Development Level

Tbio 3,393 | 10,625
Tchem 695 | 1,890
Tdark 685 | 7,003
Tclin 214 | 602

Collection

Eligible Kinase Proteins 23 | 134
Eligible Ion Channel Proteins 21 | 117
Eligible non-olfactory GPCR Proteins 9 | 145

IMPC Term

preweaning lethality, complete... 233 | 633
preweaning lethality, incomple... 95 | 260
embryonic lethality prior to t... 72 | 187
abnormal behavior 65 | 226
decreased lean body mass 65 | 195
embryonic lethality prior to o... 65 | 148
decreased total body fat amoun... 64 | 186
decreased body weight 56 | 174
decreased bone mineral content 52 | 157
abnormal bone structure 49 | 131
decreased bone mineral density 44 | 126
hyperactivity 44 | 108
increased circulating alkaline... 44 | 119
decreased body length 41 | 108
abnormal embryo size 39 | 112
increased or absent threshold ... 39 | 128
abnormal retina morphology 38 | 100
decreased grip strength 38 | 123
enlarged heart 35 | 111
increased mean corpuscular vol... 34 | 91
increased mean corpuscular hem... 33 | 93
increased lean body mass 32 | 107
decreased circulating glucose ... 31 | 121
hypoactivity 30 | 89
increased grip strength 30 | 83
short tibia 30 | 82
decreased circulating HDL chol... 28 | 77
decreased circulating triglyce... 27 | 83
increased bone mineral content 26 | 92
abnormal lens morphology 25 | 73
decreased circulating choleste... 25 | 85
increased fasted circulating g... 25 | 68
decreased circulating serum al... 24 | 79
decreased circulating insulin ... 23 | 75
decreased mean corpuscular vol... 22 | 50
improved glucose tolerance 22 | 56
increased circulating HDL chol... 21 | 63
increased circulating choleste... 21 | 53
prenatal lethality prior to he... 21 | 64
abnormal bone mineralization 19 | 55
abnormal coat/hair pigmentatio... 19 | 54
abnormal sleep behavior 19 | 63
decreased hemoglobin content 19 | 53
increased circulating sodium l... 19 | 71
increased exploration in new e... 19 | 56
abnormal retinal pigmentation 18 | 61
impaired glucose tolerance 18 | 52
male infertility 18 | 62
abnormal seminal vesicle morph... 16 | 47
decreased circulating alanine ... 16 | 53
increased total body fat amoun... 16 | 57
thrombocytopenia 16 | 46
cardiovascular system phenotyp... 15 | 35
decreased fasted circulating g... 15 | 49
increased circulating chloride... 15 | 43
increased circulating creatini... 15 | 29
increased heart weight 15 | 37
increased sacral vertebrae num... 15 | 62
abnormal neural tube closure 14 | 37
decreased caudal vertebrae num... 14 | 49
decreased circulating LDL chol... 14 | 37
decreased circulating calcium ... 14 | 33
decreased mean corpuscular hem... 14 | 34
decreased prepulse inhibition 14 | 52
decreased threshold for audito... 14 | 32
increased blood urea nitrogen ... 14 | 44
increased hemoglobin content 14 | 45
increased startle reflex 14 | 38
small testis 14 | 37
abnormal gait 13 | 51
abnormal heart morphology 13 | 51
decreased NK T cell number 13 | 28
decreased heart weight 13 | 44
decreased leukocyte cell numbe... 13 | 54
decreased lumbar vertebrae num... 13 | 62
decreased rib number 13 | 59
decreased startle reflex 13 | 48
increased body weight 13 | 42
increased leukocyte cell numbe... 13 | 37
decreased circulating alkaline... 12 | 41
decreased circulating fructosa... 12 | 31
decreased circulating total pr... 12 | 41
decreased erythrocyte cell num... 12 | 43
decreased mean corpuscular hem... 12 | 19
increased bone mineral density 12 | 52
increased circulating calcium ... 12 | 32
abnormal behavioral response t... 11 | 52
abnormal epididymis morphology 11 | 31
abnormal eye morphology 11 | 38
abnormal hindbrain development 11 | 24
abnormal skin morphology 11 | 23
cataract 11 | 26
decreased circulating free fat... 11 | 39
enlarged epididymis 11 | 27
female infertility 11 | 34
increased circulating total pr... 11 | 20
decreased circulating iron lev... 10 | 25
increased hematocrit 10 | 36
straub tail 10 | 26
tremors 10 | 34

Disease

ovarian cancer 3,157 | 8,492
osteosarcoma 2,352 | 7,933
psoriasis 2,189 | 6,685
glioblastoma 2,045 | 5,572
lung cancer 2,013 | 4,473
medulloblastoma, large-cell 2,005 | 6,234
atypical teratoid / rhabdoid tumor 1,361 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,250 | 3,289
malignant mesothelioma 1,211 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 1,175 | 2,988
Breast cancer 1,166 | 3,099
non-small cell lung cancer 1,137 | 2,798
pilocytic astrocytoma 1,135 | 3,086
lung adenocarcinoma 1,132 | 2,714
invasive ductal carcinoma 1,129 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 1,116 | 2,956
lung carcinoma 1,088 | 2,844
oligodendroglioma 1,087 | 2,849
Cancer 1,081 | 2,346
pancreatic cancer 1,043 | 2,300
pediatric high grade glioma 1,006 | 2,712
primitive neuroectodermal tumor 1,002 | 3,031
Multiple myeloma 946 | 1,328
ulcerative colitis 939 | 2,087
subependymal giant cell astrocytoma 926 | 2,287
ependymoma 883 | 2,514
interstitial cystitis 876 | 2,299
astrocytoma 792 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 792 | 1,795
pituitary cancer 733 | 1,972
astrocytic glioma 712 | 2,241
Pick disease 710 | 1,893
breast carcinoma 685 | 1,614
group 3 medulloblastoma 684 | 2,254
adult high grade glioma 677 | 2,148
colon cancer 668 | 1,475
ductal carcinoma in situ 648 | 1,745
diabetes mellitus 642 | 1,663
cystic fibrosis 639 | 1,670
group 4 medulloblastoma 631 | 1,875
dermatomyositis 624 | 967
primary pancreatic ductal adenocarcinoma 617 | 1,271
tuberculosis 604 | 1,563
posterior fossa group A ependymoma 598 | 1,511
Waldenstrons macroglobulinemia 582 | 765
adrenocortical carcinoma 577 | 1,427
juvenile dermatomyositis 570 | 1,189
acute quadriplegic myopathy 564 | 1,157
sonic hedgehog group medulloblastoma 527 | 1,482
cutaneous lupus erythematosus 501 | 1,056
Carcinoma 499 | 2,147
medulloblastoma 461 | 1,524
Rheumatoid Arthritis 458 | 1,171
atypical teratoid/rhabdoid tumor 415 | 1,095
esophageal adenocarcinoma 414 | 737
primary Sjogren syndrome 410 | 789
nasopharyngeal carcinoma 386 | 1,056
gastric carcinoma 369 | 832
Atopic dermatitis 364 | 944
Duchenne muscular dystrophy 364 | 602
active Crohn's disease 359 | 918
posterior fossa group B ependymoma 358 | 1,530
spina bifida 341 | 1,064
Down syndrome 334 | 548
acute myeloid leukemia 334 | 785
autosomal dominant Emery-Dreifuss muscular dystrophy 309 | 499
non primary Sjogren syndrome sicca 291 | 840
aldosterone-producing adenoma 266 | 664
IGA Glomerulonephritis 260 | 454
Alzheimer's disease 254 | 644
mucosa-associated lymphoid tissue lymphoma 240 | 480
progressive supranuclear palsy 240 | 674
pancreatic carcinoma 233 | 567
Endometriosis 218 | 535
Obesity 216 | 616
fibroadenoma 215 | 557
Prostatic Neoplasms 211 | 471
nephrosclerosis 211 | 329
hepatocellular carcinoma 203 | 550
tuberculosis and treatment for 6 months 199 | 686
Amyotrophic Lateral Sclerosis 197 | 432
Mammary Neoplasms 188 | 410
Intellectual disability 182 | 573
Multiple Sclerosis 181 | 498
Schizophrenia 179 | 503
active ulcerative colitis 174 | 477
chronic rhinosinusitis 166 | 512
Kidney disease 163 | 397
gastric cancer 161 | 436
sarcoidosis 160 | 368
Neurodegenerative disease 156 | 383
Parkinson's disease 156 | 364
hereditary spastic paraplegia 156 | 313
inflammatory breast cancer 156 | 404
Stomach Neoplasms 149 | 282
chronic lymphocytic leukemia 148 | 244
Polycystic Ovary Syndrome 142 | 335
non-small cell lung carcinoma 140 | 413
Asthma 138 | 349
interstitial lung disease 137 | 292

Tissue

Nervous System 4,929 | 18,561
Female tissues 4,925 | 18,647
Digestive Tract 4,924 | 18,473
Endocrine System 4,922 | 18,512
Liver and Pancreas 4,921 | 18,136
Urinary Tract 4,913 | 18,444
Blood and immune system 4,906 | 17,995
Male tissues 4,902 | 17,969
Cardiovascular System 4,899 | 17,958
Skin and soft tissues 4,884 | 18,115
Respiratory system 4,878 | 17,484

Target Family

Non-IDG 3,024 | 11,969
Enzyme 1,308 | 4,146
Transcription Factor 210 | 1,400
Kinase 162 | 634
Transporter 108 | 473
Ion Channel 56 | 341
Epigenetic 53 | 242
GPCR 45 | 408
Nuclear Receptor 12 | 48
TF/Epigenetic 8 | 38
oGPCR 1 | 421

Data Source

JensenLab Experiment GNF 4,987 | 4,987
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 Tbio Non-IDG 0.08 0.71 6
Ubiquitin-associated domain-containing protein 1 UBAC1 Tbio Non-IDG -2.56341 358.4 116
tRNA-splicing endonuclease subunit Sen15 TSEN15 Tdark Enzyme -0.33090 2.16 47
Syncollin SYCN Tdark Non-IDG -2.12341 132.9 35
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.67656 3.42 165
Latexin LXN Tbio Enzyme -2.51597 319.1 359