Development Level

Tbio 6,681 | 11,178
Tdark 2,727 | 6,569
Tchem 1,274 | 1,885
Tclin 462 | 612

Collection

Kinase: IDG Consortium (Target... 94 | 125
GPCR: IDG Consortium (Targets) 82 | 126
Ion Channel: IDG Consortium (T... 68 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 642 | 979
preweaning lethality, incomple... 334 | 499
abnormal behavior 196 | 298
embryonic lethality prior to t... 175 | 278
embryonic lethality prior to o... 144 | 239
abnormal embryo size 142 | 220
decreased total body fat amoun... 139 | 207
abnormal bone structure 135 | 187
decreased body weight 130 | 161
increased lean body mass 121 | 172
enlarged heart 118 | 210
decreased vertical activity 112 | 208
decreased bone mineral content 100 | 151
hyperactivity 93 | 148
male infertility 92 | 123
abnormal heart morphology 91 | 162
decreased bone mineral density 91 | 126
hypoactivity 88 | 132
decreased lean body mass 87 | 135
increased total body fat amoun... 87 | 134
decreased circulating glucose ... 82 | 126
increased startle reflex 81 | 112
increased circulating alkaline... 77 | 122
decreased grip strength 76 | 116
decreased circulating choleste... 73 | 93
increased or absent threshold ... 73 | 101
increased bone mineral content 72 | 108
decreased body length 67 | 101
embryonic growth retardation 66 | 106
short tibia 66 | 97
abnormal seminal vesicle morph... 63 | 114
decreased prepulse inhibition 62 | 82
increased mean corpuscular hem... 61 | 96
impaired glucose tolerance 58 | 75
increased mean corpuscular vol... 58 | 92
decreased startle reflex 56 | 75
prenatal lethality prior to he... 56 | 87
decreased mean corpuscular vol... 55 | 79
cataract 54 | 92
decreased circulating triglyce... 53 | 79
decreased hemoglobin content 53 | 68
decreased lymphocyte cell numb... 53 | 83
increased bone mineral density 53 | 72
decreased circulating serum al... 51 | 82
improved glucose tolerance 51 | 79
increased circulating HDL chol... 51 | 80
increased heart weight 51 | 62
abnormal lens morphology 50 | 81
decreased leukocyte cell numbe... 48 | 73
decreased circulating HDL chol... 47 | 68
abnormal retina morphology 46 | 71
increased fasted circulating g... 45 | 76
abnormal behavioral response t... 44 | 66
increased monocyte cell number 44 | 63
decreased circulating insulin ... 43 | 76
increased circulating choleste... 43 | 66
decreased fasted circulating g... 42 | 65
abnormal eye morphology 41 | 68
increased circulating sodium l... 41 | 71
abnormal gait 40 | 69
abnormal sleep behavior 40 | 70
decreased circulating alanine ... 39 | 47
thrombocytopenia 39 | 56
abnormal kidney morphology 38 | 65
decreased caudal vertebrae num... 38 | 53
female infertility 38 | 60
small superior vagus ganglion 38 | 74
decreased blood urea nitrogen ... 37 | 51
decreased circulating total pr... 37 | 49
decreased mean corpuscular hem... 36 | 50
edema 36 | 59
increased hemoglobin content 36 | 45
decreased erythrocyte cell num... 35 | 62
increased mean platelet volume 35 | 45
small testis 35 | 58
abnormal coat-hair pigmentatio... 34 | 64
decreased circulating alkaline... 34 | 46
abnormal bone mineralization 32 | 38
abnormal spleen morphology 32 | 55
decreased circulating LDL chol... 32 | 38
increased circulating triglyce... 32 | 42
increased grip strength 32 | 41
decreased hematocrit 31 | 46
increased hematocrit 31 | 46
increased leukocyte cell numbe... 31 | 47
abnormal cranium morphology 30 | 36
tremors 30 | 39
increased blood urea nitrogen ... 29 | 48
enlarged spleen 28 | 41
abnormal neural tube closure 27 | 46
cardiovascular system phenotyp... 27 | 36
increased erythrocyte cell num... 27 | 39
limb grasping 27 | 41
abnormal cornea morphology 26 | 31
abnormal epididymis morphology 26 | 42
abnormal skin morphology 26 | 50
decreased circulating aspartat... 26 | 34
decreased neutrophil cell numb... 26 | 42
hydrometra 26 | 53
increased circulating chloride... 26 | 41

Disease

Carcinoma 11,124 | 11,192
ovarian cancer 5,351 | 8,297
osteosarcoma 5,033 | 7,766
psoriasis 4,071 | 6,514
medulloblastoma, large-cell 4,066 | 6,086
glioblastoma 3,765 | 5,635
atypical teratoid / rhabdoid tumor 3,387 | 4,971
lung cancer 3,150 | 4,607
ependymoma 3,127 | 4,559
group 3 medulloblastoma 2,737 | 4,002
Kidney cancer 2,546 | 2,548
adult high grade glioma 2,477 | 3,701
Breast cancer 2,368 | 3,469
malignant mesothelioma 2,163 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 2,097 | 3,204
Astrocytoma, Pilocytic 2,053 | 3,006
primitive neuroectodermal tumor 2,039 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 1,975 | 2,902
lung carcinoma 1,963 | 2,755
intraductal papillary-mucinous adenoma (IPMA) 1,957 | 2,872
oligodendroglioma 1,903 | 2,768
invasive ductal carcinoma 1,892 | 2,867
non-small cell lung cancer 1,839 | 2,799
lung adenocarcinoma 1,688 | 2,627
astrocytic glioma 1,678 | 2,530
Cancer 1,528 | 2,388
pancreatic cancer 1,522 | 2,322
subependymal giant cell astrocytoma 1,488 | 2,230
interstitial cystitis 1,449 | 2,237
Pick disease 1,357 | 1,856
pituitary cancer 1,311 | 1,915
tuberculosis 1,245 | 1,963
group 4 medulloblastoma 1,206 | 1,806
pancreatic ductal adenocarcinoma liver metastasis 1,172 | 1,911
ulcerative colitis 1,146 | 1,765
ductal carcinoma in situ 1,110 | 1,686
cystic fibrosis 1,096 | 1,629
breast carcinoma 1,028 | 1,589
Autosomal recessive predisposition 998 | 1,407
colon cancer 980 | 1,428
diabetes mellitus 972 | 1,683
adrenocortical carcinoma 930 | 1,385
Schizophrenia 807 | 1,136
juvenile dermatomyositis 788 | 1,147
acute quadriplegic myopathy 786 | 1,133
Rheumatoid arthritis 779 | 1,156
Intellectual disability 770 | 998
astrocytoma 768 | 1,113
spina bifida 724 | 1,053
pediatric high grade glioma 689 | 1,035
nasopharyngeal carcinoma 688 | 1,024
Multiple myeloma 679 | 1,296
primary pancreatic ductal adenocarcinoma 676 | 1,071
cutaneous lupus erythematosus 645 | 1,016
dermatomyositis 628 | 941
Melanoma 603 | 689
Atopic dermatitis 590 | 915
Liver cancer 588 | 589
Epilepsy 572 | 775
active Crohn's disease 555 | 882
gastric carcinoma 529 | 781
progressive supranuclear palsy 509 | 656
non primary Sjogren syndrome sicca 495 | 861
Dull intelligence 491 | 634
Low intelligence 491 | 634
Mental Retardation 491 | 634
Mental deficiency 491 | 634
Poor school performance 491 | 634
primary Sjogren syndrome 474 | 710
Alzheimer's disease 470 | 640
acute myeloid leukemia 465 | 760
Bipolar Disorder 460 | 646
medulloblastoma 460 | 702
active ulcerative colitis 453 | 736
Obesity 451 | 655
Skin cancer 443 | 451
aldosterone-producing adenoma 441 | 646
Waldenstrons macroglobulinemia 438 | 742
Cognitive delay 437 | 596
Global developmental delay 437 | 596
Mental and motor retardation 437 | 596
esophageal adenocarcinoma 435 | 696
Liver Cirrhosis, Experimental 434 | 733
Seizures 425 | 584
Muscle hypotonia 406 | 562
Short stature 401 | 514
Duchenne muscular dystrophy 378 | 587
pancreatic carcinoma 376 | 555
chronic rhinosinusitis 375 | 505
Multiple Sclerosis 355 | 527
autosomal dominant Emery-Dreifuss muscular dystrophy 349 | 492
hepatocellular carcinoma 346 | 536
Amyotrophic lateral sclerosis 341 | 437
fibroadenoma 339 | 538
Endometriosis 336 | 521
sonic hedgehog group medulloblastoma 313 | 459
posterior fossa group A ependymoma 308 | 456
Prostatic Neoplasms 303 | 472
mucosa-associated lymphoid tissue lymphoma 301 | 473
Endometrial cancer 299 | 301

Tissue

Endocrine System 10,588 | 18,159
Female tissues 10,217 | 17,400
Digestive Tract 10,182 | 17,369
Skin and soft tissues 10,120 | 17,230
Male tissues 10,085 | 17,142
Nervous System 9,909 | 16,725
Blood and immune system 9,906 | 16,909
Liver and Pancreas 9,886 | 16,750
Urinary Tract 9,877 | 16,678
Respiratory system 9,671 | 16,393
Cardiovascular System 9,054 | 15,192

Target Family

Non-IDG 5,966 | 12,091
Enzyme 2,270 | 4,145
Transcription Factor 898 | 1,400
Kinase 506 | 634
Transporter 352 | 473
oGPCR 319 | 421
GPCR 302 | 408
Ion Channel 269 | 344
Epigenetic 189 | 242
Nuclear Receptor 37 | 48
TF/Epigenetic 36 | 38

Data Source

JensenLab Experiment COSMIC 11,144 | 11,144
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254