Development Level

Tbio 7,304 | 11,445
Tdark 1,827 | 6,588
Tchem 1,112 | 1,598
Tclin 394 | 613

Collection

RFA-RM-18-021 146 | 328
Kinase: IDG Consortium (Target... 72 | 125
Ion Channel: IDG Consortium (T... 45 | 99
GPCR: IDG Consortium (Targets) 30 | 126
Kinase: IDG Consortium (Comple... 24 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 718 | 979
preweaning lethality, incomple... 316 | 499
embryonic lethality prior to t... 213 | 278
abnormal behavior 182 | 298
embryonic lethality prior to o... 182 | 239
abnormal embryo size 149 | 220
decreased total body fat amoun... 144 | 207
abnormal bone structure 126 | 187
enlarged heart 126 | 210
decreased vertical activity 125 | 208
increased lean body mass 114 | 172
decreased body weight 106 | 161
hyperactivity 103 | 148
decreased bone mineral content 102 | 151
abnormal heart morphology 97 | 162
increased total body fat amoun... 86 | 134
decreased lean body mass 85 | 135
increased startle reflex 82 | 112
decreased bone mineral density 80 | 126
hypoactivity 80 | 132
increased circulating alkaline... 80 | 122
embryonic growth retardation 76 | 106
decreased grip strength 75 | 116
decreased circulating glucose ... 72 | 126
increased mean corpuscular hem... 72 | 96
increased bone mineral content 69 | 108
abnormal seminal vesicle morph... 67 | 114
decreased circulating choleste... 65 | 93
male infertility 65 | 123
decreased body length 64 | 101
increased or absent threshold ... 64 | 101
cataract 62 | 92
decreased lymphocyte cell numb... 62 | 83
increased mean corpuscular vol... 62 | 92
prenatal lethality prior to he... 59 | 87
short tibia 58 | 97
decreased mean corpuscular vol... 57 | 79
decreased circulating serum al... 56 | 82
decreased prepulse inhibition 56 | 82
abnormal lens morphology 55 | 81
abnormal gait 52 | 69
increased circulating HDL chol... 52 | 80
improved glucose tolerance 50 | 79
decreased circulating HDL chol... 49 | 68
decreased circulating triglyce... 49 | 79
decreased startle reflex 49 | 75
increased fasted circulating g... 49 | 76
impaired glucose tolerance 47 | 75
small superior vagus ganglion 46 | 74
abnormal sleep behavior 45 | 70
decreased leukocyte cell numbe... 45 | 73
abnormal retina morphology 44 | 71
decreased circulating insulin ... 44 | 76
increased circulating choleste... 44 | 66
abnormal coat-hair pigmentatio... 43 | 64
abnormal eye morphology 43 | 68
edema 43 | 59
increased circulating sodium l... 43 | 71
abnormal behavioral response t... 42 | 66
decreased fasted circulating g... 42 | 65
decreased hemoglobin content 42 | 68
increased bone mineral density 42 | 72
decreased erythrocyte cell num... 41 | 62
increased monocyte cell number 40 | 63
abnormal kidney morphology 39 | 65
increased heart weight 38 | 62
hydrometra 37 | 53
decreased caudal vertebrae num... 36 | 53
decreased circulating total pr... 36 | 49
small testis 36 | 58
decreased circulating alanine ... 35 | 47
increased circulating triglyce... 34 | 42
thrombocytopenia 34 | 56
abnormal neural tube closure 33 | 46
decreased circulating alkaline... 33 | 46
decreased mean corpuscular hem... 33 | 50
decreased neutrophil cell numb... 33 | 42
increased hemoglobin content 33 | 45
increased leukocyte cell numbe... 33 | 47
increased hematocrit 32 | 46
tremors 32 | 39
female infertility 31 | 60
increased neutrophil cell numb... 31 | 46
abnormal skin morphology 30 | 50
abnormal spleen morphology 30 | 55
increased blood urea nitrogen ... 30 | 48
increased circulating chloride... 30 | 41
decreased circulating LDL chol... 29 | 38
decreased hematocrit 29 | 46
decreased red blood cell distr... 29 | 41
increased mean platelet volume 29 | 45
limb grasping 29 | 41
increased erythrocyte cell num... 27 | 39
decreased circulating calcium ... 26 | 36
decreased circulating iron lev... 26 | 32
decreased mean corpuscular hem... 26 | 31
increased circulating creatini... 26 | 38
prolonged QT interval 26 | 38
abnormal bone mineralization 25 | 38
increased grip strength 25 | 41

Disease

Carcinoma 6,676 | 11,493
ovarian cancer 6,084 | 8,520
osteosarcoma 5,140 | 7,950
psoriasis 4,348 | 6,694
medulloblastoma, large-cell 4,126 | 6,241
glioblastoma 4,113 | 5,792
lung cancer 3,745 | 4,740
atypical teratoid / rhabdoid tumor 3,438 | 5,112
ependymoma 3,133 | 4,679
group 3 medulloblastoma 2,733 | 4,104
adult high grade glioma 2,551 | 3,801
malignant mesothelioma 2,533 | 3,232
Breast cancer 2,496 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,344 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 2,182 | 2,989
Astrocytoma, Pilocytic 2,129 | 3,081
invasive ductal carcinoma 2,113 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,110 | 2,955
non-small cell lung cancer 2,105 | 2,890
primitive neuroectodermal tumor 2,033 | 3,035
oligodendroglioma 2,009 | 2,850
lung adenocarcinoma 1,954 | 2,716
lung carcinoma 1,931 | 2,843
Cancer 1,857 | 2,499
astrocytic glioma 1,800 | 2,597
pancreatic cancer 1,777 | 2,398
Kidney cancer 1,675 | 2,613
subependymal giant cell astrocytoma 1,675 | 2,287
interstitial cystitis 1,594 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,488 | 1,962
Pick disease 1,443 | 1,894
tuberculosis 1,406 | 2,010
ulcerative colitis 1,352 | 1,819
pituitary cancer 1,350 | 1,972
Multiple myeloma 1,232 | 1,332
group 4 medulloblastoma 1,228 | 1,855
ductal carcinoma in situ 1,222 | 1,745
colon cancer 1,208 | 1,478
breast carcinoma 1,186 | 1,638
cystic fibrosis 1,166 | 1,696
diabetes mellitus 1,097 | 1,728
Autosomal recessive predisposition 1,082 | 1,442
adrenocortical carcinoma 1,054 | 1,428
astrocytoma 953 | 1,146
juvenile dermatomyositis 924 | 1,187
acute quadriplegic myopathy 908 | 1,158
dermatomyositis 885 | 966
cutaneous lupus erythematosus 860 | 1,057
Rheumatoid arthritis 858 | 1,191
primary pancreatic ductal adenocarcinoma 811 | 1,109
Schizophrenia 803 | 1,160
pediatric high grade glioma 758 | 1,064
Waldenstrons macroglobulinemia 728 | 765
Intellectual disability 724 | 1,016
spina bifida 721 | 1,074
nasopharyngeal carcinoma 704 | 1,058
Atopic dermatitis 659 | 952
active Crohn's disease 651 | 922
esophageal adenocarcinoma 636 | 737
non primary Sjogren syndrome sicca 612 | 891
Liver Cirrhosis, Experimental 606 | 769
acute myeloid leukemia 594 | 783
gastric carcinoma 592 | 807
primary Sjogren syndrome 589 | 735
Epilepsy 583 | 792
active ulcerative colitis 539 | 764
aldosterone-producing adenoma 520 | 665
progressive supranuclear palsy 514 | 676
Duchenne muscular dystrophy 495 | 601
Cognitive delay 483 | 608
Global developmental delay 483 | 608
Mental and motor retardation 483 | 608
medulloblastoma 483 | 720
Dull intelligence 480 | 645
Low intelligence 480 | 645
Mental Retardation 480 | 645
Mental deficiency 480 | 645
Poor school performance 480 | 645
Obesity 474 | 678
Alzheimer's disease 461 | 658
Seizures 454 | 596
Muscle hypotonia 452 | 571
Bipolar Disorder 451 | 666
Down syndrome 449 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 436 | 510
pancreatic carcinoma 436 | 562
Melanoma 418 | 711
hepatocellular carcinoma 396 | 547
Short stature 387 | 531
fibroadenoma 384 | 559
Liver cancer 376 | 604
Endometriosis 375 | 540
Prostatic Neoplasms 372 | 495
mucosa-associated lymphoid tissue lymphoma 369 | 484
Amyotrophic lateral sclerosis 357 | 451
Breast Neoplasms 341 | 445
Multiple Sclerosis 336 | 540
Mammary Neoplasms 327 | 425
gastric cancer 327 | 459
posterior fossa group A ependymoma 323 | 468

Tissue

Endocrine System 10,421 | 18,159
Digestive Tract 10,323 | 17,369
Female tissues 10,297 | 17,400
Skin and soft tissues 10,281 | 17,230
Male tissues 10,210 | 17,142
Blood and immune system 10,190 | 16,909
Liver and Pancreas 10,183 | 16,750
Urinary Tract 10,157 | 16,678
Nervous System 10,152 | 16,725
Respiratory system 10,024 | 16,393
Cardiovascular System 9,646 | 15,192

Target Family

Non-IDG 6,154 | 12,091
Enzyme 2,646 | 4,145
Transcription Factor 620 | 1,400
Kinase 429 | 634
Transporter 277 | 473
Epigenetic 157 | 242
Ion Channel 156 | 344
GPCR 133 | 408
Nuclear Receptor 30 | 48
TF/Epigenetic 25 | 38
oGPCR 10 | 421

Data Source

JensenLab Experiment GNF 10,637 | 10,637
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181