Development Level

Tbio 994 | 10,625
Tchem 215 | 1,890
Tclin 130 | 602
Tdark 24 | 7,003

Collection

Eligible Ion Channel Proteins 10 | 117
Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 2 | 145

IMPC Term

preweaning lethality, complete... 83 | 633
preweaning lethality, incomple... 28 | 260
abnormal behavior 25 | 226
embryonic lethality prior to t... 24 | 187
decreased body weight 21 | 174
embryonic lethality prior to o... 18 | 148
decreased lean body mass 17 | 195
increased circulating alkaline... 17 | 119
decreased grip strength 16 | 123
decreased bone mineral content 15 | 157
hypoactivity 15 | 89
decreased total body fat amoun... 14 | 186
increased mean corpuscular hem... 14 | 93
increased or absent threshold ... 14 | 128
abnormal embryo size 13 | 112
decreased bone mineral density 12 | 126
decreased circulating glucose ... 12 | 121
increased mean corpuscular vol... 12 | 91
short tibia 12 | 82
abnormal bone structure 11 | 131
abnormal retina morphology 11 | 100
decreased body length 11 | 108
decreased circulating triglyce... 11 | 83
abnormal bone mineralization 10 | 55
decreased circulating HDL chol... 10 | 77
decreased circulating amylase ... 10 | 24
decreased circulating choleste... 10 | 85
enlarged heart 10 | 111
hyperactivity 10 | 108
increased circulating HDL chol... 10 | 63
increased circulating sodium l... 10 | 71
decreased hemoglobin content 9 | 53
decreased startle reflex 9 | 48
increased circulating choleste... 9 | 53
increased heart weight 9 | 37
small testis 9 | 37
abnormal lens morphology 8 | 73
decreased circulating fructosa... 8 | 31
decreased circulating serum al... 8 | 79
increased bone mineral content 8 | 92
thrombocytopenia 8 | 46
abnormal coat/hair pigmentatio... 7 | 54
abnormal retinal pigmentation 7 | 61
decreased circulating insulin ... 7 | 75
decreased prepulse inhibition 7 | 52
improved glucose tolerance 7 | 56
increased body weight 7 | 42
increased hemoglobin content 7 | 45
increased total body fat amoun... 7 | 57
male infertility 7 | 62
prenatal lethality prior to he... 7 | 64
abnormal gait 6 | 51
cataract 6 | 26
decreased fasted circulating g... 6 | 49
decreased heart weight 6 | 44
decreased mean corpuscular hem... 6 | 34
decreased rib number 6 | 59
increased blood urea nitrogen ... 6 | 44
increased bone mineral density 6 | 52
increased fasted circulating g... 6 | 68
increased grip strength 6 | 83
increased lean body mass 6 | 107
limb grasping 6 | 35
persistence of hyaloid vascula... 6 | 22
abnormal cornea morphology 5 | 24
abnormal pelvic girdle bone mo... 5 | 11
abnormal seminal vesicle morph... 5 | 47
abnormal testis morphology 5 | 30
corneal opacity 5 | 25
decreased caudal vertebrae num... 5 | 49
decreased circulating alanine ... 5 | 53
decreased erythrocyte cell num... 5 | 43
decreased mean corpuscular vol... 5 | 50
decreased neutrophil cell numb... 5 | 37
hydrops fetalis 5 | 22
impaired glucose tolerance 5 | 52
impaired righting response 5 | 19
increased circulating chloride... 5 | 43
increased circulating potassiu... 5 | 31
increased hematocrit 5 | 36
increased sacral vertebrae num... 5 | 62
abnormal behavioral response t... 4 | 52
abnormal heart morphology 4 | 51
abnormal rib morphology 4 | 28
abnormal skin morphology 4 | 23
abnormal tooth morphology 4 | 24
abnormal vertebrae morphology 4 | 14
absent startle reflex 4 | 15
decreased NK T cell number 4 | 28
decreased circulating bilirubi... 4 | 14
decreased circulating calcium ... 4 | 33
decreased circulating chloride... 4 | 32
decreased circulating iron lev... 4 | 25
decreased eosinophil cell numb... 4 | 41
decreased lumbar vertebrae num... 4 | 62
increased circulating aspartat... 4 | 17
increased circulating bilirubi... 4 | 16
prenatal lethality 4 | 16
tremors 4 | 34
trunk curl 4 | 15

Disease

ovarian cancer 651 | 8,492
osteosarcoma 595 | 7,933
psoriasis 580 | 6,685
medulloblastoma, large-cell 448 | 6,234
lung cancer 444 | 4,473
Cancer 414 | 2,346
glioblastoma 412 | 5,572
atypical teratoid / rhabdoid tumor 311 | 4,369
malignant mesothelioma 308 | 3,163
Carcinoma 301 | 2,147
Breast cancer 265 | 3,099
lung carcinoma 264 | 2,844
intraductal papillary-mucinous neoplasm (IPMN) 258 | 3,289
lung adenocarcinoma 248 | 2,714
pilocytic astrocytoma 246 | 3,086
non-small cell lung cancer 241 | 2,798
invasive ductal carcinoma 239 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 238 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 233 | 2,988
diabetes mellitus 223 | 1,663
primitive neuroectodermal tumor 221 | 3,031
pituitary cancer 206 | 1,972
oligodendroglioma 202 | 2,849
pancreatic cancer 202 | 2,300
pediatric high grade glioma 202 | 2,712
pancreatic ductal adenocarcinoma liver metastasis 190 | 1,795
ulcerative colitis 190 | 2,087
interstitial cystitis 188 | 2,299
Rheumatoid Arthritis 186 | 1,171
subependymal giant cell astrocytoma 186 | 2,287
ependymoma 181 | 2,514
group 3 medulloblastoma 170 | 2,254
adult high grade glioma 157 | 2,148
tuberculosis 157 | 1,563
ductal carcinoma in situ 156 | 1,745
cystic fibrosis 154 | 1,670
colon cancer 145 | 1,475
astrocytoma 143 | 1,493
breast carcinoma 141 | 1,614
astrocytic glioma 138 | 2,241
group 4 medulloblastoma 138 | 1,875
Pick disease 136 | 1,893
Intellectual disability 131 | 573
Neurodegenerative disease 127 | 383
Kidney disease 124 | 397
posterior fossa group B ependymoma 124 | 1,530
dermatomyositis 122 | 967
posterior fossa group A ependymoma 120 | 1,511
adrenocortical carcinoma 115 | 1,427
sonic hedgehog group medulloblastoma 115 | 1,482
cutaneous lupus erythematosus 108 | 1,056
Anemia 106 | 252
medulloblastoma 105 | 1,524
Hypersensitivity reaction type II disease 104 | 235
nasopharyngeal carcinoma 102 | 1,056
Multiple myeloma 99 | 1,328
primary pancreatic ductal adenocarcinoma 93 | 1,271
Multiple Sclerosis 92 | 498
acute quadriplegic myopathy 92 | 1,157
Neuropathy 90 | 210
atypical teratoid/rhabdoid tumor 90 | 1,095
juvenile dermatomyositis 90 | 1,189
Arthritis 89 | 248
Retinitis pigmentosa 86 | 156
Ankylosing spondylitis 85 | 138
Prostatic Neoplasms 83 | 471
gastric carcinoma 81 | 832
Alzheimer's disease 80 | 644
Obesity 79 | 616
Mammary Neoplasms 78 | 410
primary Sjogren syndrome 76 | 789
Juvenile rheumatoid arthritis 75 | 105
Acquired immunodeficiency syndrome 74 | 164
Atopic dermatitis 74 | 944
Cardiomyopathy 74 | 110
Liver disease 73 | 219
Uveitis 73 | 103
spina bifida 73 | 1,064
esophageal adenocarcinoma 72 | 737
active Crohn's disease 71 | 918
Down syndrome 68 | 548
Duchenne muscular dystrophy 68 | 602
Psoriatic arthritis 68 | 85
Heart disease 63 | 279
non primary Sjogren syndrome sicca 63 | 840
Amyotrophic Lateral Sclerosis 62 | 432
Human immunodeficiency virus infectious disease 62 | 129
non-small cell lung carcinoma 62 | 413
Sensorineural hearing loss 61 | 107
acute myeloid leukemia 61 | 785
fibroadenoma 61 | 557
Peripheral Neuropathy 60 | 303
Behcet's disease 59 | 74
Epilepsy 59 | 346
Hypertension 59 | 293
Waldenstrons macroglobulinemia 59 | 765
Stevens-Johnson syndrome 58 | 91
Autistic Disorder 57 | 320
aldosterone-producing adenoma 57 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 56 | 499

Tissue

Digestive Tract 1,286 | 18,473
Female tissues 1,285 | 18,647
Endocrine System 1,282 | 18,512
Nervous System 1,281 | 18,561
Urinary Tract 1,280 | 18,444
Liver and Pancreas 1,275 | 18,136
Cardiovascular System 1,274 | 17,958
Male tissues 1,274 | 17,969
Blood and immune system 1,273 | 17,995
Skin and soft tissues 1,263 | 18,115
Respiratory system 1,253 | 17,484

Target Family

Non-IDG 729 | 11,969
Enzyme 334 | 4,146
Transcription Factor 97 | 1,400
Kinase 68 | 634
Ion Channel 58 | 341
Transporter 44 | 473
GPCR 14 | 408
Epigenetic 11 | 242
Nuclear Receptor 6 | 48
TF/Epigenetic 2 | 38

Data Source

JensenLab Knowledge GHR 1,363 | 1,363
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
Lebercilin LCA5 Tbio Non-IDG -1.21162 16.7 65
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.23140 15.5 156
Lipopolysaccharide-induced tumor necrosis factor-alpha factor LITAF Tbio Transcription Factor -2.00894 100.6 155
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Adenine DNA glycosylase MUTYH Tbio Enzyme -2.83418 699.9 239
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 Tbio Enzyme -2.08075 121.5 75
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.89144 80.2 134
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.59865 595.2 0
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.59865 595.2 386