Development Level

Tbio 10,837 | 11,445
Tdark 4,447 | 6,588
Tchem 1,543 | 1,598
Tclin 575 | 613

Collection

RFA-RM-18-021 310 | 328
Kinase: IDG Consortium (Target... 122 | 125
GPCR: IDG Consortium (Targets) 112 | 126
Ion Channel: IDG Consortium (T... 95 | 99
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 972 | 979
preweaning lethality, incomple... 490 | 499
abnormal behavior 294 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 235 | 239
abnormal embryo size 218 | 220
decreased total body fat amoun... 206 | 207
enlarged heart 205 | 210
decreased vertical activity 204 | 208
abnormal bone structure 182 | 187
increased lean body mass 170 | 172
abnormal heart morphology 159 | 162
decreased body weight 159 | 161
decreased bone mineral content 150 | 151
hyperactivity 142 | 148
decreased lean body mass 134 | 135
increased total body fat amoun... 132 | 134
hypoactivity 128 | 132
decreased circulating glucose ... 126 | 126
decreased bone mineral density 125 | 126
increased circulating alkaline... 121 | 122
male infertility 120 | 123
decreased grip strength 114 | 116
abnormal seminal vesicle morph... 113 | 114
increased startle reflex 110 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 96 | 97
increased mean corpuscular hem... 94 | 96
cataract 91 | 92
decreased circulating choleste... 91 | 93
increased mean corpuscular vol... 89 | 92
prenatal lethality prior to he... 87 | 87
decreased circulating serum al... 82 | 82
decreased lymphocyte cell numb... 81 | 83
decreased prepulse inhibition 81 | 82
abnormal lens morphology 80 | 81
improved glucose tolerance 79 | 79
increased circulating HDL chol... 79 | 80
decreased circulating triglyce... 78 | 79
decreased mean corpuscular vol... 76 | 79
decreased circulating insulin ... 75 | 76
decreased startle reflex 75 | 75
increased fasted circulating g... 75 | 76
small superior vagus ganglion 74 | 74
impaired glucose tolerance 73 | 75
decreased leukocyte cell numbe... 72 | 73
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal retina morphology 69 | 71
abnormal sleep behavior 69 | 70
abnormal gait 68 | 69
abnormal eye morphology 67 | 68
decreased circulating HDL chol... 66 | 68
decreased hemoglobin content 66 | 68
increased circulating choleste... 66 | 66
abnormal behavioral response t... 65 | 66
abnormal coat-hair pigmentatio... 63 | 64
decreased fasted circulating g... 63 | 65
abnormal kidney morphology 61 | 65
decreased erythrocyte cell num... 61 | 62
increased heart weight 61 | 62
increased monocyte cell number 61 | 63
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
hydrometra 53 | 53
abnormal spleen morphology 52 | 55
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased caudal vertebrae num... 50 | 53
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
decreased mean corpuscular hem... 47 | 50
decreased circulating alkaline... 46 | 46
increased neutrophil cell numb... 46 | 46
abnormal neural tube closure 45 | 46
increased leukocyte cell numbe... 45 | 47
decreased hematocrit 44 | 46
abnormal testis morphology 43 | 43
increased hematocrit 43 | 46
increased hemoglobin content 43 | 45
decreased neutrophil cell numb... 42 | 42
increased mean platelet volume 42 | 45
abnormal epididymis morphology 41 | 42
decreased red blood cell distr... 41 | 41
increased circulating chloride... 41 | 41
increased circulating triglyce... 41 | 42
limb grasping 41 | 41
increased grip strength 40 | 41
decreased circulating creatini... 39 | 39
abnormal bone mineralization 38 | 38
increased circulating creatini... 38 | 38
increased erythrocyte cell num... 38 | 39
prolonged QT interval 38 | 38
tremors 38 | 39

Disease

Carcinoma 10,757 | 11,493
ovarian cancer 8,171 | 8,520
osteosarcoma 7,488 | 7,950
psoriasis 6,174 | 6,694
medulloblastoma, large-cell 5,974 | 6,241
glioblastoma 5,586 | 5,792
atypical teratoid / rhabdoid tumor 4,920 | 5,112
ependymoma 4,520 | 4,679
lung cancer 4,495 | 4,740
group 3 medulloblastoma 3,943 | 4,104
adult high grade glioma 3,654 | 3,801
Breast cancer 3,434 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,145 | 3,291
malignant mesothelioma 3,100 | 3,232
Astrocytoma, Pilocytic 2,985 | 3,081
primitive neuroectodermal tumor 2,922 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,869 | 2,989
invasive ductal carcinoma 2,857 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,842 | 2,955
non-small cell lung cancer 2,783 | 2,890
oligodendroglioma 2,752 | 2,850
lung carcinoma 2,713 | 2,843
lung adenocarcinoma 2,597 | 2,716
astrocytic glioma 2,497 | 2,597
Kidney cancer 2,484 | 2,613
Cancer 2,316 | 2,499
pancreatic cancer 2,299 | 2,398
subependymal giant cell astrocytoma 2,215 | 2,287
interstitial cystitis 2,196 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,899 | 1,962
pituitary cancer 1,894 | 1,972
tuberculosis 1,894 | 2,010
Pick disease 1,827 | 1,894
group 4 medulloblastoma 1,777 | 1,855
ulcerative colitis 1,734 | 1,819
ductal carcinoma in situ 1,698 | 1,745
cystic fibrosis 1,616 | 1,696
breast carcinoma 1,576 | 1,638
diabetes mellitus 1,495 | 1,728
Autosomal recessive predisposition 1,406 | 1,442
colon cancer 1,401 | 1,478
adrenocortical carcinoma 1,368 | 1,428
Multiple myeloma 1,293 | 1,332
juvenile dermatomyositis 1,144 | 1,187
acute quadriplegic myopathy 1,120 | 1,158
astrocytoma 1,110 | 1,146
Schizophrenia 1,108 | 1,160
Rheumatoid arthritis 1,105 | 1,191
primary pancreatic ductal adenocarcinoma 1,076 | 1,109
spina bifida 1,033 | 1,074
pediatric high grade glioma 1,023 | 1,064
nasopharyngeal carcinoma 1,009 | 1,058
Intellectual disability 992 | 1,016
cutaneous lupus erythematosus 984 | 1,057
dermatomyositis 908 | 966
Atopic dermatitis 900 | 952
active Crohn's disease 867 | 922
non primary Sjogren syndrome sicca 854 | 891
gastric carcinoma 779 | 807
Epilepsy 777 | 792
acute myeloid leukemia 754 | 783
Liver Cirrhosis, Experimental 752 | 769
Waldenstrons macroglobulinemia 748 | 765
active ulcerative colitis 727 | 764
esophageal adenocarcinoma 703 | 737
primary Sjogren syndrome 693 | 735
medulloblastoma 690 | 720
Melanoma 676 | 711
Obesity 659 | 678
aldosterone-producing adenoma 649 | 665
progressive supranuclear palsy 644 | 676
Bipolar Disorder 643 | 666
Dull intelligence 631 | 645
Low intelligence 631 | 645
Mental Retardation 631 | 645
Mental deficiency 631 | 645
Poor school performance 631 | 645
Alzheimer's disease 628 | 658
Cognitive delay 600 | 608
Global developmental delay 600 | 608
Mental and motor retardation 600 | 608
Seizures 590 | 596
Duchenne muscular dystrophy 587 | 601
Liver cancer 569 | 604
Muscle hypotonia 567 | 571
fibroadenoma 542 | 559
pancreatic carcinoma 535 | 562
Short stature 516 | 531
Endometriosis 513 | 540
hepatocellular carcinoma 510 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 510
chronic rhinosinusitis 491 | 512
Down syndrome 481 | 499
Multiple Sclerosis 481 | 540
Prostatic Neoplasms 477 | 495
sonic hedgehog group medulloblastoma 451 | 467
posterior fossa group A ependymoma 450 | 468
Skin cancer 449 | 469
mucosa-associated lymphoid tissue lymphoma 445 | 484
Amyotrophic lateral sclerosis 437 | 451

Tissue

Endocrine System 16,771 | 18,159
Female tissues 16,201 | 17,400
Digestive Tract 16,199 | 17,369
Skin and soft tissues 16,075 | 17,230
Male tissues 16,004 | 17,142
Blood and immune system 15,789 | 16,909
Nervous System 15,701 | 16,725
Liver and Pancreas 15,678 | 16,750
Urinary Tract 15,651 | 16,678
Respiratory system 15,362 | 16,393
Cardiovascular System 14,332 | 15,192

Target Family

Non-IDG 9,925 | 12,091
Enzyme 3,823 | 4,145
Transcription Factor 1,228 | 1,400
Kinase 616 | 634
Transporter 456 | 473
GPCR 379 | 408
Ion Channel 337 | 344
oGPCR 317 | 421
Epigenetic 236 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 37 | 38

Data Source

Inparanoid 17,402 | 17,402
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39