Development Level

Tbio 1,457 | 11,178
Tchem 294 | 1,885
Tclin 206 | 612
Tdark 47 | 6,569

Collection

Ion Channel: IDG Consortium (T... 18 | 99
Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Targets) 4 | 126
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 173 | 979
preweaning lethality, incomple... 68 | 499
embryonic lethality prior to t... 50 | 278
abnormal behavior 48 | 298
decreased vertical activity 36 | 208
embryonic lethality prior to o... 36 | 239
abnormal embryo size 34 | 220
enlarged heart 32 | 210
decreased total body fat amoun... 31 | 207
abnormal bone structure 29 | 187
decreased body weight 29 | 161
hypoactivity 28 | 132
increased or absent threshold ... 28 | 101
increased circulating alkaline... 25 | 122
increased lean body mass 24 | 172
decreased bone mineral content 23 | 151
hyperactivity 23 | 148
abnormal heart morphology 21 | 162
decreased circulating choleste... 21 | 93
increased startle reflex 21 | 112
increased total body fat amoun... 21 | 134
short tibia 21 | 97
increased mean corpuscular hem... 20 | 96
decreased grip strength 19 | 116
decreased bone mineral density 18 | 126
decreased prepulse inhibition 18 | 82
decreased mean corpuscular vol... 17 | 79
decreased startle reflex 17 | 75
decreased circulating glucose ... 16 | 126
improved glucose tolerance 16 | 79
increased circulating choleste... 16 | 66
increased heart weight 16 | 62
prenatal lethality prior to he... 16 | 87
abnormal lens morphology 15 | 81
abnormal retina morphology 15 | 71
abnormal seminal vesicle morph... 15 | 114
cataract 15 | 92
decreased circulating serum al... 15 | 82
decreased lean body mass 15 | 135
impaired glucose tolerance 15 | 75
increased circulating HDL chol... 14 | 80
increased circulating sodium l... 14 | 71
abnormal coat-hair pigmentatio... 13 | 64
decreased body length 13 | 101
decreased circulating HDL chol... 13 | 68
decreased fasted circulating g... 13 | 65
decreased lymphocyte cell numb... 13 | 83
increased bone mineral content 13 | 108
male infertility 13 | 123
thrombocytopenia 13 | 56
abnormal eye morphology 12 | 68
abnormal gait 12 | 69
abnormal skin morphology 12 | 50
decreased hemoglobin content 12 | 68
embryonic growth retardation 12 | 106
increased bone mineral density 12 | 72
small superior vagus ganglion 12 | 74
corneal opacity 11 | 32
decreased erythrocyte cell num... 11 | 62
small testis 11 | 58
decreased circulating amylase ... 10 | 28
decreased circulating fructosa... 10 | 30
edema 10 | 59
increased hemoglobin content 10 | 45
increased leukocyte cell numbe... 10 | 47
increased neutrophil cell numb... 10 | 46
persistence of hyaloid vascula... 10 | 33
absent startle reflex 9 | 24
decreased blood urea nitrogen ... 9 | 51
decreased mean corpuscular hem... 9 | 50
hydrometra 9 | 53
increased circulating amylase ... 9 | 25
increased circulating phosphat... 9 | 26
increased lymphocyte cell numb... 9 | 32
increased mean corpuscular vol... 9 | 92
abnormal cornea morphology 8 | 31
abnormal testis morphology 8 | 43
decreased circulating LDL chol... 8 | 38
decreased circulating alkaline... 8 | 46
decreased circulating triglyce... 8 | 79
decreased heart weight 8 | 27
decreased mean platelet volume 8 | 25
enlarged lymph nodes 8 | 37
enlarged spleen 8 | 41
impaired pupillary reflex 8 | 26
increased blood urea nitrogen ... 8 | 48
increased mean platelet volume 8 | 45
limb grasping 8 | 41
tremors 8 | 39
abnormal behavioral response t... 7 | 66
abnormal bone mineralization 7 | 38
abnormal spleen morphology 7 | 55
decreased caudal vertebrae num... 7 | 53
decreased circulating total pr... 7 | 49
decreased neutrophil cell numb... 7 | 42
decreased red blood cell distr... 7 | 41
increased fasted circulating g... 7 | 76
long tibia 7 | 25
abnormal kidney morphology 6 | 65
decreased circulating aspartat... 6 | 34

Disease

Carcinoma 1,442 | 11,192
ovarian cancer 988 | 8,297
osteosarcoma 870 | 7,766
psoriasis 835 | 6,514
Autosomal recessive predisposition 749 | 1,407
medulloblastoma, large-cell 695 | 6,086
lung cancer 669 | 4,607
glioblastoma 658 | 5,635
atypical teratoid / rhabdoid tumor 572 | 4,971
ependymoma 555 | 4,559
Cancer 537 | 2,388
Kidney cancer 471 | 2,548
Breast cancer 465 | 3,469
Intellectual disability 461 | 998
group 3 medulloblastoma 446 | 4,002
malignant mesothelioma 424 | 3,135
adult high grade glioma 422 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 388 | 3,204
Astrocytoma, Pilocytic 386 | 3,006
Dull intelligence 384 | 634
Low intelligence 384 | 634
Mental Retardation 384 | 634
Mental deficiency 384 | 634
Poor school performance 384 | 634
lung carcinoma 380 | 2,755
Epilepsy 374 | 775
non-small cell lung cancer 366 | 2,799
intraductal papillary-mucinous adenoma (IPMA) 357 | 2,872
invasive ductal carcinoma 354 | 2,867
Muscle hypotonia 343 | 562
lung adenocarcinoma 343 | 2,627
intraductal papillary-mucinous carcinoma (IPMC) 339 | 2,902
primitive neuroectodermal tumor 334 | 2,957
Cognitive delay 326 | 596
Global developmental delay 326 | 596
Mental and motor retardation 326 | 596
Seizures 325 | 584
pancreatic cancer 321 | 2,322
diabetes mellitus 314 | 1,683
oligodendroglioma 312 | 2,768
Short stature 309 | 514
subependymal giant cell astrocytoma 288 | 2,230
pancreatic ductal adenocarcinoma liver metastasis 286 | 1,911
interstitial cystitis 281 | 2,237
pituitary cancer 281 | 1,915
astrocytic glioma 274 | 2,530
tuberculosis 273 | 1,963
Rheumatoid arthritis 253 | 1,156
ulcerative colitis 245 | 1,765
Schizophrenia 244 | 1,136
breast carcinoma 235 | 1,589
ductal carcinoma in situ 231 | 1,686
Failure to gain weight 228 | 359
Pediatric failure to thrive 228 | 359
Sensorineural Hearing Loss (disorder) 221 | 281
Nystagmus 217 | 309
Pick disease 216 | 1,856
cystic fibrosis 214 | 1,629
colon cancer 208 | 1,428
Cerebellar Ataxia 207 | 302
group 4 medulloblastoma 206 | 1,806
Small head 193 | 366
Obesity 187 | 655
Cataract 182 | 290
Strabismus 182 | 265
Anemia 177 | 353
Melanoma 175 | 689
Curvature of spine 174 | 275
Acquired scoliosis 173 | 274
Hepatomegaly 173 | 280
Cryptorchidism 172 | 287
Neurodegenerative disease 168 | 402
astrocytoma 168 | 1,113
Optic Atrophy 167 | 239
Blepharoptosis 166 | 229
Lens Opacities 165 | 227
adrenocortical carcinoma 165 | 1,385
Broad flat nasal bridge 162 | 232
Nasal bridge wide 162 | 232
Depressive disorder 158 | 401
Hypoplastic mandible condyle 158 | 273
Mandibular hypoplasia 158 | 273
Micrognathism 158 | 273
Bipolar Disorder 155 | 646
Retinitis Pigmentosa 155 | 223
Liver cancer 153 | 589
dermatomyositis 153 | 941
Kidney disease 151 | 411
Multiple myeloma 147 | 1,296
acute quadriplegic myopathy 147 | 1,133
Orbital separation excessive 142 | 240
nasopharyngeal carcinoma 141 | 1,024
Deafness 140 | 193
Muscle Spasticity 139 | 192
Neuropathy 139 | 254
cutaneous lupus erythematosus 139 | 1,016
Low Vision 137 | 167
Visual Impairment 137 | 167
hearing impairment 137 | 194
Skin cancer 135 | 451

Tissue

Endocrine System 1,881 | 18,159
Digestive Tract 1,845 | 17,369
Skin and soft tissues 1,836 | 17,230
Female tissues 1,828 | 17,400
Male tissues 1,809 | 17,142
Blood and immune system 1,798 | 16,909
Liver and Pancreas 1,797 | 16,750
Urinary Tract 1,793 | 16,678
Nervous System 1,779 | 16,725
Respiratory system 1,740 | 16,393
Cardiovascular System 1,634 | 15,192

Target Family

Non-IDG 1,044 | 12,091
Enzyme 490 | 4,145
Transcription Factor 137 | 1,400
Ion Channel 93 | 344
Kinase 92 | 634
Transporter 63 | 473
GPCR 42 | 408
Epigenetic 27 | 242
Nuclear Receptor 8 | 48
TF/Epigenetic 8 | 38

Data Source

JensenLab Knowledge GHR 2,004 | 2,004
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Protein KIAA0556 KIAA0556 Tdark Non-IDG -0.22617 2.09 22
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
RNA-binding protein 20 RBM20 Tbio Non-IDG -1.40778 24.2 73
Zinc finger protein 423 ZNF423 Tbio Transcription Factor -1.62303 45.3 77
HLA class I histocompatibility antigen, B-67 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 362