Development Level

Tbio 10,019 | 10,625
Tdark 4,259 | 7,003
Tchem 1,815 | 1,890
Tclin 575 | 602

Collection

Eligible Kinase Proteins 122 | 134
Eligible Ion Channel Proteins 104 | 117
Eligible non-olfactory GPCR Proteins 94 | 145

IMPC Term

preweaning lethality, complete... 617 | 633
preweaning lethality, incomple... 249 | 260
abnormal behavior 215 | 226
decreased lean body mass 190 | 195
embryonic lethality prior to t... 183 | 187
decreased total body fat amoun... 177 | 186
decreased body weight 167 | 174
decreased bone mineral content 152 | 157
embryonic lethality prior to o... 146 | 148
abnormal bone structure 128 | 131
decreased bone mineral density 121 | 126
increased or absent threshold ... 121 | 128
increased circulating alkaline... 113 | 119
decreased grip strength 112 | 123
abnormal embryo size 109 | 112
decreased circulating glucose ... 107 | 121
decreased body length 105 | 108
enlarged heart 100 | 111
hyperactivity 100 | 108
increased lean body mass 99 | 107
abnormal retina morphology 98 | 100
increased mean corpuscular hem... 88 | 93
increased mean corpuscular vol... 88 | 91
increased bone mineral content 86 | 92
hypoactivity 84 | 89
decreased circulating choleste... 82 | 85
decreased circulating triglyce... 80 | 83
short tibia 78 | 82
increased grip strength 77 | 83
decreased circulating HDL chol... 75 | 77
decreased circulating serum al... 75 | 79
abnormal lens morphology 72 | 73
decreased circulating insulin ... 70 | 75
increased circulating sodium l... 66 | 71
increased fasted circulating g... 65 | 68
prenatal lethality prior to he... 62 | 64
abnormal sleep behavior 61 | 63
increased circulating HDL chol... 61 | 63
increased sacral vertebrae num... 58 | 62
abnormal retinal pigmentation 57 | 61
decreased lumbar vertebrae num... 57 | 62
male infertility 57 | 62
decreased rib number 56 | 59
increased total body fat amoun... 56 | 57
abnormal bone mineralization 54 | 55
improved glucose tolerance 54 | 56
decreased circulating alanine ... 52 | 53
decreased leukocyte cell numbe... 52 | 54
increased exploration in new e... 52 | 56
abnormal behavioral response t... 51 | 52
abnormal coat/hair pigmentatio... 51 | 54
decreased hemoglobin content 51 | 53
increased circulating choleste... 51 | 53
decreased prepulse inhibition 50 | 52
decreased mean corpuscular vol... 49 | 50
impaired glucose tolerance 49 | 52
increased bone mineral density 49 | 52
decreased fasted circulating g... 48 | 49
abnormal gait 46 | 51
decreased startle reflex 46 | 48
decreased caudal vertebrae num... 45 | 49
thrombocytopenia 45 | 46
abnormal heart morphology 43 | 51
decreased heart weight 43 | 44
abnormal seminal vesicle morph... 42 | 47
decreased erythrocyte cell num... 41 | 43
increased blood urea nitrogen ... 41 | 44
increased circulating chloride... 41 | 43
increased hemoglobin content 41 | 45
decreased circulating alkaline... 40 | 41
decreased circulating total pr... 40 | 41
increased body weight 40 | 42
abnormal eye morphology 38 | 38
decreased circulating free fat... 37 | 39
decreased circulating LDL chol... 36 | 37
decreased eosinophil cell numb... 36 | 41
increased leukocyte cell numbe... 36 | 37
increased startle reflex 36 | 38
abnormal neural tube closure 35 | 37
cardiovascular system phenotyp... 35 | 35
increased rib number 35 | 41
abnormal spleen morphology 34 | 36
increased heart weight 34 | 37
increased hematocrit 34 | 36
small testis 34 | 37
decreased neutrophil cell numb... 33 | 37
tremors 33 | 34
decreased circulating calcium ... 32 | 33
decreased circulating chloride... 32 | 32
decreased mean corpuscular hem... 32 | 34
female infertility 32 | 34
decreased T cell number 31 | 31
increased circulating calcium ... 31 | 32
increased circulating potassiu... 31 | 31
limb grasping 31 | 35
abnormal cranium morphology 30 | 32
abnormal kidney morphology 30 | 30
abnormal epididymis morphology 29 | 31
decreased blood urea nitrogen ... 29 | 31
decreased circulating fructosa... 29 | 31

Disease

ovarian cancer 8,002 | 8,492
osteosarcoma 7,326 | 7,933
psoriasis 6,081 | 6,685
medulloblastoma, large-cell 5,810 | 6,234
glioblastoma 5,254 | 5,572
lung cancer 4,308 | 4,473
atypical teratoid / rhabdoid tumor 4,067 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,127 | 3,289
malignant mesothelioma 3,049 | 3,163
Breast cancer 2,956 | 3,099
pilocytic astrocytoma 2,911 | 3,086
primitive neuroectodermal tumor 2,849 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,841 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,801 | 2,956
invasive ductal carcinoma 2,798 | 2,950
oligodendroglioma 2,672 | 2,849
non-small cell lung cancer 2,665 | 2,798
lung carcinoma 2,654 | 2,844
pediatric high grade glioma 2,565 | 2,712
lung adenocarcinoma 2,537 | 2,714
ependymoma 2,354 | 2,514
Cancer 2,272 | 2,346
pancreatic cancer 2,203 | 2,300
interstitial cystitis 2,146 | 2,299
subependymal giant cell astrocytoma 2,145 | 2,287
group 3 medulloblastoma 2,107 | 2,254
astrocytic glioma 2,076 | 2,241
Carcinoma 2,018 | 2,147
ulcerative colitis 1,983 | 2,087
adult high grade glioma 1,977 | 2,148
pituitary cancer 1,849 | 1,972
Pick disease 1,822 | 1,893
group 4 medulloblastoma 1,771 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,722 | 1,795
ductal carcinoma in situ 1,665 | 1,745
cystic fibrosis 1,582 | 1,670
breast carcinoma 1,542 | 1,614
tuberculosis 1,475 | 1,563
diabetes mellitus 1,470 | 1,663
astrocytoma 1,452 | 1,493
colon cancer 1,426 | 1,475
medulloblastoma 1,421 | 1,524
posterior fossa group A ependymoma 1,421 | 1,511
sonic hedgehog group medulloblastoma 1,385 | 1,482
adrenocortical carcinoma 1,353 | 1,427
posterior fossa group B ependymoma 1,339 | 1,530
Multiple myeloma 1,303 | 1,328
primary pancreatic ductal adenocarcinoma 1,228 | 1,271
juvenile dermatomyositis 1,139 | 1,189
Rheumatoid Arthritis 1,116 | 1,171
acute quadriplegic myopathy 1,116 | 1,157
atypical teratoid/rhabdoid tumor 1,034 | 1,095
cutaneous lupus erythematosus 1,006 | 1,056
spina bifida 1,004 | 1,064
nasopharyngeal carcinoma 956 | 1,056
dermatomyositis 951 | 967
Atopic dermatitis 898 | 944
active Crohn's disease 865 | 918
gastric carcinoma 791 | 832
non primary Sjogren syndrome sicca 781 | 840
Waldenstrons macroglobulinemia 756 | 765
acute myeloid leukemia 750 | 785
primary Sjogren syndrome 741 | 789
esophageal adenocarcinoma 710 | 737
tuberculosis and treatment for 6 months 655 | 686
progressive supranuclear palsy 645 | 674
aldosterone-producing adenoma 639 | 664
Alzheimer's disease 612 | 644
Duchenne muscular dystrophy 586 | 602
Obesity 585 | 616
Intellectual disability 553 | 573
fibroadenoma 537 | 557
pancreatic carcinoma 535 | 567
Down syndrome 530 | 548
hepatocellular carcinoma 528 | 550
Endometriosis 509 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 483 | 499
Schizophrenia 477 | 503
Prostatic Neoplasms 458 | 471
Multiple Sclerosis 451 | 498
chronic rhinosinusitis 451 | 512
mucosa-associated lymphoid tissue lymphoma 451 | 480
IGA Glomerulonephritis 444 | 454
active ulcerative colitis 442 | 477
Amyotrophic Lateral Sclerosis 418 | 432
gastric cancer 409 | 436
Mammary Neoplasms 399 | 410
Kidney disease 387 | 397
inflammatory breast cancer 381 | 404
Neurodegenerative disease 376 | 383
non-small cell lung carcinoma 371 | 413
Parkinson's disease 344 | 364
sarcoidosis 340 | 368
Asthma 335 | 349
Epilepsy 331 | 346
glioblastoma multiforme 330 | 347
Polycystic Ovary Syndrome 319 | 335
nephrosclerosis 313 | 329
Autistic Disorder 309 | 320
hereditary spastic paraplegia 306 | 313

Tissue

Female tissues 16,277 | 18,647
Nervous System 16,259 | 18,561
Endocrine System 16,236 | 18,512
Digestive Tract 16,227 | 18,473
Urinary Tract 16,184 | 18,444
Liver and Pancreas 16,072 | 18,136
Skin and soft tissues 16,034 | 18,115
Cardiovascular System 15,978 | 17,958
Male tissues 15,973 | 17,969
Blood and immune system 15,967 | 17,995
Respiratory system 15,691 | 17,484

Target Family

Non-IDG 9,449 | 11,969
Enzyme 3,860 | 4,146
Transcription Factor 1,264 | 1,400
Kinase 610 | 634
Transporter 437 | 473
GPCR 330 | 408
Ion Channel 314 | 341
Epigenetic 230 | 242
oGPCR 93 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 34 | 38

Data Source

JensenLab Knowledge UniProtKB-... 16,668 | 16,668
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24