Development Level

Tbio 9,854 | 11,178
Tdark 3,850 | 6,569
Tchem 1,667 | 1,885
Tclin 515 | 612

Collection

Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 73 | 99
GPCR: IDG Consortium (Targets) 52 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 920 | 979
preweaning lethality, incomple... 450 | 499
abnormal behavior 267 | 298
embryonic lethality prior to t... 266 | 278
embryonic lethality prior to o... 231 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 186 | 207
enlarged heart 173 | 210
abnormal bone structure 171 | 187
decreased vertical activity 165 | 208
increased lean body mass 154 | 172
decreased body weight 151 | 161
abnormal heart morphology 135 | 162
hyperactivity 133 | 148
decreased bone mineral content 128 | 151
decreased lean body mass 117 | 135
hypoactivity 117 | 132
increased total body fat amoun... 117 | 134
decreased bone mineral density 112 | 126
increased circulating alkaline... 110 | 122
male infertility 110 | 123
decreased circulating glucose ... 109 | 126
increased startle reflex 106 | 112
decreased grip strength 104 | 116
embryonic growth retardation 103 | 106
abnormal seminal vesicle morph... 98 | 114
increased bone mineral content 93 | 108
decreased body length 92 | 101
short tibia 92 | 97
increased or absent threshold ... 89 | 101
decreased circulating choleste... 86 | 93
increased mean corpuscular hem... 85 | 96
cataract 84 | 92
prenatal lethality prior to he... 83 | 87
decreased lymphocyte cell numb... 77 | 83
decreased mean corpuscular vol... 77 | 79
decreased prepulse inhibition 77 | 82
increased mean corpuscular vol... 77 | 92
abnormal lens morphology 75 | 81
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 73 | 79
increased circulating HDL chol... 72 | 80
improved glucose tolerance 71 | 79
small superior vagus ganglion 69 | 74
decreased startle reflex 67 | 75
decreased leukocyte cell numbe... 66 | 73
impaired glucose tolerance 66 | 75
abnormal retina morphology 64 | 71
increased bone mineral density 64 | 72
increased fasted circulating g... 64 | 76
decreased circulating insulin ... 63 | 76
abnormal sleep behavior 62 | 70
abnormal gait 61 | 69
decreased hemoglobin content 61 | 68
increased circulating sodium l... 60 | 71
increased heart weight 60 | 62
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
abnormal eye morphology 58 | 68
decreased circulating HDL chol... 58 | 68
increased monocyte cell number 58 | 63
increased circulating choleste... 57 | 66
abnormal coat-hair pigmentatio... 56 | 64
decreased fasted circulating g... 54 | 65
edema 54 | 59
decreased caudal vertebrae num... 51 | 53
small testis 51 | 58
abnormal kidney morphology 49 | 65
decreased blood urea nitrogen ... 49 | 51
female infertility 49 | 60
abnormal spleen morphology 48 | 55
thrombocytopenia 48 | 56
hydrometra 47 | 53
abnormal skin morphology 46 | 50
decreased circulating total pr... 46 | 49
abnormal neural tube closure 44 | 46
decreased mean corpuscular hem... 44 | 50
decreased circulating alkaline... 43 | 46
increased blood urea nitrogen ... 43 | 48
increased mean platelet volume 43 | 45
decreased circulating alanine ... 42 | 47
increased hematocrit 42 | 46
increased hemoglobin content 42 | 45
decreased hematocrit 41 | 46
increased circulating triglyce... 40 | 42
increased neutrophil cell numb... 40 | 46
increased circulating chloride... 39 | 41
increased erythrocyte cell num... 38 | 39
increased leukocyte cell numbe... 38 | 47
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
tremors 37 | 39
abnormal testis morphology 36 | 43
increased circulating creatini... 36 | 38
abnormal epididymis morphology 35 | 42
decreased neutrophil cell numb... 35 | 42
enlarged spleen 35 | 41
limb grasping 35 | 41
decreased circulating creatini... 34 | 39
prolonged QT interval 34 | 38

Disease

Carcinoma 9,833 | 11,192
ovarian cancer 7,511 | 8,297
osteosarcoma 6,861 | 7,766
psoriasis 5,539 | 6,514
medulloblastoma, large-cell 5,440 | 6,086
glioblastoma 5,090 | 5,635
atypical teratoid / rhabdoid tumor 4,476 | 4,971
lung cancer 4,170 | 4,607
ependymoma 4,116 | 4,559
group 3 medulloblastoma 3,614 | 4,002
adult high grade glioma 3,305 | 3,701
Breast cancer 3,128 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,912 | 3,204
malignant mesothelioma 2,808 | 3,135
primitive neuroectodermal tumor 2,682 | 2,957
Astrocytoma, Pilocytic 2,678 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,642 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,614 | 2,872
invasive ductal carcinoma 2,572 | 2,867
oligodendroglioma 2,516 | 2,768
non-small cell lung cancer 2,477 | 2,799
lung carcinoma 2,444 | 2,755
Kidney cancer 2,423 | 2,548
astrocytic glioma 2,300 | 2,530
lung adenocarcinoma 2,294 | 2,627
Cancer 2,102 | 2,388
pancreatic cancer 2,084 | 2,322
subependymal giant cell astrocytoma 2,033 | 2,230
interstitial cystitis 1,906 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,789 | 1,911
Pick disease 1,749 | 1,856
tuberculosis 1,713 | 1,963
pituitary cancer 1,682 | 1,915
group 4 medulloblastoma 1,635 | 1,806
ulcerative colitis 1,561 | 1,765
ductal carcinoma in situ 1,499 | 1,686
cystic fibrosis 1,442 | 1,629
breast carcinoma 1,418 | 1,589
diabetes mellitus 1,359 | 1,683
Autosomal recessive predisposition 1,298 | 1,407
colon cancer 1,287 | 1,428
adrenocortical carcinoma 1,243 | 1,385
Multiple myeloma 1,215 | 1,296
juvenile dermatomyositis 1,068 | 1,147
acute quadriplegic myopathy 1,061 | 1,133
Rheumatoid arthritis 1,055 | 1,156
astrocytoma 1,035 | 1,113
Schizophrenia 996 | 1,136
primary pancreatic ductal adenocarcinoma 980 | 1,071
spina bifida 955 | 1,053
Intellectual disability 944 | 998
pediatric high grade glioma 931 | 1,035
dermatomyositis 897 | 941
nasopharyngeal carcinoma 893 | 1,024
cutaneous lupus erythematosus 879 | 1,016
Atopic dermatitis 794 | 915
active Crohn's disease 785 | 882
non primary Sjogren syndrome sicca 764 | 861
Epilepsy 737 | 775
Waldenstrons macroglobulinemia 700 | 742
gastric carcinoma 692 | 781
acute myeloid leukemia 688 | 760
Liver Cirrhosis, Experimental 661 | 733
active ulcerative colitis 639 | 736
primary Sjogren syndrome 634 | 710
esophageal adenocarcinoma 632 | 696
Melanoma 629 | 689
medulloblastoma 626 | 702
progressive supranuclear palsy 616 | 656
Dull intelligence 606 | 634
Low intelligence 606 | 634
Mental Retardation 606 | 634
Mental deficiency 606 | 634
Poor school performance 606 | 634
aldosterone-producing adenoma 590 | 646
Alzheimer's disease 583 | 640
Cognitive delay 574 | 596
Global developmental delay 574 | 596
Mental and motor retardation 574 | 596
Liver cancer 562 | 589
Obesity 559 | 655
Bipolar Disorder 556 | 646
Seizures 551 | 584
Duchenne muscular dystrophy 545 | 587
Muscle hypotonia 545 | 562
pancreatic carcinoma 489 | 555
Short stature 476 | 514
hepatocellular carcinoma 472 | 536
fibroadenoma 470 | 538
autosomal dominant Emery-Dreifuss muscular dystrophy 459 | 492
Endometriosis 458 | 521
Down syndrome 438 | 480
chronic rhinosinusitis 438 | 505
Multiple Sclerosis 436 | 527
Prostatic Neoplasms 428 | 472
Skin cancer 420 | 451
mucosa-associated lymphoid tissue lymphoma 413 | 473
sonic hedgehog group medulloblastoma 406 | 459
Amyotrophic lateral sclerosis 405 | 437
posterior fossa group A ependymoma 400 | 456

Tissue

Endocrine System 15,342 | 18,159
Digestive Tract 14,883 | 17,369
Female tissues 14,875 | 17,400
Skin and soft tissues 14,779 | 17,230
Male tissues 14,703 | 17,142
Blood and immune system 14,559 | 16,909
Liver and Pancreas 14,484 | 16,750
Nervous System 14,463 | 16,725
Urinary Tract 14,440 | 16,678
Respiratory system 14,210 | 16,393
Cardiovascular System 13,378 | 15,192

Target Family

Non-IDG 9,205 | 12,091
Enzyme 3,676 | 4,145
Transcription Factor 1,138 | 1,400
Kinase 597 | 634
Transporter 402 | 473
Ion Channel 273 | 344
Epigenetic 231 | 242
GPCR 213 | 408
oGPCR 74 | 421
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38

Data Source

JensenLab Experiment HPM 15,886 | 15,886
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153