Development Level

Tbio 9,243 | 11,178
Tdark 4,306 | 6,569
Tchem 1,620 | 1,885
Tclin 496 | 612

Collection

Kinase: IDG Consortium (Target... 110 | 125
GPCR: IDG Consortium (Targets) 75 | 126
Ion Channel: IDG Consortium (T... 69 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 862 | 979
preweaning lethality, incomple... 428 | 499
abnormal behavior 252 | 298
embryonic lethality prior to t... 237 | 278
embryonic lethality prior to o... 202 | 239
abnormal embryo size 194 | 220
decreased total body fat amoun... 179 | 207
enlarged heart 178 | 210
decreased vertical activity 172 | 208
abnormal bone structure 165 | 187
increased lean body mass 147 | 172
decreased body weight 140 | 161
abnormal heart morphology 135 | 162
decreased bone mineral content 124 | 151
hyperactivity 124 | 148
decreased lean body mass 116 | 135
increased total body fat amoun... 114 | 134
hypoactivity 110 | 132
decreased circulating glucose ... 108 | 126
decreased bone mineral density 107 | 126
male infertility 107 | 123
abnormal seminal vesicle morph... 103 | 114
increased circulating alkaline... 101 | 122
decreased grip strength 99 | 116
increased startle reflex 98 | 112
embryonic growth retardation 94 | 106
increased or absent threshold ... 92 | 101
increased bone mineral content 91 | 108
decreased body length 90 | 101
short tibia 85 | 97
cataract 81 | 92
increased mean corpuscular hem... 81 | 96
decreased circulating choleste... 79 | 93
prenatal lethality prior to he... 78 | 87
increased mean corpuscular vol... 77 | 92
decreased prepulse inhibition 72 | 82
decreased lymphocyte cell numb... 71 | 83
decreased circulating triglyce... 70 | 79
abnormal lens morphology 69 | 81
improved glucose tolerance 69 | 79
decreased circulating insulin ... 66 | 76
decreased mean corpuscular vol... 66 | 79
increased circulating HDL chol... 66 | 80
increased fasted circulating g... 65 | 76
decreased circulating serum al... 64 | 82
small superior vagus ganglion 64 | 74
impaired glucose tolerance 63 | 75
increased bone mineral density 63 | 72
abnormal eye morphology 61 | 68
abnormal sleep behavior 61 | 70
decreased leukocyte cell numbe... 61 | 73
decreased startle reflex 61 | 75
increased circulating sodium l... 60 | 71
abnormal behavioral response t... 58 | 66
abnormal kidney morphology 58 | 65
decreased circulating HDL chol... 58 | 68
decreased hemoglobin content 58 | 68
abnormal retina morphology 57 | 71
increased circulating choleste... 56 | 66
abnormal coat-hair pigmentatio... 55 | 64
abnormal gait 55 | 69
decreased erythrocyte cell num... 55 | 62
increased monocyte cell number 55 | 63
increased heart weight 54 | 62
decreased caudal vertebrae num... 52 | 53
decreased fasted circulating g... 52 | 65
abnormal spleen morphology 50 | 55
edema 50 | 59
small testis 48 | 58
hydrometra 47 | 53
female infertility 46 | 60
thrombocytopenia 46 | 56
abnormal skin morphology 43 | 50
decreased circulating alanine ... 43 | 47
decreased circulating alkaline... 41 | 46
decreased mean corpuscular hem... 41 | 50
increased blood urea nitrogen ... 41 | 48
increased mean platelet volume 41 | 45
decreased circulating total pr... 40 | 49
decreased hematocrit 40 | 46
increased hematocrit 39 | 46
abnormal neural tube closure 38 | 46
abnormal testis morphology 38 | 43
decreased circulating LDL chol... 38 | 38
abnormal epididymis morphology 37 | 42
decreased neutrophil cell numb... 36 | 42
increased grip strength 36 | 41
increased neutrophil cell numb... 36 | 46
decreased blood urea nitrogen ... 35 | 51
increased circulating chloride... 35 | 41
increased hemoglobin content 35 | 45
limb grasping 35 | 41
prolonged QT interval 35 | 38
abnormal cranium morphology 34 | 36
cardiovascular system phenotyp... 34 | 36
decreased red blood cell distr... 34 | 41
enlarged spleen 34 | 41
increased circulating triglyce... 34 | 42
increased erythrocyte cell num... 34 | 39
prolonged ST segment 34 | 36

Disease

Carcinoma 9,453 | 11,192
ovarian cancer 7,234 | 8,297
osteosarcoma 6,642 | 7,766
psoriasis 5,358 | 6,514
medulloblastoma, large-cell 5,242 | 6,086
glioblastoma 4,871 | 5,635
atypical teratoid / rhabdoid tumor 4,310 | 4,971
lung cancer 3,998 | 4,607
ependymoma 3,980 | 4,559
group 3 medulloblastoma 3,446 | 4,002
adult high grade glioma 3,166 | 3,701
Breast cancer 3,015 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,829 | 3,204
malignant mesothelioma 2,726 | 3,135
Astrocytoma, Pilocytic 2,601 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,569 | 2,902
primitive neuroectodermal tumor 2,557 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 2,532 | 2,872
invasive ductal carcinoma 2,495 | 2,867
non-small cell lung cancer 2,442 | 2,799
oligodendroglioma 2,420 | 2,768
lung carcinoma 2,401 | 2,755
lung adenocarcinoma 2,290 | 2,627
Kidney cancer 2,255 | 2,548
astrocytic glioma 2,207 | 2,530
pancreatic cancer 2,045 | 2,322
Cancer 1,987 | 2,388
subependymal giant cell astrocytoma 1,950 | 2,230
interstitial cystitis 1,907 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,707 | 1,911
tuberculosis 1,664 | 1,963
pituitary cancer 1,645 | 1,915
Pick disease 1,644 | 1,856
group 4 medulloblastoma 1,567 | 1,806
ulcerative colitis 1,536 | 1,765
ductal carcinoma in situ 1,468 | 1,686
cystic fibrosis 1,404 | 1,629
breast carcinoma 1,387 | 1,589
diabetes mellitus 1,293 | 1,683
colon cancer 1,247 | 1,428
adrenocortical carcinoma 1,219 | 1,385
Autosomal recessive predisposition 1,211 | 1,407
Multiple myeloma 1,139 | 1,296
juvenile dermatomyositis 1,019 | 1,147
acute quadriplegic myopathy 1,000 | 1,133
astrocytoma 989 | 1,113
primary pancreatic ductal adenocarcinoma 947 | 1,071
Rheumatoid arthritis 938 | 1,156
Schizophrenia 933 | 1,136
spina bifida 933 | 1,053
nasopharyngeal carcinoma 911 | 1,024
pediatric high grade glioma 888 | 1,035
Intellectual disability 863 | 998
cutaneous lupus erythematosus 854 | 1,016
dermatomyositis 803 | 941
Atopic dermatitis 783 | 915
active Crohn's disease 769 | 882
non primary Sjogren syndrome sicca 731 | 861
gastric carcinoma 680 | 781
Waldenstrons macroglobulinemia 676 | 742
Epilepsy 674 | 775
acute myeloid leukemia 670 | 760
Liver Cirrhosis, Experimental 643 | 733
active ulcerative colitis 631 | 736
esophageal adenocarcinoma 629 | 696
primary Sjogren syndrome 613 | 710
medulloblastoma 603 | 702
Melanoma 597 | 689
progressive supranuclear palsy 582 | 656
Alzheimer's disease 578 | 640
aldosterone-producing adenoma 574 | 646
Obesity 549 | 655
Dull intelligence 541 | 634
Low intelligence 541 | 634
Mental Retardation 541 | 634
Mental deficiency 541 | 634
Poor school performance 541 | 634
Bipolar Disorder 533 | 646
Cognitive delay 523 | 596
Global developmental delay 523 | 596
Mental and motor retardation 523 | 596
Duchenne muscular dystrophy 517 | 587
Seizures 514 | 584
Liver cancer 507 | 589
Muscle hypotonia 493 | 562
pancreatic carcinoma 491 | 555
fibroadenoma 464 | 538
hepatocellular carcinoma 462 | 536
Endometriosis 448 | 521
chronic rhinosinusitis 447 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 444 | 492
Short stature 437 | 514
Down syndrome 430 | 480
Prostatic Neoplasms 420 | 472
Multiple Sclerosis 406 | 527
mucosa-associated lymphoid tissue lymphoma 406 | 473
Amyotrophic lateral sclerosis 402 | 437
posterior fossa group A ependymoma 397 | 456
gastric cancer 393 | 445
Skin cancer 389 | 451

Tissue

Endocrine System 15,081 | 18,159
Female tissues 14,609 | 17,400
Digestive Tract 14,575 | 17,369
Skin and soft tissues 14,480 | 17,230
Male tissues 14,457 | 17,142
Blood and immune system 14,229 | 16,909
Liver and Pancreas 14,176 | 16,750
Nervous System 14,157 | 16,725
Urinary Tract 14,121 | 16,678
Respiratory system 13,910 | 16,393
Cardiovascular System 13,028 | 15,192

Target Family

Non-IDG 9,203 | 12,091
Enzyme 3,521 | 4,145
Transcription Factor 1,068 | 1,400
Kinase 566 | 634
Transporter 399 | 473
GPCR 268 | 408
Ion Channel 263 | 344
Epigenetic 208 | 242
oGPCR 105 | 421
Nuclear Receptor 32 | 48
TF/Epigenetic 32 | 38

Data Source

JensenLab Experiment HPA 15,665 | 15,665
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Putative uncharacterized protein C14orf144 C14orf144 Tdark Non-IDG 0.00000 0