Development Level

Tbio 9,555 | 10,625
Tdark 4,454 | 7,003
Tchem 1,719 | 1,890
Tclin 530 | 602

Collection

Eligible Kinase Proteins 125 | 134
Eligible Ion Channel Proteins 97 | 117
Eligible non-olfactory GPCR Proteins 71 | 145

IMPC Term

preweaning lethality, complete... 599 | 633
preweaning lethality, incomple... 238 | 260
abnormal behavior 213 | 226
decreased lean body mass 183 | 195
embryonic lethality prior to t... 180 | 187
decreased total body fat amoun... 177 | 186
decreased body weight 159 | 174
embryonic lethality prior to o... 143 | 148
decreased bone mineral content 142 | 157
abnormal bone structure 121 | 131
decreased grip strength 116 | 123
decreased bone mineral density 115 | 126
increased circulating alkaline... 115 | 119
increased or absent threshold ... 114 | 128
abnormal embryo size 105 | 112
decreased body length 105 | 108
decreased circulating glucose ... 104 | 121
hyperactivity 103 | 108
increased lean body mass 98 | 107
enlarged heart 94 | 111
abnormal retina morphology 93 | 100
increased mean corpuscular hem... 88 | 93
increased bone mineral content 85 | 92
hypoactivity 82 | 89
increased mean corpuscular vol... 81 | 91
short tibia 80 | 82
decreased circulating choleste... 79 | 85
decreased circulating triglyce... 79 | 83
decreased circulating HDL chol... 74 | 77
decreased circulating serum al... 73 | 79
increased grip strength 71 | 83
abnormal lens morphology 70 | 73
decreased circulating insulin ... 64 | 75
increased circulating sodium l... 63 | 71
increased fasted circulating g... 62 | 68
prenatal lethality prior to he... 61 | 64
male infertility 59 | 62
abnormal sleep behavior 57 | 63
increased sacral vertebrae num... 57 | 62
abnormal retinal pigmentation 56 | 61
decreased lumbar vertebrae num... 56 | 62
increased circulating HDL chol... 55 | 63
decreased leukocyte cell numbe... 53 | 54
improved glucose tolerance 52 | 56
decreased rib number 51 | 59
impaired glucose tolerance 51 | 52
increased total body fat amoun... 51 | 57
abnormal bone mineralization 50 | 55
abnormal coat/hair pigmentatio... 50 | 54
abnormal gait 50 | 51
decreased hemoglobin content 50 | 53
decreased mean corpuscular vol... 50 | 50
abnormal behavioral response t... 49 | 52
increased exploration in new e... 49 | 56
decreased fasted circulating g... 47 | 49
increased bone mineral density 47 | 52
decreased circulating alanine ... 46 | 53
increased circulating choleste... 46 | 53
decreased prepulse inhibition 45 | 52
increased hemoglobin content 45 | 45
decreased caudal vertebrae num... 44 | 49
thrombocytopenia 44 | 46
abnormal heart morphology 43 | 51
decreased startle reflex 41 | 48
decreased circulating alkaline... 40 | 41
decreased erythrocyte cell num... 40 | 43
increased blood urea nitrogen ... 40 | 44
abnormal seminal vesicle morph... 39 | 47
decreased circulating total pr... 39 | 41
increased circulating chloride... 39 | 43
decreased heart weight 38 | 44
increased body weight 38 | 42
increased rib number 37 | 41
decreased circulating LDL chol... 36 | 37
decreased eosinophil cell numb... 36 | 41
abnormal eye morphology 35 | 38
abnormal neural tube closure 34 | 37
decreased circulating free fat... 34 | 39
increased hematocrit 34 | 36
increased startle reflex 34 | 38
cardiovascular system phenotyp... 33 | 35
decreased neutrophil cell numb... 33 | 37
increased heart weight 33 | 37
increased leukocyte cell numbe... 33 | 37
tremors 33 | 34
abnormal spleen morphology 32 | 36
decreased circulating chloride... 32 | 32
decreased circulating calcium ... 31 | 33
decreased mean corpuscular hem... 31 | 34
increased circulating calcium ... 31 | 32
small testis 31 | 37
abnormal cranium morphology 30 | 32
decreased blood urea nitrogen ... 30 | 31
decreased circulating fructosa... 30 | 31
decreased threshold for audito... 30 | 32
increased circulating potassiu... 30 | 31
limb grasping 30 | 35
decreased circulating creatini... 29 | 31
female infertility 29 | 34
embryonic growth retardation 28 | 28

Disease

ovarian cancer 7,828 | 8,492
osteosarcoma 7,204 | 7,933
psoriasis 5,817 | 6,685
medulloblastoma, large-cell 5,672 | 6,234
glioblastoma 5,125 | 5,572
lung cancer 4,145 | 4,473
atypical teratoid / rhabdoid tumor 4,007 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,047 | 3,289
malignant mesothelioma 2,919 | 3,163
Breast cancer 2,847 | 3,099
pilocytic astrocytoma 2,804 | 3,086
primitive neuroectodermal tumor 2,794 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,763 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,740 | 2,956
invasive ductal carcinoma 2,703 | 2,950
oligodendroglioma 2,638 | 2,849
lung carcinoma 2,552 | 2,844
non-small cell lung cancer 2,525 | 2,798
pediatric high grade glioma 2,486 | 2,712
lung adenocarcinoma 2,425 | 2,714
ependymoma 2,330 | 2,514
pancreatic cancer 2,120 | 2,300
subependymal giant cell astrocytoma 2,101 | 2,287
astrocytic glioma 2,076 | 2,241
group 3 medulloblastoma 2,054 | 2,254
Cancer 2,044 | 2,346
interstitial cystitis 2,043 | 2,299
Carcinoma 2,000 | 2,147
adult high grade glioma 1,931 | 2,148
ulcerative colitis 1,898 | 2,087
Pick disease 1,796 | 1,893
pituitary cancer 1,784 | 1,972
group 4 medulloblastoma 1,743 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,707 | 1,795
ductal carcinoma in situ 1,587 | 1,745
cystic fibrosis 1,527 | 1,670
breast carcinoma 1,466 | 1,614
tuberculosis 1,404 | 1,563
medulloblastoma 1,402 | 1,524
astrocytoma 1,401 | 1,493
sonic hedgehog group medulloblastoma 1,377 | 1,482
posterior fossa group B ependymoma 1,359 | 1,530
posterior fossa group A ependymoma 1,357 | 1,511
colon cancer 1,351 | 1,475
diabetes mellitus 1,326 | 1,663
adrenocortical carcinoma 1,303 | 1,427
Multiple myeloma 1,266 | 1,328
primary pancreatic ductal adenocarcinoma 1,188 | 1,271
juvenile dermatomyositis 1,113 | 1,189
acute quadriplegic myopathy 1,100 | 1,157
Rheumatoid Arthritis 1,047 | 1,171
atypical teratoid/rhabdoid tumor 1,010 | 1,095
spina bifida 981 | 1,064
nasopharyngeal carcinoma 955 | 1,056
cutaneous lupus erythematosus 951 | 1,056
dermatomyositis 896 | 967
active Crohn's disease 837 | 918
Atopic dermatitis 827 | 944
gastric carcinoma 765 | 832
non primary Sjogren syndrome sicca 756 | 840
Waldenstrons macroglobulinemia 730 | 765
primary Sjogren syndrome 726 | 789
acute myeloid leukemia 724 | 785
esophageal adenocarcinoma 673 | 737
tuberculosis and treatment for 6 months 637 | 686
progressive supranuclear palsy 634 | 674
aldosterone-producing adenoma 627 | 664
Alzheimer's disease 594 | 644
Duchenne muscular dystrophy 566 | 602
Intellectual disability 547 | 573
Obesity 540 | 616
pancreatic carcinoma 522 | 567
Down syndrome 504 | 548
hepatocellular carcinoma 502 | 550
fibroadenoma 498 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 472 | 499
Endometriosis 467 | 535
chronic rhinosinusitis 458 | 512
Prostatic Neoplasms 441 | 471
Schizophrenia 439 | 503
mucosa-associated lymphoid tissue lymphoma 433 | 480
active ulcerative colitis 429 | 477
IGA Glomerulonephritis 423 | 454
Amyotrophic Lateral Sclerosis 409 | 432
Multiple Sclerosis 406 | 498
gastric cancer 403 | 436
Mammary Neoplasms 371 | 410
Neurodegenerative disease 369 | 383
non-small cell lung carcinoma 363 | 413
inflammatory breast cancer 353 | 404
Kidney disease 335 | 397
Epilepsy 326 | 346
Parkinson's disease 326 | 364
sarcoidosis 324 | 368
glioblastoma multiforme 315 | 347
hereditary spastic paraplegia 309 | 313
Polycystic Ovary Syndrome 306 | 335
nephrosclerosis 301 | 329
tuberculosis and treatment for 3 months 295 | 327
Asthma 288 | 349

Tissue

Female tissues 16,091 | 18,647
Nervous System 16,079 | 18,561
Digestive Tract 16,016 | 18,473
Endocrine System 16,010 | 18,512
Urinary Tract 15,966 | 18,444
Liver and Pancreas 15,899 | 18,136
Male tissues 15,854 | 17,969
Blood and immune system 15,835 | 17,995
Cardiovascular System 15,785 | 17,958
Skin and soft tissues 15,749 | 18,115
Respiratory system 15,461 | 17,484

Target Family

Non-IDG 9,324 | 11,969
Enzyme 3,748 | 4,146
Transcription Factor 1,223 | 1,400
Kinase 604 | 634
Transporter 414 | 473
Ion Channel 292 | 341
GPCR 236 | 408
Epigenetic 229 | 242
oGPCR 104 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

Data Source

HPM Protein 16,258 | 16,258
TCRDv4.6.9 20,120 | 20,120
UniProt 20,120 | 20,120
Consensus 18,976 | 18,976
HCA RNA 18,677 | 18,677
GTEx 18,382 | 18,382
UniProt Tissue 17,991 | 17,991
HPA RNA 17,455 | 17,455
OMA 17,167 | 17,167
JensenLab Knowledge UniProtKB-... 16,668 | 16,668
Inparanoid 16,625 | 16,625
Expression Atlas 16,567 | 16,567
HPM Gene 16,185 | 16,185
EggNOG 15,927 | 15,927
JensenLab Text Mining 14,737 | 14,737
JensenLab Experiment HPA-RNA 13,152 | 13,152
JensenLab Experiment UniGene 12,700 | 12,700
JensenLab Experiment HPA 12,024 | 12,024
JensenLab Experiment RNA-seq 9,979 | 9,979
JAX/MGI Human Ortholog Phenoty... 9,387 | 9,387
JensenLab Experiment Exon arra... 8,764 | 8,764
DisGeNET 7,822 | 7,822
JensenLab Experiment HPM 5,553 | 5,553
GWAS Catalog 5,176 | 5,176
HPA Protein 5,060 | 5,060
JensenLab Experiment GNF 4,987 | 4,987
Monarch 3,825 | 3,825
OMIM 3,644 | 3,644
UniProt Disease 3,349 | 3,349
JensenLab Experiment DistiLD 3,240 | 3,240
IMPC 2,664 | 2,664
JensenLab Knowledge UniProtKB-... 2,162 | 2,162
JensenLab Experiment COSMIC 2,130 | 2,130
JensenLab Knowledge GHR 1,363 | 1,363
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 889 | 889

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
NACHT, LRR and PYD domains-containing protein 14 NLRP14 Tbio Non-IDG -1.33032 17.6 30
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Keratin-associated protein 9-1 KRTAP9-1 Tdark Non-IDG 0.00000 0