Development Level

Tbio 9,678 | 11,445
Tdark 3,432 | 6,588
Tchem 1,355 | 1,598
Tclin 470 | 613

Collection

RFA-RM-18-021 220 | 328
Kinase: IDG Consortium (Target... 112 | 125
Ion Channel: IDG Consortium (T... 69 | 99
GPCR: IDG Consortium (Targets) 42 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 913 | 979
preweaning lethality, incomple... 437 | 499
embryonic lethality prior to t... 262 | 278
abnormal behavior 258 | 298
embryonic lethality prior to o... 227 | 239
abnormal embryo size 202 | 220
decreased total body fat amoun... 180 | 207
abnormal bone structure 167 | 187
enlarged heart 165 | 210
decreased vertical activity 162 | 208
increased lean body mass 150 | 172
decreased body weight 142 | 161
abnormal heart morphology 131 | 162
decreased bone mineral content 130 | 151
hyperactivity 124 | 148
decreased lean body mass 114 | 135
male infertility 113 | 123
increased total body fat amoun... 112 | 134
decreased circulating glucose ... 108 | 126
hypoactivity 108 | 132
decreased bone mineral density 107 | 126
increased circulating alkaline... 106 | 122
decreased grip strength 100 | 116
embryonic growth retardation 97 | 106
increased startle reflex 97 | 112
increased bone mineral content 92 | 108
abnormal seminal vesicle morph... 91 | 114
decreased body length 89 | 101
increased mean corpuscular vol... 86 | 92
increased mean corpuscular hem... 85 | 96
short tibia 85 | 97
increased or absent threshold ... 84 | 101
decreased circulating choleste... 82 | 93
prenatal lethality prior to he... 82 | 87
cataract 77 | 92
decreased circulating serum al... 73 | 82
decreased lymphocyte cell numb... 73 | 83
decreased mean corpuscular vol... 72 | 79
decreased prepulse inhibition 71 | 82
improved glucose tolerance 71 | 79
decreased circulating triglyce... 70 | 79
abnormal lens morphology 68 | 81
increased circulating HDL chol... 68 | 80
decreased startle reflex 66 | 75
decreased leukocyte cell numbe... 65 | 73
impaired glucose tolerance 64 | 75
small superior vagus ganglion 64 | 74
increased bone mineral density 62 | 72
increased fasted circulating g... 62 | 76
abnormal retina morphology 61 | 71
decreased circulating HDL chol... 61 | 68
decreased circulating insulin ... 61 | 76
increased circulating sodium l... 59 | 71
abnormal eye morphology 58 | 68
decreased hemoglobin content 58 | 68
decreased erythrocyte cell num... 57 | 62
abnormal gait 56 | 69
abnormal sleep behavior 56 | 70
abnormal coat-hair pigmentatio... 55 | 64
decreased fasted circulating g... 55 | 65
increased circulating choleste... 55 | 66
increased monocyte cell number 55 | 63
abnormal behavioral response t... 53 | 66
increased heart weight 53 | 62
abnormal kidney morphology 51 | 65
small testis 51 | 58
decreased caudal vertebrae num... 49 | 53
female infertility 49 | 60
edema 48 | 59
abnormal spleen morphology 46 | 55
decreased circulating total pr... 45 | 49
decreased mean corpuscular hem... 45 | 50
hydrometra 44 | 53
thrombocytopenia 44 | 56
abnormal skin morphology 43 | 50
decreased blood urea nitrogen ... 43 | 51
decreased hematocrit 43 | 46
abnormal neural tube closure 42 | 46
decreased circulating alkaline... 42 | 46
increased hematocrit 40 | 46
increased leukocyte cell numbe... 40 | 47
increased mean platelet volume 40 | 45
increased circulating chloride... 39 | 41
increased circulating triglyce... 39 | 42
increased blood urea nitrogen ... 38 | 48
increased neutrophil cell numb... 38 | 46
abnormal epididymis morphology 37 | 42
decreased circulating alanine ... 37 | 47
decreased neutrophil cell numb... 37 | 42
increased circulating creatini... 37 | 38
tremors 37 | 39
abnormal testis morphology 36 | 43
decreased red blood cell distr... 36 | 41
increased hemoglobin content 36 | 45
abnormal bone mineralization 35 | 38
decreased circulating LDL chol... 35 | 38
decreased circulating calcium ... 34 | 36
enlarged spleen 34 | 41
increased erythrocyte cell num... 34 | 39
increased grip strength 33 | 41

Disease

Carcinoma 9,448 | 11,493
ovarian cancer 7,704 | 8,520
osteosarcoma 6,901 | 7,950
medulloblastoma, large-cell 5,603 | 6,241
psoriasis 5,442 | 6,694
glioblastoma 5,312 | 5,792
atypical teratoid / rhabdoid tumor 4,673 | 5,112
lung cancer 4,282 | 4,740
ependymoma 4,272 | 4,679
group 3 medulloblastoma 3,699 | 4,104
adult high grade glioma 3,401 | 3,801
Breast cancer 3,229 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,987 | 3,291
malignant mesothelioma 2,958 | 3,232
Astrocytoma, Pilocytic 2,802 | 3,081
primitive neuroectodermal tumor 2,760 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,720 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,688 | 2,955
invasive ductal carcinoma 2,671 | 2,951
oligodendroglioma 2,633 | 2,850
non-small cell lung cancer 2,597 | 2,890
lung carcinoma 2,495 | 2,843
astrocytic glioma 2,387 | 2,597
lung adenocarcinoma 2,375 | 2,716
Kidney cancer 2,282 | 2,613
Cancer 2,220 | 2,499
pancreatic cancer 2,156 | 2,398
subependymal giant cell astrocytoma 2,131 | 2,287
interstitial cystitis 1,950 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,825 | 1,962
Pick disease 1,816 | 1,894
pituitary cancer 1,772 | 1,972
tuberculosis 1,755 | 2,010
group 4 medulloblastoma 1,704 | 1,855
ulcerative colitis 1,590 | 1,819
ductal carcinoma in situ 1,566 | 1,745
cystic fibrosis 1,505 | 1,696
breast carcinoma 1,486 | 1,638
diabetes mellitus 1,342 | 1,728
colon cancer 1,340 | 1,478
adrenocortical carcinoma 1,306 | 1,428
Multiple myeloma 1,274 | 1,332
Autosomal recessive predisposition 1,269 | 1,442
juvenile dermatomyositis 1,126 | 1,187
acute quadriplegic myopathy 1,105 | 1,158
astrocytoma 1,097 | 1,146
Rheumatoid arthritis 1,063 | 1,191
primary pancreatic ductal adenocarcinoma 1,042 | 1,109
Schizophrenia 996 | 1,160
pediatric high grade glioma 980 | 1,064
spina bifida 980 | 1,074
dermatomyositis 935 | 966
Intellectual disability 927 | 1,016
nasopharyngeal carcinoma 915 | 1,058
cutaneous lupus erythematosus 899 | 1,057
active Crohn's disease 813 | 922
Atopic dermatitis 802 | 952
non primary Sjogren syndrome sicca 771 | 891
Waldenstrons macroglobulinemia 740 | 765
Epilepsy 732 | 792
gastric carcinoma 732 | 807
acute myeloid leukemia 705 | 783
Liver Cirrhosis, Experimental 694 | 769
esophageal adenocarcinoma 685 | 737
active ulcerative colitis 668 | 764
primary Sjogren syndrome 648 | 735
medulloblastoma 645 | 720
progressive supranuclear palsy 638 | 676
aldosterone-producing adenoma 627 | 665
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
Alzheimer's disease 595 | 658
Melanoma 578 | 711
Duchenne muscular dystrophy 574 | 601
Cognitive delay 569 | 608
Global developmental delay 569 | 608
Mental and motor retardation 569 | 608
Obesity 569 | 678
Bipolar Disorder 566 | 666
Seizures 553 | 596
Muscle hypotonia 537 | 571
Liver cancer 531 | 604
fibroadenoma 494 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 493 | 510
pancreatic carcinoma 491 | 562
hepatocellular carcinoma 487 | 547
Down syndrome 475 | 499
Endometriosis 474 | 540
Short stature 468 | 531
chronic rhinosinusitis 451 | 512
Prostatic Neoplasms 449 | 495
Amyotrophic lateral sclerosis 426 | 451
Multiple Sclerosis 423 | 540
posterior fossa group A ependymoma 410 | 468
sonic hedgehog group medulloblastoma 406 | 467
Breast Neoplasms 405 | 445
mucosa-associated lymphoid tissue lymphoma 405 | 484

Tissue

Endocrine System 14,542 | 18,159
Digestive Tract 14,260 | 17,369
Female tissues 14,247 | 17,400
Skin and soft tissues 14,201 | 17,230
Male tissues 14,122 | 17,142
Blood and immune system 13,983 | 16,909
Liver and Pancreas 13,980 | 16,750
Nervous System 13,962 | 16,725
Urinary Tract 13,935 | 16,678
Respiratory system 13,758 | 16,393
Cardiovascular System 13,087 | 15,192

Target Family

Non-IDG 8,740 | 12,091
Enzyme 3,468 | 4,145
Transcription Factor 1,028 | 1,400
Kinase 571 | 634
Transporter 387 | 473
Ion Channel 241 | 344
Epigenetic 227 | 242
GPCR 184 | 408
Nuclear Receptor 43 | 48
TF/Epigenetic 29 | 38
oGPCR 17 | 421

Data Source

JensenLab Experiment UniGene 14,935 | 14,935
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39