Development Level

Tbio 11,008 | 11,445
Tdark 4,749 | 6,588
Tchem 1,566 | 1,598
Tclin 596 | 613

Collection

RFA-RM-18-021 313 | 328
Kinase: IDG Consortium (Target... 122 | 125
GPCR: IDG Consortium (Targets) 117 | 126
Ion Channel: IDG Consortium (T... 95 | 99
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 25 | 25

IMPC Phenotype

preweaning lethality, complete... 974 | 979
preweaning lethality, incomple... 491 | 499
abnormal behavior 294 | 298
embryonic lethality prior to t... 277 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 219 | 220
enlarged heart 209 | 210
decreased total body fat amoun... 206 | 207
decreased vertical activity 204 | 208
abnormal bone structure 185 | 187
increased lean body mass 168 | 172
abnormal heart morphology 162 | 162
decreased body weight 160 | 161
decreased bone mineral content 150 | 151
hyperactivity 146 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 133 | 134
hypoactivity 128 | 132
decreased bone mineral density 124 | 126
decreased circulating glucose ... 124 | 126
increased circulating alkaline... 121 | 122
male infertility 120 | 123
abnormal seminal vesicle morph... 114 | 114
decreased grip strength 114 | 116
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 94 | 96
decreased circulating choleste... 92 | 93
cataract 91 | 92
increased mean corpuscular vol... 91 | 92
prenatal lethality prior to he... 86 | 87
decreased lymphocyte cell numb... 83 | 83
decreased prepulse inhibition 82 | 82
decreased circulating serum al... 81 | 82
abnormal lens morphology 80 | 81
improved glucose tolerance 79 | 79
increased circulating HDL chol... 79 | 80
decreased circulating triglyce... 78 | 79
decreased mean corpuscular vol... 76 | 79
increased fasted circulating g... 76 | 76
decreased circulating insulin ... 75 | 76
decreased startle reflex 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
impaired glucose tolerance 73 | 75
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal retina morphology 70 | 71
abnormal eye morphology 68 | 68
abnormal gait 68 | 69
abnormal sleep behavior 68 | 70
decreased circulating HDL chol... 67 | 68
decreased hemoglobin content 67 | 68
increased circulating choleste... 66 | 66
abnormal behavioral response t... 65 | 66
abnormal kidney morphology 64 | 65
decreased fasted circulating g... 64 | 65
increased monocyte cell number 63 | 63
abnormal coat-hair pigmentatio... 62 | 64
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 59 | 60
edema 58 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
hydrometra 53 | 53
decreased caudal vertebrae num... 51 | 53
decreased blood urea nitrogen ... 50 | 51
abnormal skin morphology 49 | 50
decreased circulating total pr... 49 | 49
decreased mean corpuscular hem... 49 | 50
decreased circulating alanine ... 47 | 47
increased blood urea nitrogen ... 47 | 48
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased leukocyte cell numbe... 45 | 47
increased neutrophil cell numb... 45 | 46
increased mean platelet volume 44 | 45
abnormal testis morphology 43 | 43
increased hematocrit 43 | 46
increased circulating triglyce... 42 | 42
increased hemoglobin content 42 | 45
abnormal epididymis morphology 41 | 42
decreased neutrophil cell numb... 41 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
decreased circulating LDL chol... 38 | 38
increased erythrocyte cell num... 38 | 39
prolonged QT interval 38 | 38

Disease

Carcinoma 11,012 | 11,493
ovarian cancer 8,259 | 8,520
osteosarcoma 7,628 | 7,950
psoriasis 6,304 | 6,694
medulloblastoma, large-cell 6,054 | 6,241
glioblastoma 5,651 | 5,792
atypical teratoid / rhabdoid tumor 4,979 | 5,112
lung cancer 4,581 | 4,740
ependymoma 4,551 | 4,679
group 3 medulloblastoma 3,988 | 4,104
adult high grade glioma 3,704 | 3,801
Breast cancer 3,486 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,198 | 3,291
malignant mesothelioma 3,146 | 3,232
Astrocytoma, Pilocytic 3,010 | 3,081
primitive neuroectodermal tumor 2,962 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,907 | 2,989
invasive ductal carcinoma 2,894 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,882 | 2,955
non-small cell lung cancer 2,821 | 2,890
oligodendroglioma 2,783 | 2,850
lung carcinoma 2,758 | 2,843
lung adenocarcinoma 2,634 | 2,716
astrocytic glioma 2,528 | 2,597
Kidney cancer 2,524 | 2,613
Cancer 2,357 | 2,499
pancreatic cancer 2,336 | 2,398
interstitial cystitis 2,234 | 2,312
subependymal giant cell astrocytoma 2,232 | 2,287
tuberculosis 1,949 | 2,010
pituitary cancer 1,918 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,913 | 1,962
Pick disease 1,854 | 1,894
group 4 medulloblastoma 1,810 | 1,855
ulcerative colitis 1,765 | 1,819
ductal carcinoma in situ 1,715 | 1,745
cystic fibrosis 1,642 | 1,696
breast carcinoma 1,593 | 1,638
diabetes mellitus 1,569 | 1,728
colon cancer 1,427 | 1,478
Autosomal recessive predisposition 1,424 | 1,442
adrenocortical carcinoma 1,392 | 1,428
Multiple myeloma 1,302 | 1,332
juvenile dermatomyositis 1,157 | 1,187
acute quadriplegic myopathy 1,133 | 1,158
Rheumatoid arthritis 1,130 | 1,191
Schizophrenia 1,122 | 1,160
astrocytoma 1,122 | 1,146
primary pancreatic ductal adenocarcinoma 1,087 | 1,109
spina bifida 1,051 | 1,074
pediatric high grade glioma 1,034 | 1,064
nasopharyngeal carcinoma 1,026 | 1,058
cutaneous lupus erythematosus 1,013 | 1,057
Intellectual disability 998 | 1,016
Atopic dermatitis 922 | 952
dermatomyositis 913 | 966
active Crohn's disease 892 | 922
non primary Sjogren syndrome sicca 862 | 891
gastric carcinoma 791 | 807
Epilepsy 781 | 792
acute myeloid leukemia 763 | 783
Waldenstrons macroglobulinemia 758 | 765
Liver Cirrhosis, Experimental 756 | 769
active ulcerative colitis 747 | 764
esophageal adenocarcinoma 715 | 737
primary Sjogren syndrome 709 | 735
medulloblastoma 696 | 720
Melanoma 690 | 711
Obesity 667 | 678
aldosterone-producing adenoma 658 | 665
progressive supranuclear palsy 655 | 676
Bipolar Disorder 650 | 666
Dull intelligence 637 | 645
Low intelligence 637 | 645
Mental Retardation 637 | 645
Mental deficiency 637 | 645
Poor school performance 637 | 645
Alzheimer's disease 633 | 658
Cognitive delay 600 | 608
Global developmental delay 600 | 608
Mental and motor retardation 600 | 608
Duchenne muscular dystrophy 592 | 601
Seizures 589 | 596
Liver cancer 585 | 604
Muscle hypotonia 566 | 571
fibroadenoma 548 | 559
pancreatic carcinoma 545 | 562
hepatocellular carcinoma 526 | 547
Endometriosis 523 | 540
Short stature 522 | 531
Multiple Sclerosis 514 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 503 | 510
chronic rhinosinusitis 500 | 512
Down syndrome 483 | 499
Prostatic Neoplasms 481 | 495
mucosa-associated lymphoid tissue lymphoma 459 | 484
posterior fossa group A ependymoma 459 | 468
sonic hedgehog group medulloblastoma 456 | 467
Skin cancer 455 | 469
Amyotrophic lateral sclerosis 443 | 451

Tissue

Endocrine System 17,194 | 18,159
Female tissues 16,569 | 17,400
Digestive Tract 16,563 | 17,369
Skin and soft tissues 16,431 | 17,230
Male tissues 16,360 | 17,142
Blood and immune system 16,138 | 16,909
Nervous System 16,025 | 16,725
Liver and Pancreas 16,019 | 16,750
Urinary Tract 15,977 | 16,678
Respiratory system 15,676 | 16,393
Cardiovascular System 14,604 | 15,192

Target Family

Non-IDG 10,215 | 12,091
Enzyme 3,932 | 4,145
Transcription Factor 1,303 | 1,400
Kinase 616 | 634
Transporter 462 | 473
GPCR 387 | 408
oGPCR 344 | 421
Ion Channel 337 | 344
Epigenetic 238 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 37 | 38

Data Source

OMA 17,919 | 17,919
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93