Development Level

Tbio 1,652 | 11,178
Tchem 328 | 1,885
Tclin 172 | 612
Tdark 77 | 6,569

Collection

Ion Channel: IDG Consortium (T... 12 | 99
Kinase: IDG Consortium (Target... 10 | 125
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 209 | 979
preweaning lethality, incomple... 84 | 499
abnormal behavior 60 | 298
embryonic lethality prior to t... 58 | 278
embryonic lethality prior to o... 52 | 239
decreased body weight 50 | 161
abnormal embryo size 41 | 220
decreased total body fat amoun... 41 | 207
enlarged heart 39 | 210
abnormal bone structure 38 | 187
increased total body fat amoun... 37 | 134
decreased vertical activity 36 | 208
increased lean body mass 33 | 172
hypoactivity 32 | 132
hyperactivity 30 | 148
decreased bone mineral content 29 | 151
decreased lean body mass 29 | 135
increased startle reflex 29 | 112
decreased bone mineral density 28 | 126
impaired glucose tolerance 27 | 75
abnormal heart morphology 26 | 162
increased circulating alkaline... 25 | 122
increased or absent threshold ... 25 | 101
decreased grip strength 23 | 116
decreased lymphocyte cell numb... 23 | 83
decreased circulating glucose ... 22 | 126
decreased startle reflex 22 | 75
male infertility 22 | 123
short tibia 22 | 97
abnormal seminal vesicle morph... 21 | 114
decreased mean corpuscular vol... 21 | 79
embryonic growth retardation 21 | 106
increased mean corpuscular hem... 21 | 96
abnormal gait 20 | 69
prenatal lethality prior to he... 20 | 87
decreased circulating choleste... 19 | 93
decreased prepulse inhibition 19 | 82
small superior vagus ganglion 19 | 74
decreased body length 18 | 101
decreased leukocyte cell numbe... 18 | 73
increased circulating HDL chol... 18 | 80
increased heart weight 18 | 62
decreased circulating serum al... 17 | 82
decreased hemoglobin content 17 | 68
improved glucose tolerance 17 | 79
increased bone mineral content 17 | 108
increased circulating sodium l... 17 | 71
cataract 16 | 92
decreased erythrocyte cell num... 16 | 62
decreased fasted circulating g... 16 | 65
increased circulating choleste... 16 | 66
increased mean corpuscular vol... 16 | 92
decreased circulating amylase ... 15 | 28
decreased circulating triglyce... 15 | 79
increased bone mineral density 15 | 72
limb grasping 15 | 41
thrombocytopenia 15 | 56
tremors 15 | 39
abnormal lens morphology 14 | 81
abnormal retina morphology 14 | 71
decreased heart weight 14 | 27
enlarged lymph nodes 14 | 37
increased neutrophil cell numb... 14 | 46
decreased circulating HDL chol... 13 | 68
increased blood urea nitrogen ... 13 | 48
increased fasted circulating g... 13 | 76
increased monocyte cell number 13 | 63
abnormal eye morphology 12 | 68
corneal opacity 12 | 32
decreased mean corpuscular hem... 12 | 50
hydrometra 12 | 53
increased mean platelet volume 12 | 45
small testis 12 | 58
abnormal coat-hair pigmentatio... 11 | 64
edema 11 | 59
female infertility 11 | 60
increased circulating calcium ... 11 | 34
increased circulating triglyce... 11 | 42
increased leukocyte cell numbe... 11 | 47
abnormal behavioral response t... 10 | 66
decreased circulating alkaline... 10 | 46
decreased circulating insulin ... 10 | 76
increased circulating chloride... 10 | 41
increased red blood cell distr... 10 | 34
pallor 10 | 34
abnormal bone mineralization 9 | 38
abnormal kidney morphology 9 | 65
abnormal retinal vasculature m... 9 | 27
abnormal skin morphology 9 | 50
abnormal testis morphology 9 | 43
absent pinna reflex 9 | 23
decreased blood urea nitrogen ... 9 | 51
decreased circulating alanine ... 9 | 47
decreased circulating iron lev... 9 | 32
enlarged spleen 9 | 41
increased circulating amylase ... 9 | 25
increased circulating phosphat... 9 | 26
increased circulating potassiu... 9 | 29
increased erythrocyte cell num... 9 | 39
increased hemoglobin content 9 | 45

Disease

Carcinoma 1,616 | 11,192
ovarian cancer 1,183 | 8,297
osteosarcoma 1,035 | 7,766
psoriasis 897 | 6,514
medulloblastoma, large-cell 876 | 6,086
glioblastoma 816 | 5,635
Autosomal recessive predisposition 763 | 1,407
lung cancer 732 | 4,607
atypical teratoid / rhabdoid tumor 713 | 4,971
ependymoma 684 | 4,559
Intellectual disability 666 | 998
Cancer 627 | 2,388
group 3 medulloblastoma 599 | 4,002
Breast cancer 556 | 3,469
Kidney cancer 541 | 2,548
adult high grade glioma 532 | 3,701
malignant mesothelioma 511 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 455 | 3,204
Astrocytoma, Pilocytic 453 | 3,006
Epilepsy 441 | 775
primitive neuroectodermal tumor 433 | 2,957
Dull intelligence 431 | 634
Low intelligence 431 | 634
Mental Retardation 431 | 634
Mental deficiency 431 | 634
Poor school performance 431 | 634
oligodendroglioma 424 | 2,768
invasive ductal carcinoma 416 | 2,867
lung carcinoma 413 | 2,755
intraductal papillary-mucinous carcinoma (IPMC) 412 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 411 | 2,872
lung adenocarcinoma 400 | 2,627
non-small cell lung cancer 391 | 2,799
Cognitive delay 373 | 596
Global developmental delay 373 | 596
Mental and motor retardation 373 | 596
astrocytic glioma 357 | 2,530
pancreatic cancer 353 | 2,322
Muscle hypotonia 349 | 562
subependymal giant cell astrocytoma 347 | 2,230
Neurodegenerative disease 327 | 402
Seizures 324 | 584
diabetes mellitus 311 | 1,683
pituitary cancer 310 | 1,915
Pick disease 307 | 1,856
Short stature 298 | 514
interstitial cystitis 277 | 2,237
tuberculosis 272 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 267 | 1,911
breast carcinoma 264 | 1,589
group 4 medulloblastoma 248 | 1,806
colon cancer 244 | 1,428
ductal carcinoma in situ 244 | 1,686
ulcerative colitis 242 | 1,765
Schizophrenia 236 | 1,136
Small head 236 | 366
cystic fibrosis 230 | 1,629
Nystagmus 216 | 309
Obesity 213 | 655
Cataract 211 | 290
Cerebellar Ataxia 207 | 302
astrocytoma 205 | 1,113
adrenocortical carcinoma 198 | 1,385
acute quadriplegic myopathy 194 | 1,133
Multiple myeloma 192 | 1,296
Sensorineural Hearing Loss (disorder) 188 | 281
juvenile dermatomyositis 181 | 1,147
Rheumatoid arthritis 178 | 1,156
Failure to gain weight 176 | 359
Pediatric failure to thrive 176 | 359
Optic Atrophy 174 | 239
Melanoma 172 | 689
Neuropathy 170 | 254
Lens Opacities 164 | 227
Retinitis Pigmentosa 162 | 223
Acquired scoliosis 161 | 274
Curvature of spine 161 | 275
Strabismus 161 | 265
nasopharyngeal carcinoma 160 | 1,024
dermatomyositis 157 | 941
Cryptorchidism 156 | 287
Depressive disorder 156 | 401
Hyperreflexia 154 | 208
Liver cancer 150 | 589
pediatric high grade glioma 149 | 1,035
Dysarthria 147 | 190
Hepatomegaly 146 | 280
Infantile onset 142 | 236
Atopic dermatitis 140 | 915
Broad flat nasal bridge 140 | 232
Nasal bridge wide 140 | 232
primary pancreatic ductal adenocarcinoma 140 | 1,071
Alzheimer's disease 139 | 640
spina bifida 137 | 1,053
cutaneous lupus erythematosus 136 | 1,016
Bipolar Disorder 134 | 646
Blepharoptosis 134 | 229
Muscle Spasticity 133 | 192
Mandibular hypoplasia 132 | 273
Micrognathism 132 | 273

Tissue

Endocrine System 2,183 | 18,159
Digestive Tract 2,144 | 17,369
Female tissues 2,128 | 17,400
Skin and soft tissues 2,121 | 17,230
Male tissues 2,109 | 17,142
Liver and Pancreas 2,086 | 16,750
Nervous System 2,083 | 16,725
Blood and immune system 2,081 | 16,909
Urinary Tract 2,064 | 16,678
Respiratory system 2,022 | 16,393
Cardiovascular System 1,937 | 15,192

Target Family

Non-IDG 1,167 | 12,091
Enzyme 508 | 4,145
Transcription Factor 166 | 1,400
Kinase 136 | 634
Ion Channel 98 | 344
Transporter 63 | 473
Epigenetic 43 | 242
GPCR 30 | 408
Nuclear Receptor 11 | 48
TF/Epigenetic 7 | 38

Data Source

JensenLab Knowledge UniProtKB-... 2,229 | 2,229
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Mitogen-activated protein kinase-binding protein 1 MAPKBP1 Tbio Enzyme -0.46630 4.01 51
RNA-binding protein 20 RBM20 Tbio Non-IDG -1.40778 24.2 73
Zinc finger protein 423 ZNF423 Tbio Transcription Factor -1.62303 45.3 77
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Keratin, type I cytoskeletal 17 KRT17 Tbio Non-IDG -2.43909 265.8 711
Copper-transporting ATPase 1 ATP7A Tbio Enzyme -3.08069 1155.0 263