Development Level

Tbio 2,463 | 11,178
Tdark 697 | 6,569
Tchem 444 | 1,885
Tclin 191 | 612

Collection

Kinase: IDG Consortium (Target... 29 | 125
Ion Channel: IDG Consortium (T... 25 | 99
GPCR: IDG Consortium (Targets) 19 | 126
Kinase: IDG Consortium (Comple... 7 | 37
GPCR: IDG Consortium (Complete... 6 | 25

IMPC Phenotype

preweaning lethality, complete... 211 | 979
preweaning lethality, incomple... 125 | 499
abnormal behavior 68 | 298
decreased vertical activity 60 | 208
abnormal bone structure 56 | 187
embryonic lethality prior to t... 54 | 278
enlarged heart 52 | 210
decreased total body fat amoun... 48 | 207
hypoactivity 46 | 132
decreased body weight 42 | 161
embryonic lethality prior to o... 40 | 239
abnormal heart morphology 39 | 162
increased lean body mass 39 | 172
abnormal embryo size 37 | 220
decreased lean body mass 36 | 135
increased total body fat amoun... 36 | 134
abnormal seminal vesicle morph... 35 | 114
short tibia 35 | 97
cataract 33 | 92
decreased grip strength 31 | 116
increased startle reflex 31 | 112
decreased bone mineral content 30 | 151
decreased bone mineral density 30 | 126
hyperactivity 28 | 148
increased circulating alkaline... 28 | 122
decreased body length 26 | 101
abnormal lens morphology 25 | 81
decreased circulating choleste... 25 | 93
decreased startle reflex 25 | 75
increased bone mineral content 25 | 108
decreased lymphocyte cell numb... 24 | 83
increased mean corpuscular vol... 24 | 92
decreased circulating glucose ... 22 | 126
increased bone mineral density 22 | 72
male infertility 22 | 123
small testis 22 | 58
abnormal retina morphology 21 | 71
impaired glucose tolerance 21 | 75
increased circulating HDL chol... 21 | 80
decreased circulating triglyce... 20 | 79
decreased erythrocyte cell num... 20 | 62
decreased hemoglobin content 20 | 68
increased fasted circulating g... 20 | 76
increased mean corpuscular hem... 20 | 96
decreased circulating HDL chol... 19 | 68
decreased circulating serum al... 19 | 82
decreased leukocyte cell numbe... 19 | 73
decreased mean corpuscular vol... 19 | 79
decreased prepulse inhibition 19 | 82
increased or absent threshold ... 19 | 101
prenatal lethality prior to he... 19 | 87
improved glucose tolerance 18 | 79
increased circulating choleste... 18 | 66
increased monocyte cell number 18 | 63
abnormal cranium morphology 17 | 36
abnormal epididymis morphology 17 | 42
decreased circulating insulin ... 17 | 76
decreased fasted circulating g... 17 | 65
abnormal gait 16 | 69
abnormal testis morphology 16 | 43
enlarged epididymis 16 | 31
increased circulating sodium l... 16 | 71
abnormal coat-hair pigmentatio... 15 | 64
abnormal spleen morphology 15 | 55
increased mean platelet volume 15 | 45
prolonged QT interval 15 | 38
abnormal eye morphology 14 | 68
decreased circulating alkaline... 14 | 46
decreased hematocrit 14 | 46
increased circulating triglyce... 14 | 42
increased hematocrit 14 | 46
increased leukocyte cell numbe... 14 | 47
limb grasping 14 | 41
small superior vagus ganglion 14 | 74
thrombocytopenia 14 | 56
abnormal bone mineralization 13 | 38
abnormal cornea morphology 13 | 31
abnormal kidney morphology 13 | 65
abnormal sleep behavior 13 | 70
decreased circulating alanine ... 13 | 47
decreased circulating total pr... 13 | 49
embryonic growth retardation 13 | 106
enlarged spleen 13 | 41
increased lymphocyte cell numb... 13 | 32
increased neutrophil cell numb... 13 | 46
prolonged ST segment 13 | 36
abnormal behavioral response t... 12 | 66
cardiovascular system phenotyp... 12 | 36
decreased circulating LDL chol... 12 | 38
increased erythrocyte cell num... 12 | 39
tremors 12 | 39
abnormal skin morphology 11 | 50
corneal opacity 11 | 32
decreased blood urea nitrogen ... 11 | 51
decreased caudal vertebrae num... 11 | 53
edema 11 | 59
increased blood urea nitrogen ... 11 | 48
increased circulating calcium ... 11 | 34
increased heart weight 11 | 62
increased red blood cell distr... 11 | 34

Disease

Carcinoma 2,810 | 11,192
ovarian cancer 1,964 | 8,297
osteosarcoma 1,796 | 7,766
medulloblastoma, large-cell 1,570 | 6,086
psoriasis 1,510 | 6,514
glioblastoma 1,508 | 5,635
atypical teratoid / rhabdoid tumor 1,341 | 4,971
ependymoma 1,263 | 4,559
lung cancer 1,262 | 4,607
Breast cancer 1,058 | 3,469
group 3 medulloblastoma 1,050 | 4,002
adult high grade glioma 1,007 | 3,701
Astrocytoma, Pilocytic 926 | 3,006
Kidney cancer 908 | 2,548
lung carcinoma 896 | 2,755
primitive neuroectodermal tumor 860 | 2,957
malignant mesothelioma 858 | 3,135
invasive ductal carcinoma 835 | 2,867
intraductal papillary-mucinous neoplasm (IPMN) 823 | 3,204
intraductal papillary-mucinous adenoma (IPMA) 805 | 2,872
oligodendroglioma 804 | 2,768
intraductal papillary-mucinous carcinoma (IPMC) 796 | 2,902
non-small cell lung cancer 773 | 2,799
lung adenocarcinoma 722 | 2,627
astrocytic glioma 718 | 2,530
pancreatic cancer 687 | 2,322
interstitial cystitis 685 | 2,237
Cancer 663 | 2,388
subependymal giant cell astrocytoma 616 | 2,230
pituitary cancer 595 | 1,915
ulcerative colitis 592 | 1,765
tuberculosis 580 | 1,963
cystic fibrosis 543 | 1,629
Pick disease 520 | 1,856
ductal carcinoma in situ 513 | 1,686
Schizophrenia 472 | 1,136
group 4 medulloblastoma 468 | 1,806
Rheumatoid arthritis 456 | 1,156
pancreatic ductal adenocarcinoma liver metastasis 455 | 1,911
breast carcinoma 430 | 1,589
colon cancer 410 | 1,428
diabetes mellitus 389 | 1,683
Autosomal recessive predisposition 369 | 1,407
adrenocortical carcinoma 367 | 1,385
Acquired metabolic disease 329 | 329
juvenile dermatomyositis 318 | 1,147
Alzheimer's disease 317 | 640
acute quadriplegic myopathy 313 | 1,133
Bipolar Disorder 295 | 646
Melanoma 291 | 689
Multiple Sclerosis 287 | 527
cutaneous lupus erythematosus 285 | 1,016
spina bifida 284 | 1,053
pediatric high grade glioma 283 | 1,035
primary pancreatic ductal adenocarcinoma 280 | 1,071
Atopic dermatitis 278 | 915
Liver cancer 277 | 589
Type 2 diabetes mellitus 267 | 268
nasopharyngeal carcinoma 262 | 1,024
Obesity 259 | 655
Crohn's disease 258 | 311
astrocytoma 258 | 1,113
Intellectual disability 254 | 998
active Crohn's disease 245 | 882
dermatomyositis 243 | 941
Cardiovascular system disease 240 | 240
gastric carcinoma 231 | 781
Multiple myeloma 230 | 1,296
active ulcerative colitis 228 | 736
primary Sjogren syndrome 218 | 710
Epilepsy 216 | 775
Liver Cirrhosis, Experimental 208 | 733
Skin cancer 208 | 451
aldosterone-producing adenoma 194 | 646
Osteoporosis 193 | 348
medulloblastoma 185 | 702
Parkinson's disease 183 | 378
progressive supranuclear palsy 183 | 656
Asthma 179 | 370
acute myeloid leukemia 179 | 760
Kidney disease 178 | 411
esophageal adenocarcinoma 178 | 696
non primary Sjogren syndrome sicca 178 | 861
Duchenne muscular dystrophy 177 | 587
Endometriosis 176 | 521
Waldenstrons macroglobulinemia 175 | 742
autosomal dominant Emery-Dreifuss muscular dystrophy 175 | 492
Mental Depression 171 | 325
Dull intelligence 169 | 634
Low intelligence 169 | 634
Mental Retardation 169 | 634
Mental deficiency 169 | 634
Poor school performance 169 | 634
Amyotrophic lateral sclerosis 167 | 437
Seizures 160 | 584
chronic rhinosinusitis 159 | 505
Autistic Disorder 156 | 358
Prostatic Neoplasms 156 | 472
substance-related disorder 156 | 156
Attention deficit hyperactivity disorder 155 | 272

Tissue

Endocrine System 3,657 | 18,159
Digestive Tract 3,543 | 17,369
Female tissues 3,539 | 17,400
Skin and soft tissues 3,507 | 17,230
Male tissues 3,494 | 17,142
Liver and Pancreas 3,452 | 16,750
Urinary Tract 3,448 | 16,678
Nervous System 3,431 | 16,725
Blood and immune system 3,418 | 16,909
Respiratory system 3,361 | 16,393
Cardiovascular System 3,118 | 15,192

Target Family

Non-IDG 2,120 | 12,091
Enzyme 772 | 4,145
Transcription Factor 300 | 1,400
Kinase 175 | 634
Transporter 123 | 473
Ion Channel 103 | 344
GPCR 95 | 408
Epigenetic 45 | 242
oGPCR 34 | 421
Nuclear Receptor 16 | 48
TF/Epigenetic 12 | 38

Data Source

JensenLab Experiment DistiLD 3,795 | 3,795
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
LIM homeobox transcription factor 1-alpha LMX1A Tbio Transcription Factor -1.82498 66.0 175
MyoD family inhibitor domain-containing protein MDFIC Tbio Non-IDG -2.90969 749.0 122
Taste receptor type 1 member 2 TAS1R2 Tchem GPCR -2.03403 100.4 150
Protocadherin-7 PCDH7 Tbio Non-IDG -1.42056 26.3 248
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
Docking protein 5 DOK5 Tbio Non-IDG -1.04456 11.4 284
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121