Development Level

Tbio 8,659 | 11,178
Tdark 2,970 | 6,569
Tchem 1,510 | 1,885
Tclin 472 | 612

Collection

Kinase: IDG Consortium (Target... 103 | 125
Ion Channel: IDG Consortium (T... 71 | 99
GPCR: IDG Consortium (Targets) 58 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 831 | 979
preweaning lethality, incomple... 399 | 499
abnormal behavior 251 | 298
embryonic lethality prior to t... 237 | 278
embryonic lethality prior to o... 201 | 239
abnormal embryo size 191 | 220
decreased total body fat amoun... 168 | 207
decreased vertical activity 153 | 208
abnormal bone structure 152 | 187
enlarged heart 151 | 210
increased lean body mass 136 | 172
decreased body weight 133 | 161
decreased bone mineral content 133 | 151
hyperactivity 125 | 148
abnormal heart morphology 117 | 162
decreased lean body mass 113 | 135
increased total body fat amoun... 109 | 134
hypoactivity 104 | 132
decreased circulating glucose ... 103 | 126
increased circulating alkaline... 99 | 122
male infertility 99 | 123
decreased bone mineral density 98 | 126
decreased grip strength 91 | 116
embryonic growth retardation 88 | 106
increased startle reflex 88 | 112
increased bone mineral content 85 | 108
decreased body length 83 | 101
decreased circulating choleste... 80 | 93
short tibia 80 | 97
abnormal seminal vesicle morph... 78 | 114
cataract 78 | 92
increased mean corpuscular vol... 78 | 92
increased or absent threshold ... 77 | 101
increased mean corpuscular hem... 75 | 96
improved glucose tolerance 73 | 79
decreased circulating triglyce... 69 | 79
abnormal lens morphology 68 | 81
prenatal lethality prior to he... 68 | 87
decreased mean corpuscular vol... 67 | 79
decreased prepulse inhibition 67 | 82
decreased circulating serum al... 66 | 82
decreased lymphocyte cell numb... 65 | 83
increased circulating HDL chol... 63 | 80
increased fasted circulating g... 63 | 76
impaired glucose tolerance 60 | 75
decreased circulating HDL chol... 59 | 68
small superior vagus ganglion 59 | 74
abnormal sleep behavior 58 | 70
abnormal behavioral response t... 56 | 66
decreased circulating insulin ... 56 | 76
decreased leukocyte cell numbe... 56 | 73
decreased startle reflex 56 | 75
abnormal gait 55 | 69
increased bone mineral density 55 | 72
decreased fasted circulating g... 54 | 65
decreased hemoglobin content 53 | 68
increased circulating sodium l... 52 | 71
increased heart weight 51 | 62
abnormal eye morphology 50 | 68
abnormal retina morphology 50 | 71
abnormal spleen morphology 50 | 55
edema 50 | 59
small testis 50 | 58
increased circulating choleste... 49 | 66
abnormal coat-hair pigmentatio... 48 | 64
decreased erythrocyte cell num... 47 | 62
abnormal kidney morphology 46 | 65
decreased caudal vertebrae num... 46 | 53
decreased mean corpuscular hem... 45 | 50
increased monocyte cell number 45 | 63
female infertility 44 | 60
thrombocytopenia 43 | 56
decreased circulating total pr... 42 | 49
hydrometra 41 | 53
abnormal neural tube closure 39 | 46
increased blood urea nitrogen ... 39 | 48
decreased circulating alanine ... 38 | 47
decreased circulating alkaline... 38 | 46
increased circulating triglyce... 38 | 42
decreased blood urea nitrogen ... 37 | 51
decreased hematocrit 37 | 46
enlarged spleen 37 | 41
tremors 37 | 39
abnormal skin morphology 36 | 50
increased circulating chloride... 36 | 41
increased leukocyte cell numbe... 36 | 47
increased hematocrit 35 | 46
increased hemoglobin content 35 | 45
abnormal bone mineralization 34 | 38
abnormal testis morphology 34 | 43
decreased circulating LDL chol... 34 | 38
increased mean platelet volume 34 | 45
increased neutrophil cell numb... 34 | 46
decreased neutrophil cell numb... 33 | 42
cardiovascular system phenotyp... 32 | 36
decreased circulating creatini... 32 | 39
increased circulating creatini... 32 | 38
increased grip strength 32 | 41
abnormal cranium morphology 31 | 36
decreased circulating calcium ... 31 | 36

Disease

Carcinoma 8,488 | 11,192
ovarian cancer 6,784 | 8,297
osteosarcoma 6,160 | 7,766
medulloblastoma, large-cell 4,947 | 6,086
psoriasis 4,855 | 6,514
glioblastoma 4,677 | 5,635
atypical teratoid / rhabdoid tumor 4,108 | 4,971
lung cancer 3,789 | 4,607
ependymoma 3,769 | 4,559
group 3 medulloblastoma 3,279 | 4,002
adult high grade glioma 3,032 | 3,701
Breast cancer 2,856 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,660 | 3,204
malignant mesothelioma 2,599 | 3,135
Astrocytoma, Pilocytic 2,491 | 3,006
primitive neuroectodermal tumor 2,429 | 2,957
invasive ductal carcinoma 2,423 | 2,867
intraductal papillary-mucinous carcinoma (IPMC) 2,412 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,397 | 2,872
oligodendroglioma 2,314 | 2,768
non-small cell lung cancer 2,274 | 2,799
lung carcinoma 2,259 | 2,755
lung adenocarcinoma 2,121 | 2,627
astrocytic glioma 2,114 | 2,530
Kidney cancer 2,026 | 2,548
Cancer 1,943 | 2,388
pancreatic cancer 1,889 | 2,322
subependymal giant cell astrocytoma 1,883 | 2,230
interstitial cystitis 1,784 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,626 | 1,911
Pick disease 1,584 | 1,856
tuberculosis 1,564 | 1,963
pituitary cancer 1,561 | 1,915
group 4 medulloblastoma 1,496 | 1,806
ulcerative colitis 1,465 | 1,765
ductal carcinoma in situ 1,415 | 1,686
breast carcinoma 1,332 | 1,589
cystic fibrosis 1,306 | 1,629
colon cancer 1,209 | 1,428
diabetes mellitus 1,203 | 1,683
Autosomal recessive predisposition 1,169 | 1,407
adrenocortical carcinoma 1,151 | 1,385
Multiple myeloma 1,109 | 1,296
acute quadriplegic myopathy 990 | 1,133
juvenile dermatomyositis 989 | 1,147
Rheumatoid arthritis 956 | 1,156
astrocytoma 955 | 1,113
Schizophrenia 910 | 1,136
primary pancreatic ductal adenocarcinoma 895 | 1,071
spina bifida 873 | 1,053
pediatric high grade glioma 859 | 1,035
Intellectual disability 840 | 998
dermatomyositis 836 | 941
cutaneous lupus erythematosus 830 | 1,016
nasopharyngeal carcinoma 795 | 1,024
active Crohn's disease 718 | 882
Atopic dermatitis 706 | 915
non primary Sjogren syndrome sicca 676 | 861
Epilepsy 669 | 775
gastric carcinoma 660 | 781
Waldenstrons macroglobulinemia 647 | 742
acute myeloid leukemia 637 | 760
active ulcerative colitis 613 | 736
Liver Cirrhosis, Experimental 610 | 733
primary Sjogren syndrome 601 | 710
medulloblastoma 581 | 702
esophageal adenocarcinoma 568 | 696
aldosterone-producing adenoma 561 | 646
progressive supranuclear palsy 548 | 656
Dull intelligence 533 | 634
Low intelligence 533 | 634
Mental Retardation 533 | 634
Mental deficiency 533 | 634
Poor school performance 533 | 634
Alzheimer's disease 527 | 640
Bipolar Disorder 524 | 646
Duchenne muscular dystrophy 517 | 587
Obesity 509 | 655
Melanoma 508 | 689
Seizures 506 | 584
Cognitive delay 503 | 596
Global developmental delay 503 | 596
Mental and motor retardation 503 | 596
Muscle hypotonia 489 | 562
Liver cancer 456 | 589
autosomal dominant Emery-Dreifuss muscular dystrophy 444 | 492
pancreatic carcinoma 439 | 555
Endometriosis 431 | 521
hepatocellular carcinoma 431 | 536
fibroadenoma 430 | 538
Short stature 422 | 514
Down syndrome 421 | 480
Prostatic Neoplasms 402 | 472
chronic rhinosinusitis 401 | 505
Amyotrophic lateral sclerosis 387 | 437
Multiple Sclerosis 381 | 527
mucosa-associated lymphoid tissue lymphoma 375 | 473
posterior fossa group A ependymoma 371 | 456
sonic hedgehog group medulloblastoma 368 | 459
gastric cancer 356 | 445

Tissue

Endocrine System 13,268 | 18,159
Digestive Tract 12,960 | 17,369
Female tissues 12,954 | 17,400
Skin and soft tissues 12,902 | 17,230
Male tissues 12,853 | 17,142
Nervous System 12,725 | 16,725
Blood and immune system 12,717 | 16,909
Liver and Pancreas 12,717 | 16,750
Urinary Tract 12,705 | 16,678
Respiratory system 12,491 | 16,393
Cardiovascular System 11,892 | 15,192

Target Family

Non-IDG 7,801 | 12,091
Enzyme 3,178 | 4,145
Transcription Factor 950 | 1,400
Kinase 536 | 634
Transporter 372 | 473
Ion Channel 239 | 344
GPCR 221 | 408
Epigenetic 203 | 242
Nuclear Receptor 43 | 48
oGPCR 36 | 421
TF/Epigenetic 32 | 38

Data Source

JensenLab Experiment Exon arra... 13,611 | 13,611
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Hydroxyacylglutathione hydrolase, mitochondrial HAGH Tbio Enzyme -1.95974 82.6 162
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
Zinc finger protein 526 ZNF526 Tdark Transcription Factor 0.70 0.20 51