Development Level

Tbio 6,347 | 10,625
Tdark 2,130 | 7,003
Tchem 1,172 | 1,890
Tclin 330 | 602

Collection

Eligible Kinase Proteins 74 | 134
Eligible Ion Channel Proteins 37 | 117
Eligible non-olfactory GPCR Proteins 19 | 145

IMPC Term

preweaning lethality, complete... 425 | 633
preweaning lethality, incomple... 175 | 260
abnormal behavior 148 | 226
embryonic lethality prior to t... 132 | 187
decreased total body fat amoun... 129 | 186
decreased lean body mass 126 | 195
decreased body weight 121 | 174
embryonic lethality prior to o... 100 | 148
decreased bone mineral content 92 | 157
abnormal bone structure 86 | 131
increased circulating alkaline... 82 | 119
decreased bone mineral density 79 | 126
abnormal embryo size 74 | 112
decreased grip strength 74 | 123
decreased body length 73 | 108
increased lean body mass 71 | 107
decreased circulating glucose ... 70 | 121
abnormal retina morphology 69 | 100
hyperactivity 69 | 108
increased or absent threshold ... 68 | 128
decreased circulating choleste... 66 | 85
decreased circulating HDL chol... 61 | 77
increased bone mineral content 61 | 92
increased mean corpuscular hem... 61 | 93
increased mean corpuscular vol... 61 | 91
enlarged heart 60 | 111
short tibia 56 | 82
hypoactivity 55 | 89
abnormal lens morphology 48 | 73
decreased circulating serum al... 48 | 79
increased grip strength 48 | 83
decreased circulating triglyce... 47 | 83
decreased circulating insulin ... 42 | 75
increased fasted circulating g... 42 | 68
prenatal lethality prior to he... 42 | 64
decreased lumbar vertebrae num... 41 | 62
decreased mean corpuscular vol... 38 | 50
increased sacral vertebrae num... 38 | 62
increased circulating sodium l... 36 | 71
abnormal bone mineralization 35 | 55
abnormal coat/hair pigmentatio... 35 | 54
abnormal sleep behavior 35 | 63
decreased leukocyte cell numbe... 35 | 54
male infertility 35 | 62
decreased fasted circulating g... 34 | 49
abnormal gait 33 | 51
decreased caudal vertebrae num... 33 | 49
decreased circulating alanine ... 33 | 53
improved glucose tolerance 33 | 56
decreased rib number 32 | 59
increased body weight 32 | 42
increased circulating HDL chol... 32 | 63
abnormal retinal pigmentation 31 | 61
decreased prepulse inhibition 31 | 52
increased total body fat amoun... 31 | 57
decreased heart weight 30 | 44
decreased hemoglobin content 30 | 53
abnormal behavioral response t... 29 | 52
abnormal neural tube closure 29 | 37
decreased eosinophil cell numb... 29 | 41
increased blood urea nitrogen ... 29 | 44
increased circulating choleste... 29 | 53
increased heart weight 29 | 37
thrombocytopenia 29 | 46
abnormal heart morphology 28 | 51
decreased circulating alkaline... 28 | 41
decreased circulating total pr... 28 | 41
decreased erythrocyte cell num... 28 | 43
increased bone mineral density 28 | 52
decreased circulating LDL chol... 27 | 37
decreased startle reflex 27 | 48
impaired glucose tolerance 27 | 52
increased startle reflex 27 | 38
increased circulating chloride... 26 | 43
increased hemoglobin content 26 | 45
increased rib number 26 | 41
tremors 26 | 34
increased exploration in new e... 25 | 56
abnormal seminal vesicle morph... 23 | 47
increased circulating calcium ... 23 | 32
cardiovascular system phenotyp... 22 | 35
increased hematocrit 22 | 36
small testis 22 | 37
decreased circulating free fat... 21 | 39
decreased circulating fructosa... 21 | 31
decreased mean corpuscular hem... 21 | 34
increased circulating creatini... 21 | 29
increased leukocyte cell numbe... 21 | 37
limb grasping 21 | 35
abnormal eye morphology 20 | 38
abnormal hindbrain development 20 | 24
decreased circulating aspartat... 20 | 27
decreased circulating creatini... 20 | 31
abnormal cranium morphology 19 | 32
abnormal spleen morphology 19 | 36
abnormal tooth morphology 19 | 24
decreased circulating chloride... 19 | 32
decreased neutrophil cell numb... 19 | 37
enlarged lymph nodes 19 | 27
abnormal epididymis morphology 18 | 31

Disease

ovarian cancer 6,054 | 8,492
osteosarcoma 4,903 | 7,933
medulloblastoma, large-cell 4,167 | 6,234
psoriasis 3,910 | 6,685
glioblastoma 3,886 | 5,572
lung cancer 3,311 | 4,473
atypical teratoid / rhabdoid tumor 2,987 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,319 | 3,289
Breast cancer 2,225 | 3,099
intraductal papillary-mucinous carcinoma (IPMC) 2,162 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,158 | 2,956
malignant mesothelioma 2,132 | 3,163
pilocytic astrocytoma 2,122 | 3,086
invasive ductal carcinoma 2,108 | 2,950
oligodendroglioma 2,067 | 2,849
lung carcinoma 2,045 | 2,844
primitive neuroectodermal tumor 2,037 | 3,031
pediatric high grade glioma 1,900 | 2,712
non-small cell lung cancer 1,889 | 2,798
lung adenocarcinoma 1,872 | 2,714
ependymoma 1,809 | 2,514
subependymal giant cell astrocytoma 1,676 | 2,287
pancreatic cancer 1,672 | 2,300
astrocytic glioma 1,587 | 2,241
Cancer 1,582 | 2,346
ulcerative colitis 1,516 | 2,087
Pick disease 1,513 | 1,893
interstitial cystitis 1,465 | 2,299
Carcinoma 1,427 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 1,419 | 1,795
pituitary cancer 1,379 | 1,972
adult high grade glioma 1,374 | 2,148
group 3 medulloblastoma 1,363 | 2,254
group 4 medulloblastoma 1,296 | 1,875
ductal carcinoma in situ 1,224 | 1,745
astrocytoma 1,201 | 1,493
Multiple myeloma 1,174 | 1,328
breast carcinoma 1,152 | 1,614
cystic fibrosis 1,152 | 1,670
colon cancer 1,100 | 1,475
diabetes mellitus 1,088 | 1,663
medulloblastoma 1,061 | 1,524
adrenocortical carcinoma 1,037 | 1,427
tuberculosis 1,032 | 1,563
acute quadriplegic myopathy 1,028 | 1,157
sonic hedgehog group medulloblastoma 1,010 | 1,482
juvenile dermatomyositis 1,009 | 1,189
primary pancreatic ductal adenocarcinoma 1,004 | 1,271
posterior fossa group A ependymoma 984 | 1,511
Rheumatoid Arthritis 891 | 1,171
posterior fossa group B ependymoma 881 | 1,530
dermatomyositis 875 | 967
spina bifida 737 | 1,064
atypical teratoid/rhabdoid tumor 712 | 1,095
Waldenstrons macroglobulinemia 699 | 765
cutaneous lupus erythematosus 680 | 1,056
nasopharyngeal carcinoma 659 | 1,056
active Crohn's disease 638 | 918
gastric carcinoma 611 | 832
acute myeloid leukemia 605 | 785
primary Sjogren syndrome 587 | 789
Atopic dermatitis 581 | 944
non primary Sjogren syndrome sicca 559 | 840
Duchenne muscular dystrophy 540 | 602
aldosterone-producing adenoma 537 | 664
tuberculosis and treatment for 6 months 533 | 686
progressive supranuclear palsy 524 | 674
esophageal adenocarcinoma 505 | 737
Alzheimer's disease 458 | 644
autosomal dominant Emery-Dreifuss muscular dystrophy 458 | 499
Down syndrome 455 | 548
pancreatic carcinoma 436 | 567
hepatocellular carcinoma 423 | 550
Intellectual disability 399 | 573
Obesity 394 | 616
fibroadenoma 389 | 557
Amyotrophic Lateral Sclerosis 365 | 432
IGA Glomerulonephritis 360 | 454
Endometriosis 353 | 535
mucosa-associated lymphoid tissue lymphoma 342 | 480
Prostatic Neoplasms 340 | 471
gastric cancer 329 | 436
chronic rhinosinusitis 327 | 512
Schizophrenia 310 | 503
active ulcerative colitis 305 | 477
Multiple Sclerosis 293 | 498
Neurodegenerative disease 281 | 383
Kidney disease 277 | 397
Mammary Neoplasms 277 | 410
sarcoidosis 277 | 368
non-small cell lung carcinoma 276 | 413
hereditary spastic paraplegia 273 | 313
nephrosclerosis 271 | 329
Parkinson's disease 251 | 364
glioblastoma multiforme 247 | 347
inflammatory breast cancer 246 | 404
interstitial lung disease 245 | 292
Polycystic Ovary Syndrome 228 | 335
urothelial carcinoma 227 | 318
tuberculosis and treatment for 3 months 226 | 327

Tissue

Nervous System 9,831 | 18,561
Digestive Tract 9,826 | 18,473
Female tissues 9,824 | 18,647
Endocrine System 9,817 | 18,512
Urinary Tract 9,816 | 18,444
Liver and Pancreas 9,809 | 18,136
Male tissues 9,793 | 17,969
Blood and immune system 9,785 | 17,995
Cardiovascular System 9,776 | 17,958
Skin and soft tissues 9,738 | 18,115
Respiratory system 9,718 | 17,484

Target Family

Non-IDG 5,892 | 11,969
Enzyme 2,362 | 4,146
Transcription Factor 646 | 1,400
Kinase 399 | 634
Transporter 247 | 473
Epigenetic 163 | 242
Ion Channel 123 | 341
GPCR 86 | 408
Nuclear Receptor 35 | 48
TF/Epigenetic 24 | 38
oGPCR 2 | 421

Data Source

JensenLab Experiment RNA-seq 9,979 | 9,979
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35
Serine/threonine-protein kinase RIO1 RIOK1 Tchem Kinase -0.72835 5.14 142