Development Level

Tbio 1,539 | 11,445
Tchem 256 | 1,598
Tclin 208 | 613
Tdark 49 | 6,588

Collection

RFA-RM-18-021 25 | 328
Ion Channel: IDG Consortium (T... 18 | 99
Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Targets) 4 | 126
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 175 | 979
preweaning lethality, incomple... 70 | 499
embryonic lethality prior to t... 51 | 278
abnormal behavior 48 | 298
embryonic lethality prior to o... 37 | 239
decreased vertical activity 36 | 208
abnormal embryo size 35 | 220
enlarged heart 32 | 210
decreased total body fat amoun... 31 | 207
abnormal bone structure 30 | 187
decreased body weight 30 | 161
hypoactivity 28 | 132
increased or absent threshold ... 28 | 101
increased circulating alkaline... 27 | 122
decreased bone mineral content 24 | 151
increased lean body mass 24 | 172
hyperactivity 23 | 148
increased total body fat amoun... 23 | 134
decreased circulating choleste... 22 | 93
short tibia 22 | 97
abnormal heart morphology 21 | 162
increased mean corpuscular hem... 21 | 96
increased startle reflex 21 | 112
decreased grip strength 20 | 116
decreased bone mineral density 19 | 126
decreased prepulse inhibition 18 | 82
decreased startle reflex 18 | 75
decreased mean corpuscular vol... 17 | 79
increased heart weight 17 | 62
decreased circulating glucose ... 16 | 126
decreased lean body mass 16 | 135
improved glucose tolerance 16 | 79
increased circulating choleste... 16 | 66
prenatal lethality prior to he... 16 | 87
abnormal lens morphology 15 | 81
abnormal retina morphology 15 | 71
abnormal seminal vesicle morph... 15 | 114
cataract 15 | 92
decreased circulating serum al... 15 | 82
impaired glucose tolerance 15 | 75
decreased body length 14 | 101
decreased circulating HDL chol... 14 | 68
decreased fasted circulating g... 14 | 65
increased circulating HDL chol... 14 | 80
increased circulating sodium l... 14 | 71
abnormal coat-hair pigmentatio... 13 | 64
abnormal gait 13 | 69
decreased lymphocyte cell numb... 13 | 83
increased bone mineral content 13 | 108
male infertility 13 | 123
thrombocytopenia 13 | 56
abnormal eye morphology 12 | 68
abnormal skin morphology 12 | 50
decreased erythrocyte cell num... 12 | 62
decreased hemoglobin content 12 | 68
embryonic growth retardation 12 | 106
increased bone mineral density 12 | 72
small superior vagus ganglion 12 | 74
corneal opacity 11 | 32
decreased circulating amylase ... 11 | 28
small testis 11 | 58
decreased blood urea nitrogen ... 10 | 51
decreased circulating fructosa... 10 | 30
edema 10 | 59
increased hemoglobin content 10 | 45
increased leukocyte cell numbe... 10 | 47
increased neutrophil cell numb... 10 | 46
persistence of hyaloid vascula... 10 | 33
absent startle reflex 9 | 24
decreased circulating triglyce... 9 | 79
decreased mean corpuscular hem... 9 | 50
hydrometra 9 | 53
increased blood urea nitrogen ... 9 | 48
increased circulating amylase ... 9 | 25
increased circulating phosphat... 9 | 26
increased lymphocyte cell numb... 9 | 32
increased mean corpuscular vol... 9 | 92
tremors 9 | 39
abnormal bone mineralization 8 | 38
abnormal cornea morphology 8 | 31
abnormal testis morphology 8 | 43
decreased circulating LDL chol... 8 | 38
decreased circulating alkaline... 8 | 46
decreased heart weight 8 | 27
decreased mean platelet volume 8 | 25
enlarged lymph nodes 8 | 37
enlarged spleen 8 | 41
impaired pupillary reflex 8 | 26
increased mean platelet volume 8 | 45
limb grasping 8 | 41
abnormal spleen morphology 7 | 55
abnormal vertebrae morphology 7 | 18
decreased caudal vertebrae num... 7 | 53
decreased circulating aspartat... 7 | 34
decreased circulating calcium ... 7 | 36
decreased circulating total pr... 7 | 49
decreased neutrophil cell numb... 7 | 42
increased circulating potassiu... 7 | 29
increased fasted circulating g... 7 | 76
prolonged ST segment 7 | 36

Disease

Carcinoma 1,482 | 11,493
ovarian cancer 1,014 | 8,520
osteosarcoma 886 | 7,950
psoriasis 854 | 6,694
Autosomal recessive predisposition 769 | 1,442
medulloblastoma, large-cell 710 | 6,241
lung cancer 688 | 4,740
glioblastoma 676 | 5,792
atypical teratoid / rhabdoid tumor 590 | 5,112
ependymoma 572 | 4,679
Cancer 559 | 2,499
Kidney cancer 487 | 2,613
Breast cancer 479 | 3,578
Intellectual disability 470 | 1,016
group 3 medulloblastoma 457 | 4,104
malignant mesothelioma 436 | 3,232
adult high grade glioma 429 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 402 | 3,291
Astrocytoma, Pilocytic 397 | 3,081
Dull intelligence 391 | 645
Low intelligence 391 | 645
Mental Retardation 391 | 645
Mental deficiency 391 | 645
Poor school performance 391 | 645
lung carcinoma 390 | 2,843
Epilepsy 381 | 792
non-small cell lung cancer 377 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 370 | 2,955
invasive ductal carcinoma 362 | 2,951
lung adenocarcinoma 355 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 353 | 2,989
Muscle hypotonia 348 | 571
primitive neuroectodermal tumor 343 | 3,035
Cognitive delay 332 | 608
Global developmental delay 332 | 608
Mental and motor retardation 332 | 608
pancreatic cancer 332 | 2,398
Seizures 331 | 596
diabetes mellitus 324 | 1,728
oligodendroglioma 320 | 2,850
Short stature 318 | 531
subependymal giant cell astrocytoma 298 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 294 | 1,962
pituitary cancer 287 | 1,972
interstitial cystitis 285 | 2,312
astrocytic glioma 281 | 2,597
tuberculosis 276 | 2,010
Rheumatoid arthritis 256 | 1,191
Schizophrenia 252 | 1,160
ulcerative colitis 252 | 1,819
breast carcinoma 244 | 1,638
ductal carcinoma in situ 238 | 1,745
Failure to gain weight 230 | 365
Pediatric failure to thrive 230 | 365
Sensorineural Hearing Loss (disorder) 223 | 284
Nystagmus 222 | 317
cystic fibrosis 222 | 1,696
Pick disease 219 | 1,894
colon cancer 218 | 1,478
group 4 medulloblastoma 215 | 1,855
Cerebellar Ataxia 209 | 304
Small head 197 | 374
Obesity 194 | 678
Cataract 186 | 297
Strabismus 184 | 270
Anemia 180 | 365
Melanoma 180 | 711
Cryptorchidism 177 | 296
Curvature of spine 177 | 282
Acquired scoliosis 176 | 281
astrocytoma 176 | 1,146
Hepatomegaly 175 | 285
Neurodegenerative disease 175 | 414
adrenocortical carcinoma 171 | 1,428
Optic Atrophy 169 | 242
Lens Opacities 168 | 231
Blepharoptosis 167 | 231
Broad flat nasal bridge 164 | 236
Nasal bridge wide 164 | 236
Depressive disorder 161 | 409
Bipolar Disorder 159 | 666
Hypoplastic mandible condyle 159 | 275
Mandibular hypoplasia 159 | 275
Micrognathism 159 | 275
Liver cancer 158 | 604
Retinitis Pigmentosa 158 | 226
dermatomyositis 157 | 966
Kidney disease 156 | 430
Multiple myeloma 149 | 1,332
acute quadriplegic myopathy 148 | 1,158
nasopharyngeal carcinoma 146 | 1,058
Orbital separation excessive 145 | 244
Deafness 143 | 198
Neuropathy 142 | 261
Low Vision 141 | 174
Muscle Spasticity 141 | 195
Visual Impairment 141 | 174
Skin cancer 140 | 469
cutaneous lupus erythematosus 140 | 1,057
hearing impairment 140 | 199

Tissue

Endocrine System 1,928 | 18,159
Digestive Tract 1,887 | 17,369
Skin and soft tissues 1,877 | 17,230
Female tissues 1,869 | 17,400
Male tissues 1,846 | 17,142
Blood and immune system 1,837 | 16,909
Liver and Pancreas 1,835 | 16,750
Urinary Tract 1,829 | 16,678
Nervous System 1,819 | 16,725
Respiratory system 1,775 | 16,393
Cardiovascular System 1,663 | 15,192

Target Family

Non-IDG 1,056 | 12,091
Enzyme 512 | 4,145
Transcription Factor 149 | 1,400
Ion Channel 93 | 344
Kinase 92 | 634
Transporter 64 | 473
GPCR 42 | 408
Epigenetic 27 | 242
Nuclear Receptor 9 | 48
TF/Epigenetic 8 | 38

Data Source

JensenLab Knowledge GHR 2,052 | 2,052
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Caspase-14 CASP14 Tchem Enzyme -1.81937 73.7 348
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436