Development Level

Tbio 8,883 | 11,445
Tdark 2,977 | 6,588
Tchem 1,278 | 1,598
Tclin 473 | 613

Collection

RFA-RM-18-021 220 | 328
Kinase: IDG Consortium (Target... 103 | 125
Ion Channel: IDG Consortium (T... 71 | 99
GPCR: IDG Consortium (Targets) 58 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 831 | 979
preweaning lethality, incomple... 399 | 499
abnormal behavior 251 | 298
embryonic lethality prior to t... 237 | 278
embryonic lethality prior to o... 201 | 239
abnormal embryo size 191 | 220
decreased total body fat amoun... 168 | 207
decreased vertical activity 153 | 208
abnormal bone structure 152 | 187
enlarged heart 151 | 210
increased lean body mass 136 | 172
decreased body weight 133 | 161
decreased bone mineral content 133 | 151
hyperactivity 125 | 148
abnormal heart morphology 117 | 162
decreased lean body mass 113 | 135
increased total body fat amoun... 109 | 134
hypoactivity 104 | 132
decreased circulating glucose ... 103 | 126
increased circulating alkaline... 99 | 122
male infertility 99 | 123
decreased bone mineral density 98 | 126
decreased grip strength 91 | 116
embryonic growth retardation 88 | 106
increased startle reflex 88 | 112
increased bone mineral content 85 | 108
decreased body length 83 | 101
decreased circulating choleste... 80 | 93
short tibia 80 | 97
abnormal seminal vesicle morph... 78 | 114
cataract 78 | 92
increased mean corpuscular vol... 78 | 92
increased or absent threshold ... 77 | 101
increased mean corpuscular hem... 75 | 96
improved glucose tolerance 73 | 79
decreased circulating triglyce... 69 | 79
abnormal lens morphology 68 | 81
prenatal lethality prior to he... 68 | 87
decreased mean corpuscular vol... 67 | 79
decreased prepulse inhibition 67 | 82
decreased circulating serum al... 66 | 82
decreased lymphocyte cell numb... 65 | 83
increased circulating HDL chol... 63 | 80
increased fasted circulating g... 63 | 76
impaired glucose tolerance 60 | 75
decreased circulating HDL chol... 59 | 68
small superior vagus ganglion 59 | 74
abnormal sleep behavior 58 | 70
abnormal behavioral response t... 56 | 66
decreased circulating insulin ... 56 | 76
decreased leukocyte cell numbe... 56 | 73
decreased startle reflex 56 | 75
abnormal gait 55 | 69
increased bone mineral density 55 | 72
decreased fasted circulating g... 54 | 65
decreased hemoglobin content 53 | 68
increased circulating sodium l... 52 | 71
increased heart weight 51 | 62
abnormal eye morphology 50 | 68
abnormal retina morphology 50 | 71
abnormal spleen morphology 50 | 55
edema 50 | 59
small testis 50 | 58
increased circulating choleste... 49 | 66
abnormal coat-hair pigmentatio... 48 | 64
decreased erythrocyte cell num... 47 | 62
abnormal kidney morphology 46 | 65
decreased caudal vertebrae num... 46 | 53
decreased mean corpuscular hem... 45 | 50
increased monocyte cell number 45 | 63
female infertility 44 | 60
thrombocytopenia 43 | 56
decreased circulating total pr... 42 | 49
hydrometra 41 | 53
abnormal neural tube closure 39 | 46
increased blood urea nitrogen ... 39 | 48
decreased circulating alanine ... 38 | 47
decreased circulating alkaline... 38 | 46
increased circulating triglyce... 38 | 42
decreased blood urea nitrogen ... 37 | 51
decreased hematocrit 37 | 46
enlarged spleen 37 | 41
tremors 37 | 39
abnormal skin morphology 36 | 50
increased circulating chloride... 36 | 41
increased leukocyte cell numbe... 36 | 47
increased hematocrit 35 | 46
increased hemoglobin content 35 | 45
abnormal bone mineralization 34 | 38
abnormal testis morphology 34 | 43
decreased circulating LDL chol... 34 | 38
increased mean platelet volume 34 | 45
increased neutrophil cell numb... 34 | 46
decreased neutrophil cell numb... 33 | 42
cardiovascular system phenotyp... 32 | 36
decreased circulating creatini... 32 | 39
increased circulating creatini... 32 | 38
increased grip strength 32 | 41
abnormal cranium morphology 31 | 36
decreased circulating calcium ... 31 | 36

Disease

Carcinoma 8,715 | 11,493
ovarian cancer 6,972 | 8,520
osteosarcoma 6,311 | 7,950
medulloblastoma, large-cell 5,072 | 6,241
psoriasis 4,994 | 6,694
glioblastoma 4,814 | 5,792
atypical teratoid / rhabdoid tumor 4,229 | 5,112
lung cancer 3,903 | 4,740
ependymoma 3,871 | 4,679
group 3 medulloblastoma 3,361 | 4,104
adult high grade glioma 3,115 | 3,801
Breast cancer 2,949 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,734 | 3,291
malignant mesothelioma 2,684 | 3,232
Astrocytoma, Pilocytic 2,554 | 3,081
primitive neuroectodermal tumor 2,495 | 3,035
invasive ductal carcinoma 2,493 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,483 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,469 | 2,955
oligodendroglioma 2,386 | 2,850
non-small cell lung cancer 2,347 | 2,890
lung carcinoma 2,336 | 2,843
lung adenocarcinoma 2,195 | 2,716
astrocytic glioma 2,172 | 2,597
Kidney cancer 2,077 | 2,613
Cancer 2,034 | 2,499
pancreatic cancer 1,949 | 2,398
subependymal giant cell astrocytoma 1,936 | 2,287
interstitial cystitis 1,842 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,669 | 1,962
Pick disease 1,620 | 1,894
pituitary cancer 1,609 | 1,972
tuberculosis 1,603 | 2,010
group 4 medulloblastoma 1,539 | 1,855
ulcerative colitis 1,507 | 1,819
ductal carcinoma in situ 1,462 | 1,745
breast carcinoma 1,375 | 1,638
cystic fibrosis 1,357 | 1,696
colon cancer 1,251 | 1,478
diabetes mellitus 1,246 | 1,728
Autosomal recessive predisposition 1,199 | 1,442
adrenocortical carcinoma 1,187 | 1,428
Multiple myeloma 1,139 | 1,332
juvenile dermatomyositis 1,024 | 1,187
acute quadriplegic myopathy 1,015 | 1,158
Rheumatoid arthritis 984 | 1,191
astrocytoma 981 | 1,146
Schizophrenia 931 | 1,160
primary pancreatic ductal adenocarcinoma 926 | 1,109
spina bifida 889 | 1,074
pediatric high grade glioma 885 | 1,064
cutaneous lupus erythematosus 860 | 1,057
Intellectual disability 857 | 1,016
dermatomyositis 857 | 966
nasopharyngeal carcinoma 818 | 1,058
active Crohn's disease 746 | 922
Atopic dermatitis 735 | 952
non primary Sjogren syndrome sicca 699 | 891
Epilepsy 686 | 792
gastric carcinoma 683 | 807
Waldenstrons macroglobulinemia 668 | 765
acute myeloid leukemia 657 | 783
Liver Cirrhosis, Experimental 639 | 769
active ulcerative colitis 634 | 764
primary Sjogren syndrome 623 | 735
esophageal adenocarcinoma 598 | 737
medulloblastoma 597 | 720
aldosterone-producing adenoma 580 | 665
progressive supranuclear palsy 564 | 676
Dull intelligence 544 | 645
Low intelligence 544 | 645
Mental Retardation 544 | 645
Mental deficiency 544 | 645
Poor school performance 544 | 645
Alzheimer's disease 542 | 658
Bipolar Disorder 541 | 666
Duchenne muscular dystrophy 529 | 601
Obesity 528 | 678
Melanoma 524 | 711
Seizures 518 | 596
Cognitive delay 515 | 608
Global developmental delay 515 | 608
Mental and motor retardation 515 | 608
Muscle hypotonia 498 | 571
Liver cancer 468 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 460 | 510
fibroadenoma 448 | 559
Endometriosis 446 | 540
pancreatic carcinoma 445 | 562
hepatocellular carcinoma 441 | 547
Down syndrome 437 | 499
Short stature 437 | 531
Prostatic Neoplasms 424 | 495
chronic rhinosinusitis 406 | 512
Amyotrophic lateral sclerosis 399 | 451
Multiple Sclerosis 394 | 540
mucosa-associated lymphoid tissue lymphoma 383 | 484
posterior fossa group A ependymoma 381 | 468
Breast Neoplasms 375 | 445
sonic hedgehog group medulloblastoma 374 | 467

Tissue

Endocrine System 13,268 | 18,159
Digestive Tract 12,960 | 17,369
Female tissues 12,954 | 17,400
Skin and soft tissues 12,902 | 17,230
Male tissues 12,853 | 17,142
Nervous System 12,725 | 16,725
Blood and immune system 12,717 | 16,909
Liver and Pancreas 12,717 | 16,750
Urinary Tract 12,705 | 16,678
Respiratory system 12,491 | 16,393
Cardiovascular System 11,892 | 15,192

Target Family

Non-IDG 7,801 | 12,091
Enzyme 3,178 | 4,145
Transcription Factor 950 | 1,400
Kinase 536 | 634
Transporter 372 | 473
Ion Channel 239 | 344
GPCR 221 | 408
Epigenetic 203 | 242
Nuclear Receptor 43 | 48
oGPCR 36 | 421
TF/Epigenetic 32 | 38

Data Source

JensenLab Experiment Exon arra... 13,611 | 13,611
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93