Development Level

Tbio 2,032 | 10,625
Tdark 628 | 7,003
Tchem 421 | 1,890
Tclin 159 | 602

Collection

Eligible Kinase Proteins 26 | 134
Eligible Ion Channel Proteins 20 | 117
Eligible non-olfactory GPCR Proteins 18 | 145

IMPC Term

preweaning lethality, complete... 110 | 633
preweaning lethality, incomple... 60 | 260
decreased lean body mass 57 | 195
abnormal behavior 42 | 226
decreased body weight 40 | 174
decreased bone mineral content 37 | 157
decreased total body fat amoun... 36 | 186
abnormal bone structure 35 | 131
embryonic lethality prior to t... 35 | 187
decreased grip strength 33 | 123
increased circulating alkaline... 32 | 119
decreased bone mineral density 28 | 126
decreased body length 27 | 108
hypoactivity 25 | 89
abnormal retina morphology 24 | 100
decreased circulating HDL chol... 24 | 77
enlarged heart 24 | 111
increased mean corpuscular hem... 24 | 93
increased or absent threshold ... 23 | 128
decreased circulating choleste... 22 | 85
decreased circulating glucose ... 21 | 121
increased mean corpuscular vol... 21 | 91
abnormal lens morphology 20 | 73
decreased circulating serum al... 20 | 79
increased fasted circulating g... 20 | 68
increased lean body mass 20 | 107
abnormal bone mineralization 18 | 55
decreased circulating triglyce... 18 | 83
hyperactivity 18 | 108
increased bone mineral content 18 | 92
decreased fasted circulating g... 17 | 49
short tibia 17 | 82
abnormal embryo size 16 | 112
decreased circulating insulin ... 16 | 75
decreased lumbar vertebrae num... 15 | 62
embryonic lethality prior to o... 15 | 148
improved glucose tolerance 15 | 56
increased circulating HDL chol... 15 | 63
increased circulating choleste... 15 | 53
increased total body fat amoun... 15 | 57
abnormal cranium morphology 14 | 32
abnormal retinal pigmentation 14 | 61
decreased erythrocyte cell num... 14 | 43
decreased hemoglobin content 14 | 53
decreased rib number 14 | 59
decreased startle reflex 14 | 48
increased circulating sodium l... 14 | 71
increased startle reflex 14 | 38
abnormal epididymis morphology 13 | 31
abnormal seminal vesicle morph... 13 | 47
decreased circulating alanine ... 13 | 53
decreased heart weight 13 | 44
decreased leukocyte cell numbe... 13 | 54
enlarged epididymis 13 | 27
increased blood urea nitrogen ... 13 | 44
increased bone mineral density 13 | 52
increased grip strength 13 | 83
abnormal heart morphology 12 | 51
abnormal testis morphology 12 | 30
decreased eosinophil cell numb... 12 | 41
decreased mean corpuscular vol... 12 | 50
impaired glucose tolerance 12 | 52
male infertility 12 | 62
abnormal gait 11 | 51
abnormal sleep behavior 11 | 63
decreased circulating LDL chol... 11 | 37
decreased threshold for audito... 11 | 32
increased hemoglobin content 11 | 45
increased leukocyte cell numbe... 11 | 37
prenatal lethality prior to he... 11 | 64
small testis 11 | 37
cardiovascular system phenotyp... 10 | 35
decreased blood urea nitrogen ... 10 | 31
decreased circulating alkaline... 10 | 41
decreased circulating free fat... 10 | 39
decreased circulating total pr... 10 | 41
decreased hematocrit 10 | 25
enlarged spleen 10 | 26
increased sacral vertebrae num... 10 | 62
thrombocytopenia 10 | 46
abnormal cornea morphology 9 | 24
abnormal heart left ventricle ... 9 | 20
abnormal snout morphology 9 | 18
decreased CD4-positive, CD25-p... 9 | 24
decreased circulating aspartat... 9 | 27
decreased prepulse inhibition 9 | 52
increased body weight 9 | 42
increased circulating calcium ... 9 | 32
increased circulating serum al... 9 | 25
increased exploration in new e... 9 | 56
increased rib number 9 | 41
limb grasping 9 | 35
abnormal coat/hair pigmentatio... 8 | 54
decreased NK T cell number 8 | 28
decreased T cell number 8 | 31
decreased caudal vertebrae num... 8 | 49
decreased circulating fructosa... 8 | 31
decreased circulating iron lev... 8 | 25
decreased effector memory CD8-... 8 | 24
decreased lactate dehydrogenas... 8 | 14

Disease

ovarian cancer 1,687 | 8,492
osteosarcoma 1,541 | 7,933
medulloblastoma, large-cell 1,331 | 6,234
psoriasis 1,323 | 6,685
glioblastoma 1,246 | 5,572
lung cancer 1,022 | 4,473
atypical teratoid / rhabdoid tumor 1,005 | 4,369
Breast cancer 805 | 3,099
pilocytic astrocytoma 788 | 3,086
lung carcinoma 767 | 2,844
malignant mesothelioma 735 | 3,163
primitive neuroectodermal tumor 728 | 3,031
invasive ductal carcinoma 720 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 705 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 688 | 2,956
oligodendroglioma 686 | 2,849
Carcinoma 684 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 678 | 2,988
non-small cell lung cancer 639 | 2,798
pediatric high grade glioma 627 | 2,712
lung adenocarcinoma 613 | 2,714
interstitial cystitis 582 | 2,299
ulcerative colitis 580 | 2,087
Cancer 570 | 2,346
pancreatic cancer 548 | 2,300
ependymoma 535 | 2,514
subependymal giant cell astrocytoma 525 | 2,287
astrocytic glioma 523 | 2,241
pituitary cancer 510 | 1,972
cystic fibrosis 473 | 1,670
adult high grade glioma 463 | 2,148
Pick disease 447 | 1,893
group 3 medulloblastoma 437 | 2,254
ductal carcinoma in situ 435 | 1,745
group 4 medulloblastoma 430 | 1,875
Rheumatoid Arthritis 405 | 1,171
tuberculosis 381 | 1,563
posterior fossa group A ependymoma 378 | 1,511
breast carcinoma 373 | 1,614
colon cancer 349 | 1,475
medulloblastoma 347 | 1,524
sonic hedgehog group medulloblastoma 344 | 1,482
posterior fossa group B ependymoma 342 | 1,530
pancreatic ductal adenocarcinoma liver metastasis 331 | 1,795
diabetes mellitus 326 | 1,663
adrenocortical carcinoma 321 | 1,427
astrocytoma 311 | 1,493
primary pancreatic ductal adenocarcinoma 297 | 1,271
juvenile dermatomyositis 274 | 1,189
Acquired metabolic disease 267 | 267
Alzheimer's disease 266 | 644
acute quadriplegic myopathy 266 | 1,157
cutaneous lupus erythematosus 254 | 1,056
Crohn's disease 248 | 304
Atopic dermatitis 247 | 944
Obesity 243 | 616
spina bifida 241 | 1,064
Multiple Sclerosis 237 | 498
atypical teratoid/rhabdoid tumor 233 | 1,095
nasopharyngeal carcinoma 224 | 1,056
Schizophrenia 219 | 503
dermatomyositis 216 | 967
gastric carcinoma 214 | 832
primary Sjogren syndrome 208 | 789
active Crohn's disease 205 | 918
Multiple myeloma 203 | 1,328
Cardiovascular system disease 194 | 194
Type 2 diabetes mellitus 189 | 192
aldosterone-producing adenoma 174 | 664
Kidney disease 160 | 397
progressive supranuclear palsy 159 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 157 | 499
acute myeloid leukemia 156 | 785
esophageal adenocarcinoma 156 | 737
Osteoporosis 155 | 259
Duchenne muscular dystrophy 153 | 602
Asthma 152 | 349
Waldenstrons macroglobulinemia 149 | 765
Parkinson's disease 148 | 364
Endometriosis 143 | 535
Bipolar Disorder 140 | 266
Prostatic Neoplasms 139 | 471
Amyotrophic Lateral Sclerosis 137 | 432
Heart disease 137 | 279
chronic rhinosinusitis 137 | 512
fibroadenoma 133 | 557
pancreatic carcinoma 129 | 567
non primary Sjogren syndrome sicca 128 | 840
Down syndrome 125 | 548
active ulcerative colitis 125 | 477
Intellectual disability 124 | 573
Autistic Disorder 123 | 320
Vascular disease 122 | 281
tuberculosis and treatment for 6 months 121 | 686
Mammary Neoplasms 120 | 410
non-small cell lung carcinoma 119 | 413
Prostate cancer 117 | 172
mucosa-associated lymphoid tissue lymphoma 112 | 480
Atherosclerosis 111 | 275
hepatocellular carcinoma 105 | 550

Tissue

Female tissues 3,175 | 18,647
Nervous System 3,169 | 18,561
Urinary Tract 3,169 | 18,444
Endocrine System 3,168 | 18,512
Digestive Tract 3,166 | 18,473
Liver and Pancreas 3,135 | 18,136
Skin and soft tissues 3,131 | 18,115
Cardiovascular System 3,113 | 17,958
Male tissues 3,109 | 17,969
Blood and immune system 3,108 | 17,995
Respiratory system 3,050 | 17,484

Target Family

Non-IDG 1,789 | 11,969
Enzyme 671 | 4,146
Transcription Factor 271 | 1,400
Kinase 149 | 634
Transporter 104 | 473
GPCR 81 | 408
Ion Channel 79 | 341
Epigenetic 39 | 242
oGPCR 31 | 421
Nuclear Receptor 16 | 48
TF/Epigenetic 10 | 38

Data Source

JensenLab Experiment DistiLD 3,240 | 3,240
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Ubiquitin-conjugating enzyme E2 Q2 UBE2Q2 Tbio Non-IDG -0.88971 8.59 121
SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 Tbio Non-IDG 0.08 0.71 6
Lebercilin LCA5 Tbio Non-IDG -1.21162 16.7 65
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.10264 130.3 456
Solute carrier organic anion transporter family member 3A1 SLCO3A1 Tbio Transporter -1.38328 23.0 28
FK506-binding protein-like FKBPL Tbio Non-IDG -1.37535 26.7 129
Nucleosome assembly protein 1-like 4 NAP1L4 Tbio Non-IDG -0.83421 6.96 51
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.50813 29.9 15