Development Level

Tbio 8,150 | 10,625
Tdark 3,073 | 7,003
Tchem 1,507 | 1,890
Tclin 422 | 602

Collection

Eligible Kinase Proteins 106 | 134
Eligible Ion Channel Proteins 52 | 117
Eligible non-olfactory GPCR Proteins 30 | 145

IMPC Term

preweaning lethality, complete... 528 | 633
preweaning lethality, incomple... 206 | 260
abnormal behavior 180 | 226
embryonic lethality prior to t... 164 | 187
decreased total body fat amoun... 161 | 186
decreased lean body mass 158 | 195
decreased body weight 150 | 174
embryonic lethality prior to o... 128 | 148
decreased bone mineral content 127 | 157
abnormal bone structure 109 | 131
decreased bone mineral density 105 | 126
increased circulating alkaline... 104 | 119
decreased circulating glucose ... 100 | 121
decreased grip strength 99 | 123
increased or absent threshold ... 97 | 128
abnormal embryo size 94 | 112
decreased body length 93 | 108
increased lean body mass 88 | 107
hyperactivity 86 | 108
abnormal retina morphology 83 | 100
enlarged heart 81 | 111
increased bone mineral content 75 | 92
increased mean corpuscular hem... 75 | 93
decreased circulating choleste... 73 | 85
short tibia 71 | 82
decreased circulating HDL chol... 69 | 77
increased mean corpuscular vol... 69 | 91
decreased circulating serum al... 68 | 79
decreased circulating triglyce... 67 | 83
hypoactivity 67 | 89
decreased circulating insulin ... 64 | 75
increased grip strength 62 | 83
abnormal lens morphology 56 | 73
decreased lumbar vertebrae num... 55 | 62
increased circulating sodium l... 55 | 71
prenatal lethality prior to he... 55 | 64
increased fasted circulating g... 54 | 68
male infertility 53 | 62
increased sacral vertebrae num... 51 | 62
abnormal retinal pigmentation 49 | 61
abnormal sleep behavior 48 | 63
increased circulating HDL chol... 47 | 63
abnormal coat/hair pigmentatio... 45 | 54
decreased mean corpuscular vol... 45 | 50
decreased hemoglobin content 44 | 53
decreased rib number 44 | 59
abnormal bone mineralization 43 | 55
decreased leukocyte cell numbe... 43 | 54
improved glucose tolerance 43 | 56
increased exploration in new e... 43 | 56
increased circulating choleste... 42 | 53
increased total body fat amoun... 42 | 57
decreased caudal vertebrae num... 41 | 49
decreased prepulse inhibition 41 | 52
abnormal gait 40 | 51
decreased fasted circulating g... 40 | 49
decreased startle reflex 39 | 48
impaired glucose tolerance 39 | 52
abnormal behavioral response t... 38 | 52
decreased circulating alanine ... 38 | 53
increased body weight 38 | 42
thrombocytopenia 38 | 46
decreased circulating total pr... 37 | 41
decreased erythrocyte cell num... 37 | 43
increased blood urea nitrogen ... 37 | 44
increased bone mineral density 37 | 52
increased hemoglobin content 37 | 45
decreased circulating alkaline... 35 | 41
decreased eosinophil cell numb... 35 | 41
decreased heart weight 35 | 44
abnormal heart morphology 34 | 51
abnormal neural tube closure 33 | 37
abnormal seminal vesicle morph... 33 | 47
decreased circulating LDL chol... 32 | 37
decreased circulating free fat... 32 | 39
increased circulating chloride... 30 | 43
increased heart weight 30 | 37
increased leukocyte cell numbe... 30 | 37
tremors 30 | 34
cardiovascular system phenotyp... 29 | 35
increased hematocrit 29 | 36
increased rib number 29 | 41
small testis 29 | 37
decreased T cell number 28 | 31
increased startle reflex 28 | 38
abnormal cranium morphology 27 | 32
abnormal eye morphology 27 | 38
decreased circulating fructosa... 27 | 31
decreased mean corpuscular hem... 27 | 34
embryonic growth retardation 27 | 28
increased circulating calcium ... 27 | 32
decreased circulating chloride... 26 | 32
decreased circulating creatini... 26 | 31
decreased neutrophil cell numb... 26 | 37
abnormal spleen morphology 25 | 36
decreased NK T cell number 25 | 28
female infertility 25 | 34
increased circulating potassiu... 25 | 31
decreased circulating calcium ... 24 | 33
increased circulating creatini... 24 | 29

Disease

ovarian cancer 7,152 | 8,492
osteosarcoma 6,235 | 7,933
psoriasis 5,044 | 6,685
medulloblastoma, large-cell 4,913 | 6,234
glioblastoma 4,553 | 5,572
lung cancer 3,819 | 4,473
atypical teratoid / rhabdoid tumor 3,483 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,852 | 3,289
malignant mesothelioma 2,641 | 3,163
Breast cancer 2,587 | 3,099
intraductal papillary-mucinous carcinoma (IPMC) 2,582 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,580 | 2,956
invasive ductal carcinoma 2,519 | 2,950
pilocytic astrocytoma 2,452 | 3,086
non-small cell lung cancer 2,431 | 2,798
primitive neuroectodermal tumor 2,367 | 3,031
oligodendroglioma 2,338 | 2,849
lung carcinoma 2,324 | 2,844
lung adenocarcinoma 2,300 | 2,714
pediatric high grade glioma 2,193 | 2,712
ependymoma 2,082 | 2,514
pancreatic cancer 2,057 | 2,300
subependymal giant cell astrocytoma 1,936 | 2,287
interstitial cystitis 1,931 | 2,299
Cancer 1,928 | 2,346
ulcerative colitis 1,868 | 2,087
astrocytic glioma 1,796 | 2,241
group 3 medulloblastoma 1,691 | 2,254
adult high grade glioma 1,676 | 2,148
Pick disease 1,655 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,655 | 1,795
pituitary cancer 1,604 | 1,972
Carcinoma 1,519 | 2,147
group 4 medulloblastoma 1,514 | 1,875
ductal carcinoma in situ 1,478 | 1,745
cystic fibrosis 1,407 | 1,670
breast carcinoma 1,382 | 1,614
astrocytoma 1,352 | 1,493
tuberculosis 1,311 | 1,563
colon cancer 1,289 | 1,475
Multiple myeloma 1,255 | 1,328
medulloblastoma 1,218 | 1,524
adrenocortical carcinoma 1,211 | 1,427
diabetes mellitus 1,202 | 1,663
primary pancreatic ductal adenocarcinoma 1,196 | 1,271
posterior fossa group A ependymoma 1,178 | 1,511
sonic hedgehog group medulloblastoma 1,168 | 1,482
posterior fossa group B ependymoma 1,133 | 1,530
juvenile dermatomyositis 1,072 | 1,189
acute quadriplegic myopathy 1,065 | 1,157
Rheumatoid Arthritis 962 | 1,171
spina bifida 937 | 1,064
cutaneous lupus erythematosus 904 | 1,056
nasopharyngeal carcinoma 879 | 1,056
dermatomyositis 878 | 967
atypical teratoid/rhabdoid tumor 874 | 1,095
active Crohn's disease 777 | 918
Atopic dermatitis 768 | 944
gastric carcinoma 746 | 832
Waldenstrons macroglobulinemia 738 | 765
primary Sjogren syndrome 704 | 789
esophageal adenocarcinoma 692 | 737
acute myeloid leukemia 675 | 785
non primary Sjogren syndrome sicca 660 | 840
aldosterone-producing adenoma 600 | 664
tuberculosis and treatment for 6 months 582 | 686
progressive supranuclear palsy 571 | 674
Duchenne muscular dystrophy 552 | 602
Alzheimer's disease 521 | 644
Down syndrome 497 | 548
Obesity 484 | 616
pancreatic carcinoma 484 | 567
fibroadenoma 477 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 468 | 499
hepatocellular carcinoma 454 | 550
Endometriosis 449 | 535
Intellectual disability 439 | 573
Prostatic Neoplasms 416 | 471
chronic rhinosinusitis 415 | 512
mucosa-associated lymphoid tissue lymphoma 413 | 480
IGA Glomerulonephritis 410 | 454
active ulcerative colitis 393 | 477
Amyotrophic Lateral Sclerosis 380 | 432
Schizophrenia 355 | 503
gastric cancer 353 | 436
Mammary Neoplasms 343 | 410
inflammatory breast cancer 339 | 404
Multiple Sclerosis 327 | 498
Neurodegenerative disease 327 | 383
non-small cell lung carcinoma 313 | 413
Kidney disease 312 | 397
nephrosclerosis 312 | 329
hereditary spastic paraplegia 303 | 313
sarcoidosis 299 | 368
glioblastoma multiforme 295 | 347
Parkinson's disease 288 | 364
tuberculosis and treatment for 3 months 280 | 327
urothelial carcinoma 277 | 318
interstitial lung disease 274 | 292
Polycystic Ovary Syndrome 268 | 335

Tissue

Female tissues 12,993 | 18,647
Nervous System 12,989 | 18,561
Digestive Tract 12,985 | 18,473
Endocrine System 12,982 | 18,512
Urinary Tract 12,961 | 18,444
Liver and Pancreas 12,947 | 18,136
Male tissues 12,920 | 17,969
Cardiovascular System 12,895 | 17,958
Blood and immune system 12,892 | 17,995
Skin and soft tissues 12,875 | 18,115
Respiratory system 12,767 | 17,484

Target Family

Non-IDG 7,780 | 11,969
Enzyme 3,233 | 4,146
Transcription Factor 688 | 1,400
Kinase 518 | 634
Transporter 363 | 473
Epigenetic 194 | 242
Ion Channel 169 | 341
GPCR 141 | 408
Nuclear Receptor 40 | 48
TF/Epigenetic 25 | 38
oGPCR 1 | 421

Data Source

JensenLab Experiment HPA-RNA 13,152 | 13,152
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240