Development Level

Tbio 10,064 | 11,178
Tdark 2,686 | 6,569
Tchem 1,776 | 1,885
Tclin 598 | 612

Collection

GPCR: IDG Consortium (Targets) 99 | 126
Kinase: IDG Consortium (Target... 96 | 125
Ion Channel: IDG Consortium (T... 78 | 99
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 889 | 979
preweaning lethality, incomple... 427 | 499
abnormal behavior 261 | 298
embryonic lethality prior to t... 256 | 278
embryonic lethality prior to o... 217 | 239
abnormal embryo size 205 | 220
enlarged heart 192 | 210
decreased vertical activity 190 | 208
decreased total body fat amoun... 177 | 207
abnormal bone structure 162 | 187
abnormal heart morphology 148 | 162
increased lean body mass 147 | 172
decreased body weight 145 | 161
decreased bone mineral content 132 | 151
hyperactivity 124 | 148
hypoactivity 122 | 132
increased total body fat amoun... 121 | 134
decreased bone mineral density 112 | 126
decreased circulating glucose ... 112 | 126
abnormal seminal vesicle morph... 110 | 114
decreased lean body mass 110 | 135
increased circulating alkaline... 106 | 122
increased startle reflex 101 | 112
male infertility 99 | 123
decreased grip strength 98 | 116
embryonic growth retardation 98 | 106
increased bone mineral content 92 | 108
increased or absent threshold ... 91 | 101
decreased body length 89 | 101
short tibia 87 | 97
increased mean corpuscular hem... 86 | 96
decreased circulating choleste... 83 | 93
cataract 80 | 92
prenatal lethality prior to he... 80 | 87
increased mean corpuscular vol... 77 | 92
decreased lymphocyte cell numb... 75 | 83
abnormal lens morphology 72 | 81
decreased circulating serum al... 72 | 82
decreased circulating triglyce... 72 | 79
impaired glucose tolerance 72 | 75
improved glucose tolerance 72 | 79
decreased mean corpuscular vol... 71 | 79
decreased prepulse inhibition 71 | 82
decreased startle reflex 71 | 75
increased circulating HDL chol... 71 | 80
small superior vagus ganglion 70 | 74
decreased circulating insulin ... 69 | 76
abnormal retina morphology 67 | 71
abnormal eye morphology 66 | 68
abnormal kidney morphology 64 | 65
increased fasted circulating g... 64 | 76
abnormal gait 61 | 69
increased bone mineral density 61 | 72
increased circulating sodium l... 61 | 71
abnormal sleep behavior 59 | 70
decreased fasted circulating g... 59 | 65
decreased hemoglobin content 59 | 68
decreased leukocyte cell numbe... 59 | 73
edema 59 | 59
decreased circulating HDL chol... 58 | 68
increased monocyte cell number 58 | 63
decreased erythrocyte cell num... 57 | 62
increased circulating choleste... 57 | 66
abnormal behavioral response t... 55 | 66
abnormal coat-hair pigmentatio... 55 | 64
increased heart weight 55 | 62
small testis 51 | 58
hydrometra 50 | 53
thrombocytopenia 50 | 56
abnormal spleen morphology 47 | 55
female infertility 47 | 60
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
abnormal skin morphology 44 | 50
increased leukocyte cell numbe... 44 | 47
decreased blood urea nitrogen ... 43 | 51
increased hemoglobin content 43 | 45
decreased circulating alanine ... 42 | 47
decreased caudal vertebrae num... 41 | 53
decreased circulating alkaline... 41 | 46
decreased mean corpuscular hem... 41 | 50
increased blood urea nitrogen ... 41 | 48
increased neutrophil cell numb... 41 | 46
increased hematocrit 40 | 46
abnormal testis morphology 39 | 43
increased circulating chloride... 39 | 41
abnormal epididymis morphology 38 | 42
decreased hematocrit 38 | 46
increased circulating triglyce... 38 | 42
increased erythrocyte cell num... 37 | 39
increased grip strength 37 | 41
prolonged QT interval 37 | 38
enlarged spleen 36 | 41
limb grasping 36 | 41
abnormal bone mineralization 35 | 38
decreased neutrophil cell numb... 35 | 42
increased mean platelet volume 35 | 45
prolonged ST segment 35 | 36
tremors 35 | 39
decreased circulating creatini... 34 | 39

Disease

Carcinoma 9,175 | 11,192
ovarian cancer 7,025 | 8,297
osteosarcoma 6,359 | 7,766
psoriasis 5,525 | 6,514
medulloblastoma, large-cell 5,118 | 6,086
glioblastoma 4,815 | 5,635
atypical teratoid / rhabdoid tumor 4,194 | 4,971
lung cancer 4,080 | 4,607
ependymoma 3,850 | 4,559
group 3 medulloblastoma 3,393 | 4,002
adult high grade glioma 3,121 | 3,701
Breast cancer 3,025 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,786 | 3,204
malignant mesothelioma 2,775 | 3,135
Astrocytoma, Pilocytic 2,576 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,531 | 2,902
invasive ductal carcinoma 2,526 | 2,867
non-small cell lung cancer 2,498 | 2,799
primitive neuroectodermal tumor 2,498 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 2,483 | 2,872
lung carcinoma 2,401 | 2,755
Cancer 2,375 | 2,388
oligodendroglioma 2,362 | 2,768
lung adenocarcinoma 2,305 | 2,627
Kidney cancer 2,206 | 2,548
astrocytic glioma 2,138 | 2,530
pancreatic cancer 2,057 | 2,322
interstitial cystitis 1,959 | 2,237
subependymal giant cell astrocytoma 1,903 | 2,230
tuberculosis 1,705 | 1,963
pituitary cancer 1,670 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,654 | 1,911
Pick disease 1,594 | 1,856
ulcerative colitis 1,559 | 1,765
group 4 medulloblastoma 1,500 | 1,806
ductal carcinoma in situ 1,482 | 1,686
cystic fibrosis 1,440 | 1,629
diabetes mellitus 1,438 | 1,683
Autosomal recessive predisposition 1,393 | 1,407
breast carcinoma 1,391 | 1,589
colon cancer 1,292 | 1,428
adrenocortical carcinoma 1,212 | 1,385
Multiple myeloma 1,158 | 1,296
Schizophrenia 1,073 | 1,136
Rheumatoid arthritis 1,048 | 1,156
juvenile dermatomyositis 1,006 | 1,147
astrocytoma 1,000 | 1,113
acute quadriplegic myopathy 996 | 1,133
Intellectual disability 978 | 998
primary pancreatic ductal adenocarcinoma 942 | 1,071
cutaneous lupus erythematosus 927 | 1,016
spina bifida 910 | 1,053
nasopharyngeal carcinoma 884 | 1,024
pediatric high grade glioma 883 | 1,035
dermatomyositis 856 | 941
Atopic dermatitis 825 | 915
active Crohn's disease 773 | 882
Epilepsy 769 | 775
non primary Sjogren syndrome sicca 710 | 861
Liver Cirrhosis, Experimental 682 | 733
Waldenstrons macroglobulinemia 679 | 742
gastric carcinoma 675 | 781
acute myeloid leukemia 651 | 760
active ulcerative colitis 647 | 736
Obesity 636 | 655
esophageal adenocarcinoma 636 | 696
Melanoma 630 | 689
primary Sjogren syndrome 628 | 710
Dull intelligence 627 | 634
Low intelligence 627 | 634
Mental Retardation 627 | 634
Mental deficiency 627 | 634
Poor school performance 627 | 634
Bipolar Disorder 618 | 646
Alzheimer's disease 591 | 640
Cognitive delay 590 | 596
Global developmental delay 590 | 596
Mental and motor retardation 590 | 596
Seizures 579 | 584
aldosterone-producing adenoma 574 | 646
medulloblastoma 568 | 702
Muscle hypotonia 559 | 562
progressive supranuclear palsy 556 | 656
Duchenne muscular dystrophy 538 | 587
Liver cancer 536 | 589
Short stature 508 | 514
Multiple Sclerosis 482 | 527
Endometriosis 475 | 521
fibroadenoma 470 | 538
pancreatic carcinoma 470 | 555
Down syndrome 459 | 480
hepatocellular carcinoma 454 | 536
Prostatic Neoplasms 450 | 472
autosomal dominant Emery-Dreifuss muscular dystrophy 450 | 492
mucosa-associated lymphoid tissue lymphoma 426 | 473
chronic rhinosinusitis 423 | 505
Skin cancer 410 | 451
Breast Neoplasms 406 | 423
Kidney disease 404 | 411
Amyotrophic lateral sclerosis 399 | 437

Tissue

Endocrine System 14,455 | 18,159
Digestive Tract 13,997 | 17,369
Female tissues 13,974 | 17,400
Skin and soft tissues 13,892 | 17,230
Male tissues 13,791 | 17,142
Blood and immune system 13,621 | 16,909
Liver and Pancreas 13,524 | 16,750
Nervous System 13,505 | 16,725
Urinary Tract 13,496 | 16,678
Respiratory system 13,233 | 16,393
Cardiovascular System 12,348 | 15,192

Target Family

Non-IDG 8,609 | 12,091
Enzyme 3,408 | 4,145
Transcription Factor 1,066 | 1,400
Kinase 579 | 634
Transporter 420 | 473
GPCR 363 | 408
Ion Channel 315 | 344
Epigenetic 211 | 242
oGPCR 70 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 36 | 38

Data Source

JensenLab Text Mining 15,124 | 15,124
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218