Development Level

Tbio 10,092 | 11,445
Tdark 3,864 | 6,588
Tchem 1,414 | 1,598
Tclin 516 | 613

Collection

RFA-RM-18-021 236 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 73 | 99
GPCR: IDG Consortium (Targets) 52 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 920 | 979
preweaning lethality, incomple... 450 | 499
abnormal behavior 267 | 298
embryonic lethality prior to t... 266 | 278
embryonic lethality prior to o... 231 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 186 | 207
enlarged heart 173 | 210
abnormal bone structure 171 | 187
decreased vertical activity 165 | 208
increased lean body mass 154 | 172
decreased body weight 151 | 161
abnormal heart morphology 135 | 162
hyperactivity 133 | 148
decreased bone mineral content 128 | 151
decreased lean body mass 117 | 135
hypoactivity 117 | 132
increased total body fat amoun... 117 | 134
decreased bone mineral density 112 | 126
increased circulating alkaline... 110 | 122
male infertility 110 | 123
decreased circulating glucose ... 109 | 126
increased startle reflex 106 | 112
decreased grip strength 104 | 116
embryonic growth retardation 103 | 106
abnormal seminal vesicle morph... 98 | 114
increased bone mineral content 93 | 108
decreased body length 92 | 101
short tibia 92 | 97
increased or absent threshold ... 89 | 101
decreased circulating choleste... 86 | 93
increased mean corpuscular hem... 85 | 96
cataract 84 | 92
prenatal lethality prior to he... 83 | 87
decreased lymphocyte cell numb... 77 | 83
decreased mean corpuscular vol... 77 | 79
decreased prepulse inhibition 77 | 82
increased mean corpuscular vol... 77 | 92
abnormal lens morphology 75 | 81
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 73 | 79
increased circulating HDL chol... 72 | 80
improved glucose tolerance 71 | 79
small superior vagus ganglion 69 | 74
decreased startle reflex 67 | 75
decreased leukocyte cell numbe... 66 | 73
impaired glucose tolerance 66 | 75
abnormal retina morphology 64 | 71
increased bone mineral density 64 | 72
increased fasted circulating g... 64 | 76
decreased circulating insulin ... 63 | 76
abnormal sleep behavior 62 | 70
abnormal gait 61 | 69
decreased hemoglobin content 61 | 68
increased circulating sodium l... 60 | 71
increased heart weight 60 | 62
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
abnormal eye morphology 58 | 68
decreased circulating HDL chol... 58 | 68
increased monocyte cell number 58 | 63
increased circulating choleste... 57 | 66
abnormal coat-hair pigmentatio... 56 | 64
decreased fasted circulating g... 54 | 65
edema 54 | 59
decreased caudal vertebrae num... 51 | 53
small testis 51 | 58
abnormal kidney morphology 49 | 65
decreased blood urea nitrogen ... 49 | 51
female infertility 49 | 60
abnormal spleen morphology 48 | 55
thrombocytopenia 48 | 56
hydrometra 47 | 53
abnormal skin morphology 46 | 50
decreased circulating total pr... 46 | 49
abnormal neural tube closure 44 | 46
decreased mean corpuscular hem... 44 | 50
decreased circulating alkaline... 43 | 46
increased blood urea nitrogen ... 43 | 48
increased mean platelet volume 43 | 45
decreased circulating alanine ... 42 | 47
increased hematocrit 42 | 46
increased hemoglobin content 42 | 45
decreased hematocrit 41 | 46
increased circulating triglyce... 40 | 42
increased neutrophil cell numb... 40 | 46
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 38 | 39
increased leukocyte cell numbe... 38 | 47
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
tremors 37 | 39
abnormal testis morphology 36 | 43
increased circulating creatini... 36 | 38
abnormal epididymis morphology 35 | 42
decreased neutrophil cell numb... 35 | 42
enlarged spleen 35 | 41
limb grasping 35 | 41
decreased circulating creatini... 34 | 39
prolonged QT interval 34 | 38

Disease

Carcinoma 10,093 | 11,493
ovarian cancer 7,714 | 8,520
osteosarcoma 7,022 | 7,950
psoriasis 5,691 | 6,694
medulloblastoma, large-cell 5,576 | 6,241
glioblastoma 5,233 | 5,792
atypical teratoid / rhabdoid tumor 4,604 | 5,112
lung cancer 4,294 | 4,740
ependymoma 4,223 | 4,679
group 3 medulloblastoma 3,703 | 4,104
adult high grade glioma 3,393 | 3,801
Breast cancer 3,223 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,988 | 3,291
malignant mesothelioma 2,899 | 3,232
primitive neuroectodermal tumor 2,754 | 3,035
Astrocytoma, Pilocytic 2,747 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,717 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,687 | 2,955
invasive ductal carcinoma 2,645 | 2,951
oligodendroglioma 2,588 | 2,850
non-small cell lung cancer 2,558 | 2,890
lung carcinoma 2,526 | 2,843
Kidney cancer 2,482 | 2,613
lung adenocarcinoma 2,369 | 2,716
astrocytic glioma 2,359 | 2,597
Cancer 2,197 | 2,499
pancreatic cancer 2,148 | 2,398
subependymal giant cell astrocytoma 2,087 | 2,287
interstitial cystitis 1,973 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,835 | 1,962
Pick disease 1,786 | 1,894
tuberculosis 1,753 | 2,010
pituitary cancer 1,732 | 1,972
group 4 medulloblastoma 1,677 | 1,855
ulcerative colitis 1,608 | 1,819
ductal carcinoma in situ 1,550 | 1,745
cystic fibrosis 1,502 | 1,696
breast carcinoma 1,459 | 1,638
diabetes mellitus 1,398 | 1,728
Autosomal recessive predisposition 1,331 | 1,442
colon cancer 1,331 | 1,478
adrenocortical carcinoma 1,281 | 1,428
Multiple myeloma 1,251 | 1,332
juvenile dermatomyositis 1,106 | 1,187
Rheumatoid arthritis 1,088 | 1,191
acute quadriplegic myopathy 1,084 | 1,158
astrocytoma 1,063 | 1,146
Schizophrenia 1,016 | 1,160
primary pancreatic ductal adenocarcinoma 1,014 | 1,109
spina bifida 975 | 1,074
Intellectual disability 960 | 1,016
pediatric high grade glioma 958 | 1,064
dermatomyositis 922 | 966
nasopharyngeal carcinoma 921 | 1,058
cutaneous lupus erythematosus 917 | 1,057
Atopic dermatitis 823 | 952
active Crohn's disease 820 | 922
non primary Sjogren syndrome sicca 791 | 891
Epilepsy 752 | 792
Waldenstrons macroglobulinemia 722 | 765
gastric carcinoma 715 | 807
acute myeloid leukemia 708 | 783
Liver Cirrhosis, Experimental 695 | 769
esophageal adenocarcinoma 667 | 737
active ulcerative colitis 662 | 764
primary Sjogren syndrome 658 | 735
Melanoma 650 | 711
medulloblastoma 643 | 720
progressive supranuclear palsy 636 | 676
Dull intelligence 615 | 645
Low intelligence 615 | 645
Mental Retardation 615 | 645
Mental deficiency 615 | 645
Poor school performance 615 | 645
aldosterone-producing adenoma 607 | 665
Alzheimer's disease 600 | 658
Cognitive delay 585 | 608
Global developmental delay 585 | 608
Mental and motor retardation 585 | 608
Obesity 581 | 678
Liver cancer 576 | 604
Bipolar Disorder 574 | 666
Seizures 561 | 596
Duchenne muscular dystrophy 559 | 601
Muscle hypotonia 554 | 571
pancreatic carcinoma 496 | 562
Short stature 491 | 531
fibroadenoma 489 | 559
hepatocellular carcinoma 482 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 476 | 510
Endometriosis 473 | 540
Down syndrome 455 | 499
Prostatic Neoplasms 449 | 495
Multiple Sclerosis 448 | 540
chronic rhinosinusitis 444 | 512
Skin cancer 438 | 469
mucosa-associated lymphoid tissue lymphoma 424 | 484
Amyotrophic lateral sclerosis 419 | 451
sonic hedgehog group medulloblastoma 412 | 467
posterior fossa group A ependymoma 411 | 468

Tissue

Endocrine System 15,342 | 18,159
Digestive Tract 14,883 | 17,369
Female tissues 14,875 | 17,400
Skin and soft tissues 14,779 | 17,230
Male tissues 14,703 | 17,142
Blood and immune system 14,559 | 16,909
Liver and Pancreas 14,484 | 16,750
Nervous System 14,463 | 16,725
Urinary Tract 14,440 | 16,678
Respiratory system 14,210 | 16,393
Cardiovascular System 13,378 | 15,192

Target Family

Non-IDG 9,205 | 12,091
Enzyme 3,676 | 4,145
Transcription Factor 1,138 | 1,400
Kinase 597 | 634
Transporter 402 | 473
Ion Channel 273 | 344
Epigenetic 231 | 242
GPCR 213 | 408
oGPCR 74 | 421
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38

Data Source

JensenLab Experiment HPM 15,886 | 15,886
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22