Development Level

Tbio 6,846 | 10,625
Tdark 3,630 | 7,003
Tchem 1,200 | 1,890
Tclin 348 | 602

Collection

Eligible Kinase Proteins 98 | 134
Eligible non-olfactory GPCR Proteins 68 | 145
Eligible Ion Channel Proteins 66 | 117

IMPC Term

preweaning lethality, complete... 426 | 633
preweaning lethality, incomple... 181 | 260
abnormal behavior 150 | 226
decreased lean body mass 135 | 195
decreased total body fat amoun... 128 | 186
decreased body weight 117 | 174
embryonic lethality prior to t... 114 | 187
decreased bone mineral content 96 | 157
embryonic lethality prior to o... 94 | 148
decreased bone mineral density 85 | 126
decreased circulating glucose ... 81 | 121
decreased grip strength 81 | 123
increased or absent threshold ... 80 | 128
abnormal bone structure 78 | 131
decreased body length 77 | 108
increased lean body mass 76 | 107
hyperactivity 74 | 108
abnormal embryo size 73 | 112
increased circulating alkaline... 71 | 119
enlarged heart 70 | 111
increased mean corpuscular hem... 67 | 93
increased bone mineral content 63 | 92
abnormal retina morphology 59 | 100
increased mean corpuscular vol... 57 | 91
decreased circulating serum al... 54 | 79
decreased circulating triglyce... 54 | 83
hypoactivity 54 | 89
abnormal lens morphology 51 | 73
decreased circulating choleste... 51 | 85
decreased circulating insulin ... 51 | 75
increased fasted circulating g... 49 | 68
increased grip strength 49 | 83
prenatal lethality prior to he... 49 | 64
short tibia 47 | 82
decreased lumbar vertebrae num... 45 | 62
increased sacral vertebrae num... 45 | 62
decreased circulating HDL chol... 42 | 77
abnormal sleep behavior 41 | 63
increased circulating sodium l... 39 | 71
male infertility 38 | 62
abnormal coat/hair pigmentatio... 37 | 54
abnormal retinal pigmentation 37 | 61
decreased rib number 37 | 59
increased circulating HDL chol... 37 | 63
increased exploration in new e... 37 | 56
decreased caudal vertebrae num... 36 | 49
increased bone mineral density 36 | 52
abnormal behavioral response t... 35 | 52
decreased circulating alanine ... 35 | 53
increased circulating choleste... 35 | 53
increased total body fat amoun... 35 | 57
abnormal seminal vesicle morph... 34 | 47
abnormal heart morphology 33 | 51
decreased startle reflex 33 | 48
impaired glucose tolerance 33 | 52
improved glucose tolerance 33 | 56
abnormal bone mineralization 32 | 55
decreased fasted circulating g... 32 | 49
decreased heart weight 32 | 44
decreased hemoglobin content 32 | 53
decreased prepulse inhibition 32 | 52
abnormal gait 30 | 51
increased body weight 30 | 42
decreased circulating total pr... 29 | 41
decreased erythrocyte cell num... 29 | 43
increased rib number 29 | 41
abnormal spleen morphology 28 | 36
decreased mean corpuscular vol... 28 | 50
increased blood urea nitrogen ... 28 | 44
decreased eosinophil cell numb... 27 | 41
decreased leukocyte cell numbe... 27 | 54
increased circulating potassiu... 27 | 31
increased startle reflex 27 | 38
thrombocytopenia 27 | 46
decreased circulating alkaline... 26 | 41
decreased neutrophil cell numb... 26 | 37
increased circulating chloride... 26 | 43
decreased circulating LDL chol... 25 | 37
decreased circulating free fat... 25 | 39
increased hemoglobin content 25 | 45
increased heart weight 24 | 37
limb grasping 24 | 35
small testis 24 | 37
abnormal eye morphology 23 | 38
cardiovascular system phenotyp... 23 | 35
abnormal kidney morphology 22 | 30
abnormal neural tube closure 22 | 37
abnormal rib morphology 22 | 28
decreased NK T cell number 22 | 28
decreased blood urea nitrogen ... 22 | 31
abnormal cranium morphology 21 | 32
abnormal testis morphology 21 | 30
decreased B cell number 21 | 30
decreased circulating aspartat... 21 | 27
decreased circulating chloride... 21 | 32
decreased monocyte cell number 21 | 28
increased circulating creatini... 21 | 29
tremors 21 | 34
abnormal epididymis morphology 20 | 31
decreased circulating fructosa... 20 | 31

Disease

ovarian cancer 5,707 | 8,492
osteosarcoma 5,210 | 7,933
psoriasis 4,178 | 6,685
medulloblastoma, large-cell 4,096 | 6,234
glioblastoma 3,662 | 5,572
lung cancer 3,000 | 4,473
atypical teratoid / rhabdoid tumor 2,865 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,234 | 3,289
malignant mesothelioma 2,110 | 3,163
Breast cancer 2,064 | 3,099
intraductal papillary-mucinous carcinoma (IPMC) 1,999 | 2,988
pilocytic astrocytoma 1,999 | 3,086
primitive neuroectodermal tumor 1,993 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 1,972 | 2,956
invasive ductal carcinoma 1,940 | 2,950
oligodendroglioma 1,905 | 2,849
lung carcinoma 1,875 | 2,844
non-small cell lung cancer 1,850 | 2,798
lung adenocarcinoma 1,792 | 2,714
pediatric high grade glioma 1,730 | 2,712
ependymoma 1,649 | 2,514
subependymal giant cell astrocytoma 1,548 | 2,287
pancreatic cancer 1,521 | 2,300
astrocytic glioma 1,495 | 2,241
group 3 medulloblastoma 1,494 | 2,254
interstitial cystitis 1,475 | 2,299
adult high grade glioma 1,408 | 2,148
Carcinoma 1,384 | 2,147
ulcerative colitis 1,384 | 2,087
Cancer 1,367 | 2,346
pituitary cancer 1,296 | 1,972
Pick disease 1,288 | 1,893
group 4 medulloblastoma 1,252 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,227 | 1,795
ductal carcinoma in situ 1,148 | 1,745
cystic fibrosis 1,085 | 1,670
breast carcinoma 1,057 | 1,614
posterior fossa group B ependymoma 1,019 | 1,530
tuberculosis 1,016 | 1,563
astrocytoma 1,003 | 1,493
colon cancer 985 | 1,475
medulloblastoma 980 | 1,524
diabetes mellitus 973 | 1,663
posterior fossa group A ependymoma 970 | 1,511
sonic hedgehog group medulloblastoma 935 | 1,482
adrenocortical carcinoma 934 | 1,427
Multiple myeloma 918 | 1,328
primary pancreatic ductal adenocarcinoma 841 | 1,271
juvenile dermatomyositis 782 | 1,189
acute quadriplegic myopathy 773 | 1,157
atypical teratoid/rhabdoid tumor 716 | 1,095
nasopharyngeal carcinoma 716 | 1,056
spina bifida 716 | 1,064
Rheumatoid Arthritis 688 | 1,171
cutaneous lupus erythematosus 661 | 1,056
active Crohn's disease 636 | 918
Atopic dermatitis 604 | 944
dermatomyositis 598 | 967
gastric carcinoma 552 | 832
non primary Sjogren syndrome sicca 548 | 840
Waldenstrons macroglobulinemia 535 | 765
acute myeloid leukemia 531 | 785
primary Sjogren syndrome 509 | 789
esophageal adenocarcinoma 504 | 737
tuberculosis and treatment for 6 months 481 | 686
progressive supranuclear palsy 458 | 674
aldosterone-producing adenoma 449 | 664
Alzheimer's disease 438 | 644
pancreatic carcinoma 390 | 567
Duchenne muscular dystrophy 389 | 602
Obesity 386 | 616
Intellectual disability 370 | 573
Down syndrome 369 | 548
hepatocellular carcinoma 369 | 550
fibroadenoma 360 | 557
chronic rhinosinusitis 356 | 512
Endometriosis 329 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 327 | 499
active ulcerative colitis 326 | 477
Schizophrenia 324 | 503
mucosa-associated lymphoid tissue lymphoma 323 | 480
IGA Glomerulonephritis 304 | 454
gastric cancer 298 | 436
Prostatic Neoplasms 297 | 471
Multiple Sclerosis 288 | 498
Amyotrophic Lateral Sclerosis 280 | 432
non-small cell lung carcinoma 255 | 413
inflammatory breast cancer 253 | 404
Neurodegenerative disease 246 | 383
Parkinson's disease 242 | 364
Mammary Neoplasms 237 | 410
sarcoidosis 233 | 368
Kidney disease 224 | 397
Epilepsy 223 | 346
glioblastoma multiforme 223 | 347
nephrosclerosis 220 | 329
hereditary spastic paraplegia 218 | 313
tuberculosis and treatment for 3 months 218 | 327
urothelial carcinoma 208 | 318
Polycystic Ovary Syndrome 206 | 335

Tissue

Nervous System 11,725 | 18,561
Female tissues 11,723 | 18,647
Endocrine System 11,702 | 18,512
Digestive Tract 11,662 | 18,473
Urinary Tract 11,649 | 18,444
Liver and Pancreas 11,552 | 18,136
Skin and soft tissues 11,541 | 18,115
Male tissues 11,494 | 17,969
Cardiovascular System 11,485 | 17,958
Blood and immune system 11,468 | 17,995
Respiratory system 11,270 | 17,484

Target Family

Non-IDG 7,020 | 11,969
Enzyme 2,769 | 4,146
Transcription Factor 823 | 1,400
Kinase 406 | 634
Transporter 305 | 473
GPCR 213 | 408
Ion Channel 206 | 341
Epigenetic 156 | 242
oGPCR 77 | 421
TF/Epigenetic 26 | 38
Nuclear Receptor 23 | 48

Data Source

JensenLab Experiment HPA 12,024 | 12,024
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57