Development Level

Tbio 3,755 | 10,625
Tdark 847 | 7,003
Tchem 746 | 1,890
Tclin 205 | 602

Collection

Eligible Kinase Proteins 39 | 134
Eligible Ion Channel Proteins 13 | 117
Eligible non-olfactory GPCR Proteins 5 | 145

IMPC Term

preweaning lethality, complete... 266 | 633
preweaning lethality, incomple... 97 | 260
abnormal behavior 90 | 226
decreased total body fat amoun... 80 | 186
embryonic lethality prior to t... 80 | 187
decreased body weight 78 | 174
decreased lean body mass 72 | 195
embryonic lethality prior to o... 71 | 148
decreased bone mineral content 51 | 157
increased circulating alkaline... 51 | 119
abnormal bone structure 49 | 131
decreased grip strength 49 | 123
decreased bone mineral density 48 | 126
increased or absent threshold ... 48 | 128
increased lean body mass 46 | 107
abnormal embryo size 45 | 112
decreased circulating glucose ... 45 | 121
decreased body length 43 | 108
hyperactivity 42 | 108
abnormal retina morphology 41 | 100
increased mean corpuscular hem... 38 | 93
decreased circulating choleste... 37 | 85
decreased circulating HDL chol... 36 | 77
increased grip strength 36 | 83
hypoactivity 35 | 89
abnormal lens morphology 33 | 73
decreased circulating triglyce... 33 | 83
enlarged heart 32 | 111
increased fasted circulating g... 31 | 68
short tibia 31 | 82
decreased circulating serum al... 30 | 79
increased bone mineral content 29 | 92
decreased circulating insulin ... 28 | 75
increased circulating sodium l... 28 | 71
prenatal lethality prior to he... 26 | 64
decreased mean corpuscular vol... 25 | 50
increased mean corpuscular vol... 25 | 91
increased heart weight 23 | 37
male infertility 23 | 62
abnormal bone mineralization 22 | 55
decreased lumbar vertebrae num... 22 | 62
decreased fasted circulating g... 21 | 49
decreased hemoglobin content 21 | 53
decreased rib number 21 | 59
improved glucose tolerance 21 | 56
increased circulating HDL chol... 21 | 63
increased hemoglobin content 21 | 45
abnormal behavioral response t... 20 | 52
abnormal retinal pigmentation 20 | 61
cardiovascular system phenotyp... 20 | 35
decreased prepulse inhibition 20 | 52
increased blood urea nitrogen ... 20 | 44
increased circulating choleste... 20 | 53
thrombocytopenia 20 | 46
abnormal coat/hair pigmentatio... 19 | 54
abnormal sleep behavior 19 | 63
decreased circulating alkaline... 19 | 41
decreased leukocyte cell numbe... 19 | 54
increased circulating chloride... 19 | 43
increased exploration in new e... 19 | 56
decreased caudal vertebrae num... 18 | 49
decreased circulating alanine ... 18 | 53
decreased circulating total pr... 18 | 41
decreased erythrocyte cell num... 18 | 43
decreased heart weight 18 | 44
decreased startle reflex 18 | 48
increased body weight 18 | 42
increased bone mineral density 18 | 52
increased startle reflex 18 | 38
abnormal neural tube closure 17 | 37
impaired glucose tolerance 17 | 52
increased hematocrit 17 | 36
increased sacral vertebrae num... 17 | 62
decreased circulating LDL chol... 16 | 37
decreased mean corpuscular hem... 16 | 34
increased total body fat amoun... 16 | 57
abnormal kidney morphology 15 | 30
decreased circulating amylase ... 15 | 24
decreased eosinophil cell numb... 15 | 41
decreased threshold for audito... 15 | 32
small testis 15 | 37
abnormal cranium morphology 14 | 32
abnormal gait 14 | 51
decreased circulating aspartat... 14 | 27
decreased circulating calcium ... 14 | 33
decreased circulating free fat... 14 | 39
decreased neutrophil cell numb... 14 | 37
increased circulating calcium ... 14 | 32
increased circulating phosphat... 14 | 24
increased leukocyte cell numbe... 14 | 37
tremors 14 | 34
abnormal heart morphology 13 | 51
abnormal seminal vesicle morph... 13 | 47
abnormal tooth morphology 13 | 24
decreased NK T cell number 13 | 28
decreased circulating creatini... 13 | 31
increased circulating creatini... 13 | 29
increased rib number 13 | 41
increased circulating potassiu... 12 | 31
increased erythrocyte cell num... 12 | 26

Disease

ovarian cancer 3,164 | 8,492
osteosarcoma 2,671 | 7,933
psoriasis 2,227 | 6,685
medulloblastoma, large-cell 2,153 | 6,234
glioblastoma 2,042 | 5,572
lung cancer 1,739 | 4,473
atypical teratoid / rhabdoid tumor 1,551 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,198 | 3,289
malignant mesothelioma 1,158 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 1,124 | 2,988
Breast cancer 1,116 | 3,099
pilocytic astrocytoma 1,101 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 1,090 | 2,956
primitive neuroectodermal tumor 1,090 | 3,031
oligodendroglioma 1,083 | 2,849
invasive ductal carcinoma 1,051 | 2,950
Carcinoma 1,047 | 2,147
pediatric high grade glioma 1,013 | 2,712
non-small cell lung cancer 1,011 | 2,798
lung carcinoma 1,002 | 2,844
ependymoma 988 | 2,514
lung adenocarcinoma 955 | 2,714
Cancer 911 | 2,346
subependymal giant cell astrocytoma 891 | 2,287
pancreatic cancer 845 | 2,300
Pick disease 831 | 1,893
astrocytic glioma 812 | 2,241
group 3 medulloblastoma 791 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 758 | 1,795
ulcerative colitis 742 | 2,087
interstitial cystitis 704 | 2,299
adult high grade glioma 702 | 2,148
diabetes mellitus 677 | 1,663
astrocytoma 675 | 1,493
pituitary cancer 640 | 1,972
Multiple myeloma 628 | 1,328
group 4 medulloblastoma 626 | 1,875
colon cancer 597 | 1,475
ductal carcinoma in situ 592 | 1,745
acute quadriplegic myopathy 566 | 1,157
cystic fibrosis 560 | 1,670
breast carcinoma 552 | 1,614
tuberculosis 538 | 1,563
medulloblastoma 537 | 1,524
sonic hedgehog group medulloblastoma 528 | 1,482
adrenocortical carcinoma 516 | 1,427
dermatomyositis 515 | 967
posterior fossa group A ependymoma 513 | 1,511
juvenile dermatomyositis 508 | 1,189
primary pancreatic ductal adenocarcinoma 505 | 1,271
Rheumatoid Arthritis 467 | 1,171
Waldenstrons macroglobulinemia 436 | 765
posterior fossa group B ependymoma 424 | 1,530
atypical teratoid/rhabdoid tumor 381 | 1,095
spina bifida 357 | 1,064
cutaneous lupus erythematosus 354 | 1,056
nasopharyngeal carcinoma 353 | 1,056
gastric carcinoma 338 | 832
Atopic dermatitis 317 | 944
primary Sjogren syndrome 311 | 789
progressive supranuclear palsy 299 | 674
acute myeloid leukemia 290 | 785
esophageal adenocarcinoma 289 | 737
active Crohn's disease 282 | 918
Duchenne muscular dystrophy 277 | 602
Alzheimer's disease 266 | 644
aldosterone-producing adenoma 265 | 664
Intellectual disability 259 | 573
non primary Sjogren syndrome sicca 255 | 840
tuberculosis and treatment for 6 months 245 | 686
Obesity 232 | 616
autosomal dominant Emery-Dreifuss muscular dystrophy 225 | 499
Down syndrome 214 | 548
pancreatic carcinoma 206 | 567
Amyotrophic Lateral Sclerosis 202 | 432
Schizophrenia 194 | 503
Neurodegenerative disease 191 | 383
Prostatic Neoplasms 191 | 471
hepatocellular carcinoma 185 | 550
IGA Glomerulonephritis 181 | 454
fibroadenoma 177 | 557
hereditary spastic paraplegia 170 | 313
Endometriosis 168 | 535
mucosa-associated lymphoid tissue lymphoma 164 | 480
Parkinson's disease 162 | 364
gastric cancer 161 | 436
chronic rhinosinusitis 158 | 512
Kidney disease 156 | 397
Mammary Neoplasms 153 | 410
Multiple Sclerosis 153 | 498
active ulcerative colitis 145 | 477
non-small cell lung carcinoma 140 | 413
Epilepsy 130 | 346
Polycystic Ovary Syndrome 129 | 335
interstitial lung disease 129 | 292
nephrosclerosis 129 | 329
Vascular disease 126 | 281
Stomach Neoplasms 123 | 282
Arthritis 119 | 248
glioblastoma multiforme 119 | 347

Tissue

Nervous System 5,436 | 18,561
Female tissues 5,435 | 18,647
Digestive Tract 5,434 | 18,473
Endocrine System 5,427 | 18,512
Liver and Pancreas 5,422 | 18,136
Male tissues 5,421 | 17,969
Urinary Tract 5,421 | 18,444
Blood and immune system 5,415 | 17,995
Cardiovascular System 5,414 | 17,958
Respiratory system 5,375 | 17,484
Skin and soft tissues 5,362 | 18,115

Target Family

Non-IDG 3,279 | 11,969
Enzyme 1,598 | 4,146
Kinase 264 | 634
Transcription Factor 123 | 1,400
Transporter 112 | 473
Epigenetic 88 | 242
Ion Channel 51 | 341
GPCR 19 | 408
TF/Epigenetic 14 | 38
Nuclear Receptor 3 | 48
oGPCR 2 | 421

Data Source

JensenLab Experiment HPM 5,553 | 5,553
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82
Cullin-associated NEDD8-dissociated protein 1 CAND1 Tbio Non-IDG -1.85520 69.1 156
Lebercilin LCA5 Tbio Non-IDG -1.21162 16.7 65
NACHT, LRR and PYD domains-containing protein 13 NLRP13 Tdark Non-IDG 0.32 0.40 30