Development Level

Tbio 2,597 | 10,625
Tchem 712 | 1,890
Tclin 335 | 602

Collection

Eligible Ion Channel Proteins 28 | 117
Eligible Kinase Proteins 18 | 134
Eligible non-olfactory GPCR Proteins 15 | 143

IMPC Term

preweaning lethality, complete... 168 | 633
preweaning lethality, incomple... 73 | 260
abnormal behavior 67 | 226
decreased lean body mass 59 | 195
embryonic lethality prior to t... 59 | 187
decreased body weight 53 | 174
decreased total body fat amoun... 51 | 186
decreased bone mineral content 46 | 157
embryonic lethality prior to o... 41 | 148
increased circulating alkaline... 38 | 119
decreased bone mineral density 36 | 126
abnormal embryo size 35 | 112
increased or absent threshold ... 35 | 128
decreased grip strength 34 | 123
increased mean corpuscular hem... 34 | 93
abnormal bone structure 33 | 131
abnormal retina morphology 32 | 100
decreased body length 32 | 108
hypoactivity 29 | 89
decreased circulating glucose ... 26 | 121
decreased circulating HDL chol... 25 | 77
enlarged heart 25 | 111
hyperactivity 24 | 108
short tibia 24 | 82
decreased circulating triglyce... 23 | 83
decreased prepulse inhibition 23 | 52
increased grip strength 23 | 83
decreased circulating choleste... 22 | 85
decreased circulating insulin ... 22 | 75
increased lean body mass 22 | 107
increased bone mineral content 21 | 92
abnormal bone mineralization 20 | 55
decreased circulating serum al... 20 | 79
decreased hemoglobin content 20 | 53
improved glucose tolerance 20 | 56
increased mean corpuscular vol... 20 | 91
abnormal lens morphology 19 | 73
decreased mean corpuscular vol... 17 | 50
increased circulating HDL chol... 17 | 63
increased circulating sodium l... 17 | 71
prenatal lethality prior to he... 17 | 64
decreased startle reflex 16 | 48
increased blood urea nitrogen ... 16 | 44
male infertility 16 | 62
abnormal neural tube closure 15 | 37
abnormal sleep behavior 15 | 63
decreased circulating alanine ... 15 | 53
impaired glucose tolerance 15 | 52
increased circulating choleste... 15 | 53
increased total body fat amoun... 15 | 57
abnormal retinal pigmentation 14 | 61
decreased erythrocyte cell num... 14 | 43
decreased heart weight 14 | 44
increased circulating chloride... 14 | 43
abnormal kidney morphology 13 | 30
abnormal seminal vesicle morph... 13 | 47
cardiovascular system phenotyp... 13 | 35
decreased circulating alkaline... 13 | 41
decreased circulating amylase ... 13 | 24
thrombocytopenia 13 | 46
abnormal behavioral response t... 12 | 52
abnormal gait 12 | 51
cataract 12 | 26
decreased eosinophil cell numb... 12 | 41
decreased leukocyte cell numbe... 12 | 54
increased circulating calcium ... 12 | 32
increased fasted circulating g... 12 | 68
increased leukocyte cell numbe... 12 | 37
limb grasping 12 | 35
abnormal eye morphology 11 | 38
decreased caudal vertebrae num... 11 | 49
decreased circulating total pr... 11 | 41
decreased fasted circulating g... 11 | 49
increased bone mineral density 11 | 52
increased heart weight 11 | 37
increased hemoglobin content 11 | 45
abnormal tail morphology 10 | 17
abnormal tooth morphology 10 | 24
decreased circulating calcium ... 10 | 33
decreased mean corpuscular hem... 10 | 34
enlarged lymph nodes 10 | 27
small superior vagus ganglion 10 | 20
small testis 10 | 37
abnormal coat/hair pigmentatio... 9 | 54
abnormal cranium morphology 9 | 32
abnormal epididymis morphology 9 | 31
abnormal heart morphology 9 | 51
abnormal spleen morphology 9 | 36
absent startle reflex 9 | 15
decreased NK T cell number 9 | 28
decreased blood urea nitrogen ... 9 | 31
decreased circulating fructosa... 9 | 31
decreased mean corpuscular hem... 9 | 19
hydrops fetalis 9 | 22
increased circulating creatini... 9 | 29
increased circulating total pr... 9 | 20
increased erythrocyte cell num... 9 | 26
increased hematocrit 9 | 36
straub tail 9 | 26
tremors 9 | 34

Disease

ovarian cancer 1,812 | 8,484
psoriasis 1,660 | 6,685
osteosarcoma 1,604 | 7,933
medulloblastoma, large-cell 1,377 | 6,234
glioblastoma 1,270 | 5,572
lung cancer 1,239 | 4,466
Cancer 1,080 | 2,346
atypical teratoid / rhabdoid tumor 929 | 4,369
malignant mesothelioma 840 | 3,162
lung carcinoma 784 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 780 | 3,289
Breast cancer 774 | 3,094
lung adenocarcinoma 766 | 2,713
invasive ductal carcinoma 749 | 2,950
pilocytic astrocytoma 749 | 3,086
non-small cell lung cancer 744 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 709 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 705 | 2,988
pancreatic cancer 656 | 2,300
Carcinoma 653 | 2,147
oligodendroglioma 650 | 2,849
pediatric high grade glioma 640 | 2,712
primitive neuroectodermal tumor 638 | 3,031
interstitial cystitis 608 | 2,299
ulcerative colitis 591 | 2,087
subependymal giant cell astrocytoma 567 | 2,287
ependymoma 550 | 2,514
diabetes mellitus 542 | 1,663
pituitary cancer 499 | 1,972
adult high grade glioma 481 | 2,148
colon cancer 455 | 1,475
ductal carcinoma in situ 454 | 1,745
astrocytic glioma 452 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 450 | 1,795
group 3 medulloblastoma 444 | 2,254
cystic fibrosis 442 | 1,665
breast carcinoma 439 | 1,614
Pick disease 428 | 1,893
tuberculosis 425 | 1,557
astrocytoma 420 | 1,493
group 4 medulloblastoma 406 | 1,875
posterior fossa group A ependymoma 386 | 1,511
Rheumatoid Arthritis 356 | 1,160
adrenocortical carcinoma 353 | 1,427
sonic hedgehog group medulloblastoma 339 | 1,482
primary pancreatic ductal adenocarcinoma 338 | 1,271
cutaneous lupus erythematosus 332 | 1,056
medulloblastoma 327 | 1,524
Multiple myeloma 316 | 1,327
acute quadriplegic myopathy 301 | 1,157
juvenile dermatomyositis 290 | 1,189
nasopharyngeal carcinoma 276 | 1,056
posterior fossa group B ependymoma 273 | 1,530
Obesity 271 | 616
atypical teratoid/rhabdoid tumor 270 | 1,095
Atopic dermatitis 255 | 944
Kidney disease 250 | 396
dermatomyositis 247 | 933
esophageal adenocarcinoma 246 | 737
active Crohn's disease 240 | 918
Intellectual disability 237 | 573
Alzheimer's disease 228 | 644
primary Sjogren syndrome 224 | 789
gastric carcinoma 223 | 832
spina bifida 215 | 1,064
Prostatic Neoplasms 213 | 471
Down syndrome 207 | 548
Mammary Neoplasms 205 | 410
Multiple Sclerosis 204 | 498
Duchenne muscular dystrophy 200 | 602
Neurodegenerative disease 199 | 383
Waldenstrons macroglobulinemia 190 | 765
non primary Sjogren syndrome sicca 182 | 840
Schizophrenia 179 | 501
Endometriosis 177 | 535
fibroadenoma 176 | 557
Epilepsy 173 | 346
Hypertension 173 | 287
aldosterone-producing adenoma 169 | 664
Asthma 168 | 349
pancreatic carcinoma 167 | 567
Arthritis 166 | 248
acute myeloid leukemia 166 | 780
Atherosclerosis 163 | 275
Hypersensitivity reaction type II disease 162 | 235
Autistic Disorder 157 | 320
Anemia 155 | 252
Heart disease 153 | 279
IGA Glomerulonephritis 149 | 454
Parkinson's disease 148 | 364
progressive supranuclear palsy 148 | 674
non-small cell lung carcinoma 146 | 413
Vascular disease 144 | 281
Cerebrovascular disease 143 | 231
autosomal dominant Emery-Dreifuss muscular dystrophy 142 | 499
mucosa-associated lymphoid tissue lymphoma 141 | 480
Coronary artery disease 140 | 240
Peripheral Neuropathy 140 | 303
active ulcerative colitis 140 | 477
Liver disease 137 | 219

Tissue

Nervous System 3,520 | 18,561
Digestive Tract 3,519 | 18,473
Female tissues 3,518 | 18,647
Endocrine System 3,509 | 18,512
Urinary Tract 3,500 | 18,444
Liver and Pancreas 3,475 | 18,136
Cardiovascular System 3,463 | 17,958
Skin and soft tissues 3,458 | 18,115
Male tissues 3,450 | 17,969
Blood and immune system 3,449 | 17,995
Respiratory system 3,381 | 17,484

Target Family

Non-IDG 1,855 | 11,971
Enzyme 895 | 4,146
Transcription Factor 281 | 1,400
Kinase 183 | 634
Transporter 125 | 473
Ion Channel 122 | 341
GPCR 115 | 406
Epigenetic 43 | 242
Nuclear Receptor 18 | 48
TF/Epigenetic 6 | 38
oGPCR 1 | 421

Data Source

OMIM 3,644 | 3,644
TCRDv4.6.0 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961