Development Level

Tbio 6,387 | 10,625
Tchem 1,495 | 1,890
Tdark 998 | 7,003
Tclin 507 | 602

Collection

Eligible Ion Channel Proteins 65 | 117
Eligible Kinase Proteins 62 | 134
Eligible non-olfactory GPCR Proteins 53 | 145

IMPC Term

preweaning lethality, complete... 623 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 218 | 226
decreased lean body mass 189 | 195
decreased total body fat amoun... 182 | 186
embryonic lethality prior to t... 182 | 187
decreased body weight 168 | 174
decreased bone mineral content 153 | 157
embryonic lethality prior to o... 144 | 148
abnormal bone structure 128 | 131
increased or absent threshold ... 127 | 128
decreased bone mineral density 122 | 126
decreased grip strength 121 | 123
increased circulating alkaline... 119 | 119
decreased circulating glucose ... 118 | 121
abnormal embryo size 110 | 112
enlarged heart 110 | 111
decreased body length 104 | 108
increased lean body mass 104 | 107
hyperactivity 103 | 108
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 92 | 93
increased mean corpuscular vol... 90 | 91
hypoactivity 87 | 89
increased bone mineral content 87 | 92
decreased circulating choleste... 85 | 85
increased grip strength 83 | 83
decreased circulating triglyce... 81 | 83
short tibia 80 | 82
decreased circulating serum al... 77 | 79
decreased circulating HDL chol... 76 | 77
abnormal lens morphology 72 | 73
decreased circulating insulin ... 72 | 75
increased circulating sodium l... 70 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 62 | 63
decreased lumbar vertebrae num... 62 | 62
increased circulating HDL chol... 62 | 63
increased sacral vertebrae num... 62 | 62
male infertility 61 | 62
abnormal retinal pigmentation 60 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
abnormal bone mineralization 54 | 55
improved glucose tolerance 54 | 56
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 52 | 53
increased circulating choleste... 52 | 53
abnormal behavioral response t... 51 | 52
abnormal coat/hair pigmentatio... 51 | 54
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased leukocyte cell numbe... 51 | 54
decreased prepulse inhibition 51 | 52
impaired glucose tolerance 51 | 52
increased bone mineral density 51 | 52
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 47 | 49
decreased fasted circulating g... 47 | 49
decreased startle reflex 47 | 48
thrombocytopenia 46 | 46
abnormal seminal vesicle morph... 45 | 47
increased hemoglobin content 44 | 45
increased blood urea nitrogen ... 43 | 44
increased exploration in new e... 43 | 56
decreased heart weight 42 | 44
increased circulating chloride... 42 | 43
decreased circulating total pr... 41 | 41
decreased erythrocyte cell num... 41 | 43
decreased circulating alkaline... 40 | 41
increased body weight 40 | 42
increased rib number 40 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 37 | 38
decreased circulating LDL chol... 37 | 37
decreased eosinophil cell numb... 37 | 41
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
increased startle reflex 37 | 38
abnormal neural tube closure 36 | 37
abnormal spleen morphology 36 | 36
decreased neutrophil cell numb... 36 | 37
small testis 36 | 37
increased hematocrit 35 | 36
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
cardiovascular system phenotyp... 33 | 35
abnormal cranium morphology 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
decreased circulating calcium ... 31 | 33
decreased circulating chloride... 31 | 32
decreased circulating creatini... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31
abnormal epididymis morphology 30 | 31
decreased T cell number 30 | 31

Disease

ovarian cancer 4,702 | 8,492
osteosarcoma 4,335 | 7,933
psoriasis 3,847 | 6,685
medulloblastoma, large-cell 3,612 | 6,234
glioblastoma 3,325 | 5,572
lung cancer 2,818 | 4,473
atypical teratoid / rhabdoid tumor 2,527 | 4,369
malignant mesothelioma 2,032 | 3,163
pilocytic astrocytoma 1,968 | 3,086
Cancer 1,939 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 1,935 | 3,289
Breast cancer 1,908 | 3,099
invasive ductal carcinoma 1,872 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 1,822 | 2,956
lung carcinoma 1,816 | 2,844
primitive neuroectodermal tumor 1,810 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 1,807 | 2,988
non-small cell lung cancer 1,802 | 2,798
oligodendroglioma 1,752 | 2,849
pediatric high grade glioma 1,710 | 2,712
lung adenocarcinoma 1,700 | 2,714
pancreatic cancer 1,522 | 2,300
interstitial cystitis 1,484 | 2,299
ependymoma 1,432 | 2,514
subependymal giant cell astrocytoma 1,417 | 2,287
Carcinoma 1,404 | 2,147
ulcerative colitis 1,391 | 2,087
pituitary cancer 1,294 | 1,972
astrocytic glioma 1,261 | 2,241
group 3 medulloblastoma 1,240 | 2,254
adult high grade glioma 1,219 | 2,148
ductal carcinoma in situ 1,130 | 1,745
group 4 medulloblastoma 1,120 | 1,875
Pick disease 1,105 | 1,893
cystic fibrosis 1,085 | 1,670
breast carcinoma 1,039 | 1,614
astrocytoma 1,012 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 996 | 1,795
colon cancer 983 | 1,475
tuberculosis 978 | 1,563
posterior fossa group A ependymoma 975 | 1,511
diabetes mellitus 958 | 1,663
medulloblastoma 891 | 1,524
adrenocortical carcinoma 890 | 1,427
sonic hedgehog group medulloblastoma 868 | 1,482
primary pancreatic ductal adenocarcinoma 863 | 1,271
posterior fossa group B ependymoma 824 | 1,530
Rheumatoid Arthritis 749 | 1,171
juvenile dermatomyositis 746 | 1,189
cutaneous lupus erythematosus 737 | 1,056
acute quadriplegic myopathy 709 | 1,157
Multiple myeloma 708 | 1,328
atypical teratoid/rhabdoid tumor 668 | 1,095
spina bifida 623 | 1,064
dermatomyositis 603 | 967
Atopic dermatitis 597 | 944
nasopharyngeal carcinoma 590 | 1,056
gastric carcinoma 567 | 832
active Crohn's disease 551 | 918
primary Sjogren syndrome 524 | 789
Obesity 498 | 616
esophageal adenocarcinoma 495 | 737
Alzheimer's disease 461 | 644
Waldenstrons macroglobulinemia 461 | 765
acute myeloid leukemia 446 | 785
non primary Sjogren syndrome sicca 433 | 840
Intellectual disability 414 | 573
aldosterone-producing adenoma 414 | 664
Duchenne muscular dystrophy 411 | 602
Down syndrome 406 | 548
Schizophrenia 384 | 503
Prostatic Neoplasms 380 | 471
Endometriosis 377 | 535
progressive supranuclear palsy 372 | 674
autosomal dominant Emery-Dreifuss muscular dystrophy 358 | 499
fibroadenoma 358 | 557
Multiple Sclerosis 356 | 498
pancreatic carcinoma 355 | 567
Kidney disease 353 | 397
tuberculosis and treatment for 6 months 351 | 686
Mammary Neoplasms 350 | 410
hepatocellular carcinoma 333 | 550
mucosa-associated lymphoid tissue lymphoma 315 | 480
IGA Glomerulonephritis 313 | 454
Neurodegenerative disease 313 | 383
Amyotrophic Lateral Sclerosis 308 | 432
Asthma 292 | 349
chronic rhinosinusitis 292 | 512
Epilepsy 287 | 346
active ulcerative colitis 285 | 477
non-small cell lung carcinoma 276 | 413
Parkinson's disease 270 | 364
Autistic Disorder 261 | 320
gastric cancer 260 | 436
Hypertension 257 | 293
Vascular disease 248 | 281
Atherosclerosis 247 | 275
inflammatory breast cancer 239 | 404
Polycystic Ovary Syndrome 235 | 335
Heart disease 230 | 279

Tissue

Nervous System 9,281 | 18,561
Female tissues 9,269 | 18,647
Endocrine System 9,268 | 18,512
Digestive Tract 9,258 | 18,473
Urinary Tract 9,226 | 18,444
Liver and Pancreas 9,175 | 18,136
Skin and soft tissues 9,147 | 18,115
Blood and immune system 9,124 | 17,995
Cardiovascular System 9,119 | 17,958
Male tissues 9,119 | 17,969
Respiratory system 8,967 | 17,484

Target Family

Non-IDG 4,902 | 11,969
Enzyme 2,147 | 4,146
Transcription Factor 765 | 1,400
Kinase 473 | 634
GPCR 300 | 408
Ion Channel 265 | 341
Transporter 261 | 473
Epigenetic 191 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 28 | 38
oGPCR 7 | 421

Data Source

JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Protein BRICK1 BRK1 Tbio Non-IDG -1.42109 29.2 53
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.01 82