Development Level

Tbio 2,368 | 11,445
Tdark 551 | 6,588
Tchem 433 | 1,598
Tclin 133 | 613

Collection

RFA-RM-18-021 74 | 328
Kinase: IDG Consortium (Target... 38 | 125
GPCR: IDG Consortium (Targets) 19 | 126
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Complete... 7 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 979 | 979
preweaning lethality, incomple... 499 | 499
abnormal behavior 298 | 298
embryonic lethality prior to t... 278 | 278
embryonic lethality prior to o... 239 | 239
abnormal embryo size 220 | 220
enlarged heart 210 | 210
decreased vertical activity 208 | 208
decreased total body fat amoun... 207 | 207
abnormal bone structure 187 | 187
increased lean body mass 172 | 172
abnormal heart morphology 162 | 162
decreased body weight 161 | 161
decreased bone mineral content 151 | 151
hyperactivity 148 | 148
decreased lean body mass 135 | 135
increased total body fat amoun... 134 | 134
hypoactivity 132 | 132
decreased bone mineral density 126 | 126
decreased circulating glucose ... 126 | 126
male infertility 123 | 123
increased circulating alkaline... 122 | 122
decreased grip strength 116 | 116
abnormal seminal vesicle morph... 114 | 114
increased startle reflex 112 | 112
increased bone mineral content 108 | 108
embryonic growth retardation 106 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 97 | 97
increased mean corpuscular hem... 96 | 96
decreased circulating choleste... 93 | 93
cataract 92 | 92
increased mean corpuscular vol... 92 | 92
prenatal lethality prior to he... 87 | 87
decreased lymphocyte cell numb... 83 | 83
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
abnormal lens morphology 81 | 81
increased circulating HDL chol... 80 | 80
decreased circulating triglyce... 79 | 79
decreased mean corpuscular vol... 79 | 79
improved glucose tolerance 79 | 79
decreased circulating insulin ... 76 | 76
increased fasted circulating g... 76 | 76
decreased startle reflex 75 | 75
impaired glucose tolerance 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
increased bone mineral density 72 | 72
abnormal retina morphology 71 | 71
increased circulating sodium l... 71 | 71
abnormal sleep behavior 70 | 70
abnormal gait 69 | 69
abnormal eye morphology 68 | 68
decreased circulating HDL chol... 68 | 68
decreased hemoglobin content 68 | 68
abnormal behavioral response t... 66 | 66
increased circulating choleste... 66 | 66
abnormal kidney morphology 65 | 65
decreased fasted circulating g... 65 | 65
abnormal coat-hair pigmentatio... 64 | 64
increased monocyte cell number 63 | 63
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
female infertility 60 | 60
edema 59 | 59
small testis 58 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
decreased caudal vertebrae num... 53 | 53
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
abnormal skin morphology 50 | 50
decreased mean corpuscular hem... 50 | 50
decreased circulating total pr... 49 | 49
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
increased leukocyte cell numbe... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased hemoglobin content 45 | 45
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
abnormal epididymis morphology 42 | 42
decreased neutrophil cell numb... 42 | 42
increased circulating triglyce... 42 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased grip strength 41 | 41
limb grasping 41 | 41
decreased circulating creatini... 39 | 39
increased erythrocyte cell num... 39 | 39
tremors 39 | 39
abnormal bone mineralization 38 | 38
prolonged QT interval 38 | 38

Disease

Carcinoma 2,285 | 11,493
ovarian cancer 1,834 | 8,520
osteosarcoma 1,652 | 7,950
medulloblastoma, large-cell 1,341 | 6,241
psoriasis 1,307 | 6,694
glioblastoma 1,239 | 5,792
atypical teratoid / rhabdoid tumor 1,100 | 5,112
lung cancer 1,023 | 4,740
ependymoma 955 | 4,679
group 3 medulloblastoma 904 | 4,104
Breast cancer 770 | 3,578
adult high grade glioma 765 | 3,801
malignant mesothelioma 712 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 709 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 660 | 2,955
primitive neuroectodermal tumor 658 | 3,035
Astrocytoma, Pilocytic 648 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 648 | 2,989
invasive ductal carcinoma 648 | 2,951
non-small cell lung cancer 626 | 2,890
oligodendroglioma 600 | 2,850
lung carcinoma 584 | 2,843
lung adenocarcinoma 578 | 2,716
Kidney cancer 573 | 2,613
Cancer 571 | 2,499
astrocytic glioma 550 | 2,597
pancreatic cancer 514 | 2,398
subependymal giant cell astrocytoma 489 | 2,287
interstitial cystitis 473 | 2,312
Pick disease 440 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 430 | 1,962
pituitary cancer 429 | 1,972
ulcerative colitis 400 | 1,819
tuberculosis 397 | 2,010
Autosomal recessive predisposition 387 | 1,442
ductal carcinoma in situ 385 | 1,745
group 4 medulloblastoma 381 | 1,855
breast carcinoma 379 | 1,638
adrenocortical carcinoma 341 | 1,428
diabetes mellitus 330 | 1,728
colon cancer 324 | 1,478
cystic fibrosis 315 | 1,696
Schizophrenia 286 | 1,160
juvenile dermatomyositis 273 | 1,187
Multiple myeloma 270 | 1,332
Rheumatoid arthritis 259 | 1,191
Intellectual disability 254 | 1,016
pediatric high grade glioma 250 | 1,064
acute quadriplegic myopathy 246 | 1,158
astrocytoma 245 | 1,146
primary pancreatic ductal adenocarcinoma 245 | 1,109
spina bifida 244 | 1,074
cutaneous lupus erythematosus 227 | 1,057
dermatomyositis 219 | 966
Atopic dermatitis 201 | 952
Epilepsy 201 | 792
nasopharyngeal carcinoma 188 | 1,058
Obesity 186 | 678
acute myeloid leukemia 185 | 783
active Crohn's disease 176 | 922
non primary Sjogren syndrome sicca 175 | 891
esophageal adenocarcinoma 172 | 737
gastric carcinoma 169 | 807
Liver Cirrhosis, Experimental 168 | 769
Cognitive delay 164 | 608
Global developmental delay 164 | 608
Mental and motor retardation 164 | 608
Dull intelligence 163 | 645
Low intelligence 163 | 645
Mental Retardation 163 | 645
Mental deficiency 163 | 645
Poor school performance 163 | 645
Waldenstrons macroglobulinemia 162 | 765
medulloblastoma 162 | 720
primary Sjogren syndrome 160 | 735
Alzheimer's disease 157 | 658
Bipolar Disorder 157 | 666
Muscle hypotonia 154 | 571
Seizures 153 | 596
Melanoma 151 | 711
progressive supranuclear palsy 148 | 676
active ulcerative colitis 145 | 764
aldosterone-producing adenoma 137 | 665
Short stature 130 | 531
Duchenne muscular dystrophy 129 | 601
fibroadenoma 128 | 559
pancreatic carcinoma 127 | 562
Neurodegenerative disease 125 | 414
autosomal dominant Emery-Dreifuss muscular dystrophy 125 | 510
Down syndrome 124 | 499
Liver cancer 124 | 604
Breast Neoplasms 122 | 445
hepatocellular carcinoma 120 | 547
Endometriosis 119 | 540
Prostatic Neoplasms 116 | 495
Mammary Neoplasms 115 | 425
posterior fossa group A ependymoma 108 | 468
Parkinson's disease 106 | 392
Depressive disorder 104 | 409
Amyotrophic lateral sclerosis 102 | 451

Tissue

Endocrine System 3,420 | 18,159
Digestive Tract 3,367 | 17,369
Female tissues 3,361 | 17,400
Skin and soft tissues 3,352 | 17,230
Male tissues 3,334 | 17,142
Blood and immune system 3,307 | 16,909
Liver and Pancreas 3,302 | 16,750
Urinary Tract 3,297 | 16,678
Nervous System 3,289 | 16,725
Respiratory system 3,249 | 16,393
Cardiovascular System 3,088 | 15,192

Target Family

Non-IDG 1,882 | 12,091
Enzyme 887 | 4,145
Transcription Factor 167 | 1,400
Kinase 163 | 634
Transporter 98 | 473
Epigenetic 95 | 242
GPCR 82 | 408
Ion Channel 78 | 344
TF/Epigenetic 18 | 38
Nuclear Receptor 15 | 48

Data Source

IMPC 3,485 | 3,485
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Protein 16,251 | 16,251
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
E3 ubiquitin-protein ligase TRIM39 TRIM39 Tbio Enzyme -1.24729 16.2 194
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Serpin B12 SERPINB12 Tbio Non-IDG -0.56624 4.27 155
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Methyl-CpG-binding domain protein 1 MBD1 Tbio Transcription Factor -2.23809 171.1 297
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204