Development Level

Tbio 1,272 | 10,625
Tdark 419 | 7,003
Tchem 286 | 1,890
Tclin 153 | 602

Collection

Eligible Kinase Proteins 20 | 134
Eligible Ion Channel Proteins 17 | 117
Eligible non-olfactory GPCR Proteins 12 | 145

IMPC Term

preweaning lethality, complete... 86 | 633
preweaning lethality, incomple... 36 | 260
decreased lean body mass 34 | 195
decreased total body fat amoun... 32 | 186
abnormal embryo size 29 | 112
abnormal behavior 28 | 226
embryonic lethality prior to t... 28 | 187
decreased body weight 27 | 174
decreased bone mineral density 22 | 126
embryonic lethality prior to o... 22 | 148
decreased bone mineral content 21 | 157
decreased grip strength 20 | 123
abnormal bone structure 19 | 131
decreased body length 18 | 108
increased bone mineral content 18 | 92
increased or absent threshold ... 18 | 128
decreased circulating serum al... 16 | 79
abnormal retina morphology 15 | 100
decreased circulating choleste... 15 | 85
decreased circulating glucose ... 15 | 121
increased lean body mass 15 | 107
increased mean corpuscular hem... 15 | 93
decreased circulating HDL chol... 14 | 77
impaired glucose tolerance 14 | 52
short tibia 14 | 82
abnormal neural tube closure 13 | 37
decreased circulating total pr... 13 | 41
increased circulating alkaline... 13 | 119
hypoactivity 12 | 89
increased fasted circulating g... 12 | 68
abnormal bone mineralization 11 | 55
abnormal lens morphology 11 | 73
decreased hemoglobin content 11 | 53
decreased lumbar vertebrae num... 11 | 62
hyperactivity 11 | 108
increased circulating sodium l... 11 | 71
decreased circulating alanine ... 10 | 53
decreased leukocyte cell numbe... 10 | 54
decreased prepulse inhibition 10 | 52
enlarged heart 10 | 111
increased blood urea nitrogen ... 10 | 44
increased sacral vertebrae num... 10 | 62
male infertility 10 | 62
abnormal hindbrain development 9 | 24
decreased circulating triglyce... 9 | 83
decreased mean corpuscular vol... 9 | 50
increased bone mineral density 9 | 52
increased circulating HDL chol... 9 | 63
abnormal gait 8 | 51
abnormal midbrain development 8 | 22
abnormal sleep behavior 8 | 63
decreased circulating free fat... 8 | 39
decreased erythrocyte cell num... 8 | 43
decreased hematocrit 8 | 25
improved glucose tolerance 8 | 56
increased mean corpuscular vol... 8 | 91
abnormal coat/hair pigmentatio... 7 | 54
abnormal forebrain development 7 | 18
cardiovascular system phenotyp... 7 | 35
cataract 7 | 26
decreased circulating LDL chol... 7 | 37
decreased circulating alkaline... 7 | 41
decreased circulating fructosa... 7 | 31
decreased mean corpuscular hem... 7 | 34
decreased startle reflex 7 | 48
increased grip strength 7 | 83
increased heart weight 7 | 37
increased hematocrit 7 | 36
increased startle reflex 7 | 38
thrombocytopenia 7 | 46
abnormal cranium morphology 6 | 32
abnormal retinal pigmentation 6 | 61
abnormal seminal vesicle morph... 6 | 47
abnormal tooth morphology 6 | 24
decreased blood urea nitrogen ... 6 | 31
decreased caudal vertebrae num... 6 | 49
decreased circulating creatini... 6 | 31
decreased circulating insulin ... 6 | 75
decreased eosinophil cell numb... 6 | 41
decreased fasted circulating g... 6 | 49
decreased heart weight 6 | 44
increased body weight 6 | 42
increased circulating choleste... 6 | 53
increased circulating potassiu... 6 | 31
increased total body fat amoun... 6 | 57
limb grasping 6 | 35
abnormal behavioral response t... 5 | 52
abnormal cornea morphology 5 | 24
abnormal head morphology 5 | 10
abnormal heart left ventricle ... 5 | 20
abnormal locomotor activation 5 | 26
abnormal startle reflex 5 | 14
corneal opacity 5 | 25
decreased circulating aspartat... 5 | 27
increased circulating calcium ... 5 | 32
persistence of hyaloid vascula... 5 | 22
prenatal lethality prior to he... 5 | 64
small testis 5 | 37
small thymus 5 | 11
vertebral fusion 5 | 23

Disease

Carcinoma 2,107 | 2,147
ovarian cancer 1,159 | 8,492
osteosarcoma 1,049 | 7,933
medulloblastoma, large-cell 974 | 6,234
glioblastoma 911 | 5,572
psoriasis 873 | 6,685
atypical teratoid / rhabdoid tumor 778 | 4,369
lung cancer 652 | 4,473
oligodendroglioma 558 | 2,849
pilocytic astrocytoma 547 | 3,086
primitive neuroectodermal tumor 546 | 3,031
lung carcinoma 519 | 2,844
Breast cancer 516 | 3,099
malignant mesothelioma 498 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 495 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 485 | 2,988
ependymoma 483 | 2,514
pediatric high grade glioma 470 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 468 | 3,289
invasive ductal carcinoma 439 | 2,950
lung adenocarcinoma 421 | 2,714
astrocytic glioma 393 | 2,241
non-small cell lung cancer 391 | 2,798
Cancer 387 | 2,346
Pick disease 380 | 1,893
subependymal giant cell astrocytoma 371 | 2,287
pituitary cancer 363 | 1,972
adult high grade glioma 337 | 2,148
interstitial cystitis 336 | 2,299
pancreatic cancer 331 | 2,300
group 4 medulloblastoma 316 | 1,875
group 3 medulloblastoma 311 | 2,254
astrocytoma 285 | 1,493
medulloblastoma 282 | 1,524
ulcerative colitis 277 | 2,087
ductal carcinoma in situ 264 | 1,745
cystic fibrosis 257 | 1,670
posterior fossa group A ependymoma 256 | 1,511
colon cancer 252 | 1,475
breast carcinoma 239 | 1,614
sonic hedgehog group medulloblastoma 236 | 1,482
adrenocortical carcinoma 211 | 1,427
posterior fossa group B ependymoma 207 | 1,530
pancreatic ductal adenocarcinoma liver metastasis 198 | 1,795
Rheumatoid Arthritis 195 | 1,171
acute quadriplegic myopathy 192 | 1,157
tuberculosis 192 | 1,563
juvenile dermatomyositis 190 | 1,189
diabetes mellitus 182 | 1,663
primary pancreatic ductal adenocarcinoma 177 | 1,271
Intellectual disability 171 | 573
nasopharyngeal carcinoma 170 | 1,056
dermatomyositis 152 | 967
atypical teratoid/rhabdoid tumor 149 | 1,095
progressive supranuclear palsy 146 | 674
Atopic dermatitis 144 | 944
spina bifida 140 | 1,064
Schizophrenia 137 | 503
Alzheimer's disease 132 | 644
gastric carcinoma 131 | 832
cutaneous lupus erythematosus 122 | 1,056
primary Sjogren syndrome 122 | 789
Autistic Disorder 117 | 320
Kidney cancer 109 | 121
non-small cell lung carcinoma 106 | 413
aldosterone-producing adenoma 105 | 664
Duchenne muscular dystrophy 103 | 602
Obesity 100 | 616
active Crohn's disease 100 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 99 | 499
non primary Sjogren syndrome sicca 98 | 840
Amyotrophic Lateral Sclerosis 97 | 432
Epilepsy 97 | 346
Mammary Neoplasms 97 | 410
Multiple myeloma 88 | 1,328
chronic rhinosinusitis 88 | 512
Colorectal Neoplasms 86 | 217
esophageal adenocarcinoma 86 | 737
acute myeloid leukemia 84 | 785
Down syndrome 82 | 548
Kidney disease 80 | 397
Multiple Sclerosis 80 | 498
tuberculosis and treatment for 6 months 79 | 686
Endometriosis 76 | 535
Waldenstrons macroglobulinemia 74 | 765
fibroadenoma 73 | 557
pancreatic carcinoma 70 | 567
Melanoma 69 | 261
Parkinson's disease 69 | 364
Renal Cell Carcinoma 69 | 199
interstitial lung disease 68 | 292
Prostatic Neoplasms 66 | 471
Neurodegenerative disease 65 | 383
Heart disease 64 | 279
glioblastoma multiforme 63 | 347
urothelial carcinoma 62 | 318
Bipolar Disorder 61 | 266
Peripheral Neuropathy 61 | 303
mucosa-associated lymphoid tissue lymphoma 58 | 480
IGA Glomerulonephritis 57 | 454

Tissue

Female tissues 2,109 | 18,647
Digestive Tract 2,105 | 18,473
Nervous System 2,104 | 18,561
Endocrine System 2,098 | 18,512
Urinary Tract 2,097 | 18,444
Liver and Pancreas 2,082 | 18,136
Male tissues 2,082 | 17,969
Cardiovascular System 2,080 | 17,958
Blood and immune system 2,070 | 17,995
Skin and soft tissues 2,066 | 18,115
Respiratory system 2,036 | 17,484

Target Family

Non-IDG 1,192 | 11,969
Enzyme 327 | 4,146
Kinase 151 | 634
Transcription Factor 140 | 1,400
Ion Channel 102 | 341
Transporter 72 | 473
Epigenetic 69 | 242
GPCR 49 | 408
TF/Epigenetic 15 | 38
oGPCR 11 | 421
Nuclear Receptor 2 | 48

Data Source

JensenLab Experiment COSMIC 2,130 | 2,130
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11
Zinc finger protein 334 ZNF334 Tdark Transcription Factor -0.12494 1.43 22
NACHT, LRR and PYD domains-containing protein 8 NLRP8 Tdark Non-IDG -0.64290 3.57 30
NACHT, LRR and PYD domains-containing protein 10 NLRP10 Tbio Non-IDG -1.30183 21.3 121
NACHT, LRR and PYD domains-containing protein 13 NLRP13 Tdark Non-IDG 0.32 0.40 30
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Bromodomain adjacent to zinc finger domain protein 2B BAZ2B Tchem TF/Epigenetic -2.13444 130.1 74