Development Level

Tbio 10,506 | 11,445
Tdark 4,415 | 6,588
Tchem 1,494 | 1,598
Tclin 564 | 613

Collection

RFA-RM-18-021 271 | 328
Kinase: IDG Consortium (Target... 120 | 125
Ion Channel: IDG Consortium (T... 80 | 99
GPCR: IDG Consortium (Targets) 73 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 948 | 979
preweaning lethality, incomple... 477 | 499
abnormal behavior 279 | 298
embryonic lethality prior to t... 267 | 278
embryonic lethality prior to o... 227 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 199 | 207
enlarged heart 191 | 210
decreased vertical activity 184 | 208
abnormal bone structure 181 | 187
increased lean body mass 163 | 172
decreased body weight 150 | 161
abnormal heart morphology 148 | 162
decreased bone mineral content 142 | 151
hyperactivity 137 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 125 | 134
hypoactivity 120 | 132
decreased circulating glucose ... 118 | 126
decreased bone mineral density 117 | 126
male infertility 116 | 123
increased circulating alkaline... 112 | 122
decreased grip strength 110 | 116
embryonic growth retardation 105 | 106
increased startle reflex 105 | 112
abnormal seminal vesicle morph... 103 | 114
increased bone mineral content 101 | 108
decreased body length 97 | 101
increased or absent threshold ... 96 | 101
short tibia 93 | 97
increased mean corpuscular hem... 92 | 96
decreased circulating choleste... 91 | 93
cataract 89 | 92
increased mean corpuscular vol... 88 | 92
prenatal lethality prior to he... 86 | 87
decreased lymphocyte cell numb... 81 | 83
abnormal lens morphology 78 | 81
decreased prepulse inhibition 78 | 82
increased circulating HDL chol... 78 | 80
decreased circulating serum al... 76 | 82
decreased mean corpuscular vol... 76 | 79
decreased circulating triglyce... 74 | 79
improved glucose tolerance 74 | 79
decreased startle reflex 73 | 75
impaired glucose tolerance 71 | 75
increased fasted circulating g... 70 | 76
decreased circulating insulin ... 69 | 76
decreased leukocyte cell numbe... 68 | 73
small superior vagus ganglion 68 | 74
increased bone mineral density 67 | 72
abnormal retina morphology 66 | 71
abnormal eye morphology 65 | 68
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 65 | 68
increased circulating sodium l... 65 | 71
decreased hemoglobin content 64 | 68
increased circulating choleste... 64 | 66
abnormal behavioral response t... 63 | 66
abnormal gait 62 | 69
decreased fasted circulating g... 62 | 65
increased monocyte cell number 62 | 63
abnormal coat-hair pigmentatio... 61 | 64
abnormal kidney morphology 60 | 65
decreased erythrocyte cell num... 60 | 62
increased heart weight 59 | 62
edema 57 | 59
abnormal spleen morphology 54 | 55
small testis 54 | 58
decreased caudal vertebrae num... 52 | 53
female infertility 52 | 60
hydrometra 51 | 53
thrombocytopenia 51 | 56
decreased mean corpuscular hem... 49 | 50
abnormal skin morphology 48 | 50
decreased circulating total pr... 47 | 49
decreased blood urea nitrogen ... 46 | 51
abnormal neural tube closure 45 | 46
decreased circulating alanine ... 45 | 47
decreased circulating alkaline... 45 | 46
increased blood urea nitrogen ... 44 | 48
increased hematocrit 44 | 46
increased mean platelet volume 44 | 45
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased leukocyte cell numbe... 42 | 47
increased hemoglobin content 41 | 45
abnormal testis morphology 40 | 43
increased circulating triglyce... 40 | 42
abnormal epididymis morphology 39 | 42
enlarged spleen 39 | 41
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
decreased neutrophil cell numb... 38 | 42
decreased red blood cell distr... 38 | 41
increased circulating chloride... 38 | 41
increased circulating creatini... 38 | 38
increased erythrocyte cell num... 38 | 39
limb grasping 38 | 41
tremors 38 | 39
prolonged QT interval 36 | 38

Disease

Carcinoma 10,459 | 11,493
ovarian cancer 8,152 | 8,520
osteosarcoma 7,509 | 7,950
psoriasis 6,081 | 6,694
medulloblastoma, large-cell 5,941 | 6,241
glioblastoma 5,578 | 5,792
atypical teratoid / rhabdoid tumor 4,918 | 5,112
ependymoma 4,533 | 4,679
lung cancer 4,532 | 4,740
group 3 medulloblastoma 3,928 | 4,104
adult high grade glioma 3,637 | 3,801
Breast cancer 3,465 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,200 | 3,291
malignant mesothelioma 3,116 | 3,232
Astrocytoma, Pilocytic 2,967 | 3,081
primitive neuroectodermal tumor 2,939 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,900 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,955
invasive ductal carcinoma 2,859 | 2,951
non-small cell lung cancer 2,805 | 2,890
oligodendroglioma 2,749 | 2,850
lung carcinoma 2,734 | 2,843
lung adenocarcinoma 2,616 | 2,716
astrocytic glioma 2,513 | 2,597
Kidney cancer 2,481 | 2,613
pancreatic cancer 2,317 | 2,398
Cancer 2,307 | 2,499
interstitial cystitis 2,208 | 2,312
subependymal giant cell astrocytoma 2,202 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,910 | 1,962
pituitary cancer 1,904 | 1,972
tuberculosis 1,896 | 2,010
Pick disease 1,854 | 1,894
group 4 medulloblastoma 1,791 | 1,855
ulcerative colitis 1,743 | 1,819
ductal carcinoma in situ 1,697 | 1,745
cystic fibrosis 1,638 | 1,696
breast carcinoma 1,578 | 1,638
colon cancer 1,428 | 1,478
diabetes mellitus 1,414 | 1,728
adrenocortical carcinoma 1,382 | 1,428
Autosomal recessive predisposition 1,350 | 1,442
Multiple myeloma 1,276 | 1,332
juvenile dermatomyositis 1,149 | 1,187
acute quadriplegic myopathy 1,128 | 1,158
astrocytoma 1,107 | 1,146
primary pancreatic ductal adenocarcinoma 1,085 | 1,109
Rheumatoid arthritis 1,084 | 1,191
Schizophrenia 1,058 | 1,160
spina bifida 1,049 | 1,074
pediatric high grade glioma 1,028 | 1,064
nasopharyngeal carcinoma 1,024 | 1,058
cutaneous lupus erythematosus 1,006 | 1,057
Intellectual disability 975 | 1,016
dermatomyositis 902 | 966
Atopic dermatitis 897 | 952
active Crohn's disease 886 | 922
non primary Sjogren syndrome sicca 837 | 891
gastric carcinoma 777 | 807
Epilepsy 758 | 792
acute myeloid leukemia 755 | 783
Liver Cirrhosis, Experimental 744 | 769
Waldenstrons macroglobulinemia 744 | 765
active ulcerative colitis 731 | 764
esophageal adenocarcinoma 707 | 737
primary Sjogren syndrome 702 | 735
medulloblastoma 693 | 720
Melanoma 659 | 711
aldosterone-producing adenoma 656 | 665
progressive supranuclear palsy 651 | 676
Obesity 637 | 678
Alzheimer's disease 636 | 658
Bipolar Disorder 618 | 666
Dull intelligence 616 | 645
Low intelligence 616 | 645
Mental Retardation 616 | 645
Mental deficiency 616 | 645
Poor school performance 616 | 645
Duchenne muscular dystrophy 583 | 601
Cognitive delay 582 | 608
Global developmental delay 582 | 608
Mental and motor retardation 582 | 608
Seizures 574 | 596
Liver cancer 571 | 604
Muscle hypotonia 550 | 571
fibroadenoma 541 | 559
pancreatic carcinoma 535 | 562
hepatocellular carcinoma 526 | 547
Endometriosis 521 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 503 | 510
Short stature 500 | 531
chronic rhinosinusitis 495 | 512
Down syndrome 484 | 499
Prostatic Neoplasms 479 | 495
Multiple Sclerosis 458 | 540
mucosa-associated lymphoid tissue lymphoma 457 | 484
posterior fossa group A ependymoma 447 | 468
sonic hedgehog group medulloblastoma 446 | 467
Amyotrophic lateral sclerosis 444 | 451
gastric cancer 442 | 459

Tissue

Endocrine System 16,560 | 18,159
Female tissues 16,142 | 17,400
Digestive Tract 16,139 | 17,369
Skin and soft tissues 16,034 | 17,230
Male tissues 15,951 | 17,142
Blood and immune system 15,756 | 16,909
Liver and Pancreas 15,713 | 16,750
Urinary Tract 15,664 | 16,678
Nervous System 15,633 | 16,725
Respiratory system 15,417 | 16,393
Cardiovascular System 14,459 | 15,192

Target Family

Non-IDG 9,959 | 12,091
Enzyme 3,837 | 4,145
Transcription Factor 1,226 | 1,400
Kinase 606 | 634
Transporter 443 | 473
Ion Channel 295 | 344
GPCR 287 | 408
Epigenetic 232 | 242
Nuclear Receptor 47 | 48
TF/Epigenetic 33 | 38
oGPCR 14 | 421

Data Source

JensenLab Experiment HPA-RNA 16,979 | 16,979
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39