Development Level

Tbio 6,980 | 11,445
Tchem 1,319 | 1,598
Tdark 904 | 6,588
Tclin 517 | 613

Collection

RFA-RM-18-021 165 | 328
Kinase: IDG Consortium (Target... 59 | 125
Ion Channel: IDG Consortium (T... 58 | 99
GPCR: IDG Consortium (Targets) 51 | 126
Kinase: IDG Consortium (Comple... 25 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 833 | 979
preweaning lethality, incomple... 423 | 499
embryonic lethality prior to t... 260 | 278
abnormal behavior 258 | 298
embryonic lethality prior to o... 218 | 239
abnormal embryo size 204 | 220
decreased total body fat amoun... 193 | 207
decreased vertical activity 186 | 208
enlarged heart 183 | 210
abnormal bone structure 164 | 187
increased lean body mass 163 | 172
decreased body weight 155 | 161
abnormal heart morphology 138 | 162
decreased bone mineral content 136 | 151
hyperactivity 123 | 148
increased total body fat amoun... 123 | 134
decreased lean body mass 121 | 135
decreased circulating glucose ... 119 | 126
increased circulating alkaline... 119 | 122
hypoactivity 117 | 132
decreased bone mineral density 116 | 126
abnormal seminal vesicle morph... 103 | 114
male infertility 101 | 123
increased startle reflex 99 | 112
embryonic growth retardation 98 | 106
increased bone mineral content 98 | 108
decreased body length 92 | 101
decreased circulating choleste... 90 | 93
decreased grip strength 89 | 116
increased mean corpuscular hem... 89 | 96
increased or absent threshold ... 89 | 101
short tibia 86 | 97
increased mean corpuscular vol... 83 | 92
cataract 81 | 92
prenatal lethality prior to he... 81 | 87
decreased circulating serum al... 79 | 82
decreased circulating insulin ... 74 | 76
decreased prepulse inhibition 74 | 82
abnormal lens morphology 73 | 81
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 72 | 79
increased circulating HDL chol... 71 | 80
increased fasted circulating g... 70 | 76
decreased startle reflex 69 | 75
impaired glucose tolerance 69 | 75
improved glucose tolerance 69 | 79
abnormal retina morphology 68 | 71
increased bone mineral density 66 | 72
increased circulating sodium l... 66 | 71
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 65 | 68
abnormal gait 64 | 69
decreased leukocyte cell numbe... 63 | 73
decreased fasted circulating g... 62 | 65
increased circulating choleste... 62 | 66
increased heart weight 61 | 62
abnormal coat-hair pigmentatio... 59 | 64
abnormal eye morphology 59 | 68
decreased lymphocyte cell numb... 58 | 83
small superior vagus ganglion 58 | 74
abnormal kidney morphology 56 | 65
edema 56 | 59
decreased hemoglobin content 55 | 68
thrombocytopenia 55 | 56
decreased erythrocyte cell num... 53 | 62
abnormal behavioral response t... 52 | 66
female infertility 50 | 60
small testis 48 | 58
decreased blood urea nitrogen ... 47 | 51
abnormal spleen morphology 46 | 55
decreased circulating total pr... 46 | 49
decreased caudal vertebrae num... 45 | 53
decreased circulating alanine ... 45 | 47
decreased mean corpuscular hem... 44 | 50
increased leukocyte cell numbe... 44 | 47
increased monocyte cell number 44 | 63
abnormal neural tube closure 43 | 46
abnormal skin morphology 42 | 50
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
increased circulating chloride... 41 | 41
increased circulating triglyce... 41 | 42
increased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased grip strength 40 | 41
abnormal testis morphology 39 | 43
hydrometra 39 | 53
limb grasping 39 | 41
tremors 39 | 39
abnormal epididymis morphology 38 | 42
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
abnormal cranium morphology 36 | 36
decreased circulating creatini... 36 | 39
decreased hematocrit 36 | 46
increased mean platelet volume 36 | 45
increased neutrophil cell numb... 36 | 46
decreased circulating calcium ... 35 | 36
decreased neutrophil cell numb... 35 | 42
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 6,455 | 11,493
ovarian cancer 4,872 | 8,520
osteosarcoma 4,491 | 7,950
psoriasis 3,960 | 6,694
medulloblastoma, large-cell 3,751 | 6,241
glioblastoma 3,588 | 5,792
atypical teratoid / rhabdoid tumor 3,085 | 5,112
lung cancer 3,029 | 4,740
ependymoma 2,818 | 4,679
group 3 medulloblastoma 2,490 | 4,104
adult high grade glioma 2,340 | 3,801
Breast cancer 2,281 | 3,578
malignant mesothelioma 2,153 | 3,232
Cancer 2,081 | 2,499
Astrocytoma, Pilocytic 2,019 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 1,992 | 3,291
invasive ductal carcinoma 1,934 | 2,951
non-small cell lung cancer 1,921 | 2,890
primitive neuroectodermal tumor 1,878 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 1,870 | 2,955
lung carcinoma 1,868 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 1,866 | 2,989
oligodendroglioma 1,824 | 2,850
lung adenocarcinoma 1,754 | 2,716
Kidney cancer 1,716 | 2,613
pancreatic cancer 1,637 | 2,398
astrocytic glioma 1,572 | 2,597
interstitial cystitis 1,525 | 2,312
subependymal giant cell astrocytoma 1,444 | 2,287
pituitary cancer 1,324 | 1,972
tuberculosis 1,296 | 2,010
ulcerative colitis 1,239 | 1,819
Autosomal recessive predisposition 1,200 | 1,442
ductal carcinoma in situ 1,165 | 1,745
Pick disease 1,147 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 1,146 | 1,962
cystic fibrosis 1,137 | 1,696
breast carcinoma 1,091 | 1,638
group 4 medulloblastoma 1,081 | 1,855
diabetes mellitus 1,021 | 1,728
colon cancer 1,012 | 1,478
Schizophrenia 947 | 1,160
adrenocortical carcinoma 924 | 1,428
Rheumatoid arthritis 790 | 1,191
Intellectual disability 787 | 1,016
astrocytoma 780 | 1,146
primary pancreatic ductal adenocarcinoma 776 | 1,109
juvenile dermatomyositis 766 | 1,187
cutaneous lupus erythematosus 756 | 1,057
Multiple myeloma 735 | 1,332
acute quadriplegic myopathy 731 | 1,158
pediatric high grade glioma 677 | 1,064
spina bifida 649 | 1,074
Epilepsy 641 | 792
dermatomyositis 623 | 966
Atopic dermatitis 620 | 952
nasopharyngeal carcinoma 615 | 1,058
Obesity 579 | 678
active Crohn's disease 574 | 922
Liver Cirrhosis, Experimental 563 | 769
gastric carcinoma 553 | 807
Bipolar Disorder 551 | 666
Dull intelligence 532 | 645
Low intelligence 532 | 645
Mental Retardation 532 | 645
Mental deficiency 532 | 645
Poor school performance 532 | 645
esophageal adenocarcinoma 510 | 737
Seizures 503 | 596
primary Sjogren syndrome 503 | 735
Melanoma 500 | 711
non primary Sjogren syndrome sicca 494 | 891
active ulcerative colitis 491 | 764
Cognitive delay 480 | 608
Global developmental delay 480 | 608
Mental and motor retardation 480 | 608
Alzheimer's disease 476 | 658
Waldenstrons macroglobulinemia 476 | 765
Muscle hypotonia 458 | 571
acute myeloid leukemia 458 | 783
Short stature 452 | 531
Liver cancer 438 | 604
medulloblastoma 435 | 720
aldosterone-producing adenoma 428 | 665
Duchenne muscular dystrophy 422 | 601
Prostatic Neoplasms 403 | 495
progressive supranuclear palsy 391 | 676
Down syndrome 389 | 499
Multiple Sclerosis 389 | 540
Endometriosis 388 | 540
Breast Neoplasms 382 | 445
Kidney disease 375 | 430
Depressive disorder 374 | 409
autosomal dominant Emery-Dreifuss muscular dystrophy 373 | 510
fibroadenoma 372 | 559
Mammary Neoplasms 366 | 425
pancreatic carcinoma 359 | 562
Hypertension 355 | 396
Skin cancer 337 | 469
Neurodegenerative disease 336 | 414

Tissue

Endocrine System 9,482 | 18,159
Digestive Tract 9,263 | 17,369
Female tissues 9,226 | 17,400
Skin and soft tissues 9,186 | 17,230
Male tissues 9,121 | 17,142
Blood and immune system 9,011 | 16,909
Nervous System 8,993 | 16,725
Liver and Pancreas 8,983 | 16,750
Urinary Tract 8,983 | 16,678
Respiratory system 8,790 | 16,393
Cardiovascular System 8,205 | 15,192

Target Family

Non-IDG 5,100 | 12,091
Enzyme 2,234 | 4,145
Transcription Factor 776 | 1,400
Kinase 486 | 634
GPCR 304 | 408
Transporter 273 | 473
Ion Channel 271 | 344
Epigenetic 193 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 28 | 38
oGPCR 7 | 421

Data Source

JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267