Development Level

Tbio 1,728 | 10,625
Tdark 482 | 7,003
Tchem 361 | 1,890
Tclin 93 | 602

Collection

Eligible Kinase Proteins 22 | 134
Eligible non-olfactory GPCR Proteins 16 | 145
Eligible Ion Channel Proteins 13 | 117

IMPC Term

preweaning lethality, complete... 633 | 633
preweaning lethality, incomple... 260 | 260
abnormal behavior 226 | 226
decreased lean body mass 195 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 186 | 186
decreased body weight 174 | 174
decreased bone mineral content 157 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 131 | 131
increased or absent threshold ... 128 | 128
decreased bone mineral density 126 | 126
decreased grip strength 123 | 123
decreased circulating glucose ... 121 | 121
increased circulating alkaline... 119 | 119
abnormal embryo size 112 | 112
enlarged heart 111 | 111
decreased body length 108 | 108
hyperactivity 108 | 108
increased lean body mass 107 | 107
abnormal retina morphology 100 | 100
increased mean corpuscular hem... 93 | 93
increased bone mineral content 92 | 92
increased mean corpuscular vol... 91 | 91
hypoactivity 89 | 89
decreased circulating choleste... 85 | 85
decreased circulating triglyce... 83 | 83
increased grip strength 83 | 83
short tibia 82 | 82
decreased circulating serum al... 79 | 79
decreased circulating HDL chol... 77 | 77
decreased circulating insulin ... 75 | 75
abnormal lens morphology 73 | 73
increased circulating sodium l... 71 | 71
increased fasted circulating g... 68 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 63 | 63
increased circulating HDL chol... 63 | 63
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
male infertility 62 | 62
abnormal retinal pigmentation 61 | 61
decreased rib number 59 | 59
increased total body fat amoun... 57 | 57
improved glucose tolerance 56 | 56
increased exploration in new e... 56 | 56
abnormal bone mineralization 55 | 55
abnormal coat/hair pigmentatio... 54 | 54
decreased leukocyte cell numbe... 54 | 54
decreased circulating alanine ... 53 | 53
decreased hemoglobin content 53 | 53
increased circulating choleste... 53 | 53
abnormal behavioral response t... 52 | 52
decreased prepulse inhibition 52 | 52
impaired glucose tolerance 52 | 52
increased bone mineral density 52 | 52
abnormal gait 51 | 51
abnormal heart morphology 51 | 51
decreased mean corpuscular vol... 50 | 50
decreased caudal vertebrae num... 49 | 49
decreased fasted circulating g... 49 | 49
decreased startle reflex 48 | 48
abnormal seminal vesicle morph... 47 | 47
thrombocytopenia 46 | 46
increased hemoglobin content 45 | 45
decreased heart weight 44 | 44
increased blood urea nitrogen ... 44 | 44
decreased erythrocyte cell num... 43 | 43
increased circulating chloride... 43 | 43
increased body weight 42 | 42
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
decreased eosinophil cell numb... 41 | 41
increased rib number 41 | 41
decreased circulating free fat... 39 | 39
abnormal eye morphology 38 | 38
increased startle reflex 38 | 38
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased neutrophil cell numb... 37 | 37
increased heart weight 37 | 37
increased leukocyte cell numbe... 37 | 37
small testis 37 | 37
abnormal spleen morphology 36 | 36
increased hematocrit 36 | 36
cardiovascular system phenotyp... 35 | 35
limb grasping 35 | 35
decreased mean corpuscular hem... 34 | 34
female infertility 34 | 34
tremors 34 | 34
decreased circulating calcium ... 33 | 33
abnormal cranium morphology 32 | 32
decreased circulating chloride... 32 | 32
decreased threshold for audito... 32 | 32
increased circulating calcium ... 32 | 32
abnormal epididymis morphology 31 | 31
decreased T cell number 31 | 31
decreased blood urea nitrogen ... 31 | 31
decreased circulating fructosa... 31 | 31
increased circulating potassiu... 31 | 31

Disease

ovarian cancer 1,389 | 8,492
osteosarcoma 1,257 | 7,933
medulloblastoma, large-cell 1,032 | 6,234
psoriasis 1,009 | 6,685
glioblastoma 939 | 5,572
lung cancer 756 | 4,473
atypical teratoid / rhabdoid tumor 747 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 563 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 534 | 2,956
malignant mesothelioma 524 | 3,163
Breast cancer 517 | 3,099
pilocytic astrocytoma 512 | 3,086
primitive neuroectodermal tumor 511 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 499 | 2,988
non-small cell lung cancer 499 | 2,798
invasive ductal carcinoma 498 | 2,950
oligodendroglioma 471 | 2,849
lung carcinoma 459 | 2,844
pediatric high grade glioma 458 | 2,712
lung adenocarcinoma 441 | 2,714
Cancer 418 | 2,346
pancreatic cancer 403 | 2,300
ependymoma 391 | 2,514
subependymal giant cell astrocytoma 390 | 2,287
interstitial cystitis 362 | 2,299
group 3 medulloblastoma 360 | 2,254
ulcerative colitis 356 | 2,087
astrocytic glioma 353 | 2,241
Pick disease 344 | 1,893
pituitary cancer 337 | 1,972
Carcinoma 335 | 2,147
adult high grade glioma 335 | 2,148
group 4 medulloblastoma 313 | 1,875
ductal carcinoma in situ 302 | 1,745
breast carcinoma 300 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 299 | 1,795
adrenocortical carcinoma 285 | 1,427
astrocytoma 268 | 1,493
tuberculosis 266 | 1,563
medulloblastoma 258 | 1,524
cystic fibrosis 252 | 1,670
colon cancer 246 | 1,475
posterior fossa group A ependymoma 243 | 1,511
diabetes mellitus 239 | 1,663
posterior fossa group B ependymoma 236 | 1,530
sonic hedgehog group medulloblastoma 233 | 1,482
primary pancreatic ductal adenocarcinoma 222 | 1,271
juvenile dermatomyositis 204 | 1,189
Multiple myeloma 200 | 1,328
Rheumatoid Arthritis 198 | 1,171
spina bifida 192 | 1,064
atypical teratoid/rhabdoid tumor 181 | 1,095
acute quadriplegic myopathy 177 | 1,157
cutaneous lupus erythematosus 170 | 1,056
dermatomyositis 159 | 967
Atopic dermatitis 157 | 944
nasopharyngeal carcinoma 143 | 1,056
acute myeloid leukemia 140 | 785
esophageal adenocarcinoma 140 | 737
gastric carcinoma 136 | 832
active Crohn's disease 135 | 918
Alzheimer's disease 134 | 644
non primary Sjogren syndrome sicca 125 | 840
primary Sjogren syndrome 125 | 789
Obesity 123 | 616
progressive supranuclear palsy 122 | 674
Waldenstrons macroglobulinemia 119 | 765
Down syndrome 117 | 548
Intellectual disability 116 | 573
aldosterone-producing adenoma 110 | 664
tuberculosis and treatment for 6 months 110 | 686
fibroadenoma 103 | 557
Neurodegenerative disease 101 | 383
pancreatic carcinoma 100 | 567
Duchenne muscular dystrophy 98 | 602
Schizophrenia 95 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 94 | 499
Mammary Neoplasms 90 | 410
hepatocellular carcinoma 89 | 550
Prostatic Neoplasms 88 | 471
Endometriosis 84 | 535
Parkinson's disease 82 | 364
mucosa-associated lymphoid tissue lymphoma 81 | 480
IGA Glomerulonephritis 80 | 454
chronic rhinosinusitis 77 | 512
Multiple Sclerosis 74 | 498
Epilepsy 71 | 346
gastric cancer 71 | 436
Kidney disease 70 | 397
Amyotrophic Lateral Sclerosis 68 | 432
active ulcerative colitis 67 | 477
hereditary spastic paraplegia 66 | 313
inflammatory breast cancer 66 | 404
Vascular disease 65 | 281
non-small cell lung carcinoma 61 | 413
Polycystic Ovary Syndrome 60 | 335
glioblastoma multiforme 59 | 347
Acquired metabolic disease 57 | 267
Peripheral Neuropathy 56 | 303
Autistic Disorder 54 | 320

Tissue

Nervous System 2,645 | 18,561
Digestive Tract 2,640 | 18,473
Endocrine System 2,638 | 18,512
Female tissues 2,637 | 18,647
Urinary Tract 2,631 | 18,444
Liver and Pancreas 2,626 | 18,136
Blood and immune system 2,618 | 17,995
Cardiovascular System 2,618 | 17,958
Male tissues 2,615 | 17,969
Skin and soft tissues 2,608 | 18,115
Respiratory system 2,582 | 17,484

Target Family

Non-IDG 1,430 | 11,969
Enzyme 704 | 4,146
Transcription Factor 128 | 1,400
Kinase 115 | 634
Transporter 79 | 473
Epigenetic 77 | 242
GPCR 61 | 408
Ion Channel 49 | 341
Nuclear Receptor 11 | 48
TF/Epigenetic 10 | 38

Data Source

IMPC 2,664 | 2,664
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Protein 16,258 | 16,258
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 Tbio Kinase -1.47950 28.8 495
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 Tbio Enzyme -2.08075 121.5 75
Fermitin family homolog 3 FERMT3 Tbio Non-IDG -1.81454 71.6 125
Lateral signaling target protein 2 homolog ZFYVE28 Tbio Non-IDG 0.38 0.33 63
Tyrosine-protein kinase BAZ1B BAZ1B Tbio Epigenetic -1.42830 30.5 140
Chromosome transmission fidelity protein 18 homolog CHTF18 Tbio Non-IDG -1.50198 33.7 113
Small kinetochore-associated protein KNSTRN Tbio Non-IDG -1.24054 16.5 27
Palmitoyltransferase ZDHHC2 ZDHHC2 Tbio Enzyme -1.85412 69.1 64