Development Level

Tbio 2,838 | 11,651
Tchem 545 | 1,388
Tclin 348 | 612

Collection

Ion Channel: IDG Consortium (T... 23 | 99
Kinase: IDG Consortium (Target... 15 | 125
GPCR: IDG Consortium (Targets) 14 | 126
Kinase: IDG Consortium (Comple... 7 | 37
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 250 | 979
preweaning lethality, incomple... 115 | 499
embryonic lethality prior to t... 78 | 278
abnormal behavior 75 | 298
embryonic lethality prior to o... 62 | 239
abnormal embryo size 59 | 220
decreased total body fat amoun... 54 | 207
decreased vertical activity 53 | 208
decreased body weight 50 | 161
enlarged heart 50 | 210
abnormal bone structure 46 | 187
decreased bone mineral content 45 | 151
abnormal heart morphology 42 | 162
hypoactivity 39 | 132
increased lean body mass 39 | 172
increased circulating alkaline... 37 | 122
abnormal seminal vesicle morph... 34 | 114
increased mean corpuscular hem... 34 | 96
increased startle reflex 33 | 112
hyperactivity 32 | 148
decreased bone mineral density 31 | 126
decreased circulating glucose ... 30 | 126
decreased grip strength 30 | 116
decreased lean body mass 30 | 135
increased bone mineral content 30 | 108
increased total body fat amoun... 30 | 134
male infertility 30 | 123
decreased body length 29 | 101
embryonic growth retardation 28 | 106
decreased prepulse inhibition 27 | 82
increased or absent threshold ... 27 | 101
impaired glucose tolerance 25 | 75
improved glucose tolerance 25 | 79
short tibia 25 | 97
prenatal lethality prior to he... 24 | 87
small superior vagus ganglion 24 | 74
abnormal retina morphology 23 | 71
cataract 23 | 92
decreased circulating triglyce... 23 | 79
abnormal lens morphology 22 | 81
decreased circulating serum al... 22 | 82
decreased mean corpuscular vol... 22 | 79
increased circulating choleste... 22 | 66
decreased circulating choleste... 21 | 93
decreased startle reflex 21 | 75
increased heart weight 21 | 62
abnormal kidney morphology 20 | 65
decreased circulating HDL chol... 20 | 68
increased circulating sodium l... 20 | 71
increased fasted circulating g... 20 | 76
abnormal eye morphology 19 | 68
decreased circulating insulin ... 19 | 76
decreased erythrocyte cell num... 19 | 62
decreased hemoglobin content 19 | 68
decreased lymphocyte cell numb... 19 | 83
increased bone mineral density 19 | 72
increased mean corpuscular vol... 19 | 92
decreased leukocyte cell numbe... 18 | 73
hydrometra 18 | 53
increased blood urea nitrogen ... 17 | 48
abnormal neural tube closure 16 | 46
abnormal sleep behavior 16 | 70
decreased blood urea nitrogen ... 16 | 51
edema 16 | 59
increased circulating HDL chol... 16 | 80
abnormal gait 15 | 69
decreased circulating amylase ... 15 | 28
decreased fasted circulating g... 15 | 65
increased leukocyte cell numbe... 15 | 47
increased neutrophil cell numb... 15 | 46
pallor 15 | 34
thrombocytopenia 15 | 56
abnormal behavioral response t... 14 | 66
decreased circulating alanine ... 14 | 47
decreased circulating total pr... 14 | 49
female infertility 14 | 60
limb grasping 14 | 41
small testis 14 | 58
abnormal skin morphology 13 | 50
decreased circulating alkaline... 13 | 46
enlarged lymph nodes 13 | 37
increased circulating triglyce... 13 | 42
increased erythrocyte cell num... 13 | 39
prolonged ST segment 13 | 36
abnormal tail morphology 12 | 25
absent startle reflex 12 | 24
cardiovascular system phenotyp... 12 | 36
decreased circulating calcium ... 12 | 36
decreased circulating creatini... 12 | 39
decreased mean corpuscular hem... 12 | 50
decreased neutrophil cell numb... 12 | 42
increased circulating calcium ... 12 | 34
increased circulating chloride... 12 | 41
increased circulating creatini... 12 | 38
increased lymphocyte cell numb... 12 | 32
abnormal bone mineralization 11 | 38
abnormal epididymis morphology 11 | 42
increased circulating total pr... 11 | 28
increased hematocrit 11 | 46
increased monocyte cell number 11 | 63

Disease

Carcinoma 2,565 | 11,493
ovarian cancer 1,870 | 8,520
psoriasis 1,694 | 6,694
osteosarcoma 1,651 | 7,950
medulloblastoma, large-cell 1,410 | 6,241
glioblastoma 1,365 | 5,792
lung cancer 1,332 | 4,740
atypical teratoid / rhabdoid tumor 1,141 | 5,112
Cancer 1,130 | 2,499
ependymoma 1,040 | 4,679
Breast cancer 945 | 3,578
adult high grade glioma 892 | 3,801
malignant mesothelioma 890 | 3,232
group 3 medulloblastoma 870 | 4,104
Autosomal recessive predisposition 829 | 1,442
lung carcinoma 799 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 796 | 3,291
non-small cell lung cancer 787 | 2,890
lung adenocarcinoma 779 | 2,716
Astrocytoma, Pilocytic 765 | 3,081
invasive ductal carcinoma 760 | 2,951
Kidney cancer 751 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 725 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 718 | 2,989
pancreatic cancer 709 | 2,398
oligodendroglioma 664 | 2,850
primitive neuroectodermal tumor 652 | 3,035
interstitial cystitis 620 | 2,312
subependymal giant cell astrocytoma 578 | 2,287
astrocytic glioma 574 | 2,597
diabetes mellitus 574 | 1,728
tuberculosis 546 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 512 | 1,962
ulcerative colitis 510 | 1,819
pituitary cancer 505 | 1,972
Intellectual disability 492 | 1,016
Schizophrenia 468 | 1,160
breast carcinoma 465 | 1,638
ductal carcinoma in situ 465 | 1,745
colon cancer 460 | 1,478
cystic fibrosis 459 | 1,696
Epilepsy 440 | 792
Pick disease 439 | 1,894
group 4 medulloblastoma 404 | 1,855
Seizures 378 | 596
Dull intelligence 377 | 645
Low intelligence 377 | 645
Mental Retardation 377 | 645
Mental deficiency 377 | 645
Poor school performance 377 | 645
Rheumatoid arthritis 376 | 1,191
adrenocortical carcinoma 362 | 1,428
Muscle hypotonia 336 | 571
cutaneous lupus erythematosus 336 | 1,057
Short stature 328 | 531
Obesity 327 | 678
astrocytoma 325 | 1,146
Cognitive delay 324 | 608
Global developmental delay 324 | 608
Mental and motor retardation 324 | 608
Multiple myeloma 322 | 1,332
acute quadriplegic myopathy 306 | 1,158
juvenile dermatomyositis 292 | 1,187
primary pancreatic ductal adenocarcinoma 285 | 1,109
Liver Cirrhosis, Experimental 284 | 769
nasopharyngeal carcinoma 282 | 1,058
dermatomyositis 281 | 966
Melanoma 273 | 711
Kidney disease 266 | 430
Bipolar Disorder 265 | 666
Atopic dermatitis 259 | 952
pediatric high grade glioma 255 | 1,064
Alzheimer's disease 250 | 658
esophageal adenocarcinoma 248 | 737
active Crohn's disease 243 | 922
Hypertension 238 | 396
active ulcerative colitis 235 | 764
Prostatic Neoplasms 228 | 495
spina bifida 227 | 1,074
Depressive disorder 226 | 409
Anemia 224 | 365
Breast Neoplasms 221 | 445
Failure to gain weight 221 | 365
Pediatric failure to thrive 221 | 365
Multiple Sclerosis 220 | 540
Mammary Neoplasms 217 | 425
gastric carcinoma 214 | 807
Neurodegenerative disease 213 | 414
primary Sjogren syndrome 213 | 735
Liver cancer 211 | 604
Duchenne muscular dystrophy 202 | 601
non primary Sjogren syndrome sicca 198 | 891
Down syndrome 195 | 499
Waldenstrons macroglobulinemia 194 | 765
Hypertensive disease 192 | 292
Small head 192 | 374
Cataract 190 | 297
Skin cancer 190 | 469
Arthritis 189 | 290
Asthma 188 | 385

Tissue

Endocrine System 3,530 | 18,159
Digestive Tract 3,474 | 17,369
Female tissues 3,445 | 17,400
Skin and soft tissues 3,423 | 17,230
Male tissues 3,389 | 17,142
Blood and immune system 3,369 | 16,909
Liver and Pancreas 3,355 | 16,750
Urinary Tract 3,345 | 16,678
Nervous System 3,318 | 16,725
Respiratory system 3,271 | 16,393
Cardiovascular System 3,002 | 15,192

Target Family

Non-IDG 1,914 | 12,091
Enzyme 913 | 4,145
Transcription Factor 284 | 1,400
Kinase 184 | 634
Transporter 125 | 473
Ion Channel 123 | 344
GPCR 118 | 408
Epigenetic 44 | 242
Nuclear Receptor 19 | 48
TF/Epigenetic 6 | 38
oGPCR 1 | 421

Data Source

OMIM 3,731 | 3,731
TCRDv5.2.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,786 | 17,786
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
HPM Protein 16,251 | 16,251
EggNOG 16,120 | 16,120
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
Inparanoid 4,903 | 4,903
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 911 | 911

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Kallikrein-9 KLK9 Tbio Enzyme -0.89030 8.64 143
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76