425
Depressive disorder 100 | 409
Duchenne muscular dystrophy 100 | 601
Endometriosis 99 | 540
Kidney disease 99 | 430
Hypertension 98 | 396
Prostatic Neoplasms 95 | 495
active ulcerative colitis 94 | 764
Multiple Sclerosis 90 | 540
Arthritis 89 | 290
pancreatic carcinoma 88 | 562
Liver cancer 86 | 604
Hypertensive disease 85 | 292
Vascular disease 85 | 319
hepatocellular carcinoma 85 | 547
aldosterone-producing adenoma 84 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 83 | 510
Small head 82 | 374

Tissue

Endocrine System 1,876 | 18,159
Digestive Tract 1,862 | 17,369
Female tissues 1,850 | 17,400
Skin and soft tissues 1,845 | 17,230
Blood and immune system 1,832 | 16,909
Male tissues 1,827 | 17,142
Urinary Tract 1,822 | 16,678
Nervous System 1,818 | 16,725
Liver and Pancreas 1,810 | 16,750
Respiratory system 1,796 | 16,393
Cardiovascular System 1,709 | 15,192

Target Family

Non-IDG 1,112 | 12,091
Enzyme 344 | 4,145
Kinase 136 | 634
Transcription Factor 107 | 1,400
GPCR 72 | 408
Ion Channel 64 | 344
Epigenetic 43 | 242
Transporter 25 | 473
Nuclear Receptor 13 | 48
TF/Epigenetic 4 | 38

Data Source

Reactome 1,920 | 1,920
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Myotubularin-related protein 2 MTMR2 Tbio Enzyme -1.64906 46.5 124
Cullin-4A CUL4A Tbio Non-IDG -1.92199 80.1 276
Cullin-3 CUL3 Tbio Non-IDG -3.26322 1670.8 307
Cullin-2 CUL2 Tbio Non-IDG -1.99844 95.1 373
Cullin-1 CUL1 Tbio Non-IDG -2.37931 182.6 416
m-AAA protease-interacting protein 1, mitochondrial MAIP1 Tdark Non-IDG 0.30 0.23 82
Kelch repeat and BTB domain-containing protein 7 KBTBD7 Tdark Non-IDG 0.14 0.94 89
DNA-directed RNA polymerase III subunit RPC5 POLR3E Tbio Enzyme -2.17742 145.9 76