Development Level

Tbio 10,242 | 11,445
Tdark 4,013 | 6,588
Tchem 1,458 | 1,598
Tclin 538 | 613

Collection

RFA-RM-18-021 265 | 328
Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 89 | 99
GPCR: IDG Consortium (Targets) 66 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 933 | 979
preweaning lethality, incomple... 460 | 499
abnormal behavior 271 | 298
embryonic lethality prior to t... 267 | 278
embryonic lethality prior to o... 233 | 239
abnormal embryo size 206 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 180 | 210
decreased vertical activity 176 | 208
abnormal bone structure 171 | 187
increased lean body mass 158 | 172
decreased body weight 146 | 161
abnormal heart morphology 141 | 162
hyperactivity 137 | 148
decreased bone mineral content 131 | 151
decreased lean body mass 122 | 135
increased total body fat amoun... 120 | 134
hypoactivity 119 | 132
increased circulating alkaline... 117 | 122
decreased bone mineral density 113 | 126
male infertility 113 | 123
decreased circulating glucose ... 110 | 126
decreased grip strength 106 | 116
increased startle reflex 105 | 112
embryonic growth retardation 103 | 106
abnormal seminal vesicle morph... 101 | 114
increased bone mineral content 95 | 108
decreased body length 94 | 101
short tibia 94 | 97
increased or absent threshold ... 89 | 101
increased mean corpuscular hem... 88 | 96
cataract 86 | 92
decreased circulating choleste... 86 | 93
prenatal lethality prior to he... 84 | 87
increased mean corpuscular vol... 83 | 92
abnormal lens morphology 79 | 81
decreased circulating triglyce... 76 | 79
increased circulating HDL chol... 76 | 80
decreased lymphocyte cell numb... 75 | 83
decreased prepulse inhibition 75 | 82
decreased circulating serum al... 74 | 82
decreased mean corpuscular vol... 74 | 79
improved glucose tolerance 73 | 79
impaired glucose tolerance 71 | 75
abnormal retina morphology 69 | 71
decreased leukocyte cell numbe... 69 | 73
increased fasted circulating g... 69 | 76
small superior vagus ganglion 68 | 74
abnormal gait 67 | 69
decreased startle reflex 67 | 75
abnormal sleep behavior 65 | 70
decreased circulating insulin ... 65 | 76
increased bone mineral density 63 | 72
abnormal behavioral response t... 62 | 66
decreased circulating HDL chol... 62 | 68
decreased fasted circulating g... 61 | 65
decreased hemoglobin content 61 | 68
increased circulating sodium l... 61 | 71
abnormal eye morphology 60 | 68
increased circulating choleste... 60 | 66
increased heart weight 59 | 62
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 57 | 62
increased monocyte cell number 56 | 63
edema 55 | 59
thrombocytopenia 53 | 56
abnormal kidney morphology 52 | 65
female infertility 52 | 60
decreased caudal vertebrae num... 51 | 53
small testis 51 | 58
abnormal spleen morphology 49 | 55
decreased blood urea nitrogen ... 49 | 51
hydrometra 49 | 53
abnormal skin morphology 46 | 50
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
decreased circulating alkaline... 45 | 46
increased blood urea nitrogen ... 44 | 48
increased hematocrit 44 | 46
increased hemoglobin content 44 | 45
increased mean platelet volume 44 | 45
decreased circulating alanine ... 43 | 47
abnormal neural tube closure 42 | 46
increased neutrophil cell numb... 42 | 46
increased leukocyte cell numbe... 41 | 47
decreased hematocrit 40 | 46
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 40 | 42
decreased red blood cell distr... 38 | 41
enlarged spleen 38 | 41
increased circulating chloride... 38 | 41
increased erythrocyte cell num... 38 | 39
increased grip strength 38 | 41
increased circulating creatini... 37 | 38
prolonged QT interval 37 | 38
tremors 37 | 39
abnormal testis morphology 36 | 43
decreased circulating LDL chol... 36 | 38
limb grasping 36 | 41
abnormal bone mineralization 35 | 38

Disease

Carcinoma 10,219 | 11,493
ovarian cancer 7,848 | 8,520
osteosarcoma 7,203 | 7,950
psoriasis 5,814 | 6,694
medulloblastoma, large-cell 5,676 | 6,241
glioblastoma 5,326 | 5,792
atypical teratoid / rhabdoid tumor 4,693 | 5,112
lung cancer 4,366 | 4,740
ependymoma 4,278 | 4,679
group 3 medulloblastoma 3,780 | 4,104
adult high grade glioma 3,449 | 3,801
Breast cancer 3,283 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,048 | 3,291
malignant mesothelioma 2,977 | 3,232
Astrocytoma, Pilocytic 2,803 | 3,081
primitive neuroectodermal tumor 2,794 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,764 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,737 | 2,955
invasive ductal carcinoma 2,705 | 2,951
oligodendroglioma 2,639 | 2,850
non-small cell lung cancer 2,602 | 2,890
lung carcinoma 2,552 | 2,843
Kidney cancer 2,451 | 2,613
lung adenocarcinoma 2,420 | 2,716
astrocytic glioma 2,410 | 2,597
pancreatic cancer 2,204 | 2,398
Cancer 2,177 | 2,499
subependymal giant cell astrocytoma 2,103 | 2,287
interstitial cystitis 2,047 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,865 | 1,962
Pick disease 1,798 | 1,894
tuberculosis 1,785 | 2,010
pituitary cancer 1,784 | 1,972
group 4 medulloblastoma 1,721 | 1,855
ulcerative colitis 1,651 | 1,819
ductal carcinoma in situ 1,586 | 1,745
cystic fibrosis 1,550 | 1,696
breast carcinoma 1,488 | 1,638
diabetes mellitus 1,384 | 1,728
colon cancer 1,352 | 1,478
Autosomal recessive predisposition 1,351 | 1,442
adrenocortical carcinoma 1,304 | 1,428
Multiple myeloma 1,268 | 1,332
juvenile dermatomyositis 1,115 | 1,187
acute quadriplegic myopathy 1,103 | 1,158
astrocytoma 1,074 | 1,146
Rheumatoid arthritis 1,068 | 1,191
Schizophrenia 1,041 | 1,160
primary pancreatic ductal adenocarcinoma 1,034 | 1,109
spina bifida 989 | 1,074
pediatric high grade glioma 970 | 1,064
Intellectual disability 963 | 1,016
nasopharyngeal carcinoma 956 | 1,058
cutaneous lupus erythematosus 951 | 1,057
dermatomyositis 896 | 966
active Crohn's disease 839 | 922
Atopic dermatitis 836 | 952
non primary Sjogren syndrome sicca 806 | 891
Epilepsy 749 | 792
gastric carcinoma 741 | 807
Waldenstrons macroglobulinemia 729 | 765
acute myeloid leukemia 724 | 783
Liver Cirrhosis, Experimental 717 | 769
active ulcerative colitis 683 | 764
primary Sjogren syndrome 678 | 735
esophageal adenocarcinoma 673 | 737
Melanoma 651 | 711
medulloblastoma 651 | 720
progressive supranuclear palsy 636 | 676
aldosterone-producing adenoma 627 | 665
Dull intelligence 617 | 645
Low intelligence 617 | 645
Mental Retardation 617 | 645
Mental deficiency 617 | 645
Poor school performance 617 | 645
Alzheimer's disease 604 | 658
Obesity 601 | 678
Bipolar Disorder 590 | 666
Cognitive delay 586 | 608
Global developmental delay 586 | 608
Mental and motor retardation 586 | 608
Duchenne muscular dystrophy 567 | 601
Seizures 562 | 596
Liver cancer 559 | 604
Muscle hypotonia 554 | 571
pancreatic carcinoma 517 | 562
fibroadenoma 499 | 559
hepatocellular carcinoma 496 | 547
Short stature 495 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 483 | 510
Endometriosis 474 | 540
Down syndrome 462 | 499
Prostatic Neoplasms 462 | 495
chronic rhinosinusitis 458 | 512
Multiple Sclerosis 444 | 540
Skin cancer 438 | 469
mucosa-associated lymphoid tissue lymphoma 434 | 484
sonic hedgehog group medulloblastoma 430 | 467
Amyotrophic lateral sclerosis 429 | 451
gastric cancer 421 | 459

Tissue

Endocrine System 15,814 | 18,159
Female tissues 15,355 | 17,400
Digestive Tract 15,327 | 17,369
Skin and soft tissues 15,244 | 17,230
Male tissues 15,144 | 17,142
Blood and immune system 14,991 | 16,909
Liver and Pancreas 14,904 | 16,750
Nervous System 14,897 | 16,725
Urinary Tract 14,851 | 16,678
Respiratory system 14,616 | 16,393
Cardiovascular System 13,726 | 15,192

Target Family

Non-IDG 9,319 | 12,091
Enzyme 3,745 | 4,145
Transcription Factor 1,222 | 1,400
Kinase 604 | 634
Transporter 413 | 473
Ion Channel 296 | 344
GPCR 236 | 408
Epigenetic 228 | 242
oGPCR 104 | 421
Nuclear Receptor 47 | 48
TF/Epigenetic 37 | 38

Data Source

HPM Protein 16,251 | 16,251
TCRDv5.4.0 20,244 | 20,244
UniProt 20,244 | 20,244
HCA RNA 18,868 | 18,868
GTEx 18,679 | 18,679
Consensus 18,503 | 18,503
HPA RNA 18,499 | 18,499
UniProt Tissue 17,989 | 17,989
OMA 17,919 | 17,919
Inparanoid 17,402 | 17,402
JensenLab Experiment HPA-RNA 16,979 | 16,979
JensenLab Knowledge UniProtKB-... 16,759 | 16,759
Expression Atlas 16,585 | 16,585
EggNOG 16,566 | 16,566
HPM Gene 16,026 | 16,026
JensenLab Experiment RNA-seq 15,916 | 15,916
JensenLab Experiment HPM 15,886 | 15,886
JensenLab Experiment HPA 15,665 | 15,665
JensenLab Text Mining 15,169 | 15,169
JensenLab Experiment UniGene 14,935 | 14,935
JensenLab Experiment Exon arra... 13,611 | 13,611
JensenLab Experiment COSMIC 11,445 | 11,445
JensenLab Experiment GNF 10,637 | 10,637
HPA Protein 10,414 | 10,414
GWAS Catalog 10,255 | 10,255
JAX/MGI Human Ortholog Phenoty... 9,720 | 9,720
DisGeNET 7,631 | 7,631
CTD 7,446 | 7,446
BioPlex 6,400 | 6,400
JensenLab Experiment DistiLD 3,914 | 3,914
Monarch 3,826 | 3,826
OMIM 3,731 | 3,731
IMPC 3,485 | 3,485
JensenLab Knowledge UniProtKB-... 2,279 | 2,279
JensenLab Knowledge GHR 2,052 | 2,052
Reactome 1,920 | 1,920
Cell Surface Protein Atlas 1,038 | 1,038
DrugCentral Indication 910 | 910

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C Tbio Non-IDG -2.61667 619.4 0
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22