Development Level

Tbio 2,608 | 11,445
Tdark 712 | 6,588
Tchem 402 | 1,598
Tclin 192 | 613

Collection

RFA-RM-18-021 74 | 328
Kinase: IDG Consortium (Target... 32 | 125
Ion Channel: IDG Consortium (T... 25 | 99
GPCR: IDG Consortium (Targets) 19 | 126
Kinase: IDG Consortium (Comple... 7 | 37
GPCR: IDG Consortium (Complete... 6 | 25

IMPC Phenotype

preweaning lethality, complete... 215 | 979
preweaning lethality, incomple... 130 | 499
abnormal behavior 71 | 298
decreased vertical activity 60 | 208
abnormal bone structure 59 | 187
embryonic lethality prior to t... 54 | 278
enlarged heart 53 | 210
decreased total body fat amoun... 50 | 207
hypoactivity 50 | 132
decreased body weight 43 | 161
abnormal embryo size 40 | 220
decreased lean body mass 40 | 135
embryonic lethality prior to o... 40 | 239
increased lean body mass 40 | 172
increased total body fat amoun... 40 | 134
abnormal heart morphology 39 | 162
short tibia 36 | 97
abnormal seminal vesicle morph... 35 | 114
cataract 33 | 92
decreased bone mineral content 32 | 151
increased startle reflex 32 | 112
decreased bone mineral density 31 | 126
decreased grip strength 31 | 116
decreased body length 30 | 101
hyperactivity 30 | 148
increased circulating alkaline... 30 | 122
decreased circulating choleste... 28 | 93
increased bone mineral content 27 | 108
decreased startle reflex 26 | 75
abnormal lens morphology 25 | 81
increased mean corpuscular vol... 25 | 92
decreased circulating glucose ... 24 | 126
decreased lymphocyte cell numb... 24 | 83
increased bone mineral density 23 | 72
increased mean corpuscular hem... 23 | 96
male infertility 23 | 123
abnormal retina morphology 22 | 71
decreased circulating HDL chol... 22 | 68
decreased erythrocyte cell num... 22 | 62
increased circulating HDL chol... 22 | 80
increased fasted circulating g... 22 | 76
small testis 22 | 58
decreased circulating triglyce... 21 | 79
impaired glucose tolerance 21 | 75
decreased hemoglobin content 20 | 68
decreased mean corpuscular vol... 20 | 79
decreased prepulse inhibition 20 | 82
prenatal lethality prior to he... 20 | 87
decreased circulating serum al... 19 | 82
decreased leukocyte cell numbe... 19 | 73
increased circulating choleste... 19 | 66
increased or absent threshold ... 19 | 101
decreased fasted circulating g... 18 | 65
improved glucose tolerance 18 | 79
increased monocyte cell number 18 | 63
abnormal cranium morphology 17 | 36
abnormal epididymis morphology 17 | 42
abnormal gait 17 | 69
decreased circulating insulin ... 17 | 76
increased circulating sodium l... 17 | 71
abnormal coat-hair pigmentatio... 16 | 64
abnormal testis morphology 16 | 43
embryonic growth retardation 16 | 106
enlarged epididymis 16 | 31
increased mean platelet volume 16 | 45
prolonged QT interval 16 | 38
abnormal eye morphology 15 | 68
abnormal spleen morphology 15 | 55
decreased circulating alkaline... 15 | 46
limb grasping 15 | 41
thrombocytopenia 15 | 56
abnormal bone mineralization 14 | 38
decreased hematocrit 14 | 46
enlarged spleen 14 | 41
increased circulating triglyce... 14 | 42
increased hematocrit 14 | 46
increased leukocyte cell numbe... 14 | 47
prolonged ST segment 14 | 36
small superior vagus ganglion 14 | 74
abnormal cornea morphology 13 | 31
abnormal kidney morphology 13 | 65
abnormal sleep behavior 13 | 70
decreased circulating alanine ... 13 | 47
decreased circulating total pr... 13 | 49
increased blood urea nitrogen ... 13 | 48
increased erythrocyte cell num... 13 | 39
increased lymphocyte cell numb... 13 | 32
increased neutrophil cell numb... 13 | 46
abnormal behavioral response t... 12 | 66
cardiovascular system phenotyp... 12 | 36
decreased blood urea nitrogen ... 12 | 51
decreased circulating LDL chol... 12 | 38
decreased circulating phosphat... 12 | 27
edema 12 | 59
female infertility 12 | 60
increased heart weight 12 | 62
tremors 12 | 39
abnormal skin morphology 11 | 50
corneal opacity 11 | 32
increased circulating calcium ... 11 | 34

Disease

Carcinoma 2,904 | 11,493
ovarian cancer 2,036 | 8,520
osteosarcoma 1,851 | 7,950
medulloblastoma, large-cell 1,619 | 6,241
psoriasis 1,563 | 6,694
glioblastoma 1,561 | 5,792
atypical teratoid / rhabdoid tumor 1,392 | 5,112
ependymoma 1,305 | 4,679
lung cancer 1,301 | 4,740
Breast cancer 1,091 | 3,578
group 3 medulloblastoma 1,078 | 4,104
adult high grade glioma 1,040 | 3,801
Astrocytoma, Pilocytic 956 | 3,081
Kidney cancer 936 | 2,613
lung carcinoma 931 | 2,843
malignant mesothelioma 891 | 3,232
primitive neuroectodermal tumor 890 | 3,035
invasive ductal carcinoma 857 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 850 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 832 | 2,955
oligodendroglioma 831 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 824 | 2,989
non-small cell lung cancer 799 | 2,890
astrocytic glioma 744 | 2,597
lung adenocarcinoma 742 | 2,716
interstitial cystitis 708 | 2,312
pancreatic cancer 708 | 2,398
Cancer 697 | 2,499
subependymal giant cell astrocytoma 631 | 2,287
pituitary cancer 611 | 1,972
ulcerative colitis 610 | 1,819
tuberculosis 589 | 2,010
cystic fibrosis 562 | 1,696
Pick disease 533 | 1,894
ductal carcinoma in situ 528 | 1,745
Schizophrenia 484 | 1,160
group 4 medulloblastoma 483 | 1,855
Rheumatoid arthritis 474 | 1,191
pancreatic ductal adenocarcinoma liver metastasis 472 | 1,962
breast carcinoma 443 | 1,638
colon cancer 419 | 1,478
diabetes mellitus 402 | 1,728
adrenocortical carcinoma 384 | 1,428
Autosomal recessive predisposition 380 | 1,442
Acquired metabolic disease 336 | 336
juvenile dermatomyositis 332 | 1,187
Alzheimer's disease 323 | 658
acute quadriplegic myopathy 321 | 1,158
Bipolar Disorder 303 | 666
Melanoma 300 | 711
Multiple Sclerosis 294 | 540
cutaneous lupus erythematosus 293 | 1,057
pediatric high grade glioma 293 | 1,064
primary pancreatic ductal adenocarcinoma 291 | 1,109
spina bifida 290 | 1,074
Atopic dermatitis 289 | 952
Liver cancer 284 | 604
Type 2 diabetes mellitus 271 | 272
nasopharyngeal carcinoma 270 | 1,058
Obesity 269 | 678
astrocytoma 269 | 1,146
Crohn's disease 268 | 321
Intellectual disability 263 | 1,016
active Crohn's disease 259 | 922
dermatomyositis 252 | 966
Cardiovascular system disease 246 | 246
gastric carcinoma 243 | 807
Multiple myeloma 236 | 1,332
active ulcerative colitis 236 | 764
primary Sjogren syndrome 227 | 735
Epilepsy 222 | 792
Liver Cirrhosis, Experimental 220 | 769
Skin cancer 216 | 469
aldosterone-producing adenoma 201 | 665
Osteoporosis 198 | 363
medulloblastoma 196 | 720
Parkinson's disease 193 | 392
non primary Sjogren syndrome sicca 189 | 891
progressive supranuclear palsy 188 | 676
esophageal adenocarcinoma 187 | 737
Duchenne muscular dystrophy 185 | 601
Kidney disease 185 | 430
acute myeloid leukemia 185 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 185 | 510
Asthma 184 | 385
Endometriosis 182 | 540
Waldenstrons macroglobulinemia 180 | 765
Dull intelligence 174 | 645
Low intelligence 174 | 645
Mental Depression 174 | 333
Mental Retardation 174 | 645
Mental deficiency 174 | 645
Poor school performance 174 | 645
Amyotrophic lateral sclerosis 173 | 451
Seizures 165 | 596
chronic rhinosinusitis 162 | 512
substance-related disorder 162 | 162
Attention deficit hyperactivity disorder 160 | 278
Heart disease 160 | 306
Prostatic Neoplasms 159 | 495

Tissue

Endocrine System 3,775 | 18,159
Female tissues 3,652 | 17,400
Digestive Tract 3,650 | 17,369
Skin and soft tissues 3,614 | 17,230
Male tissues 3,602 | 17,142
Liver and Pancreas 3,554 | 16,750
Urinary Tract 3,554 | 16,678
Nervous System 3,537 | 16,725
Blood and immune system 3,525 | 16,909
Respiratory system 3,462 | 16,393
Cardiovascular System 3,206 | 15,192

Target Family

Non-IDG 2,150 | 12,091
Enzyme 831 | 4,145
Transcription Factor 322 | 1,400
Kinase 178 | 634
Transporter 126 | 473
Ion Channel 103 | 344
GPCR 95 | 408
Epigenetic 46 | 242
oGPCR 34 | 421
Nuclear Receptor 17 | 48
TF/Epigenetic 12 | 38

Data Source

JensenLab Experiment DistiLD 3,914 | 3,914
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.18122 1.46 28
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
DNA dC->dU-editing enzyme APOBEC-3A APOBEC3A Tbio Non-IDG -1.79111 52.4 187
Nck-associated protein 5-like NCKAP5L Tdark Non-IDG -0.22123 2.83 11
Zinc finger protein 99 ZNF99 Tdark Transcription Factor 1.38 0.03 50