Development Level

Tbio 9,450 | 11,178
Tdark 3,426 | 6,569
Tchem 1,590 | 1,885
Tclin 469 | 612

Collection

Kinase: IDG Consortium (Target... 112 | 125
Ion Channel: IDG Consortium (T... 69 | 99
GPCR: IDG Consortium (Targets) 42 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 913 | 979
preweaning lethality, incomple... 437 | 499
embryonic lethality prior to t... 262 | 278
abnormal behavior 258 | 298
embryonic lethality prior to o... 227 | 239
abnormal embryo size 202 | 220
decreased total body fat amoun... 180 | 207
abnormal bone structure 167 | 187
enlarged heart 165 | 210
decreased vertical activity 162 | 208
increased lean body mass 150 | 172
decreased body weight 142 | 161
abnormal heart morphology 131 | 162
decreased bone mineral content 130 | 151
hyperactivity 124 | 148
decreased lean body mass 114 | 135
male infertility 113 | 123
increased total body fat amoun... 112 | 134
decreased circulating glucose ... 108 | 126
hypoactivity 108 | 132
decreased bone mineral density 107 | 126
increased circulating alkaline... 106 | 122
decreased grip strength 100 | 116
embryonic growth retardation 97 | 106
increased startle reflex 97 | 112
increased bone mineral content 92 | 108
abnormal seminal vesicle morph... 91 | 114
decreased body length 89 | 101
increased mean corpuscular vol... 86 | 92
increased mean corpuscular hem... 85 | 96
short tibia 85 | 97
increased or absent threshold ... 84 | 101
decreased circulating choleste... 82 | 93
prenatal lethality prior to he... 82 | 87
cataract 77 | 92
decreased circulating serum al... 73 | 82
decreased lymphocyte cell numb... 73 | 83
decreased mean corpuscular vol... 72 | 79
decreased prepulse inhibition 71 | 82
improved glucose tolerance 71 | 79
decreased circulating triglyce... 70 | 79
abnormal lens morphology 68 | 81
increased circulating HDL chol... 68 | 80
decreased startle reflex 66 | 75
decreased leukocyte cell numbe... 65 | 73
impaired glucose tolerance 64 | 75
small superior vagus ganglion 64 | 74
increased bone mineral density 62 | 72
increased fasted circulating g... 62 | 76
abnormal retina morphology 61 | 71
decreased circulating HDL chol... 61 | 68
decreased circulating insulin ... 61 | 76
increased circulating sodium l... 59 | 71
abnormal eye morphology 58 | 68
decreased hemoglobin content 58 | 68
decreased erythrocyte cell num... 57 | 62
abnormal gait 56 | 69
abnormal sleep behavior 56 | 70
abnormal coat-hair pigmentatio... 55 | 64
decreased fasted circulating g... 55 | 65
increased circulating choleste... 55 | 66
increased monocyte cell number 55 | 63
abnormal behavioral response t... 53 | 66
increased heart weight 53 | 62
abnormal kidney morphology 51 | 65
small testis 51 | 58
decreased caudal vertebrae num... 49 | 53
female infertility 49 | 60
edema 48 | 59
abnormal spleen morphology 46 | 55
decreased circulating total pr... 45 | 49
decreased mean corpuscular hem... 45 | 50
hydrometra 44 | 53
thrombocytopenia 44 | 56
abnormal skin morphology 43 | 50
decreased blood urea nitrogen ... 43 | 51
decreased hematocrit 43 | 46
abnormal neural tube closure 42 | 46
decreased circulating alkaline... 42 | 46
increased hematocrit 40 | 46
increased leukocyte cell numbe... 40 | 47
increased mean platelet volume 40 | 45
increased circulating chloride... 39 | 41
increased circulating triglyce... 39 | 42
increased blood urea nitrogen ... 38 | 48
increased neutrophil cell numb... 38 | 46
abnormal epididymis morphology 37 | 42
decreased circulating alanine ... 37 | 47
decreased neutrophil cell numb... 37 | 42
increased circulating creatini... 37 | 38
tremors 37 | 39
abnormal testis morphology 36 | 43
decreased red blood cell distr... 36 | 41
increased hemoglobin content 36 | 45
abnormal bone mineralization 35 | 38
decreased circulating LDL chol... 35 | 38
decreased circulating calcium ... 34 | 36
enlarged spleen 34 | 41
increased erythrocyte cell num... 34 | 39
increased grip strength 33 | 41

Disease

Carcinoma 9,188 | 11,192
ovarian cancer 7,498 | 8,297
osteosarcoma 6,736 | 7,766
medulloblastoma, large-cell 5,463 | 6,086
psoriasis 5,293 | 6,514
glioblastoma 5,170 | 5,635
atypical teratoid / rhabdoid tumor 4,541 | 4,971
ependymoma 4,161 | 4,559
lung cancer 4,161 | 4,607
group 3 medulloblastoma 3,605 | 4,002
adult high grade glioma 3,314 | 3,701
Breast cancer 3,125 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,908 | 3,204
malignant mesothelioma 2,864 | 3,135
Astrocytoma, Pilocytic 2,733 | 3,006
primitive neuroectodermal tumor 2,687 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,642 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,612 | 2,872
invasive ductal carcinoma 2,592 | 2,867
oligodendroglioma 2,556 | 2,768
non-small cell lung cancer 2,514 | 2,799
lung carcinoma 2,414 | 2,755
astrocytic glioma 2,324 | 2,530
lung adenocarcinoma 2,293 | 2,627
Kidney cancer 2,224 | 2,548
Cancer 2,116 | 2,388
pancreatic cancer 2,088 | 2,322
subependymal giant cell astrocytoma 2,077 | 2,230
interstitial cystitis 1,883 | 2,237
Pick disease 1,778 | 1,856
pancreatic ductal adenocarcinoma liver metastasis 1,777 | 1,911
pituitary cancer 1,720 | 1,915
tuberculosis 1,713 | 1,963
group 4 medulloblastoma 1,661 | 1,806
ulcerative colitis 1,540 | 1,765
ductal carcinoma in situ 1,511 | 1,686
cystic fibrosis 1,444 | 1,629
breast carcinoma 1,438 | 1,589
diabetes mellitus 1,298 | 1,683
colon cancer 1,293 | 1,428
adrenocortical carcinoma 1,264 | 1,385
Autosomal recessive predisposition 1,239 | 1,407
Multiple myeloma 1,239 | 1,296
juvenile dermatomyositis 1,088 | 1,147
acute quadriplegic myopathy 1,080 | 1,133
astrocytoma 1,066 | 1,113
Rheumatoid arthritis 1,030 | 1,156
primary pancreatic ductal adenocarcinoma 1,006 | 1,071
Schizophrenia 974 | 1,136
spina bifida 962 | 1,053
pediatric high grade glioma 954 | 1,035
dermatomyositis 911 | 941
Intellectual disability 909 | 998
nasopharyngeal carcinoma 887 | 1,024
cutaneous lupus erythematosus 865 | 1,016
active Crohn's disease 780 | 882
Atopic dermatitis 769 | 915
non primary Sjogren syndrome sicca 743 | 861
Waldenstrons macroglobulinemia 718 | 742
Epilepsy 715 | 775
gastric carcinoma 708 | 781
acute myeloid leukemia 682 | 760
Liver Cirrhosis, Experimental 659 | 733
esophageal adenocarcinoma 651 | 696
active ulcerative colitis 645 | 736
medulloblastoma 627 | 702
primary Sjogren syndrome 627 | 710
progressive supranuclear palsy 618 | 656
aldosterone-producing adenoma 608 | 646
Dull intelligence 589 | 634
Low intelligence 589 | 634
Mental Retardation 589 | 634
Mental deficiency 589 | 634
Poor school performance 589 | 634
Alzheimer's disease 577 | 640
Duchenne muscular dystrophy 560 | 587
Melanoma 559 | 689
Cognitive delay 557 | 596
Global developmental delay 557 | 596
Mental and motor retardation 557 | 596
Bipolar Disorder 548 | 646
Obesity 547 | 655
Seizures 541 | 584
Muscle hypotonia 528 | 562
Liver cancer 518 | 589
pancreatic carcinoma 486 | 555
hepatocellular carcinoma 476 | 536
autosomal dominant Emery-Dreifuss muscular dystrophy 475 | 492
fibroadenoma 474 | 538
Down syndrome 456 | 480
Endometriosis 456 | 521
Short stature 452 | 514
chronic rhinosinusitis 445 | 505
Prostatic Neoplasms 426 | 472
Amyotrophic lateral sclerosis 412 | 437
Multiple Sclerosis 412 | 527
posterior fossa group A ependymoma 399 | 456
sonic hedgehog group medulloblastoma 399 | 459
mucosa-associated lymphoid tissue lymphoma 397 | 473
gastric cancer 388 | 445

Tissue

Endocrine System 14,542 | 18,159
Digestive Tract 14,260 | 17,369
Female tissues 14,247 | 17,400
Skin and soft tissues 14,201 | 17,230
Male tissues 14,122 | 17,142
Blood and immune system 13,983 | 16,909
Liver and Pancreas 13,980 | 16,750
Nervous System 13,962 | 16,725
Urinary Tract 13,935 | 16,678
Respiratory system 13,758 | 16,393
Cardiovascular System 13,087 | 15,192

Target Family

Non-IDG 8,740 | 12,091
Enzyme 3,468 | 4,145
Transcription Factor 1,028 | 1,400
Kinase 571 | 634
Transporter 387 | 473
Ion Channel 241 | 344
Epigenetic 227 | 242
GPCR 184 | 408
Nuclear Receptor 43 | 48
TF/Epigenetic 29 | 38
oGPCR 17 | 421

Data Source

JensenLab Experiment UniGene 14,935 | 14,935
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83