Development Level

Tbio 9,464 | 11,445
Tdark 4,319 | 6,588
Tchem 1,385 | 1,598
Tclin 497 | 613

Collection

RFA-RM-18-021 251 | 328
Kinase: IDG Consortium (Target... 110 | 125
GPCR: IDG Consortium (Targets) 75 | 126
Ion Channel: IDG Consortium (T... 69 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 862 | 979
preweaning lethality, incomple... 428 | 499
abnormal behavior 252 | 298
embryonic lethality prior to t... 237 | 278
embryonic lethality prior to o... 202 | 239
abnormal embryo size 194 | 220
decreased total body fat amoun... 179 | 207
enlarged heart 178 | 210
decreased vertical activity 172 | 208
abnormal bone structure 165 | 187
increased lean body mass 147 | 172
decreased body weight 140 | 161
abnormal heart morphology 135 | 162
decreased bone mineral content 124 | 151
hyperactivity 124 | 148
decreased lean body mass 116 | 135
increased total body fat amoun... 114 | 134
hypoactivity 110 | 132
decreased circulating glucose ... 108 | 126
decreased bone mineral density 107 | 126
male infertility 107 | 123
abnormal seminal vesicle morph... 103 | 114
increased circulating alkaline... 101 | 122
decreased grip strength 99 | 116
increased startle reflex 98 | 112
embryonic growth retardation 94 | 106
increased or absent threshold ... 92 | 101
increased bone mineral content 91 | 108
decreased body length 90 | 101
short tibia 85 | 97
cataract 81 | 92
increased mean corpuscular hem... 81 | 96
decreased circulating choleste... 79 | 93
prenatal lethality prior to he... 78 | 87
increased mean corpuscular vol... 77 | 92
decreased prepulse inhibition 72 | 82
decreased lymphocyte cell numb... 71 | 83
decreased circulating triglyce... 70 | 79
abnormal lens morphology 69 | 81
improved glucose tolerance 69 | 79
decreased circulating insulin ... 66 | 76
decreased mean corpuscular vol... 66 | 79
increased circulating HDL chol... 66 | 80
increased fasted circulating g... 65 | 76
decreased circulating serum al... 64 | 82
small superior vagus ganglion 64 | 74
impaired glucose tolerance 63 | 75
increased bone mineral density 63 | 72
abnormal eye morphology 61 | 68
abnormal sleep behavior 61 | 70
decreased leukocyte cell numbe... 61 | 73
decreased startle reflex 61 | 75
increased circulating sodium l... 60 | 71
abnormal behavioral response t... 58 | 66
abnormal kidney morphology 58 | 65
decreased circulating HDL chol... 58 | 68
decreased hemoglobin content 58 | 68
abnormal retina morphology 57 | 71
increased circulating choleste... 56 | 66
abnormal coat-hair pigmentatio... 55 | 64
abnormal gait 55 | 69
decreased erythrocyte cell num... 55 | 62
increased monocyte cell number 55 | 63
increased heart weight 54 | 62
decreased caudal vertebrae num... 52 | 53
decreased fasted circulating g... 52 | 65
abnormal spleen morphology 50 | 55
edema 50 | 59
small testis 48 | 58
hydrometra 47 | 53
female infertility 46 | 60
thrombocytopenia 46 | 56
abnormal skin morphology 43 | 50
decreased circulating alanine ... 43 | 47
decreased circulating alkaline... 41 | 46
decreased mean corpuscular hem... 41 | 50
increased blood urea nitrogen ... 41 | 48
increased mean platelet volume 41 | 45
decreased circulating total pr... 40 | 49
decreased hematocrit 40 | 46
increased hematocrit 39 | 46
abnormal neural tube closure 38 | 46
abnormal testis morphology 38 | 43
decreased circulating LDL chol... 38 | 38
abnormal epididymis morphology 37 | 42
decreased neutrophil cell numb... 36 | 42
increased grip strength 36 | 41
increased neutrophil cell numb... 36 | 46
decreased blood urea nitrogen ... 35 | 51
increased circulating chloride... 35 | 41
increased hemoglobin content 35 | 45
limb grasping 35 | 41
prolonged QT interval 35 | 38
abnormal cranium morphology 34 | 36
cardiovascular system phenotyp... 34 | 36
decreased red blood cell distr... 34 | 41
enlarged spleen 34 | 41
increased circulating triglyce... 34 | 42
increased erythrocyte cell num... 34 | 39
prolonged ST segment 34 | 36

Disease

Carcinoma 9,713 | 11,493
ovarian cancer 7,430 | 8,520
osteosarcoma 6,800 | 7,950
psoriasis 5,509 | 6,694
medulloblastoma, large-cell 5,370 | 6,241
glioblastoma 4,998 | 5,792
atypical teratoid / rhabdoid tumor 4,428 | 5,112
lung cancer 4,112 | 4,740
ependymoma 4,076 | 4,679
group 3 medulloblastoma 3,526 | 4,104
adult high grade glioma 3,245 | 3,801
Breast cancer 3,112 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,900 | 3,291
malignant mesothelioma 2,808 | 3,232
Astrocytoma, Pilocytic 2,661 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,641 | 2,989
primitive neuroectodermal tumor 2,620 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,597 | 2,955
invasive ductal carcinoma 2,562 | 2,951
non-small cell lung cancer 2,517 | 2,890
oligodendroglioma 2,481 | 2,850
lung carcinoma 2,478 | 2,843
lung adenocarcinoma 2,363 | 2,716
Kidney cancer 2,310 | 2,613
astrocytic glioma 2,260 | 2,597
pancreatic cancer 2,101 | 2,398
Cancer 2,082 | 2,499
subependymal giant cell astrocytoma 1,998 | 2,287
interstitial cystitis 1,966 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,753 | 1,962
tuberculosis 1,704 | 2,010
pituitary cancer 1,693 | 1,972
Pick disease 1,676 | 1,894
group 4 medulloblastoma 1,606 | 1,855
ulcerative colitis 1,583 | 1,819
ductal carcinoma in situ 1,515 | 1,745
cystic fibrosis 1,453 | 1,696
breast carcinoma 1,429 | 1,638
diabetes mellitus 1,335 | 1,728
colon cancer 1,293 | 1,478
adrenocortical carcinoma 1,258 | 1,428
Autosomal recessive predisposition 1,237 | 1,442
Multiple myeloma 1,171 | 1,332
juvenile dermatomyositis 1,054 | 1,187
acute quadriplegic myopathy 1,024 | 1,158
astrocytoma 1,015 | 1,146
primary pancreatic ductal adenocarcinoma 978 | 1,109
Rheumatoid arthritis 967 | 1,191
Schizophrenia 953 | 1,160
spina bifida 951 | 1,074
nasopharyngeal carcinoma 938 | 1,058
pediatric high grade glioma 910 | 1,064
cutaneous lupus erythematosus 885 | 1,057
Intellectual disability 878 | 1,016
dermatomyositis 825 | 966
Atopic dermatitis 812 | 952
active Crohn's disease 805 | 922
non primary Sjogren syndrome sicca 755 | 891
gastric carcinoma 703 | 807
Waldenstrons macroglobulinemia 696 | 765
Epilepsy 690 | 792
acute myeloid leukemia 690 | 783
Liver Cirrhosis, Experimental 673 | 769
esophageal adenocarcinoma 665 | 737
active ulcerative colitis 654 | 764
primary Sjogren syndrome 633 | 735
medulloblastoma 621 | 720
Melanoma 615 | 711
progressive supranuclear palsy 598 | 676
Alzheimer's disease 596 | 658
aldosterone-producing adenoma 590 | 665
Obesity 570 | 678
Dull intelligence 551 | 645
Low intelligence 551 | 645
Mental Retardation 551 | 645
Mental deficiency 551 | 645
Poor school performance 551 | 645
Bipolar Disorder 549 | 666
Cognitive delay 533 | 608
Global developmental delay 533 | 608
Mental and motor retardation 533 | 608
Duchenne muscular dystrophy 529 | 601
Seizures 525 | 596
Liver cancer 521 | 604
Muscle hypotonia 502 | 571
pancreatic carcinoma 495 | 562
fibroadenoma 481 | 559
hepatocellular carcinoma 472 | 547
Endometriosis 465 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 462 | 510
chronic rhinosinusitis 452 | 512
Short stature 451 | 531
Down syndrome 446 | 499
Prostatic Neoplasms 440 | 495
Multiple Sclerosis 416 | 540
mucosa-associated lymphoid tissue lymphoma 416 | 484
Amyotrophic lateral sclerosis 415 | 451
posterior fossa group A ependymoma 409 | 468
gastric cancer 406 | 459
Skin cancer 403 | 469

Tissue

Endocrine System 15,081 | 18,159
Female tissues 14,609 | 17,400
Digestive Tract 14,575 | 17,369
Skin and soft tissues 14,480 | 17,230
Male tissues 14,457 | 17,142
Blood and immune system 14,229 | 16,909
Liver and Pancreas 14,176 | 16,750
Nervous System 14,157 | 16,725
Urinary Tract 14,121 | 16,678
Respiratory system 13,910 | 16,393
Cardiovascular System 13,028 | 15,192

Target Family

Non-IDG 9,203 | 12,091
Enzyme 3,521 | 4,145
Transcription Factor 1,068 | 1,400
Kinase 566 | 634
Transporter 399 | 473
GPCR 268 | 408
Ion Channel 263 | 344
Epigenetic 208 | 242
oGPCR 105 | 421
Nuclear Receptor 32 | 48
TF/Epigenetic 32 | 38

Data Source

JensenLab Experiment HPA 15,665 | 15,665
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22