Development Level

Tbio 10,336 | 11,445
Tdark 2,704 | 6,588
Tchem 1,529 | 1,598
Tclin 600 | 613

Collection

RFA-RM-18-021 258 | 328
GPCR: IDG Consortium (Targets) 99 | 126
Kinase: IDG Consortium (Target... 98 | 125
Ion Channel: IDG Consortium (T... 78 | 99
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 890 | 979
preweaning lethality, incomple... 427 | 499
abnormal behavior 262 | 298
embryonic lethality prior to t... 256 | 278
embryonic lethality prior to o... 217 | 239
abnormal embryo size 205 | 220
enlarged heart 192 | 210
decreased vertical activity 190 | 208
decreased total body fat amoun... 177 | 207
abnormal bone structure 162 | 187
abnormal heart morphology 148 | 162
increased lean body mass 147 | 172
decreased body weight 145 | 161
decreased bone mineral content 132 | 151
hyperactivity 125 | 148
hypoactivity 122 | 132
increased total body fat amoun... 121 | 134
decreased bone mineral density 112 | 126
decreased circulating glucose ... 112 | 126
abnormal seminal vesicle morph... 110 | 114
decreased lean body mass 110 | 135
increased circulating alkaline... 106 | 122
increased startle reflex 101 | 112
male infertility 99 | 123
decreased grip strength 98 | 116
embryonic growth retardation 98 | 106
increased bone mineral content 92 | 108
increased or absent threshold ... 91 | 101
decreased body length 89 | 101
short tibia 87 | 97
increased mean corpuscular hem... 86 | 96
decreased circulating choleste... 83 | 93
cataract 80 | 92
prenatal lethality prior to he... 80 | 87
increased mean corpuscular vol... 77 | 92
decreased lymphocyte cell numb... 75 | 83
abnormal lens morphology 72 | 81
decreased circulating serum al... 72 | 82
decreased circulating triglyce... 72 | 79
decreased prepulse inhibition 72 | 82
impaired glucose tolerance 72 | 75
improved glucose tolerance 72 | 79
decreased mean corpuscular vol... 71 | 79
decreased startle reflex 71 | 75
increased circulating HDL chol... 71 | 80
small superior vagus ganglion 70 | 74
decreased circulating insulin ... 69 | 76
abnormal retina morphology 67 | 71
abnormal eye morphology 66 | 68
abnormal kidney morphology 64 | 65
increased fasted circulating g... 64 | 76
abnormal gait 62 | 69
increased bone mineral density 61 | 72
increased circulating sodium l... 61 | 71
abnormal sleep behavior 59 | 70
decreased fasted circulating g... 59 | 65
decreased hemoglobin content 59 | 68
decreased leukocyte cell numbe... 59 | 73
edema 59 | 59
decreased circulating HDL chol... 58 | 68
increased monocyte cell number 58 | 63
decreased erythrocyte cell num... 57 | 62
increased circulating choleste... 57 | 66
abnormal behavioral response t... 55 | 66
abnormal coat-hair pigmentatio... 55 | 64
increased heart weight 55 | 62
small testis 51 | 58
hydrometra 50 | 53
thrombocytopenia 50 | 56
abnormal spleen morphology 47 | 55
female infertility 47 | 60
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
abnormal skin morphology 44 | 50
increased leukocyte cell numbe... 44 | 47
decreased blood urea nitrogen ... 43 | 51
increased hemoglobin content 43 | 45
decreased circulating alanine ... 42 | 47
increased blood urea nitrogen ... 42 | 48
decreased caudal vertebrae num... 41 | 53
decreased circulating alkaline... 41 | 46
decreased mean corpuscular hem... 41 | 50
increased neutrophil cell numb... 41 | 46
increased circulating chloride... 40 | 41
increased hematocrit 40 | 46
abnormal testis morphology 39 | 43
abnormal epididymis morphology 38 | 42
decreased hematocrit 38 | 46
increased circulating triglyce... 38 | 42
increased erythrocyte cell num... 37 | 39
increased grip strength 37 | 41
limb grasping 37 | 41
prolonged QT interval 37 | 38
enlarged spleen 36 | 41
abnormal bone mineralization 35 | 38
decreased neutrophil cell numb... 35 | 42
increased mean platelet volume 35 | 45
prolonged ST segment 35 | 36
tremors 35 | 39
decreased circulating creatini... 34 | 39

Disease

Carcinoma 9,438 | 11,493
ovarian cancer 7,221 | 8,520
osteosarcoma 6,517 | 7,950
psoriasis 5,688 | 6,694
medulloblastoma, large-cell 5,253 | 6,241
glioblastoma 4,956 | 5,792
atypical teratoid / rhabdoid tumor 4,317 | 5,112
lung cancer 4,200 | 4,740
ependymoma 3,960 | 4,679
group 3 medulloblastoma 3,481 | 4,104
adult high grade glioma 3,208 | 3,801
Breast cancer 3,127 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,867 | 3,291
malignant mesothelioma 2,862 | 3,232
Astrocytoma, Pilocytic 2,648 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,607 | 2,989
invasive ductal carcinoma 2,599 | 2,951
non-small cell lung cancer 2,581 | 2,890
primitive neuroectodermal tumor 2,569 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,556 | 2,955
Cancer 2,486 | 2,499
lung carcinoma 2,477 | 2,843
oligodendroglioma 2,437 | 2,850
lung adenocarcinoma 2,387 | 2,716
Kidney cancer 2,268 | 2,613
astrocytic glioma 2,198 | 2,597
pancreatic cancer 2,130 | 2,398
interstitial cystitis 2,026 | 2,312
subependymal giant cell astrocytoma 1,957 | 2,287
tuberculosis 1,745 | 2,010
pituitary cancer 1,724 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,697 | 1,962
Pick disease 1,627 | 1,894
ulcerative colitis 1,609 | 1,819
group 4 medulloblastoma 1,542 | 1,855
ductal carcinoma in situ 1,533 | 1,745
cystic fibrosis 1,503 | 1,696
diabetes mellitus 1,479 | 1,728
breast carcinoma 1,435 | 1,638
Autosomal recessive predisposition 1,428 | 1,442
colon cancer 1,340 | 1,478
adrenocortical carcinoma 1,253 | 1,428
Multiple myeloma 1,188 | 1,332
Schizophrenia 1,097 | 1,160
Rheumatoid arthritis 1,080 | 1,191
juvenile dermatomyositis 1,040 | 1,187
astrocytoma 1,033 | 1,146
acute quadriplegic myopathy 1,018 | 1,158
Intellectual disability 996 | 1,016
primary pancreatic ductal adenocarcinoma 979 | 1,109
cutaneous lupus erythematosus 964 | 1,057
spina bifida 930 | 1,074
nasopharyngeal carcinoma 914 | 1,058
pediatric high grade glioma 910 | 1,064
dermatomyositis 880 | 966
Atopic dermatitis 858 | 952
active Crohn's disease 810 | 922
Epilepsy 786 | 792
non primary Sjogren syndrome sicca 739 | 891
Liver Cirrhosis, Experimental 718 | 769
Waldenstrons macroglobulinemia 700 | 765
gastric carcinoma 700 | 807
esophageal adenocarcinoma 676 | 737
active ulcerative colitis 673 | 764
acute myeloid leukemia 669 | 783
Obesity 658 | 678
Melanoma 652 | 711
primary Sjogren syndrome 650 | 735
Bipolar Disorder 638 | 666
Dull intelligence 638 | 645
Low intelligence 638 | 645
Mental Retardation 638 | 645
Mental deficiency 638 | 645
Poor school performance 638 | 645
Alzheimer's disease 609 | 658
Cognitive delay 602 | 608
Global developmental delay 602 | 608
Mental and motor retardation 602 | 608
aldosterone-producing adenoma 592 | 665
Seizures 591 | 596
medulloblastoma 584 | 720
progressive supranuclear palsy 572 | 676
Muscle hypotonia 568 | 571
Duchenne muscular dystrophy 552 | 601
Liver cancer 550 | 604
Short stature 525 | 531
Multiple Sclerosis 495 | 540
Endometriosis 492 | 540
fibroadenoma 490 | 559
Down syndrome 477 | 499
pancreatic carcinoma 476 | 562
Prostatic Neoplasms 473 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 468 | 510
hepatocellular carcinoma 463 | 547
mucosa-associated lymphoid tissue lymphoma 436 | 484
chronic rhinosinusitis 429 | 512
Breast Neoplasms 428 | 445
Skin cancer 428 | 469
Kidney disease 423 | 430
Amyotrophic lateral sclerosis 413 | 451

Tissue

Endocrine System 14,498 | 18,159
Digestive Tract 14,038 | 17,369
Female tissues 14,015 | 17,400
Skin and soft tissues 13,932 | 17,230
Male tissues 13,830 | 17,142
Blood and immune system 13,663 | 16,909
Liver and Pancreas 13,562 | 16,750
Nervous System 13,542 | 16,725
Urinary Tract 13,535 | 16,678
Respiratory system 13,272 | 16,393
Cardiovascular System 12,383 | 15,192

Target Family

Non-IDG 8,621 | 12,091
Enzyme 3,434 | 4,145
Transcription Factor 1,071 | 1,400
Kinase 581 | 634
Transporter 420 | 473
GPCR 363 | 408
Ion Channel 315 | 344
Epigenetic 211 | 242
oGPCR 70 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 36 | 38

Data Source

JensenLab Text Mining 15,169 | 15,169
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19