Development Level

Tbio 10,002 | 11,178
Tdark 3,999 | 6,569
Tchem 1,713 | 1,885
Tclin 537 | 612

Collection

Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 89 | 99
GPCR: IDG Consortium (Targets) 66 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 933 | 979
preweaning lethality, incomple... 460 | 499
abnormal behavior 271 | 298
embryonic lethality prior to t... 267 | 278
embryonic lethality prior to o... 233 | 239
abnormal embryo size 206 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 180 | 210
decreased vertical activity 176 | 208
abnormal bone structure 171 | 187
increased lean body mass 158 | 172
decreased body weight 146 | 161
abnormal heart morphology 141 | 162
hyperactivity 137 | 148
decreased bone mineral content 131 | 151
decreased lean body mass 122 | 135
increased total body fat amoun... 120 | 134
hypoactivity 119 | 132
increased circulating alkaline... 117 | 122
decreased bone mineral density 113 | 126
male infertility 113 | 123
decreased circulating glucose ... 110 | 126
decreased grip strength 106 | 116
increased startle reflex 105 | 112
embryonic growth retardation 103 | 106
abnormal seminal vesicle morph... 101 | 114
increased bone mineral content 95 | 108
decreased body length 94 | 101
short tibia 94 | 97
increased or absent threshold ... 89 | 101
increased mean corpuscular hem... 88 | 96
cataract 86 | 92
decreased circulating choleste... 86 | 93
prenatal lethality prior to he... 84 | 87
increased mean corpuscular vol... 83 | 92
abnormal lens morphology 79 | 81
decreased circulating triglyce... 76 | 79
increased circulating HDL chol... 76 | 80
decreased lymphocyte cell numb... 75 | 83
decreased prepulse inhibition 75 | 82
decreased circulating serum al... 74 | 82
decreased mean corpuscular vol... 74 | 79
improved glucose tolerance 73 | 79
impaired glucose tolerance 71 | 75
abnormal retina morphology 69 | 71
decreased leukocyte cell numbe... 69 | 73
increased fasted circulating g... 69 | 76
small superior vagus ganglion 68 | 74
abnormal gait 67 | 69
decreased startle reflex 67 | 75
abnormal sleep behavior 65 | 70
decreased circulating insulin ... 65 | 76
increased bone mineral density 63 | 72
abnormal behavioral response t... 62 | 66
decreased circulating HDL chol... 62 | 68
decreased fasted circulating g... 61 | 65
decreased hemoglobin content 61 | 68
increased circulating sodium l... 61 | 71
abnormal eye morphology 60 | 68
increased circulating choleste... 60 | 66
increased heart weight 59 | 62
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 57 | 62
increased monocyte cell number 56 | 63
edema 55 | 59
thrombocytopenia 53 | 56
abnormal kidney morphology 52 | 65
female infertility 52 | 60
decreased caudal vertebrae num... 51 | 53
small testis 51 | 58
abnormal spleen morphology 49 | 55
decreased blood urea nitrogen ... 49 | 51
hydrometra 49 | 53
abnormal skin morphology 46 | 50
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
decreased circulating alkaline... 45 | 46
increased blood urea nitrogen ... 44 | 48
increased hematocrit 44 | 46
increased hemoglobin content 44 | 45
increased mean platelet volume 44 | 45
decreased circulating alanine ... 43 | 47
abnormal neural tube closure 42 | 46
increased neutrophil cell numb... 42 | 46
increased leukocyte cell numbe... 41 | 47
decreased hematocrit 40 | 46
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 40 | 42
decreased red blood cell distr... 38 | 41
enlarged spleen 38 | 41
increased circulating chloride... 38 | 41
increased erythrocyte cell num... 38 | 39
increased grip strength 38 | 41
increased circulating creatini... 37 | 38
prolonged QT interval 37 | 38
tremors 37 | 39
abnormal testis morphology 36 | 43
decreased circulating LDL chol... 36 | 38
limb grasping 36 | 41
abnormal bone mineralization 35 | 38

Disease

Carcinoma 9,949 | 11,192
ovarian cancer 7,638 | 8,297
osteosarcoma 7,034 | 7,766
psoriasis 5,654 | 6,514
medulloblastoma, large-cell 5,532 | 6,086
glioblastoma 5,177 | 5,635
atypical teratoid / rhabdoid tumor 4,560 | 4,971
lung cancer 4,238 | 4,607
ependymoma 4,164 | 4,559
group 3 medulloblastoma 3,687 | 4,002
adult high grade glioma 3,355 | 3,701
Breast cancer 3,184 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,966 | 3,204
malignant mesothelioma 2,884 | 3,135
Astrocytoma, Pilocytic 2,732 | 3,006
primitive neuroectodermal tumor 2,718 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,684 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,657 | 2,872
invasive ductal carcinoma 2,626 | 2,867
oligodendroglioma 2,563 | 2,768
non-small cell lung cancer 2,515 | 2,799
lung carcinoma 2,468 | 2,755
Kidney cancer 2,390 | 2,548
astrocytic glioma 2,347 | 2,530
lung adenocarcinoma 2,337 | 2,627
pancreatic cancer 2,134 | 2,322
Cancer 2,078 | 2,388
subependymal giant cell astrocytoma 2,049 | 2,230
interstitial cystitis 1,975 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,815 | 1,911
Pick disease 1,760 | 1,856
tuberculosis 1,745 | 1,963
pituitary cancer 1,730 | 1,915
group 4 medulloblastoma 1,673 | 1,806
ulcerative colitis 1,600 | 1,765
ductal carcinoma in situ 1,530 | 1,686
cystic fibrosis 1,488 | 1,629
breast carcinoma 1,443 | 1,589
diabetes mellitus 1,343 | 1,683
Autosomal recessive predisposition 1,318 | 1,407
colon cancer 1,306 | 1,428
adrenocortical carcinoma 1,266 | 1,385
Multiple myeloma 1,232 | 1,296
acute quadriplegic myopathy 1,080 | 1,133
juvenile dermatomyositis 1,077 | 1,147
astrocytoma 1,044 | 1,113
Rheumatoid arthritis 1,033 | 1,156
Schizophrenia 1,019 | 1,136
primary pancreatic ductal adenocarcinoma 999 | 1,071
spina bifida 968 | 1,053
Intellectual disability 946 | 998
pediatric high grade glioma 942 | 1,035
nasopharyngeal carcinoma 926 | 1,024
cutaneous lupus erythematosus 913 | 1,016
dermatomyositis 871 | 941
Atopic dermatitis 803 | 915
active Crohn's disease 803 | 882
non primary Sjogren syndrome sicca 776 | 861
Epilepsy 733 | 775
gastric carcinoma 718 | 781
Waldenstrons macroglobulinemia 706 | 742
acute myeloid leukemia 702 | 760
Liver Cirrhosis, Experimental 681 | 733
active ulcerative colitis 659 | 736
primary Sjogren syndrome 653 | 710
esophageal adenocarcinoma 636 | 696
medulloblastoma 633 | 702
Melanoma 631 | 689
progressive supranuclear palsy 616 | 656
aldosterone-producing adenoma 609 | 646
Dull intelligence 607 | 634
Low intelligence 607 | 634
Mental Retardation 607 | 634
Mental deficiency 607 | 634
Poor school performance 607 | 634
Alzheimer's disease 586 | 640
Obesity 578 | 655
Cognitive delay 575 | 596
Global developmental delay 575 | 596
Mental and motor retardation 575 | 596
Bipolar Disorder 571 | 646
Duchenne muscular dystrophy 553 | 587
Seizures 551 | 584
Liver cancer 545 | 589
Muscle hypotonia 545 | 562
pancreatic carcinoma 510 | 555
hepatocellular carcinoma 485 | 536
Short stature 480 | 514
fibroadenoma 480 | 538
autosomal dominant Emery-Dreifuss muscular dystrophy 466 | 492
Endometriosis 457 | 521
chronic rhinosinusitis 451 | 505
Down syndrome 443 | 480
Prostatic Neoplasms 441 | 472
Multiple Sclerosis 432 | 527
mucosa-associated lymphoid tissue lymphoma 423 | 473
sonic hedgehog group medulloblastoma 422 | 459
Skin cancer 420 | 451
Amyotrophic lateral sclerosis 415 | 437
gastric cancer 407 | 445

Tissue

Endocrine System 15,814 | 18,159
Female tissues 15,355 | 17,400
Digestive Tract 15,327 | 17,369
Skin and soft tissues 15,244 | 17,230
Male tissues 15,144 | 17,142
Blood and immune system 14,991 | 16,909
Liver and Pancreas 14,904 | 16,750
Nervous System 14,897 | 16,725
Urinary Tract 14,851 | 16,678
Respiratory system 14,616 | 16,393
Cardiovascular System 13,726 | 15,192

Target Family

Non-IDG 9,319 | 12,091
Enzyme 3,745 | 4,145
Transcription Factor 1,222 | 1,400
Kinase 604 | 634
Transporter 413 | 473
Ion Channel 296 | 344
GPCR 236 | 408
Epigenetic 228 | 242
oGPCR 104 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

Data Source

HPM Protein 16,251 | 16,251
TCRDv5.1.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,347 | 17,347
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,180 | 16,180
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
EggNOG 15,733 | 15,733
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,124 | 15,124
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,144 | 11,144
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,416 | 7,416
CTD 7,231 | 7,231
BioPlex 6,400 | 6,400
Inparanoid 4,784 | 4,784
JensenLab Experiment DistiLD 3,795 | 3,795
Monarch 3,731 | 3,731
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,229 | 2,229
JensenLab Knowledge GHR 2,004 | 2,004
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 896 | 896

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116