Development Level

Tbio 1,574 | 10,625
Tchem 330 | 1,890
Tclin 163 | 602
Tdark 95 | 7,003

Collection

Eligible Ion Channel Proteins 15 | 117
Eligible Kinase Proteins 10 | 134
Eligible non-olfactory GPCR Proteins 2 | 145

IMPC Term

preweaning lethality, complete... 128 | 633
abnormal behavior 46 | 226
preweaning lethality, incomple... 45 | 260
decreased body weight 44 | 174
decreased lean body mass 44 | 195
embryonic lethality prior to t... 42 | 187
decreased total body fat amoun... 38 | 186
decreased bone mineral content 33 | 157
embryonic lethality prior to o... 32 | 148
increased or absent threshold ... 27 | 128
decreased body length 25 | 108
abnormal bone structure 24 | 131
decreased bone mineral density 24 | 126
increased mean corpuscular hem... 24 | 93
decreased grip strength 23 | 123
hyperactivity 22 | 108
abnormal retina morphology 21 | 100
hypoactivity 21 | 89
increased circulating alkaline... 21 | 119
increased bone mineral content 20 | 92
abnormal embryo size 19 | 112
enlarged heart 19 | 111
increased lean body mass 19 | 107
decreased circulating glucose ... 18 | 121
decreased prepulse inhibition 18 | 52
decreased circulating triglyce... 17 | 83
increased mean corpuscular vol... 17 | 91
abnormal bone mineralization 16 | 55
abnormal gait 16 | 51
decreased hemoglobin content 16 | 53
increased blood urea nitrogen ... 16 | 44
increased circulating HDL chol... 16 | 63
increased circulating sodium l... 16 | 71
decreased circulating HDL chol... 15 | 77
decreased circulating choleste... 15 | 85
decreased startle reflex 15 | 48
increased circulating choleste... 15 | 53
decreased circulating serum al... 14 | 79
decreased heart weight 14 | 44
increased grip strength 14 | 83
short tibia 14 | 82
decreased circulating insulin ... 13 | 75
decreased erythrocyte cell num... 13 | 43
decreased mean corpuscular vol... 13 | 50
increased total body fat amoun... 13 | 57
limb grasping 13 | 35
thrombocytopenia 13 | 46
decreased circulating alanine ... 12 | 53
decreased eosinophil cell numb... 12 | 41
decreased rib number 12 | 59
improved glucose tolerance 12 | 56
increased bone mineral density 12 | 52
prenatal lethality prior to he... 12 | 64
decreased circulating amylase ... 11 | 24
impaired glucose tolerance 11 | 52
increased circulating calcium ... 11 | 32
increased heart weight 11 | 37
increased hemoglobin content 11 | 45
abnormal coat/hair pigmentatio... 10 | 54
abnormal lens morphology 10 | 73
decreased caudal vertebrae num... 10 | 49
decreased fasted circulating g... 10 | 49
decreased leukocyte cell numbe... 10 | 54
decreased mean corpuscular hem... 10 | 34
enlarged lymph nodes 10 | 27
male infertility 10 | 62
tremors 10 | 34
abnormal retinal pigmentation 9 | 61
cataract 9 | 26
corneal opacity 9 | 25
decreased circulating LDL chol... 9 | 37
decreased circulating total pr... 9 | 41
increased circulating chloride... 9 | 43
increased fasted circulating g... 9 | 68
abnormal heart morphology 8 | 51
cardiovascular system phenotyp... 8 | 35
decreased circulating iron lev... 8 | 25
increased circulating aspartat... 8 | 17
increased sacral vertebrae num... 8 | 62
small testis 8 | 37
thrombocytosis 8 | 23
abnormal behavioral response t... 7 | 52
abnormal cornea morphology 7 | 24
abnormal cranium morphology 7 | 32
abnormal seminal vesicle morph... 7 | 47
abnormal sleep behavior 7 | 63
absent startle reflex 7 | 15
decreased circulating chloride... 7 | 32
decreased circulating fructosa... 7 | 31
decreased lumbar vertebrae num... 7 | 62
increased body weight 7 | 42
increased circulating phosphat... 7 | 24
increased circulating potassiu... 7 | 31
increased circulating total pr... 7 | 20
increased hematocrit 7 | 36
increased mean corpuscular hem... 7 | 25
increased mean platelet volume 7 | 19
persistence of hyaloid vascula... 7 | 22
decreased circulating glycerol... 6 | 19
increased prepulse inhibition 6 | 21

Disease

ovarian cancer 1,140 | 8,492
osteosarcoma 993 | 7,933
psoriasis 874 | 6,685
medulloblastoma, large-cell 842 | 6,234
glioblastoma 742 | 5,572
lung cancer 677 | 4,473
Cancer 613 | 2,346
atypical teratoid / rhabdoid tumor 556 | 4,369
malignant mesothelioma 482 | 3,163
Carcinoma 459 | 2,147
Breast cancer 447 | 3,099
pilocytic astrocytoma 447 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 442 | 3,289
primitive neuroectodermal tumor 419 | 3,031
oligodendroglioma 415 | 2,849
lung carcinoma 408 | 2,844
invasive ductal carcinoma 405 | 2,950
Intellectual disability 403 | 573
intraductal papillary-mucinous carcinoma (IPMC) 402 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 396 | 2,956
lung adenocarcinoma 393 | 2,714
pediatric high grade glioma 391 | 2,712
non-small cell lung cancer 380 | 2,798
ependymoma 345 | 2,514
subependymal giant cell astrocytoma 337 | 2,287
pancreatic cancer 318 | 2,300
Neurodegenerative disease 317 | 383
group 3 medulloblastoma 307 | 2,254
pituitary cancer 303 | 1,972
Pick disease 291 | 1,893
astrocytic glioma 284 | 2,241
diabetes mellitus 281 | 1,663
ulcerative colitis 272 | 2,087
interstitial cystitis 271 | 2,299
adult high grade glioma 266 | 2,148
astrocytoma 262 | 1,493
group 4 medulloblastoma 259 | 1,875
breast carcinoma 249 | 1,614
colon cancer 248 | 1,475
ductal carcinoma in situ 242 | 1,745
posterior fossa group A ependymoma 227 | 1,511
pancreatic ductal adenocarcinoma liver metastasis 221 | 1,795
sonic hedgehog group medulloblastoma 220 | 1,482
cystic fibrosis 217 | 1,670
tuberculosis 215 | 1,563
posterior fossa group B ependymoma 205 | 1,530
medulloblastoma 202 | 1,524
adrenocortical carcinoma 196 | 1,427
Epilepsy 189 | 346
acute quadriplegic myopathy 188 | 1,157
atypical teratoid/rhabdoid tumor 183 | 1,095
Multiple myeloma 180 | 1,328
juvenile dermatomyositis 174 | 1,189
primary pancreatic ductal adenocarcinoma 173 | 1,271
Rheumatoid Arthritis 170 | 1,171
nasopharyngeal carcinoma 159 | 1,056
dermatomyositis 156 | 967
Obesity 147 | 616
Alzheimer's disease 141 | 644
Neuropathy 141 | 210
Atopic dermatitis 138 | 944
cutaneous lupus erythematosus 136 | 1,056
spina bifida 128 | 1,064
gastric carcinoma 120 | 832
active Crohn's disease 110 | 918
primary Sjogren syndrome 110 | 789
esophageal adenocarcinoma 109 | 737
Waldenstrons macroglobulinemia 108 | 765
acute myeloid leukemia 107 | 785
Retinitis pigmentosa 106 | 156
Duchenne muscular dystrophy 104 | 602
progressive supranuclear palsy 104 | 674
Amyotrophic Lateral Sclerosis 103 | 432
Parkinson's disease 103 | 364
non primary Sjogren syndrome sicca 102 | 840
Schizophrenia 100 | 503
Kidney disease 99 | 397
Prostatic Neoplasms 98 | 471
Nonsyndromic deafness 96 | 121
Cardiomyopathy 94 | 110
aldosterone-producing adenoma 92 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 92 | 499
Down syndrome 90 | 548
Mammary Neoplasms 90 | 410
Multiple Sclerosis 90 | 498
hereditary spastic paraplegia 90 | 313
Cataract 88 | 104
Microcephaly 86 | 149
Endometriosis 82 | 535
Heart disease 79 | 279
chronic rhinosinusitis 79 | 512
fibroadenoma 77 | 557
Autistic Disorder 76 | 320
hepatocellular carcinoma 76 | 550
Hypertension 75 | 293
Anemia 73 | 252
IGA Glomerulonephritis 73 | 454
Peripheral Neuropathy 73 | 303
non-small cell lung carcinoma 73 | 413
mucosa-associated lymphoid tissue lymphoma 72 | 480

Tissue

Nervous System 2,135 | 18,561
Endocrine System 2,133 | 18,512
Digestive Tract 2,131 | 18,473
Female tissues 2,131 | 18,647
Urinary Tract 2,125 | 18,444
Liver and Pancreas 2,119 | 18,136
Skin and soft tissues 2,113 | 18,115
Cardiovascular System 2,112 | 17,958
Blood and immune system 2,111 | 17,995
Male tissues 2,107 | 17,969
Respiratory system 2,078 | 17,484

Target Family

Non-IDG 1,117 | 11,969
Enzyme 498 | 4,146
Transcription Factor 173 | 1,400
Kinase 130 | 634
Ion Channel 97 | 341
Transporter 59 | 473
Epigenetic 40 | 242
GPCR 29 | 408
Nuclear Receptor 12 | 48
TF/Epigenetic 7 | 38

Data Source

JensenLab Knowledge UniProtKB-... 2,162 | 2,162
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Lebercilin LCA5 Tbio Non-IDG -1.21162 16.7 65
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.10264 130.3 456
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 11
Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF Tbio Transcription Factor -2.00894 100.6 155
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 Tbio Enzyme -2.08075 121.5 75
Synapsin-1 SYN1 Tbio Non-IDG -2.85684 687.9 716
Protein FAM83A FAM83A Tbio Non-IDG -0.91978 7.91 58
Tyrosine-protein kinase BAZ1B BAZ1B Tbio Epigenetic -1.42830 30.5 140