Development Level

Tbio 7,947 | 10,625
Tdark 2,951 | 7,003
Tchem 1,403 | 1,890
Tclin 399 | 602

Collection

Eligible Kinase Proteins 106 | 134
Eligible Ion Channel Proteins 61 | 117
Eligible non-olfactory GPCR Proteins 30 | 145

IMPC Term

preweaning lethality, complete... 538 | 633
preweaning lethality, incomple... 212 | 260
abnormal behavior 186 | 226
embryonic lethality prior to t... 168 | 187
decreased lean body mass 159 | 195
decreased total body fat amoun... 157 | 186
decreased body weight 141 | 174
embryonic lethality prior to o... 137 | 148
decreased bone mineral content 130 | 157
abnormal bone structure 108 | 131
decreased bone mineral density 106 | 126
increased circulating alkaline... 103 | 119
decreased body length 96 | 108
increased or absent threshold ... 96 | 128
decreased grip strength 94 | 123
decreased circulating glucose ... 91 | 121
abnormal embryo size 90 | 112
increased lean body mass 87 | 107
hyperactivity 86 | 108
abnormal retina morphology 85 | 100
increased mean corpuscular hem... 80 | 93
increased mean corpuscular vol... 76 | 91
enlarged heart 74 | 111
increased bone mineral content 73 | 92
short tibia 70 | 82
decreased circulating choleste... 68 | 85
decreased circulating HDL chol... 65 | 77
decreased circulating serum al... 65 | 79
hypoactivity 65 | 89
decreased circulating triglyce... 62 | 83
increased grip strength 62 | 83
prenatal lethality prior to he... 59 | 64
abnormal lens morphology 57 | 73
male infertility 56 | 62
decreased circulating insulin ... 54 | 75
decreased lumbar vertebrae num... 51 | 62
increased fasted circulating g... 51 | 68
increased circulating sodium l... 49 | 71
abnormal retinal pigmentation 48 | 61
increased sacral vertebrae num... 48 | 62
decreased mean corpuscular vol... 47 | 50
abnormal bone mineralization 46 | 55
abnormal sleep behavior 46 | 63
decreased leukocyte cell numbe... 44 | 54
decreased hemoglobin content 43 | 53
decreased rib number 43 | 59
abnormal coat/hair pigmentatio... 42 | 54
increased total body fat amoun... 42 | 57
impaired glucose tolerance 41 | 52
abnormal behavioral response t... 40 | 52
abnormal gait 40 | 51
decreased caudal vertebrae num... 40 | 49
decreased fasted circulating g... 40 | 49
decreased prepulse inhibition 40 | 52
decreased startle reflex 40 | 48
increased circulating HDL chol... 40 | 63
improved glucose tolerance 39 | 56
increased circulating choleste... 39 | 53
increased blood urea nitrogen ... 38 | 44
increased bone mineral density 38 | 52
increased exploration in new e... 38 | 56
decreased circulating alanine ... 37 | 53
increased circulating chloride... 37 | 43
decreased heart weight 36 | 44
decreased circulating total pr... 35 | 41
decreased erythrocyte cell num... 35 | 43
increased hemoglobin content 35 | 45
decreased eosinophil cell numb... 34 | 41
thrombocytopenia 34 | 46
increased body weight 33 | 42
abnormal seminal vesicle morph... 32 | 47
decreased circulating LDL chol... 32 | 37
decreased circulating alkaline... 32 | 41
abnormal neural tube closure 31 | 37
abnormal eye morphology 30 | 38
decreased circulating free fat... 30 | 39
increased rib number 30 | 41
tremors 30 | 34
abnormal heart morphology 29 | 51
decreased circulating fructosa... 29 | 31
decreased mean corpuscular hem... 29 | 34
increased leukocyte cell numbe... 29 | 37
small testis 29 | 37
decreased circulating calcium ... 28 | 33
increased circulating calcium ... 28 | 32
increased hematocrit 28 | 36
increased startle reflex 28 | 38
decreased T cell number 27 | 31
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
cardiovascular system phenotyp... 26 | 35
increased circulating creatini... 26 | 29
increased circulating potassiu... 26 | 31
abnormal cranium morphology 25 | 32
decreased circulating creatini... 25 | 31
decreased blood urea nitrogen ... 24 | 31
female infertility 24 | 34
limb grasping 24 | 35
abnormal epididymis morphology 23 | 31
decreased neutrophil cell numb... 23 | 37

Disease

ovarian cancer 6,934 | 8,492
osteosarcoma 6,021 | 7,933
medulloblastoma, large-cell 4,995 | 6,234
psoriasis 4,766 | 6,685
glioblastoma 4,604 | 5,572
lung cancer 3,703 | 4,473
atypical teratoid / rhabdoid tumor 3,572 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,624 | 3,289
malignant mesothelioma 2,597 | 3,163
Breast cancer 2,489 | 3,099
pilocytic astrocytoma 2,479 | 3,086
primitive neuroectodermal tumor 2,461 | 3,031
oligodendroglioma 2,416 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 2,396 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,362 | 2,956
invasive ductal carcinoma 2,341 | 2,950
pediatric high grade glioma 2,231 | 2,712
non-small cell lung cancer 2,209 | 2,798
ependymoma 2,136 | 2,514
lung carcinoma 2,129 | 2,844
lung adenocarcinoma 2,100 | 2,714
subependymal giant cell astrocytoma 1,957 | 2,287
Cancer 1,884 | 2,346
pancreatic cancer 1,846 | 2,300
astrocytic glioma 1,845 | 2,241
group 3 medulloblastoma 1,741 | 2,254
Pick disease 1,727 | 1,893
adult high grade glioma 1,665 | 2,148
interstitial cystitis 1,640 | 2,299
Carcinoma 1,619 | 2,147
ulcerative colitis 1,615 | 2,087
group 4 medulloblastoma 1,572 | 1,875
pituitary cancer 1,556 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,501 | 1,795
astrocytoma 1,370 | 1,493
ductal carcinoma in situ 1,362 | 1,745
breast carcinoma 1,302 | 1,614
cystic fibrosis 1,295 | 1,670
medulloblastoma 1,245 | 1,524
Multiple myeloma 1,241 | 1,328
colon cancer 1,207 | 1,475
posterior fossa group A ependymoma 1,203 | 1,511
sonic hedgehog group medulloblastoma 1,196 | 1,482
tuberculosis 1,196 | 1,563
diabetes mellitus 1,193 | 1,663
adrenocortical carcinoma 1,144 | 1,427
primary pancreatic ductal adenocarcinoma 1,111 | 1,271
posterior fossa group B ependymoma 1,097 | 1,530
juvenile dermatomyositis 1,048 | 1,189
acute quadriplegic myopathy 1,033 | 1,157
Rheumatoid Arthritis 945 | 1,171
dermatomyositis 905 | 967
atypical teratoid/rhabdoid tumor 903 | 1,095
spina bifida 853 | 1,064
nasopharyngeal carcinoma 788 | 1,056
cutaneous lupus erythematosus 769 | 1,056
Waldenstrons macroglobulinemia 713 | 765
active Crohn's disease 695 | 918
gastric carcinoma 673 | 832
Atopic dermatitis 667 | 944
acute myeloid leukemia 642 | 785
non primary Sjogren syndrome sicca 642 | 840
esophageal adenocarcinoma 623 | 737
progressive supranuclear palsy 608 | 674
primary Sjogren syndrome 594 | 789
aldosterone-producing adenoma 573 | 664
tuberculosis and treatment for 6 months 561 | 686
Duchenne muscular dystrophy 536 | 602
Alzheimer's disease 530 | 644
Down syndrome 488 | 548
Intellectual disability 476 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 453 | 499
Obesity 452 | 616
pancreatic carcinoma 443 | 567
hepatocellular carcinoma 440 | 550
fibroadenoma 421 | 557
Endometriosis 407 | 535
Prostatic Neoplasms 388 | 471
Amyotrophic Lateral Sclerosis 383 | 432
chronic rhinosinusitis 382 | 512
IGA Glomerulonephritis 379 | 454
Schizophrenia 377 | 503
active ulcerative colitis 355 | 477
mucosa-associated lymphoid tissue lymphoma 348 | 480
gastric cancer 345 | 436
Multiple Sclerosis 341 | 498
Neurodegenerative disease 339 | 383
Mammary Neoplasms 338 | 410
inflammatory breast cancer 304 | 404
Kidney disease 299 | 397
hereditary spastic paraplegia 297 | 313
Parkinson's disease 292 | 364
Epilepsy 289 | 346
glioblastoma multiforme 287 | 347
sarcoidosis 280 | 368
non-small cell lung carcinoma 279 | 413
nephrosclerosis 278 | 329
Polycystic Ovary Syndrome 275 | 335
tuberculosis and treatment for 3 months 263 | 327
interstitial lung disease 257 | 292

Tissue

Nervous System 12,469 | 18,561
Female tissues 12,460 | 18,647
Digestive Tract 12,459 | 18,473
Endocrine System 12,447 | 18,512
Urinary Tract 12,420 | 18,444
Liver and Pancreas 12,412 | 18,136
Male tissues 12,411 | 17,969
Cardiovascular System 12,384 | 17,958
Blood and immune system 12,367 | 17,995
Skin and soft tissues 12,334 | 18,115
Respiratory system 12,262 | 17,484

Target Family

Non-IDG 7,424 | 11,969
Enzyme 3,048 | 4,146
Transcription Factor 782 | 1,400
Kinase 515 | 634
Transporter 328 | 473
Epigenetic 212 | 242
Ion Channel 190 | 341
GPCR 129 | 408
Nuclear Receptor 36 | 48
TF/Epigenetic 28 | 38
oGPCR 8 | 421

Data Source

JensenLab Experiment UniGene 12,700 | 12,700
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363