Development Level

Tbio 10,783 | 11,445
Tdark 3,855 | 6,588
Tchem 1,539 | 1,598
Tclin 582 | 613

Collection

RFA-RM-18-021 283 | 328
Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 91 | 99
GPCR: IDG Consortium (Targets) 86 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 956 | 979
preweaning lethality, incomple... 475 | 499
abnormal behavior 280 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 233 | 239
abnormal embryo size 215 | 220
decreased total body fat amoun... 197 | 207
decreased vertical activity 193 | 208
enlarged heart 193 | 210
abnormal bone structure 184 | 187
increased lean body mass 165 | 172
decreased body weight 156 | 161
abnormal heart morphology 149 | 162
decreased bone mineral content 144 | 151
hyperactivity 140 | 148
decreased lean body mass 131 | 135
increased total body fat amoun... 130 | 134
hypoactivity 124 | 132
decreased bone mineral density 121 | 126
increased circulating alkaline... 115 | 122
decreased circulating glucose ... 114 | 126
male infertility 112 | 123
increased startle reflex 110 | 112
abnormal seminal vesicle morph... 109 | 114
decreased grip strength 108 | 116
embryonic growth retardation 104 | 106
increased bone mineral content 103 | 108
decreased body length 99 | 101
increased or absent threshold ... 96 | 101
short tibia 91 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 90 | 96
cataract 88 | 92
increased mean corpuscular vol... 88 | 92
prenatal lethality prior to he... 84 | 87
abnormal lens morphology 79 | 81
decreased prepulse inhibition 79 | 82
decreased circulating triglyce... 77 | 79
decreased lymphocyte cell numb... 77 | 83
decreased mean corpuscular vol... 77 | 79
decreased circulating serum al... 75 | 82
improved glucose tolerance 74 | 79
increased circulating HDL chol... 74 | 80
decreased startle reflex 72 | 75
impaired glucose tolerance 72 | 75
increased fasted circulating g... 72 | 76
small superior vagus ganglion 72 | 74
decreased circulating insulin ... 71 | 76
increased bone mineral density 71 | 72
abnormal retina morphology 69 | 71
decreased leukocyte cell numbe... 68 | 73
abnormal eye morphology 67 | 68
abnormal sleep behavior 67 | 70
decreased circulating HDL chol... 66 | 68
increased circulating sodium l... 66 | 71
abnormal behavioral response t... 64 | 66
abnormal kidney morphology 64 | 65
decreased hemoglobin content 64 | 68
decreased fasted circulating g... 63 | 65
abnormal gait 62 | 69
abnormal coat-hair pigmentatio... 61 | 64
increased circulating choleste... 61 | 66
increased monocyte cell number 59 | 63
decreased erythrocyte cell num... 58 | 62
increased heart weight 58 | 62
edema 57 | 59
female infertility 54 | 60
small testis 54 | 58
thrombocytopenia 54 | 56
abnormal spleen morphology 53 | 55
hydrometra 53 | 53
decreased caudal vertebrae num... 51 | 53
abnormal skin morphology 47 | 50
decreased circulating alanine ... 47 | 47
decreased mean corpuscular hem... 47 | 50
decreased blood urea nitrogen ... 46 | 51
decreased circulating total pr... 46 | 49
increased leukocyte cell numbe... 46 | 47
increased blood urea nitrogen ... 45 | 48
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
increased mean platelet volume 44 | 45
increased hematocrit 43 | 46
abnormal epididymis morphology 42 | 42
decreased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 41 | 43
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
decreased neutrophil cell numb... 39 | 42
increased circulating chloride... 39 | 41
increased circulating triglyce... 39 | 42
tremors 39 | 39
decreased red blood cell distr... 38 | 41
limb grasping 38 | 41
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
decreased circulating creatini... 37 | 39
increased grip strength 37 | 41
prolonged ST segment 36 | 36

Disease

Carcinoma 10,472 | 11,493
ovarian cancer 8,063 | 8,520
osteosarcoma 7,377 | 7,950
psoriasis 6,091 | 6,694
medulloblastoma, large-cell 5,834 | 6,241
glioblastoma 5,485 | 5,792
atypical teratoid / rhabdoid tumor 4,794 | 5,112
lung cancer 4,551 | 4,740
ependymoma 4,358 | 4,679
group 3 medulloblastoma 3,877 | 4,104
adult high grade glioma 3,552 | 3,801
Breast cancer 3,414 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,140 | 3,291
malignant mesothelioma 3,127 | 3,232
Astrocytoma, Pilocytic 2,910 | 3,081
primitive neuroectodermal tumor 2,860 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,852 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,815 | 2,955
invasive ductal carcinoma 2,812 | 2,951
non-small cell lung cancer 2,762 | 2,890
oligodendroglioma 2,684 | 2,850
lung carcinoma 2,661 | 2,843
lung adenocarcinoma 2,551 | 2,716
Kidney cancer 2,479 | 2,613
astrocytic glioma 2,432 | 2,597
Cancer 2,415 | 2,499
pancreatic cancer 2,302 | 2,398
interstitial cystitis 2,158 | 2,312
subependymal giant cell astrocytoma 2,153 | 2,287
tuberculosis 1,896 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,893 | 1,962
pituitary cancer 1,860 | 1,972
Pick disease 1,824 | 1,894
group 4 medulloblastoma 1,739 | 1,855
ulcerative colitis 1,726 | 1,819
ductal carcinoma in situ 1,672 | 1,745
cystic fibrosis 1,616 | 1,696
breast carcinoma 1,573 | 1,638
diabetes mellitus 1,528 | 1,728
colon cancer 1,431 | 1,478
Autosomal recessive predisposition 1,388 | 1,442
adrenocortical carcinoma 1,363 | 1,428
Multiple myeloma 1,308 | 1,332
juvenile dermatomyositis 1,144 | 1,187
Rheumatoid arthritis 1,139 | 1,191
acute quadriplegic myopathy 1,122 | 1,158
astrocytoma 1,118 | 1,146
Schizophrenia 1,098 | 1,160
primary pancreatic ductal adenocarcinoma 1,070 | 1,109
spina bifida 1,019 | 1,074
pediatric high grade glioma 1,012 | 1,064
cutaneous lupus erythematosus 1,008 | 1,057
Intellectual disability 986 | 1,016
nasopharyngeal carcinoma 966 | 1,058
dermatomyositis 951 | 966
Atopic dermatitis 904 | 952
active Crohn's disease 872 | 922
non primary Sjogren syndrome sicca 838 | 891
Epilepsy 771 | 792
gastric carcinoma 770 | 807
Waldenstrons macroglobulinemia 755 | 765
acute myeloid leukemia 753 | 783
Liver Cirrhosis, Experimental 745 | 769
active ulcerative colitis 718 | 764
esophageal adenocarcinoma 711 | 737
primary Sjogren syndrome 692 | 735
Melanoma 663 | 711
medulloblastoma 659 | 720
Obesity 648 | 678
progressive supranuclear palsy 648 | 676
aldosterone-producing adenoma 640 | 665
Bipolar Disorder 631 | 666
Dull intelligence 631 | 645
Low intelligence 631 | 645
Mental Retardation 631 | 645
Mental deficiency 631 | 645
Poor school performance 631 | 645
Alzheimer's disease 630 | 658
Cognitive delay 597 | 608
Global developmental delay 597 | 608
Mental and motor retardation 597 | 608
Duchenne muscular dystrophy 587 | 601
Seizures 586 | 596
Liver cancer 568 | 604
Muscle hypotonia 562 | 571
fibroadenoma 541 | 559
pancreatic carcinoma 529 | 562
hepatocellular carcinoma 525 | 547
Endometriosis 515 | 540
Short stature 512 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 496 | 510
Multiple Sclerosis 490 | 540
Down syndrome 486 | 499
Prostatic Neoplasms 484 | 495
chronic rhinosinusitis 457 | 512
mucosa-associated lymphoid tissue lymphoma 456 | 484
sonic hedgehog group medulloblastoma 446 | 467
Amyotrophic lateral sclerosis 439 | 451
Skin cancer 439 | 469
gastric cancer 436 | 459

Tissue

Endocrine System 16,127 | 18,159
Digestive Tract 15,727 | 17,369
Female tissues 15,710 | 17,400
Skin and soft tissues 15,620 | 17,230
Male tissues 15,540 | 17,142
Blood and immune system 15,373 | 16,909
Liver and Pancreas 15,285 | 16,750
Nervous System 15,258 | 16,725
Urinary Tract 15,255 | 16,678
Respiratory system 14,994 | 16,393
Cardiovascular System 14,100 | 15,192

Target Family

Non-IDG 9,531 | 12,091
Enzyme 3,864 | 4,145
Transcription Factor 1,264 | 1,400
Kinase 613 | 634
Transporter 437 | 473
GPCR 326 | 408
Ion Channel 317 | 344
Epigenetic 233 | 242
oGPCR 93 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 34 | 38

Data Source

JensenLab Knowledge UniProtKB-... 16,759 | 16,759
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39