Development Level

Tbio 2,862 | 11,445
Tchem 507 | 1,598
Tclin 310 | 613
Tdark 147 | 6,588

Collection

RFA-RM-18-021 38 | 328
Ion Channel: IDG Consortium (T... 20 | 99
Kinase: IDG Consortium (Target... 12 | 125
GPCR: IDG Consortium (Targets) 7 | 126
Kinase: IDG Consortium (Comple... 7 | 37
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 350 | 979
preweaning lethality, incomple... 134 | 499
embryonic lethality prior to t... 102 | 278
embryonic lethality prior to o... 92 | 239
abnormal behavior 87 | 298
abnormal embryo size 76 | 220
decreased body weight 62 | 161
decreased vertical activity 62 | 208
enlarged heart 58 | 210
decreased total body fat amoun... 53 | 207
abnormal bone structure 47 | 187
hypoactivity 47 | 132
increased circulating alkaline... 46 | 122
decreased bone mineral content 45 | 151
increased lean body mass 44 | 172
increased total body fat amoun... 44 | 134
decreased bone mineral density 43 | 126
abnormal heart morphology 42 | 162
increased startle reflex 40 | 112
hyperactivity 39 | 148
abnormal seminal vesicle morph... 38 | 114
decreased lean body mass 36 | 135
increased mean corpuscular hem... 36 | 96
increased or absent threshold ... 36 | 101
embryonic growth retardation 35 | 106
decreased circulating choleste... 33 | 93
abnormal lens morphology 32 | 81
decreased mean corpuscular vol... 32 | 79
cataract 31 | 92
male infertility 31 | 123
decreased startle reflex 30 | 75
decreased prepulse inhibition 29 | 82
short tibia 29 | 97
decreased grip strength 28 | 116
impaired glucose tolerance 28 | 75
prenatal lethality prior to he... 28 | 87
small superior vagus ganglion 28 | 74
abnormal retina morphology 27 | 71
decreased circulating glucose ... 27 | 126
decreased lymphocyte cell numb... 27 | 83
decreased body length 25 | 101
decreased circulating HDL chol... 25 | 68
decreased circulating triglyce... 25 | 79
increased bone mineral content 25 | 108
increased bone mineral density 24 | 72
decreased erythrocyte cell num... 23 | 62
decreased hemoglobin content 23 | 68
increased fasted circulating g... 23 | 76
increased heart weight 23 | 62
abnormal eye morphology 22 | 68
decreased circulating serum al... 22 | 82
improved glucose tolerance 22 | 79
increased circulating choleste... 22 | 66
increased circulating sodium l... 22 | 71
thrombocytopenia 22 | 56
abnormal gait 21 | 69
abnormal kidney morphology 21 | 65
decreased fasted circulating g... 21 | 65
decreased leukocyte cell numbe... 21 | 73
hydrometra 21 | 53
increased circulating HDL chol... 21 | 80
edema 20 | 59
increased mean corpuscular vol... 20 | 92
small testis 20 | 58
abnormal coat-hair pigmentatio... 19 | 64
decreased circulating alkaline... 19 | 46
enlarged lymph nodes 19 | 37
increased leukocyte cell numbe... 19 | 47
decreased blood urea nitrogen ... 18 | 51
decreased circulating amylase ... 18 | 28
increased neutrophil cell numb... 18 | 46
decreased neutrophil cell numb... 17 | 42
increased blood urea nitrogen ... 17 | 48
increased mean platelet volume 16 | 45
persistence of hyaloid vascula... 16 | 33
tremors 16 | 39
abnormal neural tube closure 15 | 46
abnormal testis morphology 15 | 43
decreased circulating insulin ... 15 | 76
decreased mean corpuscular hem... 15 | 50
increased hemoglobin content 15 | 45
increased lymphocyte cell numb... 15 | 32
limb grasping 15 | 41
pallor 15 | 34
abnormal behavioral response t... 14 | 66
abnormal skin morphology 14 | 50
abnormal sleep behavior 14 | 70
corneal opacity 14 | 32
decreased circulating alanine ... 14 | 47
decreased heart weight 14 | 27
female infertility 14 | 60
increased circulating amylase ... 14 | 25
increased circulating triglyce... 14 | 42
abnormal embryo turning 13 | 31
abnormal retinal vasculature m... 13 | 27
decreased circulating LDL chol... 13 | 38
decreased red blood cell distr... 13 | 41
increased circulating calcium ... 13 | 34
increased circulating chloride... 13 | 41
prolonged ST segment 12 | 36

Disease

Carcinoma 2,720 | 11,493
ovarian cancer 1,962 | 8,520
osteosarcoma 1,708 | 7,950
psoriasis 1,566 | 6,694
Autosomal recessive predisposition 1,405 | 1,442
medulloblastoma, large-cell 1,363 | 6,241
glioblastoma 1,306 | 5,792
lung cancer 1,266 | 4,740
atypical teratoid / rhabdoid tumor 1,118 | 5,112
ependymoma 1,090 | 4,679
Cancer 926 | 2,499
group 3 medulloblastoma 922 | 4,104
Breast cancer 916 | 3,578
malignant mesothelioma 871 | 3,232
Kidney cancer 836 | 2,613
Intellectual disability 826 | 1,016
adult high grade glioma 812 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 794 | 3,291
lung carcinoma 751 | 2,843
Astrocytoma, Pilocytic 747 | 3,081
non-small cell lung cancer 733 | 2,890
invasive ductal carcinoma 724 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 710 | 2,955
lung adenocarcinoma 700 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 695 | 2,989
primitive neuroectodermal tumor 661 | 3,035
oligodendroglioma 654 | 2,850
Epilepsy 631 | 792
pancreatic cancer 624 | 2,398
Dull intelligence 617 | 645
Low intelligence 617 | 645
Mental Retardation 617 | 645
Mental deficiency 617 | 645
Poor school performance 617 | 645
Cognitive delay 583 | 608
Global developmental delay 583 | 608
Mental and motor retardation 583 | 608
interstitial cystitis 578 | 2,312
astrocytic glioma 577 | 2,597
Muscle hypotonia 548 | 571
diabetes mellitus 542 | 1,728
subependymal giant cell astrocytoma 540 | 2,287
Seizures 539 | 596
pancreatic ductal adenocarcinoma liver metastasis 524 | 1,962
tuberculosis 521 | 2,010
Short stature 507 | 531
ulcerative colitis 502 | 1,819
pituitary cancer 498 | 1,972
breast carcinoma 458 | 1,638
ductal carcinoma in situ 456 | 1,745
Pick disease 453 | 1,894
cystic fibrosis 452 | 1,696
colon cancer 415 | 1,478
Schizophrenia 404 | 1,160
group 4 medulloblastoma 397 | 1,855
Rheumatoid arthritis 363 | 1,191
adrenocortical carcinoma 360 | 1,428
Failure to gain weight 352 | 365
Pediatric failure to thrive 352 | 365
Small head 352 | 374
Obesity 339 | 678
astrocytoma 312 | 1,146
Neurodegenerative disease 308 | 414
Nystagmus 306 | 317
cutaneous lupus erythematosus 290 | 1,057
Multiple myeloma 288 | 1,332
acute quadriplegic myopathy 285 | 1,158
juvenile dermatomyositis 284 | 1,187
Cerebellar Ataxia 283 | 304
Sensorineural Hearing Loss (disorder) 277 | 284
Cataract 273 | 297
Curvature of spine 269 | 282
nasopharyngeal carcinoma 269 | 1,058
Acquired scoliosis 268 | 281
Melanoma 266 | 711
dermatomyositis 265 | 966
pediatric high grade glioma 265 | 1,064
Anemia 261 | 365
Hypoplastic mandible condyle 261 | 275
Mandibular hypoplasia 261 | 275
Micrognathism 261 | 275
primary pancreatic ductal adenocarcinoma 261 | 1,109
Strabismus 259 | 270
Hepatomegaly 252 | 285
Cryptorchidism 250 | 296
Atopic dermatitis 246 | 952
Depressive disorder 238 | 409
Kidney disease 237 | 430
Liver cancer 236 | 604
Bipolar Disorder 235 | 666
spina bifida 234 | 1,074
Infantile onset 233 | 238
Liver Cirrhosis, Experimental 233 | 769
Orbital separation excessive 232 | 244
Lens Opacities 225 | 231
Broad flat nasal bridge 224 | 236
Nasal bridge wide 224 | 236
Blepharoptosis 221 | 231
Optic Atrophy 221 | 242
active Crohn's disease 219 | 922

Tissue

Endocrine System 3,654 | 18,159
Digestive Tract 3,581 | 17,369
Female tissues 3,549 | 17,400
Skin and soft tissues 3,546 | 17,230
Male tissues 3,505 | 17,142
Blood and immune system 3,476 | 16,909
Liver and Pancreas 3,475 | 16,750
Urinary Tract 3,465 | 16,678
Nervous System 3,451 | 16,725
Respiratory system 3,376 | 16,393
Cardiovascular System 3,158 | 15,192

Target Family

Non-IDG 1,949 | 12,091
Enzyme 1,014 | 4,145
Transcription Factor 288 | 1,400
Kinase 166 | 634
Transporter 134 | 473
Ion Channel 131 | 344
GPCR 72 | 408
Epigenetic 42 | 242
Nuclear Receptor 21 | 48
TF/Epigenetic 8 | 38
oGPCR 1 | 421

Data Source

Monarch 3,826 | 3,826
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298