Development Level

Tbio 2,328 | 11,178
Tdark 549 | 6,569
Tchem 476 | 1,885
Tclin 132 | 612

Collection

Kinase: IDG Consortium (Target... 38 | 125
GPCR: IDG Consortium (Targets) 19 | 126
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Complete... 7 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 2,217 | 11,192
ovarian cancer 1,782 | 8,297
osteosarcoma 1,604 | 7,766
medulloblastoma, large-cell 1,300 | 6,086
psoriasis 1,277 | 6,514
glioblastoma 1,206 | 5,635
atypical teratoid / rhabdoid tumor 1,071 | 4,971
lung cancer 993 | 4,607
ependymoma 929 | 4,559
group 3 medulloblastoma 882 | 4,002
Breast cancer 755 | 3,469
adult high grade glioma 744 | 3,701
malignant mesothelioma 693 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 689 | 3,204
primitive neuroectodermal tumor 645 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 644 | 2,872
Astrocytoma, Pilocytic 636 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 633 | 2,902
invasive ductal carcinoma 628 | 2,867
non-small cell lung cancer 612 | 2,799
oligodendroglioma 587 | 2,768
lung carcinoma 566 | 2,755
Kidney cancer 562 | 2,548
lung adenocarcinoma 560 | 2,627
Cancer 540 | 2,388
astrocytic glioma 535 | 2,530
pancreatic cancer 502 | 2,322
subependymal giant cell astrocytoma 481 | 2,230
interstitial cystitis 458 | 2,237
Pick disease 428 | 1,856
pituitary cancer 418 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 414 | 1,911
ulcerative colitis 390 | 1,765
tuberculosis 383 | 1,963
Autosomal recessive predisposition 375 | 1,407
ductal carcinoma in situ 372 | 1,686
breast carcinoma 369 | 1,589
group 4 medulloblastoma 368 | 1,806
adrenocortical carcinoma 326 | 1,385
colon cancer 315 | 1,428
diabetes mellitus 315 | 1,683
cystic fibrosis 304 | 1,629
Schizophrenia 279 | 1,136
Multiple myeloma 263 | 1,296
juvenile dermatomyositis 260 | 1,147
Intellectual disability 251 | 998
Rheumatoid arthritis 250 | 1,156
pediatric high grade glioma 246 | 1,035
acute quadriplegic myopathy 239 | 1,133
spina bifida 238 | 1,053
astrocytoma 237 | 1,113
primary pancreatic ductal adenocarcinoma 236 | 1,071
cutaneous lupus erythematosus 225 | 1,016
dermatomyositis 211 | 941
Epilepsy 197 | 775
Atopic dermatitis 194 | 915
nasopharyngeal carcinoma 186 | 1,024
Obesity 180 | 655
acute myeloid leukemia 176 | 760
non primary Sjogren syndrome sicca 170 | 861
active Crohn's disease 169 | 882
esophageal adenocarcinoma 166 | 696
gastric carcinoma 164 | 781
Cognitive delay 162 | 596
Dull intelligence 162 | 634
Global developmental delay 162 | 596
Low intelligence 162 | 634
Mental Retardation 162 | 634
Mental and motor retardation 162 | 596
Mental deficiency 162 | 634
Poor school performance 162 | 634
medulloblastoma 160 | 702
Waldenstrons macroglobulinemia 159 | 742
Liver Cirrhosis, Experimental 158 | 733
primary Sjogren syndrome 158 | 710
Muscle hypotonia 153 | 562
Seizures 152 | 584
Alzheimer's disease 151 | 640
Bipolar Disorder 150 | 646
Melanoma 146 | 689
progressive supranuclear palsy 141 | 656
active ulcerative colitis 140 | 736
aldosterone-producing adenoma 131 | 646
Duchenne muscular dystrophy 127 | 587
Short stature 127 | 514
pancreatic carcinoma 126 | 555
Liver cancer 123 | 589
fibroadenoma 123 | 538
Neurodegenerative disease 122 | 402
Breast Neoplasms 119 | 423
autosomal dominant Emery-Dreifuss muscular dystrophy 119 | 492
Down syndrome 118 | 480
Endometriosis 117 | 521
hepatocellular carcinoma 116 | 536
Mammary Neoplasms 112 | 403
Prostatic Neoplasms 108 | 472
posterior fossa group A ependymoma 107 | 456
Depressive disorder 99 | 401
Parkinson's disease 99 | 378
chronic rhinosinusitis 99 | 505

Tissue

Endocrine System 3,420 | 18,159
Digestive Tract 3,367 | 17,369
Female tissues 3,361 | 17,400
Skin and soft tissues 3,352 | 17,230
Male tissues 3,334 | 17,142
Blood and immune system 3,307 | 16,909
Liver and Pancreas 3,302 | 16,750
Urinary Tract 3,297 | 16,678
Nervous System 3,289 | 16,725
Respiratory system 3,249 | 16,393
Cardiovascular System 3,088 | 15,192

Target Family

Non-IDG 1,882 | 12,091
Enzyme 887 | 4,145
Transcription Factor 167 | 1,400
Kinase 163 | 634
Transporter 98 | 473
Epigenetic 95 | 242
GPCR 82 | 408
Ion Channel 78 | 344
TF/Epigenetic 18 | 38
Nuclear Receptor 15 | 48

Data Source

IMPC 3,485 | 3,485
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
HPM Protein 16,251 | 16,251
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
Somatostatin receptor type 4 SSTR4 Tclin GPCR -1.72615 44.8 147
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Mitogen-activated protein kinase-binding protein 1 MAPKBP1 Tbio Enzyme -0.46630 4.01 51
Prominin-2 PROM2 Tbio Non-IDG -1.12562 11.0 199
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Solute carrier family 22 member 8 SLC22A8 Tclin Transporter -2.40126 258.4 113
Neutrophil gelatinase-associated lipocalin LCN2 Tbio Enzyme -3.35178 2368.1 847
Secreted frizzled-related protein 5 SFRP5 Tbio Non-IDG -1.81796 74.9 180