Development Level

Tbio 10,263 | 11,178
Tdark 4,401 | 6,569
Tchem 1,752 | 1,885
Tclin 563 | 612

Collection

Kinase: IDG Consortium (Target... 120 | 125
Ion Channel: IDG Consortium (T... 80 | 99
GPCR: IDG Consortium (Targets) 73 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 948 | 979
preweaning lethality, incomple... 477 | 499
abnormal behavior 279 | 298
embryonic lethality prior to t... 267 | 278
embryonic lethality prior to o... 227 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 199 | 207
enlarged heart 191 | 210
decreased vertical activity 184 | 208
abnormal bone structure 181 | 187
increased lean body mass 163 | 172
decreased body weight 150 | 161
abnormal heart morphology 148 | 162
decreased bone mineral content 142 | 151
hyperactivity 137 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 125 | 134
hypoactivity 120 | 132
decreased circulating glucose ... 118 | 126
decreased bone mineral density 117 | 126
male infertility 116 | 123
increased circulating alkaline... 112 | 122
decreased grip strength 110 | 116
embryonic growth retardation 105 | 106
increased startle reflex 105 | 112
abnormal seminal vesicle morph... 103 | 114
increased bone mineral content 101 | 108
decreased body length 97 | 101
increased or absent threshold ... 96 | 101
short tibia 93 | 97
increased mean corpuscular hem... 92 | 96
decreased circulating choleste... 91 | 93
cataract 89 | 92
increased mean corpuscular vol... 88 | 92
prenatal lethality prior to he... 86 | 87
decreased lymphocyte cell numb... 81 | 83
abnormal lens morphology 78 | 81
decreased prepulse inhibition 78 | 82
increased circulating HDL chol... 78 | 80
decreased circulating serum al... 76 | 82
decreased mean corpuscular vol... 76 | 79
decreased circulating triglyce... 74 | 79
improved glucose tolerance 74 | 79
decreased startle reflex 73 | 75
impaired glucose tolerance 71 | 75
increased fasted circulating g... 70 | 76
decreased circulating insulin ... 69 | 76
decreased leukocyte cell numbe... 68 | 73
small superior vagus ganglion 68 | 74
increased bone mineral density 67 | 72
abnormal retina morphology 66 | 71
abnormal eye morphology 65 | 68
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 65 | 68
increased circulating sodium l... 65 | 71
decreased hemoglobin content 64 | 68
increased circulating choleste... 64 | 66
abnormal behavioral response t... 63 | 66
abnormal gait 62 | 69
decreased fasted circulating g... 62 | 65
increased monocyte cell number 62 | 63
abnormal coat-hair pigmentatio... 61 | 64
abnormal kidney morphology 60 | 65
decreased erythrocyte cell num... 60 | 62
increased heart weight 59 | 62
edema 57 | 59
abnormal spleen morphology 54 | 55
small testis 54 | 58
decreased caudal vertebrae num... 52 | 53
female infertility 52 | 60
hydrometra 51 | 53
thrombocytopenia 51 | 56
decreased mean corpuscular hem... 49 | 50
abnormal skin morphology 48 | 50
decreased circulating total pr... 47 | 49
decreased blood urea nitrogen ... 46 | 51
abnormal neural tube closure 45 | 46
decreased circulating alanine ... 45 | 47
decreased circulating alkaline... 45 | 46
increased blood urea nitrogen ... 44 | 48
increased hematocrit 44 | 46
increased mean platelet volume 44 | 45
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased leukocyte cell numbe... 42 | 47
increased hemoglobin content 41 | 45
abnormal testis morphology 40 | 43
increased circulating triglyce... 40 | 42
abnormal epididymis morphology 39 | 42
enlarged spleen 39 | 41
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
decreased neutrophil cell numb... 38 | 42
decreased red blood cell distr... 38 | 41
increased circulating chloride... 38 | 41
increased circulating creatini... 38 | 38
increased erythrocyte cell num... 38 | 39
limb grasping 38 | 41
tremors 38 | 39
prolonged QT interval 36 | 38

Disease

Carcinoma 10,185 | 11,192
ovarian cancer 7,938 | 8,297
osteosarcoma 7,332 | 7,766
psoriasis 5,916 | 6,514
medulloblastoma, large-cell 5,798 | 6,086
glioblastoma 5,430 | 5,635
atypical teratoid / rhabdoid tumor 4,784 | 4,971
ependymoma 4,421 | 4,559
lung cancer 4,405 | 4,607
group 3 medulloblastoma 3,834 | 4,002
adult high grade glioma 3,546 | 3,701
Breast cancer 3,359 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,116 | 3,204
malignant mesothelioma 3,021 | 3,135
Astrocytoma, Pilocytic 2,896 | 3,006
primitive neuroectodermal tumor 2,865 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,816 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,793 | 2,872
invasive ductal carcinoma 2,778 | 2,867
non-small cell lung cancer 2,717 | 2,799
oligodendroglioma 2,674 | 2,768
lung carcinoma 2,649 | 2,755
lung adenocarcinoma 2,531 | 2,627
astrocytic glioma 2,450 | 2,530
Kidney cancer 2,419 | 2,548
pancreatic cancer 2,247 | 2,322
Cancer 2,201 | 2,388
subependymal giant cell astrocytoma 2,149 | 2,230
interstitial cystitis 2,138 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,860 | 1,911
tuberculosis 1,852 | 1,963
pituitary cancer 1,848 | 1,915
Pick disease 1,817 | 1,856
group 4 medulloblastoma 1,744 | 1,806
ulcerative colitis 1,691 | 1,765
ductal carcinoma in situ 1,640 | 1,686
cystic fibrosis 1,574 | 1,629
breast carcinoma 1,530 | 1,589
colon cancer 1,380 | 1,428
diabetes mellitus 1,369 | 1,683
adrenocortical carcinoma 1,340 | 1,385
Autosomal recessive predisposition 1,318 | 1,407
Multiple myeloma 1,242 | 1,296
juvenile dermatomyositis 1,111 | 1,147
acute quadriplegic myopathy 1,103 | 1,133
astrocytoma 1,077 | 1,113
Rheumatoid arthritis 1,051 | 1,156
primary pancreatic ductal adenocarcinoma 1,048 | 1,071
Schizophrenia 1,036 | 1,136
spina bifida 1,028 | 1,053
pediatric high grade glioma 1,001 | 1,035
nasopharyngeal carcinoma 993 | 1,024
cutaneous lupus erythematosus 967 | 1,016
Intellectual disability 959 | 998
dermatomyositis 879 | 941
Atopic dermatitis 862 | 915
active Crohn's disease 849 | 882
non primary Sjogren syndrome sicca 809 | 861
gastric carcinoma 752 | 781
Epilepsy 744 | 775
acute myeloid leukemia 733 | 760
Waldenstrons macroglobulinemia 722 | 742
Liver Cirrhosis, Experimental 711 | 733
active ulcerative colitis 705 | 736
primary Sjogren syndrome 680 | 710
medulloblastoma 676 | 702
esophageal adenocarcinoma 669 | 696
Melanoma 638 | 689
aldosterone-producing adenoma 637 | 646
progressive supranuclear palsy 632 | 656
Alzheimer's disease 618 | 640
Obesity 616 | 655
Dull intelligence 606 | 634
Low intelligence 606 | 634
Mental Retardation 606 | 634
Mental deficiency 606 | 634
Poor school performance 606 | 634
Bipolar Disorder 599 | 646
Cognitive delay 572 | 596
Global developmental delay 572 | 596
Mental and motor retardation 572 | 596
Duchenne muscular dystrophy 570 | 587
Seizures 565 | 584
Liver cancer 557 | 589
Muscle hypotonia 543 | 562
pancreatic carcinoma 528 | 555
fibroadenoma 520 | 538
hepatocellular carcinoma 515 | 536
Endometriosis 503 | 521
chronic rhinosinusitis 490 | 505
Short stature 486 | 514
autosomal dominant Emery-Dreifuss muscular dystrophy 485 | 492
Down syndrome 466 | 480
Prostatic Neoplasms 457 | 472
Multiple Sclerosis 446 | 527
mucosa-associated lymphoid tissue lymphoma 446 | 473
sonic hedgehog group medulloblastoma 439 | 459
posterior fossa group A ependymoma 435 | 456
Amyotrophic lateral sclerosis 430 | 437
gastric cancer 428 | 445

Tissue

Endocrine System 16,560 | 18,159
Female tissues 16,142 | 17,400
Digestive Tract 16,139 | 17,369
Skin and soft tissues 16,034 | 17,230
Male tissues 15,951 | 17,142
Blood and immune system 15,756 | 16,909
Liver and Pancreas 15,713 | 16,750
Urinary Tract 15,664 | 16,678
Nervous System 15,633 | 16,725
Respiratory system 15,417 | 16,393
Cardiovascular System 14,459 | 15,192

Target Family

Non-IDG 9,959 | 12,091
Enzyme 3,837 | 4,145
Transcription Factor 1,226 | 1,400
Kinase 606 | 634
Transporter 443 | 473
Ion Channel 295 | 344
GPCR 287 | 408
Epigenetic 232 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 33 | 38
oGPCR 14 | 421

Data Source

JensenLab Experiment HPA-RNA 16,979 | 16,979
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218