Development Level

Tbio 9,850 | 11,178
Tdark 3,853 | 6,569
Tchem 1,681 | 1,885
Tclin 532 | 612

Collection

Kinase: IDG Consortium (Target... 113 | 125
Ion Channel: IDG Consortium (T... 72 | 99
GPCR: IDG Consortium (Targets) 69 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 936 | 979
preweaning lethality, incomple... 458 | 499
embryonic lethality prior to t... 269 | 278
abnormal behavior 267 | 298
embryonic lethality prior to o... 231 | 239
abnormal embryo size 207 | 220
decreased total body fat amoun... 187 | 207
enlarged heart 182 | 210
abnormal bone structure 171 | 187
decreased vertical activity 169 | 208
increased lean body mass 153 | 172
decreased body weight 150 | 161
abnormal heart morphology 138 | 162
decreased bone mineral content 135 | 151
hyperactivity 134 | 148
decreased lean body mass 119 | 135
increased total body fat amoun... 118 | 134
hypoactivity 117 | 132
decreased bone mineral density 113 | 126
decreased circulating glucose ... 111 | 126
male infertility 110 | 123
increased circulating alkaline... 108 | 122
decreased grip strength 101 | 116
increased startle reflex 101 | 112
abnormal seminal vesicle morph... 100 | 114
embryonic growth retardation 100 | 106
increased bone mineral content 97 | 108
decreased body length 92 | 101
short tibia 89 | 97
increased or absent threshold ... 88 | 101
increased mean corpuscular hem... 87 | 96
cataract 86 | 92
decreased circulating choleste... 86 | 93
increased mean corpuscular vol... 85 | 92
prenatal lethality prior to he... 81 | 87
decreased lymphocyte cell numb... 79 | 83
decreased mean corpuscular vol... 77 | 79
abnormal lens morphology 76 | 81
decreased prepulse inhibition 75 | 82
decreased circulating serum al... 74 | 82
improved glucose tolerance 74 | 79
increased circulating HDL chol... 72 | 80
decreased circulating triglyce... 70 | 79
decreased startle reflex 70 | 75
small superior vagus ganglion 68 | 74
decreased leukocyte cell numbe... 67 | 73
increased bone mineral density 66 | 72
increased fasted circulating g... 66 | 76
abnormal retina morphology 64 | 71
decreased circulating insulin ... 64 | 76
impaired glucose tolerance 64 | 75
abnormal eye morphology 63 | 68
abnormal sleep behavior 62 | 70
decreased circulating HDL chol... 61 | 68
decreased fasted circulating g... 61 | 65
increased circulating sodium l... 61 | 71
increased heart weight 60 | 62
abnormal behavioral response t... 59 | 66
abnormal gait 58 | 69
increased circulating choleste... 58 | 66
abnormal coat-hair pigmentatio... 57 | 64
increased monocyte cell number 57 | 63
decreased hemoglobin content 56 | 68
edema 56 | 59
abnormal kidney morphology 55 | 65
decreased erythrocyte cell num... 55 | 62
small testis 53 | 58
decreased caudal vertebrae num... 50 | 53
female infertility 50 | 60
abnormal spleen morphology 48 | 55
decreased mean corpuscular hem... 48 | 50
hydrometra 48 | 53
decreased blood urea nitrogen ... 46 | 51
thrombocytopenia 46 | 56
abnormal neural tube closure 45 | 46
decreased circulating total pr... 45 | 49
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
increased neutrophil cell numb... 44 | 46
abnormal skin morphology 43 | 50
increased hematocrit 43 | 46
increased leukocyte cell numbe... 43 | 47
increased blood urea nitrogen ... 42 | 48
increased mean platelet volume 41 | 45
decreased hematocrit 40 | 46
increased circulating triglyce... 40 | 42
decreased neutrophil cell numb... 39 | 42
increased circulating chloride... 39 | 41
increased hemoglobin content 39 | 45
tremors 39 | 39
abnormal bone mineralization 38 | 38
abnormal testis morphology 38 | 43
decreased circulating LDL chol... 38 | 38
enlarged spleen 38 | 41
abnormal epididymis morphology 37 | 42
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
decreased circulating creatini... 36 | 39
increased circulating creatini... 36 | 38
increased erythrocyte cell num... 36 | 39

Disease

Carcinoma 9,817 | 11,192
ovarian cancer 7,833 | 8,297
osteosarcoma 7,136 | 7,766
medulloblastoma, large-cell 5,667 | 6,086
psoriasis 5,598 | 6,514
glioblastoma 5,351 | 5,635
atypical teratoid / rhabdoid tumor 4,699 | 4,971
lung cancer 4,365 | 4,607
ependymoma 4,348 | 4,559
group 3 medulloblastoma 3,763 | 4,002
adult high grade glioma 3,465 | 3,701
Breast cancer 3,272 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,068 | 3,204
malignant mesothelioma 2,965 | 3,135
Astrocytoma, Pilocytic 2,850 | 3,006
primitive neuroectodermal tumor 2,813 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,792 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,764 | 2,872
invasive ductal carcinoma 2,747 | 2,867
oligodendroglioma 2,663 | 2,768
non-small cell lung cancer 2,648 | 2,799
lung carcinoma 2,633 | 2,755
lung adenocarcinoma 2,462 | 2,627
astrocytic glioma 2,432 | 2,530
Kidney cancer 2,376 | 2,548
pancreatic cancer 2,191 | 2,322
Cancer 2,186 | 2,388
subependymal giant cell astrocytoma 2,142 | 2,230
interstitial cystitis 2,076 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,854 | 1,911
tuberculosis 1,840 | 1,963
Pick disease 1,804 | 1,856
pituitary cancer 1,801 | 1,915
group 4 medulloblastoma 1,713 | 1,806
ulcerative colitis 1,665 | 1,765
ductal carcinoma in situ 1,617 | 1,686
cystic fibrosis 1,514 | 1,629
breast carcinoma 1,499 | 1,589
colon cancer 1,378 | 1,428
diabetes mellitus 1,373 | 1,683
adrenocortical carcinoma 1,330 | 1,385
Autosomal recessive predisposition 1,271 | 1,407
Multiple myeloma 1,258 | 1,296
acute quadriplegic myopathy 1,114 | 1,133
juvenile dermatomyositis 1,112 | 1,147
Rheumatoid arthritis 1,098 | 1,156
astrocytoma 1,086 | 1,113
primary pancreatic ductal adenocarcinoma 1,029 | 1,071
Schizophrenia 1,005 | 1,136
pediatric high grade glioma 985 | 1,035
spina bifida 976 | 1,053
nasopharyngeal carcinoma 958 | 1,024
cutaneous lupus erythematosus 942 | 1,016
Intellectual disability 936 | 998
dermatomyositis 927 | 941
active Crohn's disease 838 | 882
Atopic dermatitis 797 | 915
non primary Sjogren syndrome sicca 797 | 861
gastric carcinoma 739 | 781
acute myeloid leukemia 736 | 760
Waldenstrons macroglobulinemia 732 | 742
Epilepsy 730 | 775
Liver Cirrhosis, Experimental 711 | 733
active ulcerative colitis 698 | 736
primary Sjogren syndrome 677 | 710
medulloblastoma 662 | 702
progressive supranuclear palsy 634 | 656
esophageal adenocarcinoma 633 | 696
aldosterone-producing adenoma 628 | 646
Melanoma 607 | 689
Alzheimer's disease 599 | 640
Dull intelligence 595 | 634
Low intelligence 595 | 634
Mental Retardation 595 | 634
Mental deficiency 595 | 634
Poor school performance 595 | 634
Obesity 584 | 655
Duchenne muscular dystrophy 579 | 587
Bipolar Disorder 565 | 646
Cognitive delay 562 | 596
Global developmental delay 562 | 596
Mental and motor retardation 562 | 596
Seizures 551 | 584
Liver cancer 544 | 589
Muscle hypotonia 534 | 562
pancreatic carcinoma 532 | 555
hepatocellular carcinoma 513 | 536
fibroadenoma 509 | 538
Endometriosis 496 | 521
autosomal dominant Emery-Dreifuss muscular dystrophy 488 | 492
chronic rhinosinusitis 480 | 505
Short stature 467 | 514
Down syndrome 463 | 480
Multiple Sclerosis 457 | 527
Prostatic Neoplasms 446 | 472
mucosa-associated lymphoid tissue lymphoma 439 | 473
sonic hedgehog group medulloblastoma 433 | 459
gastric cancer 426 | 445
Amyotrophic lateral sclerosis 424 | 437
posterior fossa group A ependymoma 423 | 456

Tissue

Endocrine System 15,508 | 18,159
Digestive Tract 15,162 | 17,369
Female tissues 15,162 | 17,400
Skin and soft tissues 15,103 | 17,230
Male tissues 15,090 | 17,142
Liver and Pancreas 14,899 | 16,750
Nervous System 14,881 | 16,725
Urinary Tract 14,878 | 16,678
Blood and immune system 14,849 | 16,909
Respiratory system 14,660 | 16,393
Cardiovascular System 13,925 | 15,192

Target Family

Non-IDG 9,290 | 12,091
Enzyme 3,644 | 4,145
Transcription Factor 1,114 | 1,400
Kinase 591 | 634
Transporter 413 | 473
Ion Channel 272 | 344
GPCR 257 | 408
Epigenetic 226 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 32 | 38
oGPCR 31 | 421

Data Source

JensenLab Experiment RNA-seq 15,916 | 15,916
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83