Development Level

Tbio 10,096 | 11,445
Tdark 3,865 | 6,588
Tchem 1,422 | 1,598
Tclin 533 | 613

Collection

RFA-RM-18-021 244 | 328
Kinase: IDG Consortium (Target... 113 | 125
Ion Channel: IDG Consortium (T... 72 | 99
GPCR: IDG Consortium (Targets) 69 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 936 | 979
preweaning lethality, incomple... 458 | 499
embryonic lethality prior to t... 269 | 278
abnormal behavior 267 | 298
embryonic lethality prior to o... 231 | 239
abnormal embryo size 207 | 220
decreased total body fat amoun... 187 | 207
enlarged heart 182 | 210
abnormal bone structure 171 | 187
decreased vertical activity 169 | 208
increased lean body mass 153 | 172
decreased body weight 150 | 161
abnormal heart morphology 138 | 162
decreased bone mineral content 135 | 151
hyperactivity 134 | 148
decreased lean body mass 119 | 135
increased total body fat amoun... 118 | 134
hypoactivity 117 | 132
decreased bone mineral density 113 | 126
decreased circulating glucose ... 111 | 126
male infertility 110 | 123
increased circulating alkaline... 108 | 122
decreased grip strength 101 | 116
increased startle reflex 101 | 112
abnormal seminal vesicle morph... 100 | 114
embryonic growth retardation 100 | 106
increased bone mineral content 97 | 108
decreased body length 92 | 101
short tibia 89 | 97
increased or absent threshold ... 88 | 101
increased mean corpuscular hem... 87 | 96
cataract 86 | 92
decreased circulating choleste... 86 | 93
increased mean corpuscular vol... 85 | 92
prenatal lethality prior to he... 81 | 87
decreased lymphocyte cell numb... 79 | 83
decreased mean corpuscular vol... 77 | 79
abnormal lens morphology 76 | 81
decreased prepulse inhibition 75 | 82
decreased circulating serum al... 74 | 82
improved glucose tolerance 74 | 79
increased circulating HDL chol... 72 | 80
decreased circulating triglyce... 70 | 79
decreased startle reflex 70 | 75
small superior vagus ganglion 68 | 74
decreased leukocyte cell numbe... 67 | 73
increased bone mineral density 66 | 72
increased fasted circulating g... 66 | 76
abnormal retina morphology 64 | 71
decreased circulating insulin ... 64 | 76
impaired glucose tolerance 64 | 75
abnormal eye morphology 63 | 68
abnormal sleep behavior 62 | 70
decreased circulating HDL chol... 61 | 68
decreased fasted circulating g... 61 | 65
increased circulating sodium l... 61 | 71
increased heart weight 60 | 62
abnormal behavioral response t... 59 | 66
abnormal gait 58 | 69
increased circulating choleste... 58 | 66
abnormal coat-hair pigmentatio... 57 | 64
increased monocyte cell number 57 | 63
decreased hemoglobin content 56 | 68
edema 56 | 59
abnormal kidney morphology 55 | 65
decreased erythrocyte cell num... 55 | 62
small testis 53 | 58
decreased caudal vertebrae num... 50 | 53
female infertility 50 | 60
abnormal spleen morphology 48 | 55
decreased mean corpuscular hem... 48 | 50
hydrometra 48 | 53
decreased blood urea nitrogen ... 46 | 51
thrombocytopenia 46 | 56
abnormal neural tube closure 45 | 46
decreased circulating total pr... 45 | 49
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
increased neutrophil cell numb... 44 | 46
abnormal skin morphology 43 | 50
increased hematocrit 43 | 46
increased leukocyte cell numbe... 43 | 47
increased blood urea nitrogen ... 42 | 48
increased mean platelet volume 41 | 45
decreased hematocrit 40 | 46
increased circulating triglyce... 40 | 42
decreased neutrophil cell numb... 39 | 42
increased circulating chloride... 39 | 41
increased hemoglobin content 39 | 45
tremors 39 | 39
abnormal bone mineralization 38 | 38
abnormal testis morphology 38 | 43
decreased circulating LDL chol... 38 | 38
enlarged spleen 38 | 41
abnormal epididymis morphology 37 | 42
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
decreased circulating creatini... 36 | 39
increased circulating creatini... 36 | 38
increased erythrocyte cell num... 36 | 39

Disease

Carcinoma 10,076 | 11,493
ovarian cancer 8,042 | 8,520
osteosarcoma 7,302 | 7,950
medulloblastoma, large-cell 5,807 | 6,241
psoriasis 5,755 | 6,694
glioblastoma 5,496 | 5,792
atypical teratoid / rhabdoid tumor 4,831 | 5,112
lung cancer 4,490 | 4,740
ependymoma 4,460 | 4,679
group 3 medulloblastoma 3,858 | 4,104
adult high grade glioma 3,556 | 3,801
Breast cancer 3,375 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,147 | 3,291
malignant mesothelioma 3,059 | 3,232
Astrocytoma, Pilocytic 2,923 | 3,081
primitive neuroectodermal tumor 2,888 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,873 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,841 | 2,955
invasive ductal carcinoma 2,826 | 2,951
oligodendroglioma 2,740 | 2,850
non-small cell lung cancer 2,733 | 2,890
lung carcinoma 2,717 | 2,843
lung adenocarcinoma 2,540 | 2,716
astrocytic glioma 2,494 | 2,597
Kidney cancer 2,432 | 2,613
Cancer 2,285 | 2,499
pancreatic cancer 2,260 | 2,398
subependymal giant cell astrocytoma 2,198 | 2,287
interstitial cystitis 2,144 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,903 | 1,962
tuberculosis 1,884 | 2,010
pituitary cancer 1,854 | 1,972
Pick disease 1,842 | 1,894
group 4 medulloblastoma 1,758 | 1,855
ulcerative colitis 1,714 | 1,819
ductal carcinoma in situ 1,673 | 1,745
cystic fibrosis 1,573 | 1,696
breast carcinoma 1,543 | 1,638
colon cancer 1,425 | 1,478
diabetes mellitus 1,412 | 1,728
adrenocortical carcinoma 1,372 | 1,428
Autosomal recessive predisposition 1,301 | 1,442
Multiple myeloma 1,293 | 1,332
juvenile dermatomyositis 1,150 | 1,187
acute quadriplegic myopathy 1,139 | 1,158
Rheumatoid arthritis 1,130 | 1,191
astrocytoma 1,118 | 1,146
primary pancreatic ductal adenocarcinoma 1,065 | 1,109
Schizophrenia 1,028 | 1,160
pediatric high grade glioma 1,012 | 1,064
spina bifida 995 | 1,074
nasopharyngeal carcinoma 988 | 1,058
cutaneous lupus erythematosus 980 | 1,057
Intellectual disability 952 | 1,016
dermatomyositis 951 | 966
active Crohn's disease 871 | 922
Atopic dermatitis 828 | 952
non primary Sjogren syndrome sicca 823 | 891
gastric carcinoma 763 | 807
acute myeloid leukemia 759 | 783
Waldenstrons macroglobulinemia 755 | 765
Epilepsy 746 | 792
Liver Cirrhosis, Experimental 746 | 769
active ulcerative colitis 722 | 764
primary Sjogren syndrome 700 | 735
medulloblastoma 680 | 720
esophageal adenocarcinoma 667 | 737
progressive supranuclear palsy 654 | 676
aldosterone-producing adenoma 646 | 665
Melanoma 627 | 711
Alzheimer's disease 617 | 658
Dull intelligence 604 | 645
Low intelligence 604 | 645
Mental Retardation 604 | 645
Mental deficiency 604 | 645
Obesity 604 | 678
Poor school performance 604 | 645
Duchenne muscular dystrophy 593 | 601
Bipolar Disorder 584 | 666
Cognitive delay 573 | 608
Global developmental delay 573 | 608
Mental and motor retardation 573 | 608
Seizures 562 | 596
Liver cancer 557 | 604
Muscle hypotonia 541 | 571
pancreatic carcinoma 539 | 562
fibroadenoma 529 | 559
hepatocellular carcinoma 524 | 547
Endometriosis 514 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 506 | 510
chronic rhinosinusitis 486 | 512
Short stature 483 | 531
Down syndrome 482 | 499
Multiple Sclerosis 469 | 540
Prostatic Neoplasms 467 | 495
mucosa-associated lymphoid tissue lymphoma 449 | 484
gastric cancer 440 | 459
sonic hedgehog group medulloblastoma 440 | 467
Amyotrophic lateral sclerosis 438 | 451
posterior fossa group A ependymoma 435 | 468

Tissue

Endocrine System 15,508 | 18,159
Digestive Tract 15,162 | 17,369
Female tissues 15,162 | 17,400
Skin and soft tissues 15,103 | 17,230
Male tissues 15,090 | 17,142
Liver and Pancreas 14,899 | 16,750
Nervous System 14,881 | 16,725
Urinary Tract 14,878 | 16,678
Blood and immune system 14,849 | 16,909
Respiratory system 14,660 | 16,393
Cardiovascular System 13,925 | 15,192

Target Family

Non-IDG 9,290 | 12,091
Enzyme 3,644 | 4,145
Transcription Factor 1,114 | 1,400
Kinase 591 | 634
Transporter 413 | 473
Ion Channel 272 | 344
GPCR 257 | 408
Epigenetic 226 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 32 | 38
oGPCR 31 | 421

Data Source

JensenLab Experiment RNA-seq 15,916 | 15,916
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19