Development Level

Tbio 1,722 | 11,445
Tchem 306 | 1,598
Tclin 173 | 613
Tdark 78 | 6,588

Collection

RFA-RM-18-021 25 | 328
Ion Channel: IDG Consortium (T... 12 | 99
Kinase: IDG Consortium (Target... 10 | 125
Kinase: IDG Consortium (Comple... 4 | 37
GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 213 | 979
preweaning lethality, incomple... 86 | 499
abnormal behavior 61 | 298
embryonic lethality prior to t... 59 | 278
embryonic lethality prior to o... 53 | 239
decreased body weight 50 | 161
abnormal embryo size 44 | 220
decreased total body fat amoun... 41 | 207
enlarged heart 39 | 210
abnormal bone structure 38 | 187
increased total body fat amoun... 37 | 134
decreased vertical activity 36 | 208
hypoactivity 33 | 132
increased lean body mass 33 | 172
hyperactivity 30 | 148
decreased bone mineral content 29 | 151
decreased bone mineral density 29 | 126
decreased lean body mass 29 | 135
increased startle reflex 29 | 112
impaired glucose tolerance 27 | 75
abnormal heart morphology 26 | 162
increased circulating alkaline... 25 | 122
increased or absent threshold ... 25 | 101
decreased grip strength 24 | 116
decreased lymphocyte cell numb... 23 | 83
decreased startle reflex 23 | 75
embryonic growth retardation 23 | 106
decreased circulating glucose ... 22 | 126
male infertility 22 | 123
short tibia 22 | 97
abnormal gait 21 | 69
abnormal seminal vesicle morph... 21 | 114
decreased mean corpuscular vol... 21 | 79
increased mean corpuscular hem... 21 | 96
prenatal lethality prior to he... 21 | 87
decreased prepulse inhibition 20 | 82
decreased circulating choleste... 19 | 93
small superior vagus ganglion 19 | 74
decreased body length 18 | 101
decreased leukocyte cell numbe... 18 | 73
increased circulating HDL chol... 18 | 80
increased heart weight 18 | 62
decreased circulating serum al... 17 | 82
decreased fasted circulating g... 17 | 65
decreased hemoglobin content 17 | 68
improved glucose tolerance 17 | 79
increased bone mineral content 17 | 108
increased circulating sodium l... 17 | 71
cataract 16 | 92
decreased erythrocyte cell num... 16 | 62
increased circulating choleste... 16 | 66
increased mean corpuscular vol... 16 | 92
tremors 16 | 39
decreased circulating amylase ... 15 | 28
decreased circulating triglyce... 15 | 79
increased bone mineral density 15 | 72
limb grasping 15 | 41
thrombocytopenia 15 | 56
abnormal lens morphology 14 | 81
abnormal retina morphology 14 | 71
decreased heart weight 14 | 27
enlarged lymph nodes 14 | 37
increased blood urea nitrogen ... 14 | 48
increased fasted circulating g... 14 | 76
increased neutrophil cell numb... 14 | 46
abnormal eye morphology 13 | 68
decreased circulating HDL chol... 13 | 68
increased monocyte cell number 13 | 63
corneal opacity 12 | 32
decreased mean corpuscular hem... 12 | 50
hydrometra 12 | 53
increased mean platelet volume 12 | 45
small testis 12 | 58
abnormal coat-hair pigmentatio... 11 | 64
edema 11 | 59
female infertility 11 | 60
increased circulating calcium ... 11 | 34
increased circulating triglyce... 11 | 42
increased leukocyte cell numbe... 11 | 47
pallor 11 | 34
abnormal behavioral response t... 10 | 66
decreased blood urea nitrogen ... 10 | 51
decreased circulating alkaline... 10 | 46
decreased circulating insulin ... 10 | 76
increased circulating chloride... 10 | 41
increased red blood cell distr... 10 | 34
abnormal bone mineralization 9 | 38
abnormal kidney morphology 9 | 65
abnormal retinal vasculature m... 9 | 27
abnormal skin morphology 9 | 50
abnormal testis morphology 9 | 43
absent pinna reflex 9 | 23
decreased circulating alanine ... 9 | 47
decreased circulating iron lev... 9 | 32
enlarged spleen 9 | 41
increased circulating amylase ... 9 | 25
increased circulating phosphat... 9 | 26
increased circulating potassiu... 9 | 29
increased erythrocyte cell num... 9 | 39
increased hemoglobin content 9 | 45

Disease

Carcinoma 1,657 | 11,493
ovarian cancer 1,212 | 8,520
osteosarcoma 1,056 | 7,950
psoriasis 915 | 6,694
medulloblastoma, large-cell 894 | 6,241
glioblastoma 836 | 5,792
Autosomal recessive predisposition 777 | 1,442
lung cancer 750 | 4,740
atypical teratoid / rhabdoid tumor 730 | 5,112
ependymoma 701 | 4,679
Intellectual disability 680 | 1,016
Cancer 646 | 2,499
group 3 medulloblastoma 613 | 4,104
Breast cancer 572 | 3,578
Kidney cancer 550 | 2,613
adult high grade glioma 539 | 3,801
malignant mesothelioma 525 | 3,232
Astrocytoma, Pilocytic 461 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 461 | 3,291
Epilepsy 452 | 792
primitive neuroectodermal tumor 441 | 3,035
Dull intelligence 440 | 645
Low intelligence 440 | 645
Mental Retardation 440 | 645
Mental deficiency 440 | 645
Poor school performance 440 | 645
oligodendroglioma 437 | 2,850
lung carcinoma 425 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 424 | 2,989
invasive ductal carcinoma 424 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 417 | 2,955
lung adenocarcinoma 408 | 2,716
non-small cell lung cancer 407 | 2,890
Cognitive delay 384 | 608
Global developmental delay 384 | 608
Mental and motor retardation 384 | 608
astrocytic glioma 370 | 2,597
pancreatic cancer 362 | 2,398
Muscle hypotonia 357 | 571
subependymal giant cell astrocytoma 355 | 2,287
Neurodegenerative disease 336 | 414
Seizures 334 | 596
diabetes mellitus 318 | 1,728
pituitary cancer 313 | 1,972
Pick disease 311 | 1,894
Short stature 307 | 531
interstitial cystitis 284 | 2,312
tuberculosis 273 | 2,010
breast carcinoma 272 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 270 | 1,962
group 4 medulloblastoma 256 | 1,855
colon cancer 254 | 1,478
ductal carcinoma in situ 251 | 1,745
ulcerative colitis 248 | 1,819
Schizophrenia 244 | 1,160
Small head 240 | 374
cystic fibrosis 234 | 1,696
Nystagmus 223 | 317
Obesity 217 | 678
Cataract 216 | 297
astrocytoma 211 | 1,146
Cerebellar Ataxia 209 | 304
adrenocortical carcinoma 201 | 1,428
acute quadriplegic myopathy 196 | 1,158
Multiple myeloma 192 | 1,332
Sensorineural Hearing Loss (disorder) 191 | 284
juvenile dermatomyositis 183 | 1,187
Rheumatoid arthritis 181 | 1,191
Failure to gain weight 179 | 365
Pediatric failure to thrive 179 | 365
Optic Atrophy 176 | 242
Melanoma 175 | 711
Neuropathy 175 | 261
Lens Opacities 167 | 231
Acquired scoliosis 166 | 281
Curvature of spine 166 | 282
nasopharyngeal carcinoma 166 | 1,058
Retinitis Pigmentosa 165 | 226
Strabismus 165 | 270
dermatomyositis 163 | 966
Cryptorchidism 162 | 296
Depressive disorder 159 | 409
Hyperreflexia 155 | 209
Liver cancer 154 | 604
pediatric high grade glioma 153 | 1,064
Dysarthria 149 | 192
Hepatomegaly 148 | 285
Alzheimer's disease 146 | 658
primary pancreatic ductal adenocarcinoma 145 | 1,109
Atopic dermatitis 143 | 952
Broad flat nasal bridge 143 | 236
Infantile onset 143 | 238
Nasal bridge wide 143 | 236
cutaneous lupus erythematosus 139 | 1,057
spina bifida 139 | 1,074
Bipolar Disorder 137 | 666
Blepharoptosis 136 | 231
Muscle Spasticity 134 | 195
Mandibular hypoplasia 132 | 275
Micrognathism 132 | 275

Tissue

Endocrine System 2,232 | 18,159
Digestive Tract 2,187 | 17,369
Female tissues 2,173 | 17,400
Skin and soft tissues 2,165 | 17,230
Male tissues 2,149 | 17,142
Liver and Pancreas 2,127 | 16,750
Nervous System 2,126 | 16,725
Blood and immune system 2,124 | 16,909
Urinary Tract 2,105 | 16,678
Respiratory system 2,062 | 16,393
Cardiovascular System 1,973 | 15,192

Target Family

Non-IDG 1,181 | 12,091
Enzyme 528 | 4,145
Transcription Factor 181 | 1,400
Kinase 136 | 634
Ion Channel 98 | 344
Transporter 63 | 473
Epigenetic 43 | 242
GPCR 30 | 408
Nuclear Receptor 12 | 48
TF/Epigenetic 7 | 38

Data Source

JensenLab Knowledge UniProtKB-... 2,279 | 2,279
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90