Development Level

Tbio 9,479 | 10,625
Tdark 2,896 | 7,003
Tchem 1,773 | 1,890
Tclin 589 | 602

Collection

Eligible Kinase Proteins 106 | 134
Eligible non-olfactory GPCR Proteins 104 | 145
Eligible Ion Channel Proteins 91 | 117

IMPC Term

preweaning lethality, complete... 569 | 633
preweaning lethality, incomple... 220 | 260
abnormal behavior 192 | 226
embryonic lethality prior to t... 168 | 187
decreased lean body mass 167 | 195
decreased total body fat amoun... 159 | 186
decreased body weight 153 | 174
decreased bone mineral content 141 | 157
embryonic lethality prior to o... 129 | 148
decreased bone mineral density 115 | 126
abnormal bone structure 111 | 131
increased or absent threshold ... 108 | 128
decreased grip strength 107 | 123
abnormal embryo size 106 | 112
increased circulating alkaline... 106 | 119
decreased circulating glucose ... 101 | 121
decreased body length 100 | 108
enlarged heart 100 | 111
abnormal retina morphology 92 | 100
increased mean corpuscular hem... 87 | 93
hyperactivity 86 | 108
increased lean body mass 84 | 107
hypoactivity 82 | 89
decreased circulating choleste... 80 | 85
increased mean corpuscular vol... 77 | 91
increased bone mineral content 73 | 92
increased grip strength 73 | 83
short tibia 73 | 82
decreased circulating HDL chol... 71 | 77
decreased circulating triglyce... 71 | 83
decreased circulating insulin ... 69 | 75
abnormal lens morphology 67 | 73
decreased circulating serum al... 65 | 79
increased circulating sodium l... 61 | 71
increased fasted circulating g... 59 | 68
prenatal lethality prior to he... 57 | 64
increased circulating HDL chol... 55 | 63
abnormal retinal pigmentation 53 | 61
improved glucose tolerance 52 | 56
male infertility 51 | 62
decreased circulating alanine ... 50 | 53
decreased lumbar vertebrae num... 50 | 62
abnormal bone mineralization 49 | 55
abnormal coat/hair pigmentatio... 49 | 54
abnormal sleep behavior 49 | 63
impaired glucose tolerance 49 | 52
increased exploration in new e... 49 | 56
decreased prepulse inhibition 48 | 52
increased circulating choleste... 48 | 53
increased sacral vertebrae num... 48 | 62
increased total body fat amoun... 48 | 57
abnormal gait 47 | 51
decreased hemoglobin content 47 | 53
decreased rib number 46 | 59
decreased fasted circulating g... 45 | 49
decreased mean corpuscular vol... 45 | 50
decreased startle reflex 45 | 48
decreased caudal vertebrae num... 44 | 49
abnormal heart morphology 43 | 51
thrombocytopenia 43 | 46
decreased leukocyte cell numbe... 42 | 54
increased hemoglobin content 42 | 45
abnormal behavioral response t... 41 | 52
abnormal seminal vesicle morph... 41 | 47
increased bone mineral density 41 | 52
decreased erythrocyte cell num... 40 | 43
decreased heart weight 40 | 44
increased circulating chloride... 40 | 43
decreased circulating total pr... 38 | 41
increased blood urea nitrogen ... 38 | 44
abnormal neural tube closure 37 | 37
decreased circulating alkaline... 37 | 41
abnormal eye morphology 35 | 38
decreased eosinophil cell numb... 35 | 41
increased body weight 35 | 42
increased startle reflex 35 | 38
increased leukocyte cell numbe... 34 | 37
decreased circulating LDL chol... 33 | 37
decreased circulating free fat... 33 | 39
cardiovascular system phenotyp... 32 | 35
abnormal spleen morphology 31 | 36
decreased mean corpuscular hem... 31 | 34
increased heart weight 31 | 37
increased rib number 31 | 41
limb grasping 31 | 35
tremors 31 | 34
abnormal cranium morphology 30 | 32
female infertility 30 | 34
increased hematocrit 30 | 36
decreased circulating calcium ... 29 | 33
decreased circulating fructosa... 29 | 31
increased circulating calcium ... 29 | 32
small testis 29 | 37
decreased T cell number 28 | 31
decreased blood urea nitrogen ... 28 | 31
abnormal epididymis morphology 27 | 31
abnormal kidney morphology 27 | 30
decreased circulating chloride... 27 | 32
decreased circulating creatini... 27 | 31
decreased neutrophil cell numb... 27 | 37

Disease

ovarian cancer 7,008 | 8,492
osteosarcoma 6,330 | 7,933
psoriasis 5,551 | 6,685
medulloblastoma, large-cell 5,118 | 6,234
glioblastoma 4,637 | 5,572
lung cancer 3,911 | 4,473
atypical teratoid / rhabdoid tumor 3,585 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,779 | 3,289
malignant mesothelioma 2,732 | 3,163
Breast cancer 2,651 | 3,099
pilocytic astrocytoma 2,579 | 3,086
invasive ductal carcinoma 2,535 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,526 | 2,988
primitive neuroectodermal tumor 2,501 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,476 | 2,956
non-small cell lung cancer 2,443 | 2,798
lung carcinoma 2,423 | 2,844
oligodendroglioma 2,367 | 2,849
lung adenocarcinoma 2,340 | 2,714
Cancer 2,330 | 2,346
pediatric high grade glioma 2,273 | 2,712
ependymoma 2,043 | 2,514
pancreatic cancer 2,007 | 2,300
interstitial cystitis 1,975 | 2,299
subependymal giant cell astrocytoma 1,906 | 2,287
Carcinoma 1,859 | 2,147
group 3 medulloblastoma 1,853 | 2,254
astrocytic glioma 1,822 | 2,241
ulcerative colitis 1,795 | 2,087
adult high grade glioma 1,735 | 2,148
pituitary cancer 1,675 | 1,972
Pick disease 1,575 | 1,893
group 4 medulloblastoma 1,558 | 1,875
ductal carcinoma in situ 1,496 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 1,494 | 1,795
cystic fibrosis 1,452 | 1,670
diabetes mellitus 1,391 | 1,663
breast carcinoma 1,383 | 1,614
tuberculosis 1,331 | 1,563
colon cancer 1,319 | 1,475
astrocytoma 1,318 | 1,493
posterior fossa group A ependymoma 1,283 | 1,511
medulloblastoma 1,231 | 1,524
adrenocortical carcinoma 1,223 | 1,427
posterior fossa group B ependymoma 1,198 | 1,530
sonic hedgehog group medulloblastoma 1,191 | 1,482
Multiple myeloma 1,164 | 1,328
primary pancreatic ductal adenocarcinoma 1,116 | 1,271
Rheumatoid Arthritis 1,047 | 1,171
juvenile dermatomyositis 1,012 | 1,189
acute quadriplegic myopathy 999 | 1,157
cutaneous lupus erythematosus 949 | 1,056
atypical teratoid/rhabdoid tumor 899 | 1,095
spina bifida 895 | 1,064
nasopharyngeal carcinoma 883 | 1,056
dermatomyositis 863 | 967
Atopic dermatitis 835 | 944
active Crohn's disease 787 | 918
gastric carcinoma 711 | 832
Waldenstrons macroglobulinemia 688 | 765
primary Sjogren syndrome 688 | 789
esophageal adenocarcinoma 669 | 737
non primary Sjogren syndrome sicca 661 | 840
acute myeloid leukemia 657 | 785
Obesity 585 | 616
aldosterone-producing adenoma 579 | 664
Alzheimer's disease 578 | 644
Intellectual disability 558 | 573
progressive supranuclear palsy 557 | 674
Duchenne muscular dystrophy 546 | 602
tuberculosis and treatment for 6 months 542 | 686
Down syndrome 508 | 548
Endometriosis 482 | 535
fibroadenoma 477 | 557
pancreatic carcinoma 476 | 567
Schizophrenia 470 | 503
Multiple Sclerosis 453 | 498
autosomal dominant Emery-Dreifuss muscular dystrophy 453 | 499
hepatocellular carcinoma 449 | 550
Prostatic Neoplasms 444 | 471
active ulcerative colitis 418 | 477
mucosa-associated lymphoid tissue lymphoma 418 | 480
chronic rhinosinusitis 410 | 512
IGA Glomerulonephritis 406 | 454
Mammary Neoplasms 391 | 410
Amyotrophic Lateral Sclerosis 390 | 432
Kidney disease 390 | 397
Neurodegenerative disease 379 | 383
gastric cancer 363 | 436
non-small cell lung carcinoma 356 | 413
Parkinson's disease 344 | 364
inflammatory breast cancer 343 | 404
Epilepsy 341 | 346
Asthma 340 | 349
sarcoidosis 312 | 368
Autistic Disorder 308 | 320
nephrosclerosis 308 | 329
Polycystic Ovary Syndrome 300 | 335
Hypertension 293 | 293
glioblastoma multiforme 292 | 347

Tissue

Female tissues 14,332 | 18,647
Nervous System 14,313 | 18,561
Endocrine System 14,297 | 18,512
Digestive Tract 14,282 | 18,473
Urinary Tract 14,228 | 18,444
Liver and Pancreas 14,107 | 18,136
Skin and soft tissues 14,084 | 18,115
Blood and immune system 14,012 | 17,995
Male tissues 14,006 | 17,969
Cardiovascular System 13,997 | 17,958
Respiratory system 13,710 | 17,484

Target Family

Non-IDG 8,324 | 11,969
Enzyme 3,343 | 4,146
Transcription Factor 1,055 | 1,400
Kinase 575 | 634
Transporter 417 | 473
GPCR 356 | 408
Ion Channel 308 | 341
Epigenetic 212 | 242
oGPCR 64 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 36 | 38

Data Source

JensenLab Text Mining 14,737 | 14,737
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101