Development Level

Tbio 7,114 | 11,178
Tdark 1,822 | 6,569
Tchem 1,308 | 1,885
Tclin 393 | 612

Collection

Kinase: IDG Consortium (Target... 72 | 125
Ion Channel: IDG Consortium (T... 45 | 99
GPCR: IDG Consortium (Targets) 30 | 126
Kinase: IDG Consortium (Comple... 24 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 718 | 979
preweaning lethality, incomple... 316 | 499
embryonic lethality prior to t... 213 | 278
abnormal behavior 182 | 298
embryonic lethality prior to o... 182 | 239
abnormal embryo size 149 | 220
decreased total body fat amoun... 144 | 207
abnormal bone structure 126 | 187
enlarged heart 126 | 210
decreased vertical activity 125 | 208
increased lean body mass 114 | 172
decreased body weight 106 | 161
hyperactivity 103 | 148
decreased bone mineral content 102 | 151
abnormal heart morphology 97 | 162
increased total body fat amoun... 86 | 134
decreased lean body mass 85 | 135
increased startle reflex 82 | 112
decreased bone mineral density 80 | 126
hypoactivity 80 | 132
increased circulating alkaline... 80 | 122
embryonic growth retardation 76 | 106
decreased grip strength 75 | 116
decreased circulating glucose ... 72 | 126
increased mean corpuscular hem... 72 | 96
increased bone mineral content 69 | 108
abnormal seminal vesicle morph... 67 | 114
decreased circulating choleste... 65 | 93
male infertility 65 | 123
decreased body length 64 | 101
increased or absent threshold ... 64 | 101
cataract 62 | 92
decreased lymphocyte cell numb... 62 | 83
increased mean corpuscular vol... 62 | 92
prenatal lethality prior to he... 59 | 87
short tibia 58 | 97
decreased mean corpuscular vol... 57 | 79
decreased circulating serum al... 56 | 82
decreased prepulse inhibition 56 | 82
abnormal lens morphology 55 | 81
abnormal gait 52 | 69
increased circulating HDL chol... 52 | 80
improved glucose tolerance 50 | 79
decreased circulating HDL chol... 49 | 68
decreased circulating triglyce... 49 | 79
decreased startle reflex 49 | 75
increased fasted circulating g... 49 | 76
impaired glucose tolerance 47 | 75
small superior vagus ganglion 46 | 74
abnormal sleep behavior 45 | 70
decreased leukocyte cell numbe... 45 | 73
abnormal retina morphology 44 | 71
decreased circulating insulin ... 44 | 76
increased circulating choleste... 44 | 66
abnormal coat-hair pigmentatio... 43 | 64
abnormal eye morphology 43 | 68
edema 43 | 59
increased circulating sodium l... 43 | 71
abnormal behavioral response t... 42 | 66
decreased fasted circulating g... 42 | 65
decreased hemoglobin content 42 | 68
increased bone mineral density 42 | 72
decreased erythrocyte cell num... 41 | 62
increased monocyte cell number 40 | 63
abnormal kidney morphology 39 | 65
increased heart weight 38 | 62
hydrometra 37 | 53
decreased caudal vertebrae num... 36 | 53
decreased circulating total pr... 36 | 49
small testis 36 | 58
decreased circulating alanine ... 35 | 47
increased circulating triglyce... 34 | 42
thrombocytopenia 34 | 56
abnormal neural tube closure 33 | 46
decreased circulating alkaline... 33 | 46
decreased mean corpuscular hem... 33 | 50
decreased neutrophil cell numb... 33 | 42
increased hemoglobin content 33 | 45
increased leukocyte cell numbe... 33 | 47
increased hematocrit 32 | 46
tremors 32 | 39
female infertility 31 | 60
increased neutrophil cell numb... 31 | 46
abnormal skin morphology 30 | 50
abnormal spleen morphology 30 | 55
increased blood urea nitrogen ... 30 | 48
increased circulating chloride... 30 | 41
decreased circulating LDL chol... 29 | 38
decreased hematocrit 29 | 46
decreased red blood cell distr... 29 | 41
increased mean platelet volume 29 | 45
limb grasping 29 | 41
increased erythrocyte cell num... 27 | 39
decreased circulating calcium ... 26 | 36
decreased circulating iron lev... 26 | 32
decreased mean corpuscular hem... 26 | 31
increased circulating creatini... 26 | 38
prolonged QT interval 26 | 38
abnormal bone mineralization 25 | 38
increased grip strength 25 | 41

Disease

Carcinoma 6,492 | 11,192
ovarian cancer 5,914 | 8,297
osteosarcoma 5,014 | 7,766
psoriasis 4,218 | 6,514
medulloblastoma, large-cell 4,023 | 6,086
glioblastoma 3,991 | 5,635
lung cancer 3,633 | 4,607
atypical teratoid / rhabdoid tumor 3,332 | 4,971
ependymoma 3,045 | 4,559
group 3 medulloblastoma 2,661 | 4,002
adult high grade glioma 2,478 | 3,701
malignant mesothelioma 2,444 | 3,135
Breast cancer 2,413 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,275 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 2,116 | 2,902
Astrocytoma, Pilocytic 2,069 | 3,006
invasive ductal carcinoma 2,051 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,047 | 2,872
non-small cell lung cancer 2,040 | 2,799
primitive neuroectodermal tumor 1,975 | 2,957
oligodendroglioma 1,948 | 2,768
lung adenocarcinoma 1,886 | 2,627
lung carcinoma 1,862 | 2,755
Cancer 1,769 | 2,388
astrocytic glioma 1,755 | 2,530
pancreatic cancer 1,715 | 2,322
subependymal giant cell astrocytoma 1,629 | 2,230
Kidney cancer 1,628 | 2,548
interstitial cystitis 1,536 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,448 | 1,911
Pick disease 1,413 | 1,856
tuberculosis 1,369 | 1,963
ulcerative colitis 1,312 | 1,765
pituitary cancer 1,309 | 1,915
Multiple myeloma 1,197 | 1,296
group 4 medulloblastoma 1,196 | 1,806
ductal carcinoma in situ 1,177 | 1,686
colon cancer 1,164 | 1,428
breast carcinoma 1,148 | 1,589
cystic fibrosis 1,119 | 1,629
diabetes mellitus 1,061 | 1,683
Autosomal recessive predisposition 1,055 | 1,407
adrenocortical carcinoma 1,016 | 1,385
astrocytoma 924 | 1,113
juvenile dermatomyositis 896 | 1,147
acute quadriplegic myopathy 887 | 1,133
dermatomyositis 862 | 941
Rheumatoid arthritis 832 | 1,156
cutaneous lupus erythematosus 823 | 1,016
Schizophrenia 784 | 1,136
primary pancreatic ductal adenocarcinoma 780 | 1,071
pediatric high grade glioma 735 | 1,035
spina bifida 709 | 1,053
Intellectual disability 708 | 998
Waldenstrons macroglobulinemia 705 | 742
nasopharyngeal carcinoma 679 | 1,024
Atopic dermatitis 632 | 915
active Crohn's disease 622 | 882
esophageal adenocarcinoma 603 | 696
non primary Sjogren syndrome sicca 586 | 861
acute myeloid leukemia 574 | 760
Liver Cirrhosis, Experimental 573 | 733
gastric carcinoma 571 | 781
Epilepsy 569 | 775
primary Sjogren syndrome 567 | 710
active ulcerative colitis 516 | 736
aldosterone-producing adenoma 503 | 646
progressive supranuclear palsy 501 | 656
Duchenne muscular dystrophy 483 | 587
Cognitive delay 474 | 596
Global developmental delay 474 | 596
Mental and motor retardation 474 | 596
Dull intelligence 470 | 634
Low intelligence 470 | 634
Mental Retardation 470 | 634
Mental deficiency 470 | 634
Poor school performance 470 | 634
medulloblastoma 468 | 702
Obesity 456 | 655
Alzheimer's disease 447 | 640
Seizures 445 | 584
Muscle hypotonia 444 | 562
Bipolar Disorder 438 | 646
Down syndrome 433 | 480
pancreatic carcinoma 429 | 555
autosomal dominant Emery-Dreifuss muscular dystrophy 421 | 492
Melanoma 404 | 689
hepatocellular carcinoma 385 | 536
Short stature 376 | 514
fibroadenoma 367 | 538
Liver cancer 366 | 589
Endometriosis 361 | 521
mucosa-associated lymphoid tissue lymphoma 359 | 473
Prostatic Neoplasms 355 | 472
Amyotrophic lateral sclerosis 345 | 437
Multiple Sclerosis 326 | 527
Breast Neoplasms 322 | 423
gastric cancer 313 | 445
posterior fossa group A ependymoma 312 | 456
Mammary Neoplasms 308 | 403

Tissue

Endocrine System 10,421 | 18,159
Digestive Tract 10,323 | 17,369
Female tissues 10,297 | 17,400
Skin and soft tissues 10,281 | 17,230
Male tissues 10,210 | 17,142
Blood and immune system 10,190 | 16,909
Liver and Pancreas 10,183 | 16,750
Urinary Tract 10,157 | 16,678
Nervous System 10,152 | 16,725
Respiratory system 10,024 | 16,393
Cardiovascular System 9,646 | 15,192

Target Family

Non-IDG 6,154 | 12,091
Enzyme 2,646 | 4,145
Transcription Factor 620 | 1,400
Kinase 429 | 634
Transporter 277 | 473
Epigenetic 157 | 242
Ion Channel 156 | 344
GPCR 133 | 408
Nuclear Receptor 30 | 48
TF/Epigenetic 25 | 38
oGPCR 10 | 421

Data Source

JensenLab Experiment GNF 10,637 | 10,637
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Probable gluconokinase IDNK Tbio Kinase -1.00330 9.91 94
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162
Zinc finger protein 526 ZNF526 Tdark Transcription Factor 0.70 0.20 51