Development Level

Tbio 6,793 | 11,178
Tchem 1,513 | 1,885
Tdark 898 | 6,569
Tclin 516 | 612

Collection

Kinase: IDG Consortium (Target... 59 | 125
Ion Channel: IDG Consortium (T... 58 | 99
GPCR: IDG Consortium (Targets) 51 | 126
Kinase: IDG Consortium (Comple... 25 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 833 | 979
preweaning lethality, incomple... 423 | 499
embryonic lethality prior to t... 260 | 278
abnormal behavior 258 | 298
embryonic lethality prior to o... 218 | 239
abnormal embryo size 204 | 220
decreased total body fat amoun... 193 | 207
decreased vertical activity 186 | 208
enlarged heart 183 | 210
abnormal bone structure 164 | 187
increased lean body mass 163 | 172
decreased body weight 155 | 161
abnormal heart morphology 138 | 162
decreased bone mineral content 136 | 151
hyperactivity 123 | 148
increased total body fat amoun... 123 | 134
decreased lean body mass 121 | 135
decreased circulating glucose ... 119 | 126
increased circulating alkaline... 119 | 122
hypoactivity 117 | 132
decreased bone mineral density 116 | 126
abnormal seminal vesicle morph... 103 | 114
male infertility 101 | 123
increased startle reflex 99 | 112
embryonic growth retardation 98 | 106
increased bone mineral content 98 | 108
decreased body length 92 | 101
decreased circulating choleste... 90 | 93
decreased grip strength 89 | 116
increased mean corpuscular hem... 89 | 96
increased or absent threshold ... 89 | 101
short tibia 86 | 97
increased mean corpuscular vol... 83 | 92
cataract 81 | 92
prenatal lethality prior to he... 81 | 87
decreased circulating serum al... 79 | 82
decreased circulating insulin ... 74 | 76
decreased prepulse inhibition 74 | 82
abnormal lens morphology 73 | 81
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 72 | 79
increased circulating HDL chol... 71 | 80
increased fasted circulating g... 70 | 76
decreased startle reflex 69 | 75
impaired glucose tolerance 69 | 75
improved glucose tolerance 69 | 79
abnormal retina morphology 68 | 71
increased bone mineral density 66 | 72
increased circulating sodium l... 66 | 71
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 65 | 68
abnormal gait 64 | 69
decreased leukocyte cell numbe... 63 | 73
decreased fasted circulating g... 62 | 65
increased circulating choleste... 62 | 66
increased heart weight 61 | 62
abnormal coat-hair pigmentatio... 59 | 64
abnormal eye morphology 59 | 68
decreased lymphocyte cell numb... 58 | 83
small superior vagus ganglion 58 | 74
abnormal kidney morphology 56 | 65
edema 56 | 59
decreased hemoglobin content 55 | 68
thrombocytopenia 55 | 56
decreased erythrocyte cell num... 53 | 62
abnormal behavioral response t... 52 | 66
female infertility 50 | 60
small testis 48 | 58
decreased blood urea nitrogen ... 47 | 51
abnormal spleen morphology 46 | 55
decreased circulating total pr... 46 | 49
decreased caudal vertebrae num... 45 | 53
decreased circulating alanine ... 45 | 47
decreased mean corpuscular hem... 44 | 50
increased leukocyte cell numbe... 44 | 47
increased monocyte cell number 44 | 63
abnormal neural tube closure 43 | 46
abnormal skin morphology 42 | 50
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
increased circulating chloride... 41 | 41
increased circulating triglyce... 41 | 42
increased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased grip strength 40 | 41
abnormal testis morphology 39 | 43
hydrometra 39 | 53
limb grasping 39 | 41
tremors 39 | 39
abnormal epididymis morphology 38 | 42
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
abnormal cranium morphology 36 | 36
decreased circulating creatini... 36 | 39
decreased hematocrit 36 | 46
increased mean platelet volume 36 | 45
increased neutrophil cell numb... 36 | 46
decreased circulating calcium ... 35 | 36
decreased neutrophil cell numb... 35 | 42
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 6,257 | 11,192
ovarian cancer 4,720 | 8,297
osteosarcoma 4,374 | 7,766
psoriasis 3,837 | 6,514
medulloblastoma, large-cell 3,639 | 6,086
glioblastoma 3,481 | 5,635
atypical teratoid / rhabdoid tumor 2,984 | 4,971
lung cancer 2,939 | 4,607
ependymoma 2,740 | 4,559
group 3 medulloblastoma 2,422 | 4,002
adult high grade glioma 2,275 | 3,701
Breast cancer 2,203 | 3,469
malignant mesothelioma 2,079 | 3,135
Cancer 1,981 | 2,388
Astrocytoma, Pilocytic 1,966 | 3,006
intraductal papillary-mucinous neoplasm (IPMN) 1,929 | 3,204
invasive ductal carcinoma 1,871 | 2,867
non-small cell lung cancer 1,849 | 2,799
primitive neuroectodermal tumor 1,823 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 1,813 | 2,872
intraductal papillary-mucinous carcinoma (IPMC) 1,810 | 2,902
lung carcinoma 1,807 | 2,755
oligodendroglioma 1,772 | 2,768
lung adenocarcinoma 1,691 | 2,627
Kidney cancer 1,667 | 2,548
pancreatic cancer 1,574 | 2,322
astrocytic glioma 1,526 | 2,530
interstitial cystitis 1,472 | 2,237
subependymal giant cell astrocytoma 1,401 | 2,230
pituitary cancer 1,286 | 1,915
tuberculosis 1,264 | 1,963
ulcerative colitis 1,197 | 1,765
Autosomal recessive predisposition 1,166 | 1,407
Pick disease 1,120 | 1,856
ductal carcinoma in situ 1,117 | 1,686
pancreatic ductal adenocarcinoma liver metastasis 1,114 | 1,911
cystic fibrosis 1,089 | 1,629
breast carcinoma 1,050 | 1,589
group 4 medulloblastoma 1,047 | 1,806
diabetes mellitus 988 | 1,683
colon cancer 978 | 1,428
Schizophrenia 925 | 1,136
adrenocortical carcinoma 890 | 1,385
Intellectual disability 770 | 998
Rheumatoid arthritis 764 | 1,156
astrocytoma 754 | 1,113
primary pancreatic ductal adenocarcinoma 744 | 1,071
juvenile dermatomyositis 741 | 1,147
cutaneous lupus erythematosus 732 | 1,016
Multiple myeloma 717 | 1,296
acute quadriplegic myopathy 712 | 1,133
pediatric high grade glioma 653 | 1,035
spina bifida 635 | 1,053
Epilepsy 625 | 775
dermatomyositis 607 | 941
Atopic dermatitis 593 | 915
nasopharyngeal carcinoma 589 | 1,024
Obesity 559 | 655
active Crohn's disease 549 | 882
gastric carcinoma 533 | 781
Bipolar Disorder 532 | 646
Liver Cirrhosis, Experimental 529 | 733
Dull intelligence 522 | 634
Low intelligence 522 | 634
Mental Retardation 522 | 634
Mental deficiency 522 | 634
Poor school performance 522 | 634
Seizures 492 | 584
primary Sjogren syndrome 491 | 710
Melanoma 487 | 689
esophageal adenocarcinoma 484 | 696
non primary Sjogren syndrome sicca 476 | 861
active ulcerative colitis 474 | 736
Cognitive delay 469 | 596
Global developmental delay 469 | 596
Mental and motor retardation 469 | 596
Waldenstrons macroglobulinemia 467 | 742
Alzheimer's disease 462 | 640
Muscle hypotonia 449 | 562
acute myeloid leukemia 442 | 760
Short stature 436 | 514
Liver cancer 426 | 589
medulloblastoma 424 | 702
aldosterone-producing adenoma 412 | 646
Duchenne muscular dystrophy 410 | 587
Prostatic Neoplasms 383 | 472
Multiple Sclerosis 377 | 527
progressive supranuclear palsy 376 | 656
Down syndrome 371 | 480
Endometriosis 371 | 521
Depressive disorder 366 | 401
Breast Neoplasms 363 | 423
Kidney disease 356 | 411
autosomal dominant Emery-Dreifuss muscular dystrophy 356 | 492
fibroadenoma 355 | 538
pancreatic carcinoma 354 | 555
Mammary Neoplasms 347 | 403
Hypertension 332 | 372
Skin cancer 328 | 451
hepatocellular carcinoma 327 | 536

Tissue

Endocrine System 9,482 | 18,159
Digestive Tract 9,263 | 17,369
Female tissues 9,226 | 17,400
Skin and soft tissues 9,186 | 17,230
Male tissues 9,121 | 17,142
Blood and immune system 9,011 | 16,909
Nervous System 8,993 | 16,725
Liver and Pancreas 8,983 | 16,750
Urinary Tract 8,983 | 16,678
Respiratory system 8,790 | 16,393
Cardiovascular System 8,205 | 15,192

Target Family

Non-IDG 5,100 | 12,091
Enzyme 2,234 | 4,145
Transcription Factor 776 | 1,400
Kinase 486 | 634
GPCR 304 | 408
Transporter 273 | 473
Ion Channel 271 | 344
Epigenetic 193 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 28 | 38
oGPCR 7 | 421

Data Source

JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254
Probable gluconokinase IDNK Tbio Kinase -1.00330 9.91 94
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
Somatostatin receptor type 4 SSTR4 Tclin GPCR -1.72615 44.8 147
LIM homeobox transcription factor 1-alpha LMX1A Tbio Transcription Factor -1.82498 66.0 175