Development Level

Tbio 5,533 | 10,625
Tdark 1,837 | 7,003
Tchem 1,072 | 1,890
Tclin 322 | 602

Collection

Eligible Kinase Proteins 72 | 134
Eligible Ion Channel Proteins 44 | 117
Eligible non-olfactory GPCR Proteins 24 | 145

IMPC Term

preweaning lethality, complete... 387 | 633
preweaning lethality, incomple... 153 | 260
abnormal behavior 130 | 226
decreased lean body mass 119 | 195
decreased total body fat amoun... 118 | 186
embryonic lethality prior to t... 114 | 187
decreased body weight 103 | 174
decreased bone mineral content 96 | 157
embryonic lethality prior to o... 90 | 148
abnormal bone structure 78 | 131
increased circulating alkaline... 74 | 119
decreased bone mineral density 73 | 126
decreased body length 71 | 108
decreased grip strength 70 | 123
hyperactivity 68 | 108
increased or absent threshold ... 68 | 128
abnormal embryo size 67 | 112
increased lean body mass 66 | 107
decreased circulating glucose ... 65 | 121
increased mean corpuscular hem... 58 | 93
abnormal retina morphology 57 | 100
decreased circulating choleste... 56 | 85
increased bone mineral content 55 | 92
increased mean corpuscular vol... 54 | 91
decreased circulating HDL chol... 52 | 77
short tibia 52 | 82
decreased circulating triglyce... 48 | 83
enlarged heart 48 | 111
increased grip strength 47 | 83
decreased circulating serum al... 46 | 79
hypoactivity 46 | 89
abnormal lens morphology 43 | 73
increased fasted circulating g... 41 | 68
decreased lumbar vertebrae num... 40 | 62
decreased circulating insulin ... 39 | 75
male infertility 39 | 62
decreased mean corpuscular vol... 37 | 50
increased sacral vertebrae num... 36 | 62
prenatal lethality prior to he... 36 | 64
decreased fasted circulating g... 34 | 49
increased circulating choleste... 34 | 53
abnormal retinal pigmentation 33 | 61
increased circulating HDL chol... 33 | 63
increased circulating sodium l... 33 | 71
increased total body fat amoun... 33 | 57
abnormal sleep behavior 32 | 63
improved glucose tolerance 32 | 56
decreased leukocyte cell numbe... 30 | 54
decreased hemoglobin content 29 | 53
decreased prepulse inhibition 29 | 52
increased body weight 29 | 42
increased bone mineral density 29 | 52
abnormal coat/hair pigmentatio... 28 | 54
abnormal gait 28 | 51
decreased caudal vertebrae num... 28 | 49
decreased circulating alanine ... 28 | 53
decreased rib number 28 | 59
abnormal behavioral response t... 27 | 52
abnormal bone mineralization 27 | 55
decreased circulating LDL chol... 27 | 37
decreased startle reflex 27 | 48
increased blood urea nitrogen ... 27 | 44
thrombocytopenia 27 | 46
decreased circulating total pr... 26 | 41
increased hemoglobin content 26 | 45
decreased heart weight 25 | 44
impaired glucose tolerance 25 | 52
cardiovascular system phenotyp... 24 | 35
decreased circulating alkaline... 24 | 41
decreased erythrocyte cell num... 24 | 43
increased circulating chloride... 24 | 43
abnormal neural tube closure 23 | 37
decreased mean corpuscular hem... 23 | 34
small testis 23 | 37
tremors 23 | 34
decreased eosinophil cell numb... 22 | 41
increased exploration in new e... 22 | 56
abnormal seminal vesicle morph... 21 | 47
decreased circulating creatini... 21 | 31
decreased circulating fructosa... 21 | 31
increased circulating creatini... 21 | 29
increased hematocrit 21 | 36
abnormal eye morphology 20 | 38
abnormal heart morphology 20 | 51
decreased neutrophil cell numb... 20 | 37
increased circulating potassiu... 20 | 31
increased leukocyte cell numbe... 20 | 37
abnormal spleen morphology 19 | 36
decreased blood urea nitrogen ... 19 | 31
decreased circulating chloride... 19 | 32
increased circulating calcium ... 19 | 32
increased startle reflex 19 | 38
abnormal testis morphology 18 | 30
decreased circulating calcium ... 18 | 33
increased circulating triglyce... 18 | 24
increased heart weight 18 | 37
increased rib number 18 | 41
straub tail 18 | 26
cataract 17 | 26
decreased T cell number 17 | 31

Disease

ovarian cancer 4,893 | 8,492
osteosarcoma 4,135 | 7,933
medulloblastoma, large-cell 3,504 | 6,234
psoriasis 3,406 | 6,685
glioblastoma 3,256 | 5,572
lung cancer 2,601 | 4,473
atypical teratoid / rhabdoid tumor 2,509 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 1,847 | 3,289
malignant mesothelioma 1,793 | 3,163
Breast cancer 1,771 | 3,099
pilocytic astrocytoma 1,767 | 3,086
oligodendroglioma 1,753 | 2,849
invasive ductal carcinoma 1,738 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 1,723 | 2,956
primitive neuroectodermal tumor 1,693 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,690 | 2,988
lung carcinoma 1,623 | 2,844
pediatric high grade glioma 1,572 | 2,712
lung adenocarcinoma 1,568 | 2,714
ependymoma 1,564 | 2,514
non-small cell lung cancer 1,519 | 2,798
subependymal giant cell astrocytoma 1,483 | 2,287
Cancer 1,379 | 2,346
pancreatic cancer 1,311 | 2,300
astrocytic glioma 1,299 | 2,241
Pick disease 1,242 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,215 | 1,795
ulcerative colitis 1,204 | 2,087
adult high grade glioma 1,203 | 2,148
interstitial cystitis 1,183 | 2,299
Carcinoma 1,150 | 2,147
group 3 medulloblastoma 1,136 | 2,254
pituitary cancer 1,122 | 1,972
group 4 medulloblastoma 1,110 | 1,875
astrocytoma 1,027 | 1,493
ductal carcinoma in situ 1,024 | 1,745
breast carcinoma 993 | 1,614
Multiple myeloma 964 | 1,328
cystic fibrosis 919 | 1,670
colon cancer 904 | 1,475
diabetes mellitus 904 | 1,663
medulloblastoma 882 | 1,524
acute quadriplegic myopathy 846 | 1,157
adrenocortical carcinoma 842 | 1,427
posterior fossa group A ependymoma 829 | 1,511
primary pancreatic ductal adenocarcinoma 824 | 1,271
sonic hedgehog group medulloblastoma 818 | 1,482
tuberculosis 808 | 1,563
juvenile dermatomyositis 789 | 1,189
posterior fossa group B ependymoma 731 | 1,530
Rheumatoid Arthritis 712 | 1,171
dermatomyositis 708 | 967
atypical teratoid/rhabdoid tumor 628 | 1,095
spina bifida 606 | 1,064
Waldenstrons macroglobulinemia 563 | 765
cutaneous lupus erythematosus 556 | 1,056
gastric carcinoma 517 | 832
active Crohn's disease 493 | 918
non primary Sjogren syndrome sicca 492 | 840
Atopic dermatitis 487 | 944
nasopharyngeal carcinoma 487 | 1,056
acute myeloid leukemia 463 | 785
Duchenne muscular dystrophy 457 | 602
esophageal adenocarcinoma 445 | 737
aldosterone-producing adenoma 437 | 664
primary Sjogren syndrome 433 | 789
Down syndrome 403 | 548
progressive supranuclear palsy 402 | 674
tuberculosis and treatment for 6 months 401 | 686
Alzheimer's disease 392 | 644
autosomal dominant Emery-Dreifuss muscular dystrophy 388 | 499
fibroadenoma 335 | 557
Obesity 330 | 616
Intellectual disability 325 | 573
Prostatic Neoplasms 312 | 471
pancreatic carcinoma 307 | 567
Amyotrophic Lateral Sclerosis 303 | 432
hepatocellular carcinoma 299 | 550
Endometriosis 294 | 535
mucosa-associated lymphoid tissue lymphoma 273 | 480
Schizophrenia 266 | 503
chronic rhinosinusitis 264 | 512
active ulcerative colitis 263 | 477
Mammary Neoplasms 260 | 410
Neurodegenerative disease 259 | 383
IGA Glomerulonephritis 253 | 454
hereditary spastic paraplegia 240 | 313
nephrosclerosis 234 | 329
gastric cancer 225 | 436
non-small cell lung carcinoma 223 | 413
Kidney disease 218 | 397
Parkinson's disease 218 | 364
Multiple Sclerosis 215 | 498
Epilepsy 212 | 346
glioblastoma multiforme 211 | 347
inflammatory breast cancer 211 | 404
interstitial lung disease 197 | 292
Polycystic Ovary Syndrome 193 | 335
sarcoidosis 188 | 368
Vascular disease 180 | 281

Tissue

Female tissues 8,611 | 18,647
Nervous System 8,610 | 18,561
Digestive Tract 8,602 | 18,473
Endocrine System 8,602 | 18,512
Urinary Tract 8,582 | 18,444
Male tissues 8,580 | 17,969
Liver and Pancreas 8,576 | 18,136
Blood and immune system 8,561 | 17,995
Cardiovascular System 8,546 | 17,958
Skin and soft tissues 8,519 | 18,115
Respiratory system 8,466 | 17,484

Target Family

Non-IDG 5,088 | 11,969
Enzyme 2,111 | 4,146
Transcription Factor 499 | 1,400
Kinase 370 | 634
Transporter 252 | 473
Epigenetic 147 | 242
Ion Channel 146 | 341
GPCR 91 | 408
Nuclear Receptor 31 | 48
TF/Epigenetic 21 | 38
oGPCR 8 | 421

Data Source

JensenLab Experiment Exon arra... 8,764 | 8,764
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Transmembrane 9 superfamily member 2 TM9SF2 Tdark Non-IDG -0.27748 1.00 57
Solute carrier family 25 member 33 SLC25A33 Tbio Transporter -0.28165 1.49 35
Serine/threonine-protein kinase RIO1 RIOK1 Tchem Kinase -0.72835 5.14 142
Ubiquitin-conjugating enzyme E2 Q2 UBE2Q2 Tbio Non-IDG -0.88971 8.59 121