Development Level

Tbio 10,526 | 11,178
Tdark 3,841 | 6,569
Tchem 1,811 | 1,885
Tclin 581 | 612

Collection

Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 91 | 99
GPCR: IDG Consortium (Targets) 86 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 956 | 979
preweaning lethality, incomple... 475 | 499
abnormal behavior 280 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 233 | 239
abnormal embryo size 215 | 220
decreased total body fat amoun... 197 | 207
decreased vertical activity 193 | 208
enlarged heart 193 | 210
abnormal bone structure 184 | 187
increased lean body mass 165 | 172
decreased body weight 156 | 161
abnormal heart morphology 149 | 162
decreased bone mineral content 144 | 151
hyperactivity 140 | 148
decreased lean body mass 131 | 135
increased total body fat amoun... 130 | 134
hypoactivity 124 | 132
decreased bone mineral density 121 | 126
increased circulating alkaline... 115 | 122
decreased circulating glucose ... 114 | 126
male infertility 112 | 123
increased startle reflex 110 | 112
abnormal seminal vesicle morph... 109 | 114
decreased grip strength 108 | 116
embryonic growth retardation 104 | 106
increased bone mineral content 103 | 108
decreased body length 99 | 101
increased or absent threshold ... 96 | 101
short tibia 91 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 90 | 96
cataract 88 | 92
increased mean corpuscular vol... 88 | 92
prenatal lethality prior to he... 84 | 87
abnormal lens morphology 79 | 81
decreased prepulse inhibition 79 | 82
decreased circulating triglyce... 77 | 79
decreased lymphocyte cell numb... 77 | 83
decreased mean corpuscular vol... 77 | 79
decreased circulating serum al... 75 | 82
improved glucose tolerance 74 | 79
increased circulating HDL chol... 74 | 80
decreased startle reflex 72 | 75
impaired glucose tolerance 72 | 75
increased fasted circulating g... 72 | 76
small superior vagus ganglion 72 | 74
decreased circulating insulin ... 71 | 76
increased bone mineral density 71 | 72
abnormal retina morphology 69 | 71
decreased leukocyte cell numbe... 68 | 73
abnormal eye morphology 67 | 68
abnormal sleep behavior 67 | 70
decreased circulating HDL chol... 66 | 68
increased circulating sodium l... 66 | 71
abnormal behavioral response t... 64 | 66
abnormal kidney morphology 64 | 65
decreased hemoglobin content 64 | 68
decreased fasted circulating g... 63 | 65
abnormal gait 62 | 69
abnormal coat-hair pigmentatio... 61 | 64
increased circulating choleste... 61 | 66
increased monocyte cell number 59 | 63
decreased erythrocyte cell num... 58 | 62
increased heart weight 58 | 62
edema 57 | 59
female infertility 54 | 60
small testis 54 | 58
thrombocytopenia 54 | 56
abnormal spleen morphology 53 | 55
hydrometra 53 | 53
decreased caudal vertebrae num... 51 | 53
abnormal skin morphology 47 | 50
decreased circulating alanine ... 47 | 47
decreased mean corpuscular hem... 47 | 50
decreased blood urea nitrogen ... 46 | 51
decreased circulating total pr... 46 | 49
increased leukocyte cell numbe... 46 | 47
increased blood urea nitrogen ... 45 | 48
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
increased mean platelet volume 44 | 45
increased hematocrit 43 | 46
abnormal epididymis morphology 42 | 42
decreased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 41 | 43
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
decreased neutrophil cell numb... 39 | 42
increased circulating chloride... 39 | 41
increased circulating triglyce... 39 | 42
tremors 39 | 39
decreased red blood cell distr... 38 | 41
limb grasping 38 | 41
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
decreased circulating creatini... 37 | 39
increased grip strength 37 | 41
prolonged ST segment 36 | 36

Disease

Carcinoma 10,190 | 11,192
ovarian cancer 7,850 | 8,297
osteosarcoma 7,202 | 7,766
psoriasis 5,928 | 6,514
medulloblastoma, large-cell 5,689 | 6,086
glioblastoma 5,335 | 5,635
atypical teratoid / rhabdoid tumor 4,660 | 4,971
lung cancer 4,421 | 4,607
ependymoma 4,244 | 4,559
group 3 medulloblastoma 3,782 | 4,002
adult high grade glioma 3,457 | 3,701
Breast cancer 3,309 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,057 | 3,204
malignant mesothelioma 3,033 | 3,135
Astrocytoma, Pilocytic 2,837 | 3,006
primitive neuroectodermal tumor 2,786 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,768 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,736 | 2,872
invasive ductal carcinoma 2,735 | 2,867
non-small cell lung cancer 2,678 | 2,799
oligodendroglioma 2,606 | 2,768
lung carcinoma 2,576 | 2,755
lung adenocarcinoma 2,467 | 2,627
Kidney cancer 2,419 | 2,548
astrocytic glioma 2,369 | 2,530
Cancer 2,308 | 2,388
pancreatic cancer 2,230 | 2,322
subependymal giant cell astrocytoma 2,097 | 2,230
interstitial cystitis 2,089 | 2,237
tuberculosis 1,850 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,844 | 1,911
pituitary cancer 1,806 | 1,915
Pick disease 1,787 | 1,856
group 4 medulloblastoma 1,692 | 1,806
ulcerative colitis 1,674 | 1,765
ductal carcinoma in situ 1,616 | 1,686
cystic fibrosis 1,550 | 1,629
breast carcinoma 1,527 | 1,589
diabetes mellitus 1,483 | 1,683
colon cancer 1,381 | 1,428
Autosomal recessive predisposition 1,354 | 1,407
adrenocortical carcinoma 1,321 | 1,385
Multiple myeloma 1,272 | 1,296
Rheumatoid arthritis 1,107 | 1,156
juvenile dermatomyositis 1,104 | 1,147
acute quadriplegic myopathy 1,097 | 1,133
astrocytoma 1,086 | 1,113
Schizophrenia 1,074 | 1,136
primary pancreatic ductal adenocarcinoma 1,033 | 1,071
spina bifida 999 | 1,053
pediatric high grade glioma 985 | 1,035
Intellectual disability 968 | 998
cutaneous lupus erythematosus 968 | 1,016
nasopharyngeal carcinoma 936 | 1,024
dermatomyositis 926 | 941
Atopic dermatitis 871 | 915
active Crohn's disease 833 | 882
non primary Sjogren syndrome sicca 809 | 861
Epilepsy 754 | 775
gastric carcinoma 745 | 781
Waldenstrons macroglobulinemia 732 | 742
acute myeloid leukemia 730 | 760
Liver Cirrhosis, Experimental 709 | 733
active ulcerative colitis 690 | 736
esophageal adenocarcinoma 672 | 696
primary Sjogren syndrome 668 | 710
Melanoma 643 | 689
medulloblastoma 641 | 702
progressive supranuclear palsy 628 | 656
Obesity 627 | 655
aldosterone-producing adenoma 622 | 646
Dull intelligence 620 | 634
Low intelligence 620 | 634
Mental Retardation 620 | 634
Mental deficiency 620 | 634
Poor school performance 620 | 634
Alzheimer's disease 613 | 640
Bipolar Disorder 612 | 646
Cognitive delay 585 | 596
Global developmental delay 585 | 596
Mental and motor retardation 585 | 596
Seizures 574 | 584
Duchenne muscular dystrophy 573 | 587
Liver cancer 554 | 589
Muscle hypotonia 553 | 562
pancreatic carcinoma 522 | 555
fibroadenoma 521 | 538
hepatocellular carcinoma 514 | 536
Endometriosis 497 | 521
Short stature 496 | 514
Multiple Sclerosis 478 | 527
autosomal dominant Emery-Dreifuss muscular dystrophy 478 | 492
Down syndrome 467 | 480
Prostatic Neoplasms 461 | 472
chronic rhinosinusitis 450 | 505
mucosa-associated lymphoid tissue lymphoma 445 | 473
sonic hedgehog group medulloblastoma 439 | 459
Amyotrophic lateral sclerosis 426 | 437
posterior fossa group A ependymoma 424 | 456
Skin cancer 423 | 451

Tissue

Endocrine System 16,127 | 18,159
Digestive Tract 15,727 | 17,369
Female tissues 15,710 | 17,400
Skin and soft tissues 15,620 | 17,230
Male tissues 15,540 | 17,142
Blood and immune system 15,373 | 16,909
Liver and Pancreas 15,285 | 16,750
Nervous System 15,258 | 16,725
Urinary Tract 15,255 | 16,678
Respiratory system 14,994 | 16,393
Cardiovascular System 14,100 | 15,192

Target Family

Non-IDG 9,531 | 12,091
Enzyme 3,864 | 4,145
Transcription Factor 1,264 | 1,400
Kinase 613 | 634
Transporter 437 | 473
GPCR 326 | 408
Ion Channel 317 | 344
Epigenetic 233 | 242
oGPCR 93 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 34 | 38

Data Source

JensenLab Knowledge UniProtKB-... 16,759 | 16,759
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93