Development Level

Tbio 7,002 | 11,445
Tdark 2,780 | 6,588
Tchem 1,194 | 1,598
Tclin 469 | 613

Collection

RFA-RM-18-021 233 | 328
Kinase: IDG Consortium (Target... 98 | 125
GPCR: IDG Consortium (Targets) 82 | 126
Ion Channel: IDG Consortium (T... 68 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 656 | 979
preweaning lethality, incomple... 341 | 499
abnormal behavior 201 | 298
embryonic lethality prior to t... 177 | 278
abnormal embryo size 148 | 220
embryonic lethality prior to o... 144 | 239
decreased total body fat amoun... 143 | 207
abnormal bone structure 138 | 187
decreased body weight 135 | 161
increased lean body mass 123 | 172
enlarged heart 119 | 210
decreased vertical activity 113 | 208
decreased bone mineral content 103 | 151
hyperactivity 96 | 148
decreased bone mineral density 94 | 126
decreased lean body mass 93 | 135
hypoactivity 93 | 132
male infertility 93 | 123
abnormal heart morphology 92 | 162
increased total body fat amoun... 90 | 134
decreased circulating glucose ... 83 | 126
increased startle reflex 83 | 112
increased circulating alkaline... 80 | 122
decreased grip strength 78 | 116
decreased circulating choleste... 77 | 93
increased bone mineral content 75 | 108
increased or absent threshold ... 74 | 101
decreased body length 73 | 101
embryonic growth retardation 71 | 106
short tibia 70 | 97
increased mean corpuscular hem... 66 | 96
abnormal seminal vesicle morph... 64 | 114
decreased prepulse inhibition 64 | 82
increased mean corpuscular vol... 60 | 92
decreased startle reflex 58 | 75
impaired glucose tolerance 58 | 75
prenatal lethality prior to he... 58 | 87
decreased circulating triglyce... 57 | 79
decreased mean corpuscular vol... 56 | 79
cataract 54 | 92
decreased lymphocyte cell numb... 54 | 83
increased bone mineral density 54 | 72
decreased hemoglobin content 53 | 68
increased circulating HDL chol... 53 | 80
increased heart weight 52 | 62
decreased circulating HDL chol... 51 | 68
decreased circulating serum al... 51 | 82
improved glucose tolerance 51 | 79
abnormal lens morphology 50 | 81
decreased leukocyte cell numbe... 50 | 73
abnormal retina morphology 48 | 71
increased fasted circulating g... 47 | 76
increased circulating choleste... 45 | 66
abnormal behavioral response t... 44 | 66
decreased fasted circulating g... 44 | 65
increased monocyte cell number 44 | 63
abnormal eye morphology 43 | 68
decreased circulating insulin ... 43 | 76
increased circulating sodium l... 43 | 71
thrombocytopenia 42 | 56
abnormal gait 41 | 69
abnormal sleep behavior 41 | 70
decreased circulating alanine ... 40 | 47
decreased blood urea nitrogen ... 39 | 51
female infertility 39 | 60
abnormal kidney morphology 38 | 65
decreased caudal vertebrae num... 38 | 53
small superior vagus ganglion 38 | 74
decreased circulating total pr... 37 | 49
decreased erythrocyte cell num... 37 | 62
decreased mean corpuscular hem... 37 | 50
edema 37 | 59
abnormal coat-hair pigmentatio... 36 | 64
increased hemoglobin content 36 | 45
decreased circulating alkaline... 35 | 46
increased mean platelet volume 35 | 45
small testis 35 | 58
abnormal bone mineralization 33 | 38
increased leukocyte cell numbe... 33 | 47
abnormal spleen morphology 32 | 55
decreased circulating LDL chol... 32 | 38
increased circulating triglyce... 32 | 42
increased grip strength 32 | 41
increased hematocrit 32 | 46
decreased hematocrit 31 | 46
increased blood urea nitrogen ... 31 | 48
tremors 31 | 39
abnormal cranium morphology 30 | 36
enlarged spleen 29 | 41
abnormal neural tube closure 28 | 46
decreased neutrophil cell numb... 28 | 42
increased erythrocyte cell num... 28 | 39
cardiovascular system phenotyp... 27 | 36
decreased circulating aspartat... 27 | 34
enlarged lymph nodes 27 | 37
increased circulating chloride... 27 | 41
limb grasping 27 | 41
abnormal cornea morphology 26 | 31
abnormal epididymis morphology 26 | 42
abnormal skin morphology 26 | 50

Disease

Carcinoma 11,423 | 11,493
ovarian cancer 5,506 | 8,520
osteosarcoma 5,160 | 7,950
psoriasis 4,188 | 6,694
medulloblastoma, large-cell 4,177 | 6,241
glioblastoma 3,871 | 5,792
atypical teratoid / rhabdoid tumor 3,488 | 5,112
lung cancer 3,248 | 4,740
ependymoma 3,209 | 4,679
group 3 medulloblastoma 2,804 | 4,104
Kidney cancer 2,611 | 2,613
adult high grade glioma 2,546 | 3,801
Breast cancer 2,446 | 3,578
malignant mesothelioma 2,226 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,157 | 3,291
Astrocytoma, Pilocytic 2,107 | 3,081
primitive neuroectodermal tumor 2,097 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,033 | 2,989
lung carcinoma 2,025 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 2,013 | 2,955
oligodendroglioma 1,964 | 2,850
invasive ductal carcinoma 1,946 | 2,951
non-small cell lung cancer 1,901 | 2,890
lung adenocarcinoma 1,752 | 2,716
astrocytic glioma 1,727 | 2,597
Cancer 1,601 | 2,499
pancreatic cancer 1,571 | 2,398
subependymal giant cell astrocytoma 1,533 | 2,287
interstitial cystitis 1,496 | 2,312
Pick disease 1,387 | 1,894
pituitary cancer 1,346 | 1,972
tuberculosis 1,274 | 2,010
group 4 medulloblastoma 1,243 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 1,199 | 1,962
ulcerative colitis 1,184 | 1,819
ductal carcinoma in situ 1,151 | 1,745
cystic fibrosis 1,136 | 1,696
breast carcinoma 1,062 | 1,638
Autosomal recessive predisposition 1,029 | 1,442
colon cancer 1,013 | 1,478
diabetes mellitus 998 | 1,728
adrenocortical carcinoma 955 | 1,428
Schizophrenia 826 | 1,160
juvenile dermatomyositis 814 | 1,187
Rheumatoid arthritis 802 | 1,191
acute quadriplegic myopathy 800 | 1,158
astrocytoma 792 | 1,146
Intellectual disability 785 | 1,016
spina bifida 740 | 1,074
nasopharyngeal carcinoma 711 | 1,058
pediatric high grade glioma 707 | 1,064
primary pancreatic ductal adenocarcinoma 703 | 1,109
Multiple myeloma 697 | 1,332
cutaneous lupus erythematosus 674 | 1,057
dermatomyositis 647 | 966
Melanoma 624 | 711
Atopic dermatitis 613 | 952
Liver cancer 603 | 604
Epilepsy 586 | 792
active Crohn's disease 581 | 922
gastric carcinoma 543 | 807
progressive supranuclear palsy 528 | 676
non primary Sjogren syndrome sicca 512 | 891
Dull intelligence 499 | 645
Low intelligence 499 | 645
Mental Retardation 499 | 645
Mental deficiency 499 | 645
Poor school performance 499 | 645
primary Sjogren syndrome 492 | 735
Alzheimer's disease 485 | 658
acute myeloid leukemia 478 | 783
Bipolar Disorder 476 | 666
medulloblastoma 473 | 720
active ulcerative colitis 472 | 764
Obesity 469 | 678
esophageal adenocarcinoma 462 | 737
Skin cancer 461 | 469
Liver Cirrhosis, Experimental 457 | 769
aldosterone-producing adenoma 454 | 665
Waldenstrons macroglobulinemia 450 | 765
Cognitive delay 447 | 608
Global developmental delay 447 | 608
Mental and motor retardation 447 | 608
Seizures 435 | 596
Short stature 416 | 531
Muscle hypotonia 415 | 571
Duchenne muscular dystrophy 385 | 601
pancreatic carcinoma 382 | 562
chronic rhinosinusitis 381 | 512
Multiple Sclerosis 364 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 359 | 510
Amyotrophic lateral sclerosis 352 | 451
hepatocellular carcinoma 351 | 547
fibroadenoma 350 | 559
Endometriosis 345 | 540
Prostatic Neoplasms 320 | 495
sonic hedgehog group medulloblastoma 317 | 467
posterior fossa group A ependymoma 316 | 468
Down syndrome 312 | 499
Endometrial cancer 309 | 311

Tissue

Endocrine System 10,874 | 18,159
Female tissues 10,493 | 17,400
Digestive Tract 10,449 | 17,369
Skin and soft tissues 10,386 | 17,230
Male tissues 10,349 | 17,142
Blood and immune system 10,172 | 16,909
Nervous System 10,165 | 16,725
Liver and Pancreas 10,140 | 16,750
Urinary Tract 10,138 | 16,678
Respiratory system 9,916 | 16,393
Cardiovascular System 9,270 | 15,192

Target Family

Non-IDG 6,033 | 12,091
Enzyme 2,450 | 4,145
Transcription Factor 940 | 1,400
Kinase 510 | 634
Transporter 358 | 473
oGPCR 319 | 421
GPCR 302 | 408
Ion Channel 269 | 344
Epigenetic 190 | 242
Nuclear Receptor 38 | 48
TF/Epigenetic 36 | 38

Data Source

JensenLab Experiment COSMIC 11,445 | 11,445
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58